BR112015001892A2 - cocleados feitos com fosfatidilserina de soja - Google Patents
cocleados feitos com fosfatidilserina de sojaInfo
- Publication number
- BR112015001892A2 BR112015001892A2 BR112015001892A BR112015001892A BR112015001892A2 BR 112015001892 A2 BR112015001892 A2 BR 112015001892A2 BR 112015001892 A BR112015001892 A BR 112015001892A BR 112015001892 A BR112015001892 A BR 112015001892A BR 112015001892 A2 BR112015001892 A2 BR 112015001892A2
- Authority
- BR
- Brazil
- Prior art keywords
- phosphatidylserine
- cochleates
- soybean phosphatidylserine
- soybean
- soy
- Prior art date
Links
- TZCPCKNHXULUIY-RGULYWFUSA-N 1,2-distearoyl-sn-glycero-3-phosphoserine Chemical compound CCCCCCCCCCCCCCCCCC(=O)OC[C@H](COP(O)(=O)OC[C@H](N)C(O)=O)OC(=O)CCCCCCCCCCCCCCCCC TZCPCKNHXULUIY-RGULYWFUSA-N 0.000 title abstract 4
- ZWZWYGMENQVNFU-UHFFFAOYSA-N Glycerophosphorylserin Natural products OC(=O)C(N)COP(O)(=O)OCC(O)CO ZWZWYGMENQVNFU-UHFFFAOYSA-N 0.000 title abstract 4
- 235000010469 Glycine max Nutrition 0.000 title abstract 4
- 244000068988 Glycine max Species 0.000 title abstract 2
- APKFDSVGJQXUKY-KKGHZKTASA-N Amphotericin-B Natural products O[C@H]1[C@@H](N)[C@H](O)[C@@H](C)O[C@H]1O[C@H]1C=CC=CC=CC=CC=CC=CC=C[C@H](C)[C@@H](O)[C@@H](C)[C@H](C)OC(=O)C[C@H](O)C[C@H](O)CC[C@@H](O)[C@H](O)C[C@H](O)C[C@](O)(C[C@H](O)[C@H]2C(O)=O)O[C@H]2C1 APKFDSVGJQXUKY-KKGHZKTASA-N 0.000 abstract 1
- APKFDSVGJQXUKY-INPOYWNPSA-N amphotericin B Chemical compound O[C@H]1[C@@H](N)[C@H](O)[C@@H](C)O[C@H]1O[C@H]1/C=C/C=C/C=C/C=C/C=C/C=C/C=C/[C@H](C)[C@@H](O)[C@@H](C)[C@H](C)OC(=O)C[C@H](O)C[C@H](O)CC[C@@H](O)[C@H](O)C[C@H](O)C[C@](O)(C[C@H](O)[C@H]2C(O)=O)O[C@H]2C1 APKFDSVGJQXUKY-INPOYWNPSA-N 0.000 abstract 1
- 229960003942 amphotericin b Drugs 0.000 abstract 1
- 229940121375 antifungal agent Drugs 0.000 abstract 1
- 239000003429 antifungal agent Substances 0.000 abstract 1
- 150000001768 cations Chemical class 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/24—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Liposomes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/12—Ketones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/12—Ketones
- A61K31/122—Ketones having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/683—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols
- A61K31/685—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols one of the hydroxy compounds having nitrogen atoms, e.g. phosphatidylserine, lecithin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
- A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
- A61K31/7036—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin having at least one amino group directly attached to the carbocyclic ring, e.g. streptomycin, gentamycin, amikacin, validamycin, fortimicins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Liposomes
- A61K9/1274—Non-vesicle bilayer structures, e.g. liquid crystals, tubules, cubic phases, cochleates; Sponge phases
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Liposomes
- A61K9/1277—Processes for preparing; Proliposomes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Dispersion Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Inorganic Chemistry (AREA)
- Biophysics (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
resumo patente de invenção: "cocleados feitos com fosfatidilserina de soja". a presente invenção refere-se à fosfatidilserina soja pura não purificada ou inferior que é usada para fazer cocleados. os cocleados contêm cerca de 40-74% de fosfatidilserina de soja, um cátion multivalente e um ativo biológico. um cocleado preferido contém o agente antifúngico anfotericina b.
