BR112015029348A8 - inibidores da bace, seus usos, e composição farmacêutica - Google Patents
inibidores da bace, seus usos, e composição farmacêutica Download PDFInfo
- Publication number
- BR112015029348A8 BR112015029348A8 BR112015029348A BR112015029348A BR112015029348A8 BR 112015029348 A8 BR112015029348 A8 BR 112015029348A8 BR 112015029348 A BR112015029348 A BR 112015029348A BR 112015029348 A BR112015029348 A BR 112015029348A BR 112015029348 A8 BR112015029348 A8 BR 112015029348A8
- Authority
- BR
- Brazil
- Prior art keywords
- pharmaceutical composition
- bace inhibitors
- inhibitors
- formula
- bace
- Prior art date
Links
- 239000003112 inhibitor Substances 0.000 title abstract 2
- 101150058765 BACE1 gene Proteins 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- -1 their uses Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5365—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/5415—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with carbocyclic ring systems, e.g. phenothiazine, chlorpromazine, piroxicam
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361836175P | 2013-06-18 | 2013-06-18 | |
| US201361877373P | 2013-09-13 | 2013-09-13 | |
| PCT/US2014/041825 WO2014204730A1 (en) | 2013-06-18 | 2014-06-11 | Bace inhibitors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| BR112015029348A2 BR112015029348A2 (pt) | 2017-07-25 |
| BR112015029348A8 true BR112015029348A8 (pt) | 2020-03-17 |
Family
ID=51059662
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112015029348A BR112015029348A8 (pt) | 2013-06-18 | 2014-06-11 | inibidores da bace, seus usos, e composição farmacêutica |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US9029367B2 (enExample) |
| EP (1) | EP3010925B1 (enExample) |
| JP (1) | JP2016522254A (enExample) |
| KR (1) | KR101780140B1 (enExample) |
| CN (1) | CN105324385A (enExample) |
| AU (1) | AU2014281032B2 (enExample) |
| BR (1) | BR112015029348A8 (enExample) |
| CA (1) | CA2910415C (enExample) |
| EA (1) | EA027880B1 (enExample) |
| ES (1) | ES2657905T3 (enExample) |
| JO (1) | JO3318B1 (enExample) |
| MX (1) | MX2015017156A (enExample) |
| TW (1) | TWI639607B (enExample) |
| WO (1) | WO2014204730A1 (enExample) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JO3458B1 (ar) | 2014-11-10 | 2020-07-05 | H Lundbeck As | 2- أمينو-6- (دايفلوروميثيل) – 5، 5- ديفلورو-6-فينيل-3،4، 5، 6-تيتراهيدروبيريدين كمثبطات bace1 |
| MA40941A (fr) | 2014-11-10 | 2017-09-19 | H Lundbeck As | 2-amino-5,5-difluoro-6-(fluorométhyl)-6-phényl-3,4,5,6-tétrahydropyridines comme inhibiteurs de bace1 |
| CR20170187A (es) | 2014-11-10 | 2018-02-01 | H Lundbeck As | 2-Amino-3,5-difluoro-6-metil-6-fenil-3,4,5,6-tetrahidropiridinas en calidad de inhibidores de BACE1 para el tratamiento de la enfermedad de Alzheimer |
| AR103680A1 (es) * | 2015-02-23 | 2017-05-24 | Lilly Co Eli | Inhibidores selectivos de bace1 |
| TW201717948A (zh) | 2015-08-10 | 2017-06-01 | Ｈ 朗德貝克公司 | 包括給予２－胺基－３，５，５－三氟－３，４，５，６－四氫吡啶的聯合治療 |
| HK1253372A1 (zh) | 2015-08-12 | 2019-06-14 | H‧隆德贝克有限公司 | 作为bace1抑制剂的2-氨基-3-氟-3-(氟甲基)-6-甲基-6-苯基-3，4，5，6-四氢吡啶 |
| US20180230160A1 (en) * | 2015-08-12 | 2018-08-16 | H. Lundbeck A/S | 2-amino-7a-phenyl-3,4,4a,5,7,7a-hexahydrofuro[3,4-b]pyridines as bace1 inhibitors |
