BR112016002646B1 - Dispositivo intravesical de entrega de fármaco - Google Patents

Dispositivo intravesical de entrega de fármaco Download PDF

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Publication number
BR112016002646B1
BR112016002646B1 BR112016002646-2A BR112016002646A BR112016002646B1 BR 112016002646 B1 BR112016002646 B1 BR 112016002646B1 BR 112016002646 A BR112016002646 A BR 112016002646A BR 112016002646 B1 BR112016002646 B1 BR 112016002646B1
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BR
Brazil
Prior art keywords
drug
housing
unit
release
reservoir
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BR112016002646-2A
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English (en)
Portuguese (pt)
Other versions
BR112016002646A2 (pt
Inventor
Heejin Lee
Karen Daniel
Matthew Sansone
Original Assignee
Taris Biomedical Llc
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Publication date
Application filed by Taris Biomedical Llc filed Critical Taris Biomedical Llc
Publication of BR112016002646A2 publication Critical patent/BR112016002646A2/pt
Publication of BR112016002646B1 publication Critical patent/BR112016002646B1/pt

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2004Excipients; Inactive ingredients
    • A61K9/2013Organic compounds, e.g. phospholipids, fats
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L31/16Biologically active materials, e.g. therapeutic substances
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M31/00Devices for introducing or retaining media, e.g. remedies, in cavities of the body
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12Carboxylic acids; Salts or anhydrides thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0002Galenical forms characterised by the drug release technique; Application systems commanded by energy
    • A61K9/0004Osmotic delivery systems; Sustained release driven by osmosis, thermal energy or gas
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0034Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2004Excipients; Inactive ingredients
    • A61K9/2022Organic macromolecular compounds
    • A61K9/2027Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/04Macromolecular materials
    • A61L31/048Macromolecular materials obtained by reactions only involving carbon-to-carbon unsaturated bonds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/08Materials for coatings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M31/00Devices for introducing or retaining media, e.g. remedies, in cavities of the body
    • A61M31/002Devices for releasing a drug at a continuous and controlled rate for a prolonged period of time
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M31/00Devices for introducing or retaining media, e.g. remedies, in cavities of the body
    • A61M31/007Injectors for solid bodies, e.g. suppositories
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/02Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/10Drugs for disorders of the urinary system of the bladder
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0087Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0092Hollow drug-filled fibres, tubes of the core-shell type, coated fibres, coated rods, microtubules or nanotubes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2210/00Anatomical parts of the body
    • A61M2210/10Trunk
    • A61M2210/1078Urinary tract
    • A61M2210/1085Bladder

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Surgery (AREA)
  • Vascular Medicine (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Anesthesiology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Gynecology & Obstetrics (AREA)
  • Reproductive Health (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Nanotechnology (AREA)
  • Biophysics (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Media Introduction/Drainage Providing Device (AREA)
  • Materials For Medical Uses (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
BR112016002646-2A 2013-08-19 2014-08-19 Dispositivo intravesical de entrega de fármaco BR112016002646B1 (pt)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201361867245P 2013-08-19 2013-08-19
US61/867,245 2013-08-19
US201361877610P 2013-09-13 2013-09-13
US61/877,610 2013-09-13
PCT/US2014/051672 WO2015026813A1 (en) 2013-08-19 2014-08-19 Multi-unit drug delivery devices and methods

Publications (2)

Publication Number Publication Date
BR112016002646A2 BR112016002646A2 (pt) 2017-08-01
BR112016002646B1 true BR112016002646B1 (pt) 2022-01-25

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ID=51422208

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112016002646-2A BR112016002646B1 (pt) 2013-08-19 2014-08-19 Dispositivo intravesical de entrega de fármaco

Country Status (25)

Country Link
US (3) US10729823B2 (enExample)
EP (3) EP3736015B1 (enExample)
JP (5) JP6486359B2 (enExample)
KR (3) KR102488491B1 (enExample)
CN (3) CN113413537A (enExample)
AU (3) AU2014309012B2 (enExample)
BR (1) BR112016002646B1 (enExample)
CA (2) CA2919215C (enExample)
CY (1) CY1123474T1 (enExample)
DK (1) DK3035991T3 (enExample)
ES (2) ES2817838T3 (enExample)
HR (1) HRP20201421T1 (enExample)
HU (1) HUE051336T2 (enExample)
IL (3) IL299897B2 (enExample)
LT (1) LT3035991T (enExample)
MX (2) MX386955B (enExample)
PL (1) PL3035991T3 (enExample)
PT (1) PT3035991T (enExample)
RS (1) RS60847B1 (enExample)
RU (1) RU2687596C2 (enExample)
SG (2) SG11201600856RA (enExample)
SI (1) SI3035991T1 (enExample)
SM (1) SMT202000472T1 (enExample)
WO (1) WO2015026813A1 (enExample)
ZA (2) ZA201600788B (enExample)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104812395A (zh) 2012-08-31 2015-07-29 塔里斯生物医药公司 用于治疗前列腺的药物递送系统和方法
ES2902833T3 (es) 2012-08-31 2022-03-30 Taris Biomedical Llc Sistemas y métodos de administración de fármacos para el tratamiento de cáncer de vejiga que comprenden oxaliplatino
US10137287B2 (en) 2013-03-05 2018-11-27 Taris Biomedical Llc Drug delivery devices and methods for controlled drug release through device orifice
MX391755B (es) 2013-03-15 2025-03-21 Taris Biomedical Llc Dispositivos de administración de medicamentos y métodos para administración de medicamentos.
