BR112014014805A2 - processos para tratamento e prevenção de constipação induzida por opióide que utilizam composições orais de metilnaltrexona - Google Patents
processos para tratamento e prevenção de constipação induzida por opióide que utilizam composições orais de metilnaltrexonaInfo
- Publication number
- BR112014014805A2 BR112014014805A2 BR112014014805A BR112014014805A BR112014014805A2 BR 112014014805 A2 BR112014014805 A2 BR 112014014805A2 BR 112014014805 A BR112014014805 A BR 112014014805A BR 112014014805 A BR112014014805 A BR 112014014805A BR 112014014805 A2 BR112014014805 A2 BR 112014014805A2
- Authority
- BR
- Brazil
- Prior art keywords
- treating
- induced constipation
- processes
- compositions
- oral
- Prior art date
Links
- 206010010774 Constipation Diseases 0.000 title abstract 4
- 208000030053 Opioid-Induced Constipation Diseases 0.000 title abstract 4
- 238000000034 method Methods 0.000 title abstract 4
- 239000000203 mixture Substances 0.000 title abstract 4
- JVLBPIPGETUEET-WIXLDOGYSA-O (3r,4r,4as,7ar,12bs)-3-(cyclopropylmethyl)-4a,9-dihydroxy-3-methyl-2,4,5,6,7a,13-hexahydro-1h-4,12-methanobenzofuro[3,2-e]isoquinoline-3-ium-7-one Chemical compound C([N@+]1(C)[C@@H]2CC=3C4=C(C(=CC=3)O)O[C@@H]3[C@]4([C@@]2(O)CCC3=O)CC1)C1CC1 JVLBPIPGETUEET-WIXLDOGYSA-O 0.000 title abstract 3
- 229960002921 methylnaltrexone Drugs 0.000 title abstract 3
- 230000002411 adverse Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/485—Morphinan derivatives, e.g. morphine, codeine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/10—Laxatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Emergency Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161577654P | 2011-12-19 | 2011-12-19 | |
| PCT/US2012/070612 WO2013096444A1 (en) | 2011-12-19 | 2012-12-19 | Methods for treatment and prevention of opioid induced constipation using oral compositions of methylnaltrexone |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR112014014805A2 true BR112014014805A2 (pt) | 2017-06-13 |
Family
ID=48669445
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112014014805A BR112014014805A2 (pt) | 2011-12-19 | 2012-12-19 | processos para tratamento e prevenção de constipação induzida por opióide que utilizam composições orais de metilnaltrexona |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US20130317050A1 (enExample) |
| EP (1) | EP2793888A4 (enExample) |
| JP (2) | JP2015501849A (enExample) |
| KR (1) | KR20140107540A (enExample) |
| CN (2) | CN104254332A (enExample) |
| AU (3) | AU2012359013A1 (enExample) |
| BR (1) | BR112014014805A2 (enExample) |
| CA (1) | CA2859203C (enExample) |
| IL (1) | IL233266A0 (enExample) |
| MX (1) | MX2014007312A (enExample) |
| WO (1) | WO2013096444A1 (enExample) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI489984B (zh) | 2006-08-04 | 2015-07-01 | Wyeth Corp | 用於非經腸道傳輸化合物之配方及其用途 |
| WO2015191686A1 (en) * | 2014-06-10 | 2015-12-17 | Salix Pharmaceuticals, Inc. | Methods of administering methylnaltrexone |
| WO2016061531A1 (en) * | 2014-10-17 | 2016-04-21 | Salix Pharmaceuticals, Inc. | Use of methylnaltrexone to attenuate tumor progression |
| JP2019513355A (ja) * | 2016-03-29 | 2019-05-30 | コロナリーコンセプツ エルエルシー | 便秘症を処置するための製剤 |
| WO2023031955A1 (en) * | 2021-08-28 | 2023-03-09 | Redasani Vijayendrakumar Virendrakumar Ji | Oral pharmaceutical compositions of methylnaltrexone and salt thereof |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS601128A (ja) * | 1983-06-15 | 1985-01-07 | Shionogi & Co Ltd | 作用持続型セフアクロル製剤 |
