BR112015021709A2 - poli(beta-amino éster)es modificados para administração de fármacos - Google Patents
poli(beta-amino éster)es modificados para administração de fármacosInfo
- Publication number
- BR112015021709A2 BR112015021709A2 BR112015021709A BR112015021709A BR112015021709A2 BR 112015021709 A2 BR112015021709 A2 BR 112015021709A2 BR 112015021709 A BR112015021709 A BR 112015021709A BR 112015021709 A BR112015021709 A BR 112015021709A BR 112015021709 A2 BR112015021709 A2 BR 112015021709A2
- Authority
- BR
- Brazil
- Prior art keywords
- polymers
- beta
- drug delivery
- modified poly
- amino ester
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/7105—Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/713—Double-stranded nucleic acids or oligonucleotides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/51—Nanocapsules; Nanoparticles
- A61K9/5107—Excipients; Inactive ingredients
- A61K9/513—Organic macromolecular compounds; Dendrimers
- A61K9/5146—Organic macromolecular compounds; Dendrimers obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyamines, polyanhydrides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/51—Nanocapsules; Nanoparticles
- A61K9/5192—Processes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G63/00—Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
- C08G63/91—Polymers modified by chemical after-treatment
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G73/00—Macromolecular compounds obtained by reactions forming a linkage containing nitrogen with or without oxygen or carbon in the main chain of the macromolecule, not provided for in groups C08G12/00 - C08G71/00
- C08G73/02—Polyamines
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G73/00—Macromolecular compounds obtained by reactions forming a linkage containing nitrogen with or without oxygen or carbon in the main chain of the macromolecule, not provided for in groups C08G12/00 - C08G71/00
- C08G73/02—Polyamines
- C08G73/028—Polyamidoamines
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
- C12N15/88—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation using microencapsulation, e.g. using amphiphile liposome vesicle
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G69/00—Macromolecular compounds obtained by reactions forming a carboxylic amide link in the main chain of the macromolecule
- C08G69/02—Polyamides derived from amino-carboxylic acids or from polyamines and polycarboxylic acids
- C08G69/08—Polyamides derived from amino-carboxylic acids or from polyamines and polycarboxylic acids derived from amino-carboxylic acids
- C08G69/10—Alpha-amino-carboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/14—Type of nucleic acid interfering N.A.
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/14—Type of nucleic acid interfering N.A.
- C12N2310/141—MicroRNAs, miRNAs
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Epidemiology (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biochemistry (AREA)
- Physics & Mathematics (AREA)
- General Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- Zoology (AREA)
- Polymers & Plastics (AREA)
- Diabetes (AREA)
- Nanotechnology (AREA)
- Optics & Photonics (AREA)
- Microbiology (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- General Chemical & Material Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Inorganic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Endocrinology (AREA)
- Hematology (AREA)
- Emergency Medicine (AREA)
- Obesity (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