RS67337B1 (sr) 2014-03-06 2025-11-28 Taris Biomedical Llc Sistemi za isporuku leka i metode za lečenje karcinoma bešike gemcitabinom
PL3142740T3 (pl) 2014-05-12 2021-06-14 Taris Biomedical Llc Urządzenia do dostarczania leku
CN114306899A (zh) 2014-06-26 2022-04-12 塔里斯生物医药公司 包含弹性聚合物-药物基质系统的膀胱内药物递送装置及方法
ES2734394T3 (es) 2015-03-30 2019-12-05 Taris Biomedical Llc Dispositivos para la administración local fármacos al tracto urinario superior
KR102658706B1 (ko) * 2015-04-23 2024-04-17 타리스 바이오메디컬 엘엘씨 약물-투과성 성분을 구비한 약물 전달 장치 및 방법
US20180117219A1 (en) * 2015-04-29 2018-05-03 Northwestern University 3d printing of biomedical implants
CN105056376A (zh) * 2015-08-21 2015-11-18 崔尚品 一种治疗宫颈炎和宫颈hpv感染的医疗器械
WO2017151983A1 (en) * 2016-03-02 2017-09-08 Taris Biomedical Llc Osmotic drug delivery devices and methods of making osmotic drug delivery devices
WO2017193098A1 (en) 2016-05-06 2017-11-09 Taris Biomedical Llc Method of treating lower tract urothelial cancer
PT3432970T (pt) * 2017-02-01 2021-05-26 Taris Biomedical Llc Dispositivos de administração de fármaco in vivo
BR112020000832A2 (pt) 2017-07-25 2020-07-21 Taris Biomedical Llc métodos para tratar metástase tumoral
IL274343B2 (en) 2017-11-08 2023-10-01 Taris Biomedical Llc Treatment methods and maintenance treatment for bladder cancer using gemcitabine
MX2021001264A (es) 2018-08-01 2021-07-02 Taris Biomedical Llc Métodos para tratar la vejiga hiperactiva con el uso de trospio.