| TWI675034B (zh) * | 2016-05-20 | 2019-10-21 | 美商美國禮來大藥廠 | 四氫呋喃并<img align="absmiddle" height="18px" width="27px" file="d10999.TIF" alt="其他非圖式 ed10999.png" img-content="tif" orientation="portrait" inline="yes" giffile="ed10999.png"></img>化合物及其作為選擇性ＢＡＣＥ１抑制劑之用途 |
| JP6889466B2 (ja) * | 2016-12-09 | 2021-06-18 | 学校法人 名城大学 | アミド基を含む単離された化合物の塩、その製造方法及びこれを用いたアミド化合物の合成方法 |
| CN107892697B (zh) | 2016-12-26 | 2020-11-03 | 郑州泰基鸿诺医药股份有限公司 | 一种[1,3]噻嗪-2-胺类化合物及应用，药物组合物 |
| CN111217709A (zh) * | 2018-11-27 | 2020-06-02 | 南京药石科技股份有限公司 | 一种（1-氟环丙基）甲胺盐酸盐的制备方法 |
Family Cites Families (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SG162790A1 (en) | 2005-06-14 | 2010-07-29 | Schering Corp | Aspartyl protease inhibitors |
| AU2006307314C1 (en) | 2005-10-25 | 2011-08-25 | Shionogi & Co., Ltd. | Aminodihydrothiazine derivative |
| JP5383483B2 (ja) | 2007-04-24 | 2014-01-08 | 塩野義製薬株式会社 | アルツハイマー症治療用医薬組成物 |
| ES2476605T3 (es) | 2007-04-24 | 2014-07-15 | Shionogi & Co., Ltd. | Derivados de aminohidrotiazina sustituidos con grupos cíclicos |
| ES2548774T3 (es) * | 2008-01-18 | 2015-10-20 | Eisai R&D Management Co., Ltd. | Derivado de aminodihidrotiazina condensado |
| TWI431004B (zh) * | 2008-05-02 | 2014-03-21 | Lilly Co Eli | Ｂａｃｅ抑制劑 |
| AU2009258496B8 (en) | 2008-06-13 | 2014-06-26 | Shionogi & Co., Ltd. | Sulfur-containing heterocyclic derivative having beta-secretase-inhibiting activity |
| KR20110076965A (ko) | 2008-09-30 | 2011-07-06 | 에자이 알앤드디 매니지먼트 가부시키가이샤 | 신규한 축합 아미노 디하이드로티아진 유도체 |
| AR077277A1 (es) * | 2009-07-09 | 2011-08-17 | Lilly Co Eli | Compuestos de biciclo (1,3)tiazin-2-amina formulacion farmaceutica que lo comprende y su uso para la manufactura de un medicamento util para el tratamiento de la enfermedad de alzheimer |
| GB0912778D0 (en) | 2009-07-22 | 2009-08-26 | Eisai London Res Lab Ltd | Fused aminodihydro-oxazine derivatives |
| EP2514747A4 (en) | 2009-12-09 | 2013-05-08 | Shionogi & Co | SUBSTITUTED AMINOTHIAZINE DERIVATIVE |
| JPWO2011071109A1 (ja) | 2009-12-11 | 2013-04-22 | 塩野義製薬株式会社 | アミノ基を有する縮合ヘテロ環化合物 |
| UA103272C2 (uk) | 2009-12-11 | 2013-09-25 | Ф. Хоффманн-Ля Рош Аг | 2-аміно-5,5-дифтор-5,6-дигідро-4h-оксазини як інгібітори bace1 і/або bace2 |
| UA110467C2 (uk) | 2009-12-11 | 2016-01-12 | Шионогі Енд Ко., Лтд. | Похідні оксазину |
| GB201100181D0 (en) | 2011-01-06 | 2011-02-23 | Eisai Ltd | Fused aminodihydrothiazine derivatives |
| GB201101140D0 (en) | 2011-01-21 | 2011-03-09 | Eisai Ltd | Fused aminodihydrothiazine derivatives |
| GB201101139D0 (en) | 2011-01-21 | 2011-03-09 | Eisai Ltd | Fused aminodihydrothiazine derivatives |
| CA2814014A1 (en) | 2011-01-21 | 2012-07-26 | Branko MITASEV | Methods and compounds useful in the synthesis of fused aminodihydrothiazine derivatives |
| US9145426B2 (en) | 2011-04-07 | 2015-09-29 | Merck Sharp & Dohme Corp. | Pyrrolidine-fused thiadiazine dioxide compounds as BACE inhibitors, compositions, and their use |
| US8754075B2 (en) | 2011-04-11 | 2014-06-17 | Hoffmann-La Roche Inc. | 1,3-oxazines as BACE1 and/or BACE2 inhibitors |
| US8785436B2 (en) | 2011-05-16 | 2014-07-22 | Hoffmann-La Roche Inc. | 1,3-oxazines as BACE 1 and/or BACE2 inhibitors |
| WO2012162334A1 (en) | 2011-05-24 | 2012-11-29 | Bristol-Myers Squibb Company | Compounds for the reduction of beta-amyloid production |
| MX2013014007A (es) | 2011-06-07 | 2014-03-12 | Hoffmann La Roche | [1,3] oxazinas. |
