BR112016000993B1 - Processo otimizado para produção de uma composição contendo isomaltulose - Google Patents
Processo otimizado para produção de uma composição contendo isomaltulose Download PDFInfo
- Publication number
- BR112016000993B1 BR112016000993B1 BR112016000993-2A BR112016000993A BR112016000993B1 BR 112016000993 B1 BR112016000993 B1 BR 112016000993B1 BR 112016000993 A BR112016000993 A BR 112016000993A BR 112016000993 B1 BR112016000993 B1 BR 112016000993B1
- Authority
- BR
- Brazil
- Prior art keywords
- weight
- sucrose
- isomaltulose
- support
- process according
- Prior art date
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- 239000000203 mixture Substances 0.000 title claims abstract description 81
- 238000004519 manufacturing process Methods 0.000 title abstract description 10
- RJPPRBMGVWEZRR-WTZPKTTFSA-N (3s,4r,5r)-1,3,4,5-tetrahydroxy-6-[(2s,3r,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyhexan-2-one Chemical compound OC[C@H]1O[C@H](OC[C@@H](O)[C@@H](O)[C@H](O)C(=O)CO)[C@H](O)[C@@H](O)[C@@H]1O RJPPRBMGVWEZRR-WTZPKTTFSA-N 0.000 title abstract 2
- 238000013386 optimize process Methods 0.000 title abstract 2
- 238000000034 method Methods 0.000 claims abstract description 70
- PVXPPJIGRGXGCY-TZLCEDOOSA-N 6-O-alpha-D-glucopyranosyl-D-fructofuranose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1OC[C@@H]1[C@@H](O)[C@H](O)C(O)(CO)O1 PVXPPJIGRGXGCY-TZLCEDOOSA-N 0.000 claims abstract description 68
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims abstract description 64
- 229930006000 Sucrose Natural products 0.000 claims abstract description 64
- 239000005720 sucrose Substances 0.000 claims abstract description 64
- 239000000758 substrate Substances 0.000 claims abstract description 35
- 239000002028 Biomass Substances 0.000 claims description 65
- 239000002245 particle Substances 0.000 claims description 42
- 108010047540 sucrose isomerase Proteins 0.000 claims description 35
- SVBWNHOBPFJIRU-UHFFFAOYSA-N 1-O-alpha-D-Glucopyranosyl-D-fructose Natural products OC1C(O)C(O)C(CO)OC1OCC1(O)C(O)C(O)C(O)CO1 SVBWNHOBPFJIRU-UHFFFAOYSA-N 0.000 claims description 21
- NMXLJRHBJVMYPD-IPFGBZKGSA-N trehalulose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@]1(O)CO[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 NMXLJRHBJVMYPD-IPFGBZKGSA-N 0.000 claims description 21
- 238000009826 distribution Methods 0.000 claims description 16
- FHVDTGUDJYJELY-UHFFFAOYSA-N 6-{[2-carboxy-4,5-dihydroxy-6-(phosphanyloxy)oxan-3-yl]oxy}-4,5-dihydroxy-3-phosphanyloxane-2-carboxylic acid Chemical group O1C(C(O)=O)C(P)C(O)C(O)C1OC1C(C(O)=O)OC(OP)C(O)C1O FHVDTGUDJYJELY-UHFFFAOYSA-N 0.000 claims description 14
- 229940072056 alginate Drugs 0.000 claims description 14
- 235000010443 alginic acid Nutrition 0.000 claims description 14
- 229920000615 alginic acid Polymers 0.000 claims description 14
- 230000000694 effects Effects 0.000 claims description 11
- SERLAGPUMNYUCK-DCUALPFSSA-N 1-O-alpha-D-glucopyranosyl-D-mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO[C@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O SERLAGPUMNYUCK-DCUALPFSSA-N 0.000 claims description 8
- 241001622809 Serratia plymuthica Species 0.000 claims description 8
- 241000083686 [Pseudomonas] mesoacidophila Species 0.000 claims description 6
- 239000000905 isomalt Substances 0.000 claims description 5
- 235000010439 isomalt Nutrition 0.000 claims description 5
- HPIGCVXMBGOWTF-UHFFFAOYSA-N isomaltol Natural products CC(=O)C=1OC=CC=1O HPIGCVXMBGOWTF-UHFFFAOYSA-N 0.000 claims description 5
- 244000005700 microbiome Species 0.000 claims description 5
- 241000531155 Pectobacterium Species 0.000 claims description 4
- 239000000284 extract Substances 0.000 claims description 4
- 150000005846 sugar alcohols Chemical class 0.000 claims description 4
- 241000589155 Agrobacterium tumefaciens Species 0.000 claims description 3
- 241000556426 Erwinia rhapontici Species 0.000 claims description 3