JP7624269B2 (ja) * 2018-11-09 2025-01-30 タリス バイオメディカル エルエルシー 上部尿路への局所薬物送達のための薬物送達装置及びシステム
US12433597B2 (en) * 2019-06-04 2025-10-07 Trisalus Life Sciences, Inc. Atraumatic occlusive system with compartment for measurement of vascular pressure change
WO2023122058A1 (en) 2021-12-21 2023-06-29 Taris Biomedical Llc Urinary placement catheter for intravesical devices
WO2024092159A1 (en) 2022-10-28 2024-05-02 Taris Biomedical Llc Methods of treating bladder cancer with gemcitabine
AU2024249710A1 (en) 2023-04-10 2025-11-20 Taris Biomedical Llc Gemcitabine for use in methods of treating high-risk non-muscle invasive bladder cancer unresponsive to bacillus calmette-guerin therapy
WO2025076007A1 (en) 2023-10-02 2025-04-10 Taris Biomedical Llc Methods of treating high-risk non-muscle invasive bladder cancer unresponsive to bacillus calmette-guérin therapy

Family Cites Families (185)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3089815A (en) 1951-10-11 1963-05-14 Lieb Hans Injectable pharmaceutical preparation, and a method of making same
US3854480A (en) 1969-04-01 1974-12-17 Alza Corp Drug-delivery system
US3625214A (en) 1970-05-18 1971-12-07 Alza Corp Drug-delivery device
US3675648A (en) 1970-08-05 1972-07-11 Alza Corp Intrauterine contraceptive device
US3675647A (en) 1970-08-05 1972-07-11 Alza Corp Intrauterine contraceptive device
US3710795A (en) 1970-09-29 1973-01-16 Alza Corp Drug-delivery device with stretched, rate-controlling membrane
US3948254A (en) * 1971-11-08 1976-04-06 Alza Corporation Novel drug delivery device
US4016251A (en) 1972-08-17 1977-04-05 Alza Corporation Vaginal drug dispensing device
US3888975A (en) 1972-12-27 1975-06-10 Alza Corp Erodible intrauterine device
US3916899A (en) * 1973-04-25 1975-11-04 Alza Corp Osmotic dispensing device with maximum and minimum sizes for the passageway
US3901232A (en) 1973-10-26 1975-08-26 Alza Corp Integrated device for administering beneficial drug at programmed rate
US3935860A (en) 1974-08-21 1976-02-03 Alza Corporation Intrauterine device with restrictor for maintaining device in uterine cavity
US4111203A (en) * 1976-11-22 1978-09-05 Alza Corporation Osmotic system with means for improving delivery kinetics of system
US4111202A (en) * 1976-11-22 1978-09-05 Alza Corporation Osmotic system for the controlled and delivery of agent over time
US4210139A (en) * 1979-01-17 1980-07-01 Alza Corporation Osmotic device with compartment for governing concentration of agent dispensed from device
US4235236A (en) 1979-02-12 1980-11-25 Alza Corporation Device for dispensing drug by combined diffusional and osmotic operations
US4392848A (en) 1979-06-25 1983-07-12 The Procter & Gamble Company Catheterization
US4309996A (en) 1980-04-28 1982-01-12 Alza Corporation System with microporous releasing diffusor
US4326522A (en) 1980-06-09 1982-04-27 Pitman-Moore, Inc. Mesh-covered bolus
AU538961B2 (en) 1980-06-09 1984-09-06 Alex Harvey Industries Limited Intra-vaginal device
US4327725A (en) 1980-11-25 1982-05-04 Alza Corporation Osmotic device with hydrogel driving member
US4475916A (en) 1982-03-18 1984-10-09 Merck & Co., Inc. Osmotic drug delivery system
US4519801A (en) * 1982-07-12 1985-05-28 Alza Corporation Osmotic device with wall comprising cellulose ether and permeability enhancer
US4629449A (en) 1982-07-29 1986-12-16 Alza Corporation Vaginal dispenser for dispensing beneficial hormone
US5366738A (en) 1982-07-29 1994-11-22 Merck & Co., Inc. Controlled release drug dispersion delivery device
US4578075A (en) 1982-12-20 1986-03-25 Alza Corporation Delivery system housing a plurality of delivery devices
US4681583A (en) 1982-12-20 1987-07-21 Alza Corporation System for dispersing drug in biological environment
US4655219A (en) 1983-07-22 1987-04-07 American Hospital Supply Corporation Multicomponent flexible grasping device
DE3332156A1 (de) 1983-09-06 1985-03-21 Peter 6000 Frankfurt Prezelj Nasenspange
GB8328916D0 (en) 1983-10-28 1983-11-30 Castex Prod Pharmaceutical pellet
GB8403138D0 (en) 1984-02-07 1984-03-14 Graham N B Sustained release of active ingredient
NZ207341A (en) 1984-03-01 1988-02-29 Harvey Alex Ind Ltd Device containing chemical impregnants for insertion into a body cavity of an animal
US4968507A (en) 1984-06-20 1990-11-06 Merck & Co., Inc. Controlled porosity osmotic pump
CH667209A5 (de) 1985-07-02 1988-09-30 Sulzer Ag Medizinische depotsonde.