resumo da patente de invenã§ã£o para: âpoli(beta-amino ãster)es modificados para administraãão de fãrmacosâ. descreve-se polãmeros que sã£o poli(beta-amino ã©ster)es (pbaes) modificados com pelo menos um oligopeptãdeo. os polãmeros podem ser usados em qualquer campo onde os polãmeros foram verificados como ãºteis, incluindo nos campos da medicina, particularmente na administraã§ã£o do fã¡rmaco. os polãmeros sã£o particularmente ãºteis na administraã§ã£o de um polinucleotãdeo, tal como dna, rna e sirna, uma pequena molã©cula ou uma proteãna. tambã©m sã£o descritas composiã§ãµes que compreendem os referidos polãmeros e um agente ativo, mã©todos de encapsulaã§ã£o de um agente em uma matriz dos referidos polãmeros, e os referidos polãmeros e composiã§ãµes para utilizaã§ã£o em medicina.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB1304245.2 | 2013-03-08 | ||
GBGB1304245.2A GB201304245D0 (en) | 2013-03-08 | 2013-03-08 | Chemical compounds |
PCT/IB2014/059594 WO2014136100A1 (en) | 2013-03-08 | 2014-03-10 | Modified poly(beta-amino ester)s for drug delivery |
Publications (3)
Publication Number | Publication Date |
---|---|
BR112015021709A2 true BR112015021709A2 (pt) | 2017-07-18 |
BR112015021709B1 BR112015021709B1 (pt) | 2022-03-03 |
BR112015021709B8 BR112015021709B8 (pt) | 2022-04-05 |
Family
ID=48189627
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112015021709A BR112015021709B8 (pt) | 2013-03-08 | 2014-03-10 | Poli(beta-amino ésteres) modificados para administração de fármacos e nanopartícula compreendendo os mesmos, uma composição compreendendo os mesmos, método de encapsulamento de um agente em uma matriz de polímeros para formar nanopartículas, e uso dos poli(beta-amino ésteres) |
Country Status (17)
Country | Link |
---|---|
US (2) | US20160038598A1 (pt) |
EP (1) | EP2964244B1 (pt) |
JP (1) | JP6473421B2 (pt) |
KR (1) | KR102191195B1 (pt) |
CN (1) | CN105324120B (pt) |
AR (1) | AR095081A1 (pt) |
AU (1) | AU2014224219B2 (pt) |
BR (1) | BR112015021709B8 (pt) |
CA (1) | CA2903663C (pt) |
DK (1) | DK2964244T3 (pt) |
ES (1) | ES2781965T3 (pt) |
GB (1) | GB201304245D0 (pt) |
MX (1) | MX364396B (pt) |
PL (1) | PL2964244T3 (pt) |
RU (1) | RU2015142677A (pt) |
TW (1) | TW201446269A (pt) |
WO (1) | WO2014136100A1 (pt) |
Families Citing this family (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN113249297A (zh) | 2014-05-28 | 2021-08-13 | 儿童医院医疗中心 | 用于经由定向分化将前体细胞转化为胃组织的方法和系统 |
EP3207123A1 (en) | 2014-10-17 | 2017-08-23 | Children's Hospital Center D/b/a Cincinnati Children's Hospital Medical Center | In vivo model of human small intestine using pluripotent stem cells and methods of making and using same |
GB201501025D0 (en) * | 2015-01-21 | 2015-03-04 | Sagetis Biotech Sl | Chemical compounds |
US10413616B2 (en) | 2015-12-23 | 2019-09-17 | Viking Scientific, Inc. | Hydrogel prodrug for treatment |
CN105535994B (zh) * | 2015-12-25 | 2018-01-19 | 华中科技大学同济医学院附属同济医院 | 一种治疗hpv感染的纳米粒制剂及其制备方法 |
US11066650B2 (en) | 2016-05-05 | 2021-07-20 | Children's Hospital Medical Center | Methods for the in vitro manufacture of gastric fundus tissue and compositions related to same |
US11767515B2 (en) | 2016-12-05 | 2023-09-26 | Children's Hospital Medical Center | Colonic organoids and methods of making and using same |
CN106727313B (zh) * | 2017-01-06 | 2020-04-10 | 国家纳米科学中心 | 一种载药聚合物纳米胶束及其制备方法和应用 |
GB201708203D0 (en) * | 2017-05-22 | 2017-07-05 | Sagetis Biotech Sl | Chemical compounds |
WO2019084229A1 (en) | 2017-10-27 | 2019-05-02 | Massachusetts Institute Of Technology | POLY (BETA-AMINO ESTERS) AND USES THEREOF |
WO2019090045A1 (en) * | 2017-11-03 | 2019-05-09 | Massachusetts Institute Of Technology | Gene delivery carrier |
CA3088933A1 (en) * | 2018-01-17 | 2019-08-01 | Aratinga Bio Tnp | Polymer-encapsulated viral vectors for genetic therapy |
CN114144521A (zh) * | 2019-05-31 | 2022-03-04 | 儿童医院医学中心 | 基于聚合物的细胞标记、条形码化和组装 |
CA3151983A1 (en) * | 2019-09-21 | 2021-03-25 | Ozgul TEZGEL | Dmso-free synthesis of oligopeptide-modified poly(beta-amino ester)s and their use in nanoparticle delivery systems |
WO2021094831A1 (en) | 2019-11-15 | 2021-05-20 | Aratinga.Bio Tnp | Polymer-encapsulated viral vectors for in vivo genetic therapy |
WO2021255262A1 (en) | 2020-06-19 | 2021-12-23 | Sylentis Sau | siRNA AND COMPOSITIONS FOR PROPHYLACTIC AND THERAPEUTIC TREATMENT OF VIRUS DISEASES |