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201261677414P | 2012-07-30 | 2012-07-30 | |
US61/677,414 | 2012-07-30 | ||
US201361835825P | 2013-06-17 | 2013-06-17 | |
US61/835,825 | 2013-06-17 | ||
PCT/US2013/052756 WO2014022414A1 (en) | 2012-07-30 | 2013-07-30 | Cochleates made with soy phosphatidylserine |
Publications (3)
Publication Number | Publication Date |
---|---|
BR112015001892A2 true BR112015001892A2 (pt) | 2017-07-04 |
BR112015001892A8 BR112015001892A8 (pt) | 2017-10-10 |
BR112015001892B1 BR112015001892B1 (pt) | 2021-02-02 |
Family
ID=50028476
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112015001892-0A BR112015001892B1 (pt) | 2012-07-30 | 2013-07-30 | cocleados feitos com fosfatidilserina de soja e método para a produção de cocleados de fosfatidilserina de soja/ativo biológico |
Country Status (14)
Country | Link |
---|---|
US (5) | US20150297725A1 (pt) |
EP (2) | EP2879502B1 (pt) |
JP (2) | JP6444865B2 (pt) |
KR (1) | KR102115718B1 (pt) |
CN (1) | CN105050409B (pt) |
AU (1) | AU2013296651B2 (pt) |
BR (1) | BR112015001892B1 (pt) |
CA (1) | CA2879931C (pt) |
DK (1) | DK2879502T3 (pt) |
ES (1) | ES2688397T3 (pt) |
HK (1) | HK1211181A1 (pt) |
MX (1) | MX361155B (pt) |
RU (1) | RU2659729C2 (pt) |
WO (1) | WO2014022414A1 (pt) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2014022414A1 (en) | 2012-07-30 | 2014-02-06 | Coordinated Program Development, Llc | Cochleates made with soy phosphatidylserine |
JP6770524B2 (ja) * | 2015-03-03 | 2020-10-14 | マティナス バイオファーマ ナノテクノロジーズ,インコーポレーテッド | コクリエート、及び薬理活性物質の組織透過性を高めるためにそれを使用する方法 |
CA2982259A1 (en) * | 2015-04-22 | 2016-10-27 | Matinas Biopharma Nanotechnologies, Inc. | Compositions and methods for treating mycobacteria infections and lung disease |
CN107920991A (zh) * | 2015-06-18 | 2018-04-17 | 马丁尼斯生物制药纳米技术公司 | 治疗炎性疾病或病状的组合物和方法 |
CN108366974A (zh) * | 2015-12-16 | 2018-08-03 | 维韦克·阿南德·帕拉库尔 | 天然化合物的三分子复合物 |
AU2017297402B2 (en) | 2016-07-12 | 2023-02-09 | Matinas Biopharma Nanotechnologies, Inc. | Encochleated antifungal compounds for central nervous system delivery and treatment of Cryptococcus infections |
US20190083518A1 (en) * | 2017-09-20 | 2019-03-21 | Atopic Medical, LLC | Compositions and methods for treating and ameliorating respiratory conditions and inflammation of mucosa |
KR101989789B1 (ko) * | 2017-11-30 | 2019-06-18 | (주) 에이치엔에이파마켐 | 포스파티딜세린/음이온계면활성제/염화칼슘을 이용한 코킬레이트 |
ES1245259Y (es) | 2019-05-10 | 2020-08-24 | Bionova Slu | Emulsiones de los cannabinoides del aceite de cáñamo |
CA3208643A1 (en) | 2021-01-18 | 2022-07-21 | Conserv Bioscience Limited | Coronavirus immunogenic compositions, methods and uses thereof |
WO2023183297A1 (en) * | 2022-03-21 | 2023-09-28 | The Board Of Trustees Of The University Of Illinois | Ion channel prosthetic compositions comprising lipid-coated crystals of amphotericin b |
WO2024039733A1 (en) | 2022-08-16 | 2024-02-22 | Matinas Biopharma Nanotechnologies, Inc. | Methods of controlling lipid nanocrystal particle size and lipid nanocrystals produced by such methods |
WO2024039729A1 (en) | 2022-08-16 | 2024-02-22 | Matinas Biopharma Nanotechnologies, Inc. | Antifungal agent encapsulated in a lipid nanocrystal for treating mucormycosis |
Family Cites Families (28)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4663161A (en) * | 1985-04-22 | 1987-05-05 | Mannino Raphael J | Liposome methods and compositions |
GB8919172D0 (en) * | 1989-08-23 | 1989-10-04 | Univ Nottingham | Useful composition |
JPH0550062A (ja) | 1991-05-29 | 1993-03-02 | Toray Ind Inc | 水溶液の浄化法 |
AU3246093A (en) * | 1991-12-11 | 1993-07-19 | Temple University - Of The Commonwealth System Of Higher Education | Amphotericin B composition with enhanced antifungal activity |
AU3244393A (en) * | 1992-12-02 | 1994-06-22 | Vestar, Inc. | Antibiotic formulation and process |
US6663885B1 (en) * | 1993-03-15 | 2003-12-16 | A. Natterman & Cie Gmbh | Aqueous liposome system and a method for the preparation of such a liposome system |
US5554382A (en) * | 1993-05-28 | 1996-09-10 | Aphios Corporation | Methods and apparatus for making liposomes |
AU4981896A (en) * | 1995-02-14 | 1996-09-04 | Sequus Pharmaceuticals, Inc. | Liposome composition and method for administering liposome-loadable drugs |