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- 238000013019 agitation Methods 0.000 claims description 3
- 238000004132 cross linking Methods 0.000 claims description 3
- 241000589151 Azotobacter Species 0.000 claims description 2
- 241000589149 Azotobacter vinelandii Species 0.000 claims description 2
- 241000194110 Bacillus sp. (in: Bacteria) Species 0.000 claims description 2
- 241000588914 Enterobacter Species 0.000 claims description 2
- 241000147019 Enterobacter sp. Species 0.000 claims description 2
- 241000588698 Erwinia Species 0.000 claims description 2
- 241000400604 Erwinia tasmaniensis Species 0.000 claims description 2
- 241000588722 Escherichia Species 0.000 claims description 2
- 241000588748 Klebsiella Species 0.000 claims description 2
- 241000588747 Klebsiella pneumoniae Species 0.000 claims description 2
- 241000588754 Klebsiella sp. Species 0.000 claims description 2
- 241000192130 Leuconostoc mesenteroides Species 0.000 claims description 2
- 241000520272 Pantoea Species 0.000 claims description 2
- 241001148142 Pectobacterium atrosepticum Species 0.000 claims description 2
- 239000004372 Polyvinyl alcohol Substances 0.000 claims description 2
- 241000586779 Protaminobacter Species 0.000 claims description 2
- 241000321184 Raoultella Species 0.000 claims description 2
- 241000588746 Raoultella planticola Species 0.000 claims description 2
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- 241000607715 Serratia marcescens Species 0.000 claims description 2
- 238000009903 catalytic hydrogenation reaction Methods 0.000 claims description 2
- 229920002451 polyvinyl alcohol Polymers 0.000 claims description 2
- 241000589516 Pseudomonas Species 0.000 claims 1
- 108090000769 Isomerases Proteins 0.000 description 28
- 102000004195 Isomerases Human genes 0.000 description 28
- 229940081974 saccharin Drugs 0.000 description 28
- 235000019204 saccharin Nutrition 0.000 description 28
- 239000000901 saccharin and its Na,K and Ca salt Substances 0.000 description 28
- 239000000126 substance Substances 0.000 description 27
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- 102000004190 Enzymes Human genes 0.000 description 12
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- 239000011942 biocatalyst Substances 0.000 description 10
- 238000002360 preparation method Methods 0.000 description 10
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 10
- 159000000007 calcium salts Chemical class 0.000 description 9
- 238000005259 measurement Methods 0.000 description 9
- 239000012266 salt solution Substances 0.000 description 9
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- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 8
- 239000008103 glucose Substances 0.000 description 8
- 229930091371 Fructose Natural products 0.000 description 7
- 239000005715 Fructose Substances 0.000 description 7
- RFSUNEUAIZKAJO-ARQDHWQXSA-N Fructose Chemical compound OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O RFSUNEUAIZKAJO-ARQDHWQXSA-N 0.000 description 7
- PXHVJJICTQNCMI-UHFFFAOYSA-N Nickel Chemical compound [Ni] PXHVJJICTQNCMI-UHFFFAOYSA-N 0.000 description 6
- 239000012736 aqueous medium Substances 0.000 description 6
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 6
- 239000007788 liquid Substances 0.000 description 6
- 235000015097 nutrients Nutrition 0.000 description 6
- 150000004043 trisaccharides Chemical class 0.000 description 6
- 235000000346 sugar Nutrition 0.000 description 5
- AYRXSINWFIIFAE-SCLMCMATSA-N Isomaltose Natural products OC[C@H]1O[C@H](OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C=O)[C@@H](O)[C@@H](O)[C@@H]1O AYRXSINWFIIFAE-SCLMCMATSA-N 0.000 description 4
- 238000007664 blowing Methods 0.000 description 4
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- 230000002255 enzymatic effect Effects 0.000 description 4
- 235000011389 fruit/vegetable juice Nutrition 0.000 description 4
