BR112015029348A8 - inibidores da bace, seus usos, e composição farmacêutica - Google Patents
inibidores da bace, seus usos, e composição farmacêutica Download PDFInfo
- Publication number
- BR112015029348A8 BR112015029348A8 BR112015029348A BR112015029348A BR112015029348A8 BR 112015029348 A8 BR112015029348 A8 BR 112015029348A8 BR 112015029348 A BR112015029348 A BR 112015029348A BR 112015029348 A BR112015029348 A BR 112015029348A BR 112015029348 A8 BR112015029348 A8 BR 112015029348A8
- Authority
- BR
- Brazil
- Prior art keywords
- pharmaceutical composition
- bace inhibitors
- inhibitors
- formula
- bace
- Prior art date
Links
- 239000003112 inhibitor Substances 0.000 title abstract 2
- 101150058765 BACE1 gene Proteins 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- -1 their uses Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5365—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/5415—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with carbocyclic ring systems, e.g. phenothiazine, chlorpromazine, piroxicam
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Hospice & Palliative Care (AREA)
- Communicable Diseases (AREA)
- Psychiatry (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361836175P | 2013-06-18 | 2013-06-18 | |
| US201361877373P | 2013-09-13 | 2013-09-13 | |
| PCT/US2014/041825 WO2014204730A1 (en) | 2013-06-18 | 2014-06-11 | Bace inhibitors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| BR112015029348A2 BR112015029348A2 (pt) | 2017-07-25 |
| BR112015029348A8 true BR112015029348A8 (pt) | 2020-03-17 |
Family
ID=51059662
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112015029348A BR112015029348A8 (pt) | 2013-06-18 | 2014-06-11 | inibidores da bace, seus usos, e composição farmacêutica |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US9029367B2 (enExample) |
| EP (1) | EP3010925B1 (enExample) |
| JP (1) | JP2016522254A (enExample) |
| KR (1) | KR101780140B1 (enExample) |
| CN (1) | CN105324385A (enExample) |
| AU (1) | AU2014281032B2 (enExample) |
| BR (1) | BR112015029348A8 (enExample) |
| CA (1) | CA2910415C (enExample) |
| EA (1) | EA027880B1 (enExample) |
| ES (1) | ES2657905T3 (enExample) |
| JO (1) | JO3318B1 (enExample) |
| MX (1) | MX2015017156A (enExample) |
| TW (1) | TWI639607B (enExample) |
| WO (1) | WO2014204730A1 (enExample) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CR20170187A (es) | 2014-11-10 | 2018-02-01 | H Lundbeck As | 2-Amino-3,5-difluoro-6-metil-6-fenil-3,4,5,6-tetrahidropiridinas en calidad de inhibidores de BACE1 para el tratamiento de la enfermedad de Alzheimer |
| JO3458B1 (ar) | 2014-11-10 | 2020-07-05 | H Lundbeck As | 2- أمينو-6- (دايفلوروميثيل) – 5، 5- ديفلورو-6-فينيل-3،4، 5، 6-تيتراهيدروبيريدين كمثبطات bace1 |
| MA40941A (fr) | 2014-11-10 | 2017-09-19 | H Lundbeck As | 2-amino-5,5-difluoro-6-(fluorométhyl)-6-phényl-3,4,5,6-tétrahydropyridines comme inhibiteurs de bace1 |
| AR103680A1 (es) * | 2015-02-23 | 2017-05-24 | Lilly Co Eli | Inhibidores selectivos de bace1 |
| TW201717948A (zh) | 2015-08-10 | 2017-06-01 | Ｈ 朗德貝克公司 | 包括給予２－胺基－３，５，５－三氟－３，４，５，６－四氫吡啶的聯合治療 |
| JP2018531889A (ja) | 2015-08-12 | 2018-11-01 | ハー・ルンドベック・アクチエゼルスカベット | Ｂａｃｅ１阻害剤としての２−アミノ−３−フルオロ−３−（フルオロメチル）−６−メチル−６−フェニル−３，４，５，６−テトラヒドロピリジン |
| WO2017025565A1 (en) * | 2015-08-12 | 2017-02-16 | H. Lundbeck A/S | 2-amino-7a-phenyl-3,4,4a,5,7,7a-hexahydrofuro[3,4-b]pyridines as bace1 inhibitors |