US5008112A (en) * 1985-12-16 1991-04-16 International Minerals & Chem. Corporation Device for the extended delivery of diffusible agents
US4871542A (en) 1987-04-30 1989-10-03 Ferring Service Center, N.V. Method and apparatus useful for delivering medicinal compositions into the bladder and urinary tract
US5340590A (en) * 1987-06-25 1994-08-23 Alza Corporation Delivery system with bilayer osmotic engine
US4936074A (en) * 1988-11-17 1990-06-26 D. M. Graham Laboratories, Inc. Process for preparing solid encapsulated medicament
US5057318A (en) * 1988-12-13 1991-10-15 Alza Corporation Delivery system for beneficial agent over a broad range of rates
US5545208A (en) 1990-02-28 1996-08-13 Medtronic, Inc. Intralumenal drug eluting prosthesis
US5324280A (en) * 1990-04-02 1994-06-28 Alza Corporation Osmotic dosage system for delivering a formulation comprising liquid carrier and drug
WO1993006792A1 (en) 1991-10-04 1993-04-15 Scimed Life Systems, Inc. Biodegradable drug delivery vascular stent
US5879920A (en) 1991-10-07 1999-03-09 Genencor International, Inc. Coated enzyme-containing granule
AU2867492A (en) 1991-10-10 1993-05-03 Alza Corporation Osmotic drug delivery devices with hydrophobic wall materials
US5441550A (en) 1992-03-26 1995-08-15 The University Of Tennessee Research Corporation Post-treatment of laminated nonwoven cellulosic fiber webs
US5499997A (en) 1992-04-10 1996-03-19 Sharpe Endosurgical Corporation Endoscopic tenaculum surgical instrument
DE69329407T2 (de) 1992-06-02 2001-05-03 Bard Inc C R Verfahren und Implantatvorrichtung für Langzeitwirkstoffabgabe
US5523092A (en) 1993-04-14 1996-06-04 Emory University Device for local drug delivery and methods for using the same
US5458887A (en) * 1994-03-02 1995-10-17 Andrx Pharmaceuticals, Inc. Controlled release tablet formulation
US5516522A (en) 1994-03-14 1996-05-14 Board Of Supervisors Of Louisiana State University Biodegradable porous device for long-term drug delivery with constant rate release and method of making the same
IL116433A (en) 1994-12-19 2002-02-10 Galen Chemicals Ltd INTRAVAGINAL DRUG DELIVERY DEVICES FOR THE ADMINISTRATION OF 17β-OESTRADIOL PRECURSORS
US5817335A (en) * 1995-05-26 1998-10-06 Alza Corporation Osmotic device with high drug loading and delayed activation of drug delivery
GB9522403D0 (en) 1995-11-01 1996-01-03 Hoechst Roussel Ltd Intravaginal drug delivery device
EP1249229A3 (en) 1996-02-02 2005-02-02 ALZA Corporation Sustained delivery of an active agent using an implantable system
US6156331A (en) * 1996-02-02 2000-12-05 Alza Corporation Sustained delivery of an active agent using an implantable system
US6171298B1 (en) 1996-05-03 2001-01-09 Situs Corporation Intravesical infuser
GB9610862D0 (en) 1996-05-23 1996-07-31 Evans Brian K Pharmaceutical products
US20070161967A1 (en) * 1996-06-04 2007-07-12 Vance Products Inc., Dba Cook Urological Inc. Implantable medical device with pharmacologically active ingredient
US5869081A (en) 1996-06-28 1999-02-09 The Population Council Progesterone vaginal ring for treatment of infertility
US5797898A (en) 1996-07-02 1998-08-25 Massachusetts Institute Of Technology Microchip drug delivery devices
US5972372A (en) 1996-07-31 1999-10-26 The Population Council, Inc. Intravaginal rings with insertable drug-containing core
US5868719A (en) 1997-01-15 1999-02-09 Boston Scientific Corporation Drug delivery balloon catheter device
US5830230A (en) 1997-03-07 1998-11-03 Micro Therapeutics, Inc. Method of intracranial vascular embolotherapy using self anchoring coils