| US20030158220A1 (en) * | 1997-11-03 | 2003-08-21 | Foss Joseph F. | Use of methylnaltrexone and related compounds to treat chronic opioid use side effects |
| EP1494683A1 (en) * | 2002-04-05 | 2005-01-12 | Merck & Co., Inc. | Method for inhibiting bone resorption with an alendronate and vitamin d formulation |
| SE0303135D0 (sv) * | 2003-11-25 | 2003-11-25 | Lipocore Holding Ab | Controlled food effect composition |
| US20070010543A1 (en) * | 2005-07-01 | 2007-01-11 | Dynogen Pharmaceuticals, Inc. | Compositions and methods for treating gastrointestinal hypomotility and associated disorders |
| EA201001643A1 (ru) * | 2008-05-07 | 2011-06-30 | Нектар Терапеутикс | Пероральное введение периферически действующих опиоидных антагонистов |
| CN101845047B (zh) * | 2009-12-31 | 2011-12-07 | 南京臣功制药有限公司 | 一种溴甲基纳曲酮的制备方法 |
| SG10201501821RA (en) * | 2010-03-11 | 2015-05-28 | Wyeth Llc | Oral formulations and lipophilic salts of methylnaltrexone |
-
2012
- 2012-12-19 WO PCT/US2012/070612 patent/WO2013096444A1/en not_active Ceased
- 2012-12-19 CN CN201280070087.9A patent/CN104254332A/zh active Pending
- 2012-12-19 AU AU2012359013A patent/AU2012359013A1/en not_active Abandoned
- 2012-12-19 US US13/720,235 patent/US20130317050A1/en not_active Abandoned
- 2012-12-19 JP JP2014548835A patent/JP2015501849A/ja active Pending
- 2012-12-19 MX MX2014007312A patent/MX2014007312A/es unknown
- 2012-12-19 CN CN201910609611.9A patent/CN110384701A/zh active Pending
- 2012-12-19 KR KR1020147020310A patent/KR20140107540A/ko not_active Ceased
- 2012-12-19 EP EP12860187.9A patent/EP2793888A4/en not_active Withdrawn
- 2012-12-19 BR BR112014014805A patent/BR112014014805A2/pt not_active Application Discontinuation
- 2012-12-19 CA CA2859203A patent/CA2859203C/en active Active
-
2014
- 2014-06-19 IL IL233266A patent/IL233266A0/en unknown
-
2017
- 2017-11-06 AU AU2017258808A patent/AU2017258808A1/en not_active Abandoned
-
2018
- 2018-10-19 JP JP2018197326A patent/JP2019048820A/ja active Pending
- 2018-11-30 US US16/206,570 patent/US20190231771A1/en not_active Abandoned
-
2019
- 2019-05-27 AU AU2019203694A patent/AU2019203694A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| CA2859203A1 (en) | 2013-06-27 |
| IL233266A0 (en) | 2014-08-31 |
| CN104254332A (zh) | 2014-12-31 |
| US20130317050A1 (en) | 2013-11-28 |
| AU2019203694A1 (en) | 2019-06-20 |
| MX2014007312A (es) | 2014-08-27 |
| US20190231771A1 (en) | 2019-08-01 |
| EP2793888A1 (en) | 2014-10-29 |
| AU2012359013A1 (en) | 2014-06-26 |
| KR20140107540A (ko) | 2014-09-04 |
| AU2017258808A1 (en) | 2017-11-23 |
| JP2019048820A (ja) | 2019-03-28 |
| JP2015501849A (ja) | 2015-01-19 |
| CA2859203C (en) | 2020-08-25 |
| CN110384701A (zh) | 2019-10-29 |
| NZ625863A (en) | 2016-11-25 |
| EP2793888A4 (en) | 2015-10-28 |
| WO2013096444A1 (en) | 2013-06-27 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] | ||
| B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
| B07E | Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] | ||
| B06T | Formal requirements before examination [chapter 6.20 patent gazette] | ||
| B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
| B09B | Patent application refused [chapter 9.2 patent gazette] | ||
| B09B | Patent application refused [chapter 9.2 patent gazette] |
Free format text: MANTIDO O INDEFERIMENTO UMA VEZ QUE NAO FOI APRESENTADO RECURSO DENTRO DO PRAZO LEGAL |
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| B350 | Update of information on the portal [chapter 15.35 patent gazette] |