US6120751A (en) * | 1997-03-21 | 2000-09-19 | Imarx Pharmaceutical Corp. | Charged lipids and uses for the same |
WO2002085337A1 (en) | 2001-04-20 | 2002-10-31 | The University Of British Columbia | Micellar drug delivery systems for hydrophobic drugs |
JP3697189B2 (ja) | 2001-01-11 | 2005-09-21 | 日清オイリオグループ株式会社 | リン脂質の塩基交換方法 |
DE10109898A1 (de) * | 2001-02-21 | 2002-09-05 | Novosom Gmbh | Lipide mit veränderlicher Ladung |
US20030219473A1 (en) * | 2002-03-26 | 2003-11-27 | Leila Zarif | Cochleates made with purified soy phosphatidylserine |
DE10228680A1 (de) * | 2002-06-27 | 2004-01-22 | Holden Development Limited, Tortola | Grundlage für transdermale Formulierungen (PTF) |
CN1674869A (zh) | 2002-08-06 | 2005-09-28 | 金拓 | 非金属阳离子作桥联剂的脂质卷 |
WO2004037271A1 (en) * | 2002-10-25 | 2004-05-06 | Vasogen Ireland Limited | Cyclooxygenase regulation with ps liposomes |
US7879351B2 (en) * | 2002-10-29 | 2011-02-01 | Transave, Inc. | High delivery rates for lipid based drug formulations, and methods of treatment thereof |
JP4886297B2 (ja) * | 2002-11-01 | 2012-02-29 | バイオデリバリー サイエンシーズ インターナショナル インコーポレイティッド | ジオデート送達媒体 |
WO2004064805A1 (en) * | 2003-01-15 | 2004-08-05 | Biodelivery Sciences International, Inc. | Cochleate preparations of fragile nutrients |
WO2004091572A2 (en) * | 2003-04-09 | 2004-10-28 | Biodelivery Sciences International, Inc. | Cochleate compositions directed against expression of proteins |
EP1624858B1 (en) | 2003-04-09 | 2018-06-06 | Rutgers, the State University of New Jersey | Novel encochleation methods |
JP4891522B2 (ja) * | 2003-10-03 | 2012-03-07 | 株式会社ファンケル | 血清got、gpt改善剤 |
CU20080215A7 (es) | 2008-11-19 | 2012-06-21 | Inst Finlay | Vacunas unitemporales |
WO2010091090A1 (en) * | 2009-02-03 | 2010-08-12 | Biodelivery Sciences International, Inc. | Cochleate compositions and methods of use |
JP5621204B2 (ja) * | 2009-03-31 | 2014-11-12 | 日油株式会社 | 血管老化予防剤 |
US20100239521A1 (en) * | 2010-06-01 | 2010-09-23 | Mohammad Reza Mozafari | Method for the preparation of micro- and nano-sized carrier systems for the encapsulation of bioactive substances |
EP2689775A1 (en) * | 2012-07-25 | 2014-01-29 | Instituto Finlay, Centro de Investigacion-Produccion de vacunas y sueros | Cochleate with only one mamp |
WO2014022414A1 (en) * | 2012-07-30 | 2014-02-06 | Coordinated Program Development, Llc | Cochleates made with soy phosphatidylserine |
-
2013
- 2013-07-30 WO PCT/US2013/052756 patent/WO2014022414A1/en active Application Filing
- 2013-07-30 EP EP13826076.5A patent/EP2879502B1/en active Active
- 2013-07-30 AU AU2013296651A patent/AU2013296651B2/en active Active
- 2013-07-30 CN CN201380051033.2A patent/CN105050409B/zh active Active
- 2013-07-30 EP EP18190254.5A patent/EP3461338A1/en not_active Withdrawn
- 2013-07-30 RU RU2015105881A patent/RU2659729C2/ru active
- 2013-07-30 KR KR1020157005368A patent/KR102115718B1/ko active IP Right Grant
- 2013-07-30 CA CA2879931A patent/CA2879931C/en active Active
- 2013-07-30 BR BR112015001892-0A patent/BR112015001892B1/pt active IP Right Grant
- 2013-07-30 MX MX2015001348A patent/MX361155B/es active IP Right Grant
- 2013-07-30 DK DK13826076.5T patent/DK2879502T3/en active
- 2013-07-30 ES ES13826076.5T patent/ES2688397T3/es active Active
- 2013-07-30 US US14/418,392 patent/US20150297725A1/en not_active Abandoned
- 2013-07-30 JP JP2015525517A patent/JP6444865B2/ja active Active
-
2015
- 2015-01-29 US US14/609,235 patent/US9370572B2/en active Active
- 2015-01-29 US US14/609,269 patent/US9775907B2/en active Active
- 2015-12-09 HK HK15112166.6A patent/HK1211181A1/xx unknown
-
2017
- 2017-11-13 US US15/811,040 patent/US10716860B2/en active Active
-
2018
- 2018-08-14 JP JP2018152560A patent/JP6751424B2/ja active Active
-
2020
- 2020-06-18 US US16/904,824 patent/US11964019B2/en active Active
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Legal Events
Date | Code | Title | Description |
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B25A | Requested transfer of rights approved |
Owner name: RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY (US) , |
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B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
B06I | Publication of requirement cancelled [chapter 6.9 patent gazette] |
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