KR20010006027A (ko) 1997-04-03 2001-01-15 포인트 바이오메디칼 코퍼레이션 방광내 약물 송달 시스템
IL123813A0 (en) 1997-04-11 1998-10-30 Akzo Nobel Nv Drug delivery system for two or more active substances
JP2001524124A (ja) 1997-05-07 2001-11-27 ガレン(ケミカルズ)リミティド テストステロンおよびテストステロン前駆体の投与のための膣内薬物送達用具
US6444224B1 (en) 1997-05-28 2002-09-03 Interag Intra-vaginal device for pigs
US6197327B1 (en) 1997-06-11 2001-03-06 Umd, Inc. Device and method for treatment of dysmenorrhea
US6039968A (en) 1997-06-24 2000-03-21 Hoechst Marion Roussel Intravaginal drug delivery device
US5820230A (en) 1997-06-27 1998-10-13 Freeman; Ernie Yieldable debris cutter
DE69724942D1 (de) 1997-07-04 2003-10-23 Thomson Tubes & Displays Farbbildröhre mit einer in-line Elektronenkanone
US6267761B1 (en) 1997-09-09 2001-07-31 Sherwood Services Ag Apparatus and method for sealing and cutting tissue
WO1999018884A1 (en) 1997-10-10 1999-04-22 Duirs Nz Limited Drug delivery system
US6749617B1 (en) 1997-11-04 2004-06-15 Scimed Life Systems, Inc. Catheter and implants for the delivery of therapeutic agents to tissues
US20060141036A1 (en) * 1997-12-12 2006-06-29 Andrx Labs Llc HMG-CoA reductase inhibitor extended release formulation
DE69834213T2 (de) * 1997-12-31 2007-01-25 Alza Corp., Mountain View Osmotisches Abgabesystem für ein nützliches Mittel
US6183461B1 (en) 1998-03-11 2001-02-06 Situs Corporation Method for delivering a medication
US6482837B1 (en) 1998-04-24 2002-11-19 University Of Rochester Antimuscarinic compounds and methods for treatment of bladder diseases
CN1272785A (zh) * 1998-06-11 2000-11-08 Em工业股份有限公司 微渗透药物控释系统
US6464999B1 (en) 1998-06-17 2002-10-15 Galt Incorporated Bioadhesive medical devices
US6159143A (en) 1998-06-17 2000-12-12 Scimed Life Systems, Inc. Method and device for delivery of therapeutic agents in conjunction with isotope seed placement
US6168801B1 (en) 1998-09-09 2001-01-02 Cardiac Pacemakers, Inc. Controlled release drug delivery
AU1853400A (en) 1999-01-06 2000-07-24 Richard Henry Topical anesthesia of the urinary bladder
US6293923B1 (en) 1999-03-15 2001-09-25 Innoventions, Inc. Intravesicular balloon
US6083933A (en) 1999-04-19 2000-07-04 Stellar International Inc. Treatment of cystitis-like symptoms with chondroitin sulfate following administration of a challenge solution
US6139535A (en) 1999-05-27 2000-10-31 Situs Corporation Method and apparatus for placement and activation of a medical device within a body cavity
DE60041825D1 (de) 1999-11-17 2009-04-30 Boston Scient Ltd Miniaturisierte vorrichtungen zur abgabe von molekülen in einer trägerflüssigkeit
JP2003516343A (ja) 1999-12-10 2003-05-13 マサチューセッツ インスティテュート オブ テクノロジー 分子を送達するマイクロチップ素子およびその製作方法
US20050238733A1 (en) 2000-01-05 2005-10-27 Richard Henry Topical anesthesia of the urinary bladder
US6753011B2 (en) 2000-01-14 2004-06-22 Osmotica Corp Combined diffusion/osmotic pumping drug delivery system
WO2001054688A1 (en) * 2000-01-28 2001-08-02 Merck & Co., Inc. Treatment or prevention of prostate cancer with a cox-2 selective inhibiting drug
US6379382B1 (en) 2000-03-13 2002-04-30 Jun Yang Stent having cover with drug delivery capability
US6682473B1 (en) 2000-04-14 2004-01-27 Solace Therapeutics, Inc. Devices and methods for attenuation of pressure waves in the body
US6988983B2 (en) 2000-04-14 2006-01-24 Solace Therapeutics, Inc. Implantable self-inflating attenuation device
US6375972B1 (en) 2000-04-26 2002-04-23 Control Delivery Systems, Inc. Sustained release drug delivery devices, methods of use, and methods of manufacturing thereof
US7232421B1 (en) 2000-05-12 2007-06-19 C. R. Bard, Inc. Agent delivery systems
