BR112015001892A8 - Cocleados feitos com fosfatidilserina de soja e método para a produção de cocleados de fosfatidilserina de soja/ativo biológico - Google Patents

Cocleados feitos com fosfatidilserina de soja e método para a produção de cocleados de fosfatidilserina de soja/ativo biológico

Info

Publication number
BR112015001892A8
BR112015001892A8 BR112015001892A BR112015001892A BR112015001892A8 BR 112015001892 A8 BR112015001892 A8 BR 112015001892A8 BR 112015001892 A BR112015001892 A BR 112015001892A BR 112015001892 A BR112015001892 A BR 112015001892A BR 112015001892 A8 BR112015001892 A8 BR 112015001892A8
Authority
BR
Brazil
Prior art keywords
cochleates
soyphosphatidylserine
biological active
production
soyphosphatidylserin
Prior art date
Application number
BR112015001892A
Other languages
English (en)
Other versions
BR112015001892A2 (pt
BR112015001892B1 (pt
Inventor
Mannino Raphael
Lu Ruying
Original Assignee
Coordinated Program Dev Llc
Matinas Biopharma Nanotechnologies Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Coordinated Program Dev Llc, Matinas Biopharma Nanotechnologies Inc filed Critical Coordinated Program Dev Llc
Publication of BR112015001892A2 publication Critical patent/BR112015001892A2/pt
Publication of BR112015001892A8 publication Critical patent/BR112015001892A8/pt
Publication of BR112015001892B1 publication Critical patent/BR112015001892B1/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/12—Ketones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/12—Ketones
    • A61K31/122—Ketones having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/683—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols
    • A61K31/685—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols one of the hydroxy compounds having nitrogen atoms, e.g. phosphatidylserine, lecithin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/7036—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin having at least one amino group directly attached to the carbocyclic ring, e.g. streptomycin, gentamycin, amikacin, validamycin, fortimicins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/24—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A61K9/1274—Non-vesicle bilayer structures, e.g. liquid crystals, tubules, cubic phases, cochleates; Sponge phases
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A61K9/1277—Processes for preparing; Proliposomes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Dispersion Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Inorganic Chemistry (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

COCLEADOS FEITOS COM FOSFATIDILSERINA DE SOJA E MÉTODO PARA A PRODUÇÃO DE COCLEADOS DE FOSFATIDILSERINA DE SOJA/ATIVO BIOLÓGICO. A presente invenção refere-se à fosfatidilserina soja pura não purificada ou inferior que é usada para fazer cocleados. Os cocleados contêm cerca de 40-74% de fosfatidilserina de soja, um cátion multivalente e um ativo biológico. Um cocleado preferido contém o agente antifúngico anfotericina B.
BR112015001892-0A 2012-07-30 2013-07-30 cocleados feitos com fosfatidilserina de soja e método para a produção de cocleados de fosfatidilserina de soja/ativo biológico BR112015001892B1 (pt)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201261677414P 2012-07-30 2012-07-30
US61/677,414 2012-07-30
US201361835825P 2013-06-17 2013-06-17
US61/835,825 2013-06-17
PCT/US2013/052756 WO2014022414A1 (en) 2012-07-30 2013-07-30 Cochleates made with soy phosphatidylserine

Publications (3)

Publication Number Publication Date
BR112015001892A2 BR112015001892A2 (pt) 2017-07-04
BR112015001892A8 true BR112015001892A8 (pt) 2017-10-10
BR112015001892B1 BR112015001892B1 (pt) 2021-02-02

Family

ID=50028476

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112015001892-0A BR112015001892B1 (pt) 2012-07-30 2013-07-30 cocleados feitos com fosfatidilserina de soja e método para a produção de cocleados de fosfatidilserina de soja/ativo biológico

Country Status (14)

Country Link
US (5) US20150297725A1 (pt)
EP (2) EP2879502B1 (pt)
JP (2) JP6444865B2 (pt)
KR (1) KR102115718B1 (pt)
CN (1) CN105050409B (pt)
AU (1) AU2013296651B2 (pt)
BR (1) BR112015001892B1 (pt)
CA (1) CA2879931C (pt)
DK (1) DK2879502T3 (pt)
ES (1) ES2688397T3 (pt)
HK (1) HK1211181A1 (pt)
MX (1) MX361155B (pt)
RU (1) RU2659729C2 (pt)
WO (1) WO2014022414A1 (pt)