CA3195358A1 (en) * | 2020-11-19 | 2022-05-27 | Encapsys, Llc | Poly acrylate and poly(beta-amino ester) capsules with enhanced degradability |
EP4015634A1 (en) | 2020-12-15 | 2022-06-22 | Sylentis, S.A.U. | Sirna and compositions for prophylactic and therapeutic treatment of virus diseases |
WO2023006651A1 (en) * | 2021-07-26 | 2023-02-02 | Institut Quimic De Sarria Cets Fundacio Privada | Covalently coated adeno-associated virus vector for its use in gene therapy |
EP4166594A1 (en) | 2021-10-14 | 2023-04-19 | Institut Químic de Sarrià CETS Fundació Privada | Zwitterionic functionalized poly(beta-aminoester) polymers and uses thereof |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BR9912070A (pt) * | 1998-07-13 | 2001-04-10 | Expression Genetics Inc | Análogo de poliéster de poli-l-lisina como um solúvel, veìculo de distribuição de gene biodegradável |
US7427394B2 (en) * | 2000-10-10 | 2008-09-23 | Massachusetts Institute Of Technology | Biodegradable poly(β-amino esters) and uses thereof |
EP1796650B1 (en) * | 2004-09-14 | 2009-01-07 | NanoDel Technologies GmbH | Delivery vehicle containing nanoparticles |
CA2658768C (en) * | 2006-07-21 | 2016-05-17 | Massachusetts Institute Of Technology | End-modified poly(beta-amino esters) and uses thereof |
US9717694B2 (en) * | 2009-05-15 | 2017-08-01 | The Johns Hopkins University | Peptide/particle delivery systems |
GB0913442D0 (en) * | 2009-07-31 | 2009-09-16 | Univ Ramot | Cell-targeting nanoparticles comprising polynucleotide agents and uses thereof |
US20140294909A1 (en) * | 2011-10-13 | 2014-10-02 | The Johns Hopkins University | Nanocomposites of gold and polymers |
-
2013
- 2013-03-08 GB GBGB1304245.2A patent/GB201304245D0/en not_active Ceased
-
2014
- 2014-03-10 AU AU2014224219A patent/AU2014224219B2/en active Active
- 2014-03-10 BR BR112015021709A patent/BR112015021709B8/pt active IP Right Grant
- 2014-03-10 EP EP14713268.2A patent/EP2964244B1/en active Active
- 2014-03-10 JP JP2015560842A patent/JP6473421B2/ja active Active
- 2014-03-10 RU RU2015142677A patent/RU2015142677A/ru not_active Application Discontinuation
- 2014-03-10 WO PCT/IB2014/059594 patent/WO2014136100A1/en active Application Filing
- 2014-03-10 AR ARP140100782A patent/AR095081A1/es active IP Right Grant
- 2014-03-10 US US14/773,671 patent/US20160038598A1/en not_active Abandoned
- 2014-03-10 KR KR1020157027431A patent/KR102191195B1/ko active IP Right Grant
- 2014-03-10 CA CA2903663A patent/CA2903663C/en active Active
- 2014-03-10 DK DK14713268.2T patent/DK2964244T3/da active
- 2014-03-10 CN CN201480025579.5A patent/CN105324120B/zh active Active
- 2014-03-10 PL PL14713268T patent/PL2964244T3/pl unknown
- 2014-03-10 ES ES14713268T patent/ES2781965T3/es active Active
- 2014-03-10 TW TW103108216A patent/TW201446269A/zh unknown
- 2014-03-10 MX MX2015011393A patent/MX364396B/es active IP Right Grant
-
2018
- 2018-02-28 US US15/908,112 patent/US20180250410A1/en active Pending
Also Published As
Publication number | Publication date |
---|---|
KR20150135334A (ko) | 2015-12-02 |
MX364396B (es) | 2019-04-25 |
AU2014224219A1 (en) | 2015-09-24 |
KR102191195B1 (ko) | 2020-12-16 |
CN105324120B (zh) | 2021-04-02 |
BR112015021709B8 (pt) | 2022-04-05 |
AU2014224219B2 (en) | 2018-12-13 |
EP2964244B1 (en) | 2020-01-08 |
JP2016511316A (ja) | 2016-04-14 |
JP6473421B2 (ja) | 2019-02-20 |
ES2781965T3 (es) | 2020-09-09 |
CN105324120A (zh) | 2016-02-10 |
TW201446269A (zh) | 2014-12-16 |
GB201304245D0 (en) | 2013-04-24 |
US20180250410A1 (en) | 2018-09-06 |
WO2014136100A1 (en) | 2014-09-12 |
RU2015142677A (ru) | 2017-04-13 |
EP2964244A1 (en) | 2016-01-13 |
DK2964244T3 (da) | 2020-04-06 |
PL2964244T3 (pl) | 2020-08-24 |
MX2015011393A (es) | 2016-06-06 |
AR095081A1 (es) | 2015-09-16 |
BR112015021709B1 (pt) | 2022-03-03 |
US20160038598A1 (en) | 2016-02-11 |
CA2903663A1 (en) | 2014-09-12 |
CA2903663C (en) | 2022-08-30 |
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