US6730072B2 (en) 2000-05-30 2004-05-04 Massachusetts Institute Of Technology Methods and devices for sealing microchip reservoir devices
US6398718B1 (en) 2000-06-15 2002-06-04 Innoventions, Inc. Intravesicular device
GB0015617D0 (en) 2000-06-26 2000-08-16 Vectura Ltd Improved preparations for dermal delivery of active substances
AU2001280597A1 (en) 2000-07-17 2002-01-30 Guilford Pharmaceuticals Inc. Compositions for sustained release of analgesic agents, and methods of making and using the same
DE60141145D1 (enExample) 2000-08-24 2010-03-11 Sidney Lerner
US6752829B2 (en) 2001-01-30 2004-06-22 Scimed Life Systems, Inc. Stent with channel(s) for containing and delivering a biologically active material and method for manufacturing the same
DE10104369A1 (de) 2001-02-01 2002-08-08 Boehringer Ingelheim Pharma Verwendung von 2-Amino-(4-hydroxy-2-methansulfonamidophenyl)ethanol zur Behandlung der Harninkontinenz
CA2442281C (en) 2001-03-27 2010-06-08 Galen (Chemicals) Limited Intravaginal drug delivery devices for the administration of an antimicrobial agent
US6632217B2 (en) 2001-04-19 2003-10-14 Microsolutions, Inc. Implantable osmotic pump
US6973718B2 (en) 2001-05-30 2005-12-13 Microchips, Inc. Methods for conformal coating and sealing microchip reservoir devices
AU2002326304A1 (en) 2001-05-31 2002-12-16 Massachusetts Institute Of Technology Microchip devices with improved reservoir opening
US7438701B2 (en) 2001-07-26 2008-10-21 Durect Corporation Local concentration management system
WO2003028660A2 (en) 2001-10-04 2003-04-10 Case Western Reserve University Drug delivery devices and methods
US7722894B2 (en) 2001-10-22 2010-05-25 Massachusetts Institute Of Technology Biodegradable polymer
US7005138B2 (en) 2001-12-21 2006-02-28 Duramed Pharmaceuticals, Inc. Method of systematically delivering SSRIs
US7473273B2 (en) 2002-01-22 2009-01-06 Medtronic Vascular, Inc. Stent assembly with therapeutic agent exterior banding
US8685427B2 (en) 2002-07-31 2014-04-01 Boston Scientific Scimed, Inc. Controlled drug delivery
GB2385273B (en) 2002-02-13 2004-05-26 Deborah Huang Drug delivery device
US6899890B2 (en) 2002-03-20 2005-05-31 Kv Pharmaceutical Company Bioadhesive drug delivery system
US8216609B2 (en) 2002-08-05 2012-07-10 Torrent Pharmaceuticals Limited Modified release composition of highly soluble drugs
DE10247689A1 (de) 2002-10-12 2004-04-22 Martin Rahe Implantat in der Harnblase
US7504387B2 (en) 2002-10-16 2009-03-17 Arthrodynamic Technologies, Animal Health Division, Inc. Glycosaminoglycan composition and method for treatment and prevention of interstitial cystitis
EP1553899A4 (en) 2002-10-22 2006-10-25 METHOD AND SYSTEM FOR INTRAVASCULAR DELIVERY OF THERAPEUTIC AGENTS
US7014636B2 (en) 2002-11-21 2006-03-21 Alza Corporation Osmotic delivery device having a two-way valve and a dynamically self-adjusting flow channel
AU2003301005A1 (en) 2002-12-16 2004-07-22 The Regents Of The University Of Michigan Assembly and planar structure for use therein which is expandable into a 3-d structure such as a stent and device for making the planar structure
DE60324192D1 (de) 2002-12-23 2008-11-27 Medtronic Inc Implantierbare austragesysteme für arzneien
CA2520610A1 (en) 2003-03-31 2004-10-21 Alza Corporation Osmotic pump with means for dissipating internal pressure
US7598287B2 (en) * 2003-04-01 2009-10-06 Medical College Of Georgia Research Institute, Inc. Use of inhibitors of indoleamine-2,3-dioxygenase in combination with other therapeutic modalities