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BR112015001892B1 (pt) 2012-07-30 2021-02-02 Rutgers, The State University Of New Jersey cocleados feitos com fosfatidilserina de soja e método para a produção de cocleados de fosfatidilserina de soja/ativo biológico
JP6770524B2 (ja) * 2015-03-03 2020-10-14 マティナス バイオファーマ ナノテクノロジーズ，インコーポレーテッド コクリエート、及び薬理活性物質の組織透過性を高めるためにそれを使用する方法
CA2982259A1 (en) * 2015-04-22 2016-10-27 Matinas Biopharma Nanotechnologies, Inc. Compositions and methods for treating mycobacteria infections and lung disease
JP2018517736A (ja) * 2015-06-18 2018-07-05 マティナス バイオファーマ ナノテクノロジーズ，インコーポレーテッド 炎症性疾患又は病態を治療する組成物及び方法
US11696900B2 (en) * 2015-12-16 2023-07-11 Olene Life Sciences Private Limited Tri-molecular complex of natural compounds
KR20190029642A (ko) * 2016-07-12 2019-03-20 마티나스 바이오파마 나노테크놀로지스, 인코포레이티드 중추 신경계 전달 및 크립토코커스(cryptococcus) 감염의 치료를 위한 코클리에이트화된(encochleated) 항진균 화합물
EP3684373A4 (en) * 2017-09-20 2021-06-23 Atopic Medical, Inc. COMPOSITIONS AND METHODS FOR TREATING AND IMPROVING RESPIRATORY CONDITIONS AND MUCOUS INFLAMMATION
KR101989789B1 (ko) * 2017-11-30 2019-06-18 (주) 에이치엔에이파마켐 포스파티딜세린/음이온계면활성제/염화칼슘을 이용한 코킬레이트
ES1245259Y (es) 2019-05-10 2020-08-24 Bionova Slu Emulsiones de los cannabinoides del aceite de cáñamo
CA3208643A1 (en) 2021-01-18 2022-07-21 Conserv Bioscience Limited Coronavirus immunogenic compositions, methods and uses thereof
WO2023183297A1 (en) * 2022-03-21 2023-09-28 The Board Of Trustees Of The University Of Illinois Ion channel prosthetic compositions comprising lipid-coated crystals of amphotericin b
WO2024039729A1 (en) 2022-08-16 2024-02-22 Matinas Biopharma Nanotechnologies, Inc. Antifungal agent encapsulated in a lipid nanocrystal for treating mucormycosis
WO2024039733A1 (en) 2022-08-16 2024-02-22 Matinas Biopharma Nanotechnologies, Inc. Methods of controlling lipid nanocrystal particle size and lipid nanocrystals produced by such methods

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EP2689775A1 (en) * 2012-07-25 2014-01-29 Instituto Finlay, Centro de Investigacion-Produccion de vacunas y sueros Cochleate with only one mamp
BR112015001892B1 (pt) 2012-07-30 2021-02-02 Rutgers, The State University Of New Jersey cocleados feitos com fosfatidilserina de soja e método para a produção de cocleados de fosfatidilserina de soja/ativo biológico

Also Published As

Publication number Publication date
AU2013296651A1 (en) 2015-03-19
RU2015105881A (ru) 2016-09-20
JP2018203750A (ja) 2018-12-27
US20150147380A1 (en) 2015-05-28
US20150297725A1 (en) 2015-10-22
CA2879931C (en) 2020-12-15
MX361155B (es) 2018-11-28
CA2879931A1 (en) 2014-02-06
US11964019B2 (en) 2024-04-23
US20210038722A1 (en) 2021-02-11
US9775907B2 (en) 2017-10-03
KR102115718B1 (ko) 2020-05-28
KR20150107707A (ko) 2015-09-23
DK2879502T3 (en) 2018-10-15
BR112015001892A2 (pt) 2017-07-04
JP6751424B2 (ja) 2020-09-02
EP2879502A4 (en) 2016-03-09
HK1211181A1 (en) 2016-05-20
US20180185491A1 (en) 2018-07-05
JP6444865B2 (ja) 2018-12-26
BR112015001892B1 (pt) 2021-02-02
US20150140074A1 (en) 2015-05-21
US9370572B2 (en) 2016-06-21
CN105050409A (zh) 2015-11-11
JP2015528021A (ja) 2015-09-24
AU2013296651B2 (en) 2017-03-02
MX2015001348A (es) 2016-03-04
EP3461338A1 (en) 2019-04-03
RU2659729C2 (ru) 2018-07-03
EP2879502B1 (en) 2018-09-05
US10716860B2 (en) 2020-07-21
EP2879502A1 (en) 2015-06-10
WO2014022414A1 (en) 2014-02-06
ES2688397T3 (es) 2018-11-02
CN105050409B (zh) 2018-05-25

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