CN104254332A - 使用甲基纳曲酮口服组合物治疗和预防阿片类诱发型便秘的方法 - Google Patents

使用甲基纳曲酮口服组合物治疗和预防阿片类诱发型便秘的方法 Download PDF

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Publication number
CN104254332A
CN104254332A CN201280070087.9A CN201280070087A CN104254332A CN 104254332 A CN104254332 A CN 104254332A CN 201280070087 A CN201280070087 A CN 201280070087A CN 104254332 A CN104254332 A CN 104254332A
Authority
CN
China
Prior art keywords
patient
mntx
pharmaceutical composition
rescue
methylnaltrexone
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201280070087.9A
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English (en)
Chinese (zh)
Inventor
E.博泰
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Salix Pharmaceuticals Ltd
Original Assignee
Salix Pharmaceuticals Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Salix Pharmaceuticals Ltd filed Critical Salix Pharmaceuticals Ltd
Priority to CN201910609611.9A priority Critical patent/CN110384701A/zh
Publication of CN104254332A publication Critical patent/CN104254332A/zh
Pending legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/10—Laxatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Emergency Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
CN201280070087.9A 2011-12-19 2012-12-19 使用甲基纳曲酮口服组合物治疗和预防阿片类诱发型便秘的方法 Pending CN104254332A (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201910609611.9A CN110384701A (zh) 2011-12-19 2012-12-19 使用甲基纳曲酮口服组合物治疗和预防阿片类诱发型便秘的方法

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161577654P 2011-12-19 2011-12-19
US61/577,654 2011-12-19
PCT/US2012/070612 WO2013096444A1 (en) 2011-12-19 2012-12-19 Methods for treatment and prevention of opioid induced constipation using oral compositions of methylnaltrexone

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CN201910609611.9A Division CN110384701A (zh) 2011-12-19 2012-12-19 使用甲基纳曲酮口服组合物治疗和预防阿片类诱发型便秘的方法

Publications (1)

Publication Number Publication Date
CN104254332A true CN104254332A (zh) 2014-12-31

Family

ID=48669445

Family Applications (2)

Application Number Title Priority Date Filing Date
CN201910609611.9A Pending CN110384701A (zh) 2011-12-19 2012-12-19 使用甲基纳曲酮口服组合物治疗和预防阿片类诱发型便秘的方法
CN201280070087.9A Pending CN104254332A (zh) 2011-12-19 2012-12-19 使用甲基纳曲酮口服组合物治疗和预防阿片类诱发型便秘的方法

Family Applications Before (1)

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CN201910609611.9A Pending CN110384701A (zh) 2011-12-19 2012-12-19 使用甲基纳曲酮口服组合物治疗和预防阿片类诱发型便秘的方法

Country Status (11)

Country