US20050186289A1 (en) * 2003-04-01 2005-08-25 Medical College Of Georgia Research Institute, Inc. Regulation of T cell-mediated immunity by D isomers of inhibitors of indoleamine-2,3-dioxygenase
DE10323278A1 (de) * 2003-05-21 2004-12-16 Stada Arzneimittel Ag Gebrauchsfertige Gemcitabin-Lösungskonzentrate
US20040249364A1 (en) 2003-06-03 2004-12-09 Ilya Kaploun Device and method for dispensing medication to tissue lining a body cavity
WO2005018697A2 (en) 2003-08-13 2005-03-03 Medtronic, Inc. Active agent delivery systems, including a single layer of a miscible polymer blend, medical devices, and methods
US20050228482A1 (en) 2003-09-26 2005-10-13 William Herzog Stent covered by a layer having a layer opening
CA2538043A1 (en) 2003-09-30 2005-04-14 Alza Corporation Osmotically driven active agent delivery device providing an ascending release profile
DE10359828A1 (de) 2003-12-12 2005-07-28 Zoser B. Dr.Rer.Nat. Salama CHP-Gemcitabin- Kombinationsmittel und ihre Verwendung als Antitumorwirkstoffe, insbesondere Antimetastasierungswirkstoffe
PL1708722T3 (pl) 2004-01-28 2014-10-31 Univ California Nowa śródmiąższowa terapia dla natychmiastowego złagodzenia objawów i przewlekła terapia śródmiąższowego zapalenia pęcherza
EP1718359B1 (en) 2004-02-10 2011-11-23 Synecor, LLC Intravascular delivery system for therapeutic agents
US7647112B2 (en) 2004-02-11 2010-01-12 Ethicon, Inc. System and method for selectively stimulating different body parts
US20080102119A1 (en) * 2006-11-01 2008-05-01 Medtronic, Inc. Osmotic pump apparatus and associated methods
WO2005115245A1 (en) 2004-05-28 2005-12-08 Dynaventions Inc. Intravesicular device
CN1976751A (zh) 2004-06-28 2007-06-06 H.隆德贝克有限公司 释放化学物质的多孔物品
US8361490B2 (en) 2004-09-16 2013-01-29 Theracoat Ltd. Biocompatible drug delivery apparatus and methods
WO2006079055A2 (en) 2005-01-24 2006-07-27 Neurosystec Corporation Apparatus and method for delivering therapeutic and/or other agents to the inner ear and to other tissues
AU2006236272B2 (en) 2005-04-20 2011-05-19 Cook Medical Technologies Llc Medical apparatus for rapid insertion
US7862552B2 (en) 2005-05-09 2011-01-04 Boston Scientific Scimed, Inc. Medical devices for treating urological and uterine conditions
US20080187590A1 (en) * 2005-06-08 2008-08-07 Kari Vahervuo Oral Dosage Form
EP1933810B1 (en) 2005-08-11 2012-10-10 Massachusetts Institute of Technology Intravesical drug delivery device and method
KR101054248B1 (ko) 2005-09-02 2011-08-08 테라비다, 인코포레이티드 질환 치료용 요법
PL116330U1 (en) * 2005-10-31 2007-04-02 Alza Corp Method for the reduction of alcohol provoked rapid increase in the released dose of the orally administered opioide with prolonged liberation
US20090186081A1 (en) 2006-01-05 2009-07-23 Lifecycle Pharma A/S Disintegrating Loadable Tablets
US20070172508A1 (en) 2006-01-26 2007-07-26 Paul Zupkas Transluminal drug delivery methods and devices
US20070172507A1 (en) 2006-01-26 2007-07-26 Paul Zupkas Transluminal drug delivery methods and devices
EP2001350A4 (en) 2006-03-20 2013-04-17 Teva Womens Health Inc FLEXIBLE COMPRESSED INTRAVAGINAL RINGS, METHOD FOR THEIR PRODUCTION AND USE AND DEVICE FOR THEIR PRODUCTION
KR101062796B1 (ko) 2006-03-31 2011-09-06 큐엘티 인코포레이티드 약물 요법을 위한 비루관 배출계 임플란트
US7824383B2 (en) 2006-06-16 2010-11-02 Family Health International Vaginal drug delivery system and method
WO2008038281A2 (en) 2006-09-28 2008-04-03 Medvision Inc. Examination device
EP2089010A1 (en) 2006-10-24 2009-08-19 The John Hopkins University Rapid release mini-tablets provide analgesia in laboratory animals