| UY34278A (es) | 2011-08-25 | 2013-04-05 | Novartis Ag | Derivados novedosos de oxazina y su uso en el tratamiento de enfermedades |
| WO2013030713A1 (en) | 2011-08-31 | 2013-03-07 | Pfizer Inc. | Hexahydropyrano [3,4-d][1,3] thiazin-2-amine compounds |
| BR112014012414B1 (pt) | 2011-11-25 | 2022-01-11 | Adverio Pharma Gmbh | Processos para preparar 5-flúor-1h-pirazolopiridinas substituídas |
| US9227942B2 (en) | 2012-04-27 | 2016-01-05 | Eisai R&D Management Co., Ltd. | Method for producing 5-(difluoromethyl)pyrazine-2-carboxylic acid and production intermediate thereof |
| CA2872154C (en) | 2012-05-04 | 2016-08-23 | Pfizer Inc. | Heterocyclic substituted hexahydropyrano [3,4-d] [1,3] thiazin-2-amine compounds as inhibitors of app, bace1 and bace2 |
| WO2014015125A1 (en) | 2012-07-19 | 2014-01-23 | Eisai R&D Management Co., Ltd. | Fused aminodihydrothiazine derivative salts and uses thereof |
| GB201212871D0 (en) | 2012-07-20 | 2012-09-05 | Eisai Ltd | Novel compounds |
-
2014
- 2014-05-29 JO JOP/2014/0177A patent/JO3318B1/ar active
- 2014-05-29 TW TW103118874A patent/TWI639607B/zh not_active IP Right Cessation
- 2014-06-11 US US14/301,358 patent/US9029367B2/en not_active Expired - Fee Related
- 2014-06-11 AU AU2014281032A patent/AU2014281032B2/en not_active Ceased
- 2014-06-11 MX MX2015017156A patent/MX2015017156A/es unknown
- 2014-06-11 CA CA2910415A patent/CA2910415C/en not_active Expired - Fee Related
- 2014-06-11 BR BR112015029348A patent/BR112015029348A8/pt not_active Application Discontinuation
- 2014-06-11 EP EP14734712.4A patent/EP3010925B1/en not_active Not-in-force
- 2014-06-11 EA EA201592183A patent/EA027880B1/ru not_active IP Right Cessation
- 2014-06-11 KR KR1020157035519A patent/KR101780140B1/ko not_active Expired - Fee Related
- 2014-06-11 ES ES14734712.4T patent/ES2657905T3/es active Active
- 2014-06-11 WO PCT/US2014/041825 patent/WO2014204730A1/en not_active Ceased
- 2014-06-11 JP JP2016521454A patent/JP2016522254A/ja active Pending
- 2014-06-11 CN CN201480034958.0A patent/CN105324385A/zh active Pending
-
2015
- 2015-04-02 US US14/677,113 patent/US9169271B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| AU2014281032A1 (en) | 2015-11-12 |
| US20140371212A1 (en) | 2014-12-18 |
| JO3318B1 (ar) | 2019-03-13 |
| MX2015017156A (es) | 2016-03-16 |
| WO2014204730A1 (en) | 2014-12-24 |
| US9169271B2 (en) | 2015-10-27 |
| ES2657905T3 (es) | 2018-03-07 |
| TW201536793A (zh) | 2015-10-01 |
| EP3010925B1 (en) | 2017-10-04 |
| CA2910415A1 (en) | 2014-12-24 |
| US20150210716A1 (en) | 2015-07-30 |
| CN105324385A (zh) | 2016-02-10 |
| AU2014281032B2 (en) | 2016-09-29 |
| KR101780140B1 (ko) | 2017-09-19 |
| EA201592183A1 (ru) | 2016-05-31 |
| BR112015029348A2 (pt) | 2017-07-25 |
| CA2910415C (en) | 2017-09-05 |
| TWI639607B (zh) | 2018-11-01 |
| US9029367B2 (en) | 2015-05-12 |
| EP3010925A1 (en) | 2016-04-27 |
| KR20160009052A (ko) | 2016-01-25 |
| JP2016522254A (ja) | 2016-07-28 |
| EA027880B1 (ru) | 2017-09-29 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] | ||
| B07E | Notice of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] | ||
| B06U | Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette] | ||
| B11B | Dismissal acc. art. 36, par 1 of ipl - no reply within 90 days to fullfil the necessary requirements | ||
| B350 | Update of information on the portal [chapter 15.35 patent gazette] |