- DLRVVLDZNNYCBX-RTPHMHGBSA-N isomaltose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1OC[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)C(O)O1 DLRVVLDZNNYCBX-RTPHMHGBSA-N 0.000 description 4
- -1 isomelesitose Chemical compound 0.000 description 4
- 238000006317 isomerization reaction Methods 0.000 description 4
- IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 description 3
- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 description 3
- 230000001580 bacterial effect Effects 0.000 description 3
- 244000052616 bacterial pathogen Species 0.000 description 3
- 238000013375 chromatographic separation Methods 0.000 description 3
- 238000004140 cleaning Methods 0.000 description 3
- 239000000306 component Substances 0.000 description 3
- 238000005520 cutting process Methods 0.000 description 3
- 150000002016 disaccharides Chemical class 0.000 description 3
- 230000001105 regulatory effect Effects 0.000 description 3
- 239000000661 sodium alginate Substances 0.000 description 3
- 235000010413 sodium alginate Nutrition 0.000 description 3
- 229940005550 sodium alginate Drugs 0.000 description 3
- SERLAGPUMNYUCK-YJOKQAJESA-N 6-O-alpha-D-glucopyranosyl-D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO[C@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O SERLAGPUMNYUCK-YJOKQAJESA-N 0.000 description 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 2
- 239000007868 Raney catalyst Substances 0.000 description 2
- 229910000564 Raney nickel Inorganic materials 0.000 description 2
- 241000209149 Zea Species 0.000 description 2
- 235000005824 Zea mays ssp. parviglumis Nutrition 0.000 description 2
- 235000002017 Zea mays subsp mays Nutrition 0.000 description 2
- 238000004458 analytical method Methods 0.000 description 2
- 239000007864 aqueous solution Substances 0.000 description 2
- 239000007900 aqueous suspension Substances 0.000 description 2
- 238000011138 biotechnological process Methods 0.000 description 2
- 235000005822 corn Nutrition 0.000 description 2
- 239000006185 dispersion Substances 0.000 description 2
- 239000002612 dispersion medium Substances 0.000 description 2
- 239000012153 distilled water Substances 0.000 description 2
- 238000000855 fermentation Methods 0.000 description 2
- 230000004151 fermentation Effects 0.000 description 2
- 235000013305 food Nutrition 0.000 description 2
- 239000012634 fragment Substances 0.000 description 2
- 238000004128 high performance liquid chromatography Methods 0.000 description 2
- 238000005984 hydrogenation reaction Methods 0.000 description 2
- 210000001822 immobilized cell Anatomy 0.000 description 2
- 238000011534 incubation Methods 0.000 description 2
- 238000011081 inoculation Methods 0.000 description 2
- 238000005342 ion exchange Methods 0.000 description 2
- 150000002772 monosaccharides Chemical group 0.000 description 2
- 230000007935 neutral effect Effects 0.000 description 2
- 229910052759 nickel Inorganic materials 0.000 description 2
- 238000000926 separation method Methods 0.000 description 2
- 238000007873 sieving Methods 0.000 description 2
- 238000001179 sorption measurement Methods 0.000 description 2
- SERLAGPUMNYUCK-SCLLYDPQSA-N (2s,3r,4r,5r)-6-[(3r,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyhexane-1,2,3,4,5-pentol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)COC1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O SERLAGPUMNYUCK-SCLLYDPQSA-N 0.000 description 1
- SERLAGPUMNYUCK-BLEZHGCXSA-N (2xi)-6-O-alpha-D-glucopyranosyl-D-arabino-hexitol Chemical compound OCC(O)[C@@H](O)[C@H](O)[C@H](O)CO[C@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O SERLAGPUMNYUCK-BLEZHGCXSA-N 0.000 description 1
- RJPPRBMGVWEZRR-HGFVSHMXSA-N (3s,4r,5r)-1,3,4,5-tetrahydroxy-6-[(3r,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyhexan-2-one Chemical compound OC[C@H]1OC(OC[C@@H](O)[C@@H](O)[C@H](O)C(=O)CO)[C@H](O)[C@@H](O)[C@@H]1O RJPPRBMGVWEZRR-HGFVSHMXSA-N 0.000 description 1