| JOP20170106A1 (ar) * | 2016-05-20 | 2017-11-20 | Eli Lilly And Company | مركبات تترا هيدرو فوروكسازين واستخداماتها كمثبطات bace1 انتقائية |
| JP6889466B2 (ja) * | 2016-12-09 | 2021-06-18 | 学校法人 名城大学 | アミド基を含む単離された化合物の塩、その製造方法及びこれを用いたアミド化合物の合成方法 |
| CN107892697B (zh) | 2016-12-26 | 2020-11-03 | 郑州泰基鸿诺医药股份有限公司 | 一种[1,3]噻嗪-2-胺类化合物及应用，药物组合物 |
| CN111217709A (zh) * | 2018-11-27 | 2020-06-02 | 南京药石科技股份有限公司 | 一种（1-氟环丙基）甲胺盐酸盐的制备方法 |
Family Cites Families (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SG162790A1 (en) | 2005-06-14 | 2010-07-29 | Schering Corp | Aspartyl protease inhibitors |
| CN101346357B (zh) | 2005-10-25 | 2014-04-02 | 盐野义制药株式会社 | 氨基二氢噻嗪衍生物 |
| EP2689780A1 (en) | 2007-04-24 | 2014-01-29 | Shionogi & Co., Ltd. | Intermediates for aminodihydrothiazine derivatives substituted with a cyclic group |
| JP5383483B2 (ja) | 2007-04-24 | 2014-01-08 | 塩野義製薬株式会社 | アルツハイマー症治療用医薬組成物 |
| BRPI0906962B8 (pt) * | 2008-01-18 | 2021-05-25 | Eisai R&D Man Co Ltd | composto de aminodiidrotiazina fundido |
| TWI431004B (zh) * | 2008-05-02 | 2014-03-21 | Lilly Co Eli | Ｂａｃｅ抑制劑 |
| KR101324426B1 (ko) | 2008-06-13 | 2013-10-31 | 시오노기세야쿠 가부시키가이샤 | β 세크레타제 저해 작용을 갖는 황 함유 복소환 유도체 |
| WO2010038686A1 (ja) | 2008-09-30 | 2010-04-08 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | 新規な縮合アミノジヒドロチアジン誘導体 |
| AR077277A1 (es) | 2009-07-09 | 2011-08-17 | Lilly Co Eli | Compuestos de biciclo (1,3)tiazin-2-amina formulacion farmaceutica que lo comprende y su uso para la manufactura de un medicamento util para el tratamiento de la enfermedad de alzheimer |
| GB0912778D0 (en) | 2009-07-22 | 2009-08-26 | Eisai London Res Lab Ltd | Fused aminodihydro-oxazine derivatives |
| EP2514747A4 (en) | 2009-12-09 | 2013-05-08 | Shionogi & Co | SUBSTITUTED AMINOTHIAZINE DERIVATIVE |
| UA103272C2 (uk) | 2009-12-11 | 2013-09-25 | Ф. Хоффманн-Ля Рош Аг | 2-аміно-5,5-дифтор-5,6-дигідро-4h-оксазини як інгібітори bace1 і/або bace2 |
| KR20120104570A (ko) | 2009-12-11 | 2012-09-21 | 시오노기세야쿠 가부시키가이샤 | 옥사진 유도체 |
| US20120245155A1 (en) | 2009-12-11 | 2012-09-27 | Shionogi & Co., Ltd. | Fused heterocyclic compound having amino group |
| GB201100181D0 (en) | 2011-01-06 | 2011-02-23 | Eisai Ltd | Fused aminodihydrothiazine derivatives |
| GB201101139D0 (en) | 2011-01-21 | 2011-03-09 | Eisai Ltd | Fused aminodihydrothiazine derivatives |
| GB201101140D0 (en) | 2011-01-21 | 2011-03-09 | Eisai Ltd | Fused aminodihydrothiazine derivatives |
| SG191710A1 (en) | 2011-01-21 | 2013-08-30 | Eisai R&D Man Co Ltd | Methods and compounds useful in the synthesis of fused aminodihydrothiazine derivatives |
| US9145426B2 (en) | 2011-04-07 | 2015-09-29 | Merck Sharp & Dohme Corp. | Pyrrolidine-fused thiadiazine dioxide compounds as BACE inhibitors, compositions, and their use |
| US8754075B2 (en) | 2011-04-11 | 2014-06-17 | Hoffmann-La Roche Inc. | 1,3-oxazines as BACE1 and/or BACE2 inhibitors |
| US8785436B2 (en) | 2011-05-16 | 2014-07-22 | Hoffmann-La Roche Inc. | 1,3-oxazines as BACE 1 and/or BACE2 inhibitors |
| WO2012162334A1 (en) | 2011-05-24 | 2012-11-29 | Bristol-Myers Squibb Company | Compounds for the reduction of beta-amyloid production |
| MX2013014007A (es) | 2011-06-07 | 2014-03-12 | Hoffmann La Roche | [1,3] oxazinas. |
| UY34278A (es) | 2011-08-25 | 2013-04-05 | Novartis Ag | Derivados novedosos de oxazina y su uso en el tratamiento de enfermedades |