JP2010522023A (ja) 2007-03-20 2010-07-01 ボストン サイエンティフィック サイムド,インコーポレイテッド 前立腺に対して有益な治療薬を放出するための泌尿器科学的医療機器
CN105581976A (zh) 2007-06-26 2016-05-18 沃纳奇尔科特有限责任公司 用于递送大分子和水溶性药物的阴道内药物递送装置
US8303536B2 (en) 2007-08-30 2012-11-06 Sunstorm Research Corp. Implantable delivery device
US8470360B2 (en) * 2008-04-18 2013-06-25 Warsaw Orthopedic, Inc. Drug depots having different release profiles for reducing, preventing or treating pain and inflammation
CN201179205Y (zh) * 2007-11-28 2009-01-14 北京星昊医药股份有限公司 双氯芬酸钠双释胶囊片
ES2481454T3 (es) 2007-12-11 2014-07-30 Massachusetts Institute Of Technology Dispositivo implantable de administración de fármacos
EP2309997A4 (en) 2008-06-16 2013-01-02 Appian Labs Llc COMPOSITION AND METHOD FOR PRODUCING A RELEASE SYSTEM FOR THE CONSTANT (NUMBERED ORDER) RELEASE OF ACTIVE SUBSTANCES
CN102176931B (zh) 2008-08-09 2015-03-04 麻省理工学院 治疗男性泌尿生殖组织和外周组织的可植入药物递送设备和方法
JP5382683B2 (ja) 2008-10-07 2014-01-08 レドックス・バイオサイエンス株式会社 胎児の慢性肺疾患の予防ないし治療剤
WO2010105093A2 (en) * 2009-03-12 2010-09-16 Delpor, Inc. Implantable device for long-term delivery of drugs
US20100247646A1 (en) * 2009-03-26 2010-09-30 Ranbaxy Laboratories Limited Extended release tablets of nisoldipine
CA2757743C (en) * 2009-04-06 2017-10-10 Eisai Inc. (2'-deoxy-ribofuranosyl)-1,3,4,7-tetrahydro-(1,3) diazepin-2-0ne derivatives for treating cancer
US8603521B2 (en) 2009-04-17 2013-12-10 Pharmacyclics, Inc. Formulations of histone deacetylase inhibitor and uses thereof
AU2010265866B2 (en) * 2009-06-26 2012-07-12 Taris Biomedical Llc Solid drug tablets for implantable drug delivery devices
US9017312B2 (en) * 2009-09-10 2015-04-28 Taris Biomedical Llc Implantable device for controlled drug delivery
US8167836B2 (en) * 2009-12-08 2012-05-01 Taris Biomedical, Inc. Tissue expander configured for drug delivery
AU2010339821B2 (en) 2009-12-17 2015-02-19 Taris Biomedical Llc Implantable device with intravesical tolerability and methods of treatment
US20110218488A1 (en) * 2010-03-05 2011-09-08 Taris Biomedical, Inc. Systems and Methods for Implanting Devices in the Bladder and Other Genitourinary Sites
JP2012017308A (ja) * 2010-07-09 2012-01-26 Nipro Corp ゲムシタビン水溶液製剤
JP5945544B2 (ja) * 2010-10-06 2016-07-05 タリス バイオメディカル エルエルシー 時間選択的に生体吸収可能または崩壊可能な薬剤送達システムおよび方法
WO2012048104A1 (en) * 2010-10-06 2012-04-12 Taris Biomedical, Inc. Implantable drug delivery device with bladden retention feature
JP2014505666A (ja) * 2010-11-18 2014-03-06 ザ ジェネラル ホスピタル コーポレイション 癌治療のための降圧剤の組成物および使用
EP2663300B1 (en) 2011-01-10 2023-03-08 TARIS Biomedical LLC Lidocaine regimen for the use of sustained treatment of bladder pain and irritative voiding
KR20140048086A (ko) * 2011-02-04 2014-04-23 타리스 바이오메디컬 인코포레이티드 저 용해성 약물의 제어 방출을 위한 이식가능한 디바이스
TWI615155B (zh) * 2011-11-01 2018-02-21 拜耳股份有限公司 滲透活性的陰道遞送系統
JP5979931B2 (ja) 2012-03-22 2016-08-31 小林製薬株式会社 医薬組成物
CN104812395A (zh) 2012-08-31 2015-07-29 塔里斯生物医药公司 用于治疗前列腺的药物递送系统和方法
MD20150035A2 (ro) * 2012-11-02 2015-10-31 Pfizer Inc. Inhibitori de tirozinkinaza Bruton
US10137287B2 (en) 2013-03-05 2018-11-27 Taris Biomedical Llc Drug delivery devices and methods for controlled drug release through device orifice
MX391755B (es) 2013-03-15 2025-03-21 Taris Biomedical Llc Dispositivos de administración de medicamentos y métodos para administración de medicamentos.
SG10201708522SA (en) 2013-03-15 2017-12-28 Taris Biomedical Llc Drug delivery devices with drug-permeable component and methods
RS67337B1 (sr) 2014-03-06 2025-11-28 Taris Biomedical Llc Sistemi za isporuku leka i metode za lečenje karcinoma bešike gemcitabinom

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