- NMELTECMHKKXLF-WQXDXBNXSA-N (3s,4r,5r)-3,4,5,6-tetrahydroxy-1-[(3r,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyhexan-2-one Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)C(=O)COC1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O NMELTECMHKKXLF-WQXDXBNXSA-N 0.000 description 1
- NWUYHJFMYQTDRP-UHFFFAOYSA-N 1,2-bis(ethenyl)benzene;1-ethenyl-2-ethylbenzene;styrene Chemical compound C=CC1=CC=CC=C1.CCC1=CC=CC=C1C=C.C=CC1=CC=CC=C1C=C NWUYHJFMYQTDRP-UHFFFAOYSA-N 0.000 description 1
- SERLAGPUMNYUCK-UHFFFAOYSA-N 1-O-D-Glucopyranosyl-D-mannitol Natural products OCC(O)C(O)C(O)C(O)COC1OC(CO)C(O)C(O)C1O SERLAGPUMNYUCK-UHFFFAOYSA-N 0.000 description 1
- PVXPPJIGRGXGCY-DJHAAKORSA-N 6-O-alpha-D-glucopyranosyl-alpha-D-fructofuranose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1OC[C@@H]1[C@@H](O)[C@H](O)[C@](O)(CO)O1 PVXPPJIGRGXGCY-DJHAAKORSA-N 0.000 description 1
- 241001083841 Aquatica Species 0.000 description 1
- 101100283604 Caenorhabditis elegans pigk-1 gene Proteins 0.000 description 1
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 1
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- 108010010525 Isomaltulose synthase Proteins 0.000 description 1
- 241000589496 Meiothermus ruber Species 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 241000203722 Pimelobacter Species 0.000 description 1
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 1
- 241000589776 Pseudomonas putida Species 0.000 description 1
- 241000589596 Thermus Species 0.000 description 1
- 108090000992 Transferases Proteins 0.000 description 1
- 102000004357 Transferases Human genes 0.000 description 1
- 230000002378 acidificating effect Effects 0.000 description 1
- 238000007605 air drying Methods 0.000 description 1
- 239000011324 bead Substances 0.000 description 1
- 238000005452 bending Methods 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 239000006227 byproduct Substances 0.000 description 1
- 239000011575 calcium Substances 0.000 description 1
- 229910052791 calcium Inorganic materials 0.000 description 1
- VSGNNIFQASZAOI-UHFFFAOYSA-L calcium acetate Chemical compound [Ca+2].CC([O-])=O.CC([O-])=O VSGNNIFQASZAOI-UHFFFAOYSA-L 0.000 description 1
- 239000001639 calcium acetate Substances 0.000 description 1
- 229960005147 calcium acetate Drugs 0.000 description 1
- 235000011092 calcium acetate Nutrition 0.000 description 1
- 239000001110 calcium chloride Substances 0.000 description 1
- 229910001628 calcium chloride Inorganic materials 0.000 description 1
- 238000004364 calculation method Methods 0.000 description 1
- 239000003054 catalyst Substances 0.000 description 1
- 238000006555 catalytic reaction Methods 0.000 description 1
- 239000003729 cation exchange resin Substances 0.000 description 1
- 230000006037 cell lysis Effects 0.000 description 1
- 238000005119 centrifugation Methods 0.000 description 1
- 238000012512 characterization method Methods 0.000 description 1
- 239000012141 concentrate Substances 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- MNNHAPBLZZVQHP-UHFFFAOYSA-N diammonium hydrogen phosphate Chemical compound [NH4+].[NH4+].OP([O-])([O-])=O MNNHAPBLZZVQHP-UHFFFAOYSA-N 0.000 description 1
- 229910000388 diammonium phosphate Inorganic materials 0.000 description 1
- 235000019838 diammonium phosphate Nutrition 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 239000000835 fiber Substances 0.000 description 1
- 235000012041 food component Nutrition 0.000 description 1
- 239000005428 food component Substances 0.000 description 1
- 238000004108 freeze drying Methods 0.000 description 1
- 230000002641 glycemic effect Effects 0.000 description 1
- 239000012510 hollow fiber Substances 0.000 description 1
- 235000012907 honey Nutrition 0.000 description 1
- 230000007062 hydrolysis Effects 0.000 description 1
- 238000006460 hydrolysis reaction Methods 0.000 description 1
- 239000002054 inoculum Substances 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 235000013379 molasses Nutrition 0.000 description 1