| WO2013030713A1 (en) | 2011-08-31 | 2013-03-07 | Pfizer Inc. | Hexahydropyrano [3,4-d][1,3] thiazin-2-amine compounds |
| PL2782914T3 (pl) | 2011-11-25 | 2019-01-31 | Adverio Pharma Gmbh | Sposób wytwarzania podstawionych 5-fluoro-1H-pirazolopirydyn |
| HUE030534T2 (hu) | 2012-04-27 | 2017-05-29 | Eisai R&D Man Co Ltd | Eljárás 5-(difluormetil)pirazin-2-karbonsav elõállítására és elõállítási intermediere |
| JP6110937B2 (ja) | 2012-05-04 | 2017-04-05 | ファイザー・インク | ＡＰＰ、ＢＡＣＥ１、およびＢＡＣＥ２の阻害剤としての複素環式置換ヘキサヒドロピラノ［３，４−ｄ］［１，３］チアジン−２−アミン化合物 |
| WO2014015125A1 (en) | 2012-07-19 | 2014-01-23 | Eisai R&D Management Co., Ltd. | Fused aminodihydrothiazine derivative salts and uses thereof |
| GB201212871D0 (en) | 2012-07-20 | 2012-09-05 | Eisai Ltd | Novel compounds |
-
2014
- 2014-05-29 JO JOP/2014/0177A patent/JO3318B1/ar active
- 2014-05-29 TW TW103118874A patent/TWI639607B/zh not_active IP Right Cessation
- 2014-06-11 KR KR1020157035519A patent/KR101780140B1/ko not_active Expired - Fee Related
- 2014-06-11 EA EA201592183A patent/EA027880B1/ru not_active IP Right Cessation
- 2014-06-11 AU AU2014281032A patent/AU2014281032B2/en not_active Ceased
- 2014-06-11 JP JP2016521454A patent/JP2016522254A/ja active Pending
- 2014-06-11 ES ES14734712.4T patent/ES2657905T3/es active Active
- 2014-06-11 BR BR112015029348A patent/BR112015029348A8/pt not_active Application Discontinuation
- 2014-06-11 EP EP14734712.4A patent/EP3010925B1/en not_active Not-in-force
- 2014-06-11 CN CN201480034958.0A patent/CN105324385A/zh active Pending
- 2014-06-11 WO PCT/US2014/041825 patent/WO2014204730A1/en not_active Ceased
- 2014-06-11 US US14/301,358 patent/US9029367B2/en not_active Expired - Fee Related
- 2014-06-11 CA CA2910415A patent/CA2910415C/en not_active Expired - Fee Related
- 2014-06-11 MX MX2015017156A patent/MX2015017156A/es unknown
-
2015
- 2015-04-02 US US14/677,113 patent/US9169271B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| CA2910415C (en) | 2017-09-05 |
| AU2014281032A1 (en) | 2015-11-12 |
| US9169271B2 (en) | 2015-10-27 |
| JO3318B1 (ar) | 2019-03-13 |
| CN105324385A (zh) | 2016-02-10 |
| US9029367B2 (en) | 2015-05-12 |
| EP3010925B1 (en) | 2017-10-04 |
| US20140371212A1 (en) | 2014-12-18 |
| EP3010925A1 (en) | 2016-04-27 |
| MX2015017156A (es) | 2016-03-16 |
| US20150210716A1 (en) | 2015-07-30 |
| EA027880B1 (ru) | 2017-09-29 |
| TWI639607B (zh) | 2018-11-01 |
| AU2014281032B2 (en) | 2016-09-29 |
| KR20160009052A (ko) | 2016-01-25 |
| JP2016522254A (ja) | 2016-07-28 |
| BR112015029348A2 (pt) | 2017-07-25 |
| WO2014204730A1 (en) | 2014-12-24 |
| TW201536793A (zh) | 2015-10-01 |
| CA2910415A1 (en) | 2014-12-24 |
| KR101780140B1 (ko) | 2017-09-19 |
| EA201592183A1 (ru) | 2016-05-31 |
| ES2657905T3 (es) | 2018-03-07 |
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Legal Events
| Date | Code | Title | Description |
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| B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] | ||
| B07E | Notice of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] | ||
| B06U | Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette] | ||
| B11B | Dismissal acc. art. 36, par 1 of ipl - no reply within 90 days to fullfil the necessary requirements | ||
| B350 | Update of information on the portal [chapter 15.35 patent gazette] |