- 239000013618 particulate matter Substances 0.000 description 1
- 239000011591 potassium Substances 0.000 description 1
- 229910052700 potassium Inorganic materials 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 230000005855 radiation Effects 0.000 description 1
- 210000000813 small intestine Anatomy 0.000 description 1
- 229910001415 sodium ion Inorganic materials 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 238000000638 solvent extraction Methods 0.000 description 1
- 239000000600 sorbitol Substances 0.000 description 1
- 229960002920 sorbitol Drugs 0.000 description 1
- 238000004611 spectroscopical analysis Methods 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 150000008163 sugars Chemical class 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- 239000002699 waste material Substances 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
Images
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/12—Disaccharides
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N11/00—Carrier-bound or immobilised enzymes; Carrier-bound or immobilised microbial cells; Preparation thereof
- C12N11/02—Enzymes or microbial cells immobilised on or in an organic carrier
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N11/00—Carrier-bound or immobilised enzymes; Carrier-bound or immobilised microbial cells; Preparation thereof
- C12N11/02—Enzymes or microbial cells immobilised on or in an organic carrier
- C12N11/04—Enzymes or microbial cells immobilised on or in an organic carrier entrapped within the carrier, e.g. gel or hollow fibres
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/24—Preparation of compounds containing saccharide radicals produced by the action of an isomerase, e.g. fructose
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y504/00—Intramolecular transferases (5.4)
- C12Y504/99—Intramolecular transferases (5.4) transferring other groups (5.4.99)
- C12Y504/99011—Isomaltulose synthase (5.4.99.11)
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Dispersion Chemistry (AREA)
- Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE201310011977 DE102013011977A1 (de) | 2013-07-18 | 2013-07-18 | Optimiertes Verfahren zur Herstellung einer Isomaltulose-haltigen Zusammensetzung |
| DE102013011977.4 | 2013-07-18 | ||
| PCT/EP2014/065358 WO2015007833A1 (de) | 2013-07-18 | 2014-07-17 | Optimiertes verfahren zur herstellung einer isomaltulose-haltigen zusammensetzung |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| BR112016000993A2 BR112016000993A2 (https=) | 2017-07-25 |
| BR112016000993B1 true BR112016000993B1 (pt) | 2022-08-16 |
Family
ID=51210486
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112016000993-2A BR112016000993B1 (pt) | 2013-07-18 | 2014-07-17 | Processo otimizado para produção de uma composição contendo isomaltulose |
Country Status (9)
| Country | Link |
|---|---|
| US (3) | US9920344B2 (https=) |
| EP (1) | EP3022311B1 (https=) |
| JP (2) | JP6622695B2 (https=) |
| CN (1) | CN105378097B (https=) |
| BR (1) | BR112016000993B1 (https=) |
| DE (1) | DE102013011977A1 (https=) |
| EA (1) | EA031887B1 (https=) |
| PL (1) | PL3022311T3 (https=) |
| WO (1) | WO2015007833A1 (https=) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102013011977A1 (de) * | 2013-07-18 | 2015-01-22 | Südzucker Aktiengesellschaft Mannheim/Ochsenfurt | Optimiertes Verfahren zur Herstellung einer Isomaltulose-haltigen Zusammensetzung |
| WO2017081666A1 (en) * | 2015-11-12 | 2017-05-18 | Petiva Private Limited | Process for preparing non-cariogenic, sustained energy release juice |
| CN106367377B (zh) * | 2016-09-22 | 2019-10-25 | 江南大学 | 一种蔗糖异构酶的固定化方法 |
| AU2018310665A1 (en) * | 2017-08-02 | 2020-03-12 | Evonik Operations Gmbh | An isomaltulose based sweetener |
| CN111033377B (zh) | 2017-08-18 | 2023-10-13 | 株式会社Lg化学 | 基板 |
| CN112920235A (zh) * | 2021-01-29 | 2021-06-08 | 山东健奕宏生物制药有限公司 | 一种异麦芽酮糖醇的制备方法 |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0028900B1 (en) * | 1979-11-07 | 1984-02-08 | TATE & LYLE PUBLIC LIMITED COMPANY | Production of isomaltulose |
| JPS5836959B2 (ja) * | 1980-08-21 | 1983-08-12 | 三井製糖株式会社 | 固定化α−グルコシルトランスフエラ−ゼによるパラチノ−スの製造法 |
| DE3038218A1 (de) * | 1980-10-09 | 1982-05-06 | Bayer Ag, 5090 Leverkusen | Saccharose-mutase, immobilisierte saccharose-mutase und verwendung von dieser immobilisierten saccharose-mutase zu herstellung von isomaltulose (6-o- a -d-glucopyranosido-d-fructose) |
| JPS58162292A (ja) * | 1982-03-23 | 1983-09-26 | Meiji Seika Kaisha Ltd | 固定化酵素，その製法および固定化酵素による甘味料の製造法 |
| DE3213107A1 (de) | 1982-04-07 | 1983-10-13 | Süddeutsche Zucker AG, 6800 Mannheim | Verfahren zur herstellung von isomaltulose (6-o-(alpha)-d-glucopyranosido-d-fructose) mit hilfe von immobilisierten bakterienzellen |
| JPH03127989A (ja) * | 1989-10-13 | 1991-05-31 | Meiji Milk Prod Co Ltd | 微生物菌体固定化物 |
| JP2756360B2 (ja) | 1990-10-31 | 1998-05-25 | 三井製糖株式会社 | トレハルロースおよびパラチノースの製造法 |
| US5229276A (en) | 1990-10-31 | 1993-07-20 | Mitsui Sugar Co., Ltd. | Process for preparing trehalulose and isomaltulose |
| EP0625578B2 (de) | 1993-05-06 | 2004-04-28 | Südzucker Aktiengesellschaft Mannheim/Ochsenfurt | Süssungsmittel, Verfahren zur Herstellung desselben sowie dessen Verwendung |
| EP0794259B1 (en) | 1996-03-04 | 2004-10-06 | Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo | Process for producing a saccharide composition containing trehalulose. |
| IL127013A (en) * | 1996-05-17 | 2001-03-19 | Xyrofin Oy | Process and carrier for the production of isomaltulose by immobilized micro-organisms |
| FI104563B (fi) * | 1996-05-17 | 2000-02-29 | Xyrofin Oy | Menetelmä ja kantaja isomaltuloosin tuottamiseksi immobilisoitujen mikro-organismien avulla |
| MY135783A (en) | 2001-09-07 | 2008-06-30 | Meiji Dairies Corp | Nutritional composition for controlling blood sugar level |
| CN101200750B (zh) * | 2007-11-29 | 2010-09-29 | 南京工业大学 | 一种大黄欧文氏菌及其在制备异麦芽酮糖中的应用 |
| JP5939558B2 (ja) * | 2011-02-18 | 2016-06-22 | 国立大学法人 千葉大学 | 非球形ハイドロゲル粒子の合成法及び非球形ハイドロゲル粒子 |
| CN102286454B (zh) * | 2011-07-01 | 2013-04-17 | 广西科学院生物研究所 | 聚乙烯醇固定产蔗糖异构酶菌体制备异麦芽酮糖方法 |
| DE102013011977A1 (de) * | 2013-07-18 | 2015-01-22 | Südzucker Aktiengesellschaft Mannheim/Ochsenfurt | Optimiertes Verfahren zur Herstellung einer Isomaltulose-haltigen Zusammensetzung |
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2013
- 2013-07-18 DE DE201310011977 patent/DE102013011977A1/de active Pending
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2014
- 2014-07-17 BR BR112016000993-2A patent/BR112016000993B1/pt active IP Right Grant
- 2014-07-17 EA EA201690245A patent/EA031887B1/ru not_active IP Right Cessation
- 2014-07-17 US US14/905,325 patent/US9920344B2/en active Active
- 2014-07-17 WO PCT/EP2014/065358 patent/WO2015007833A1/de not_active Ceased
- 2014-07-17 EP EP14739832.5A patent/EP3022311B1/de active Active
- 2014-07-17 PL PL14739832T patent/PL3022311T3/pl unknown
- 2014-07-17 CN CN201480040641.8A patent/CN105378097B/zh active Active
- 2014-07-17 JP JP2016526637A patent/JP6622695B2/ja active Active
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Also Published As
| Publication number | Publication date |
|---|---|
| EA201690245A1 (ru) | 2016-05-31 |
| EP3022311A1 (de) | 2016-05-25 |
| US20180208956A1 (en) | 2018-07-26 |
| EP3022311B1 (de) | 2019-09-18 |
| WO2015007833A1 (de) | 2015-01-22 |
| PL3022311T3 (pl) | 2020-03-31 |
| EA031887B1 (ru) | 2019-03-29 |
| JP6622695B2 (ja) | 2019-12-18 |
| US9920344B2 (en) | 2018-03-20 |
| CN105378097B (zh) | 2019-06-21 |
| BR112016000993A2 (https=) | 2017-07-25 |
| CN105378097A (zh) | 2016-03-02 |
| US20220010345A1 (en) | 2022-01-13 |
| US20160160251A1 (en) | 2016-06-09 |
| DE102013011977A1 (de) | 2015-01-22 |
| JP6926155B2 (ja) | 2021-08-25 |
| JP2016524907A (ja) | 2016-08-22 |
| JP2019213533A (ja) | 2019-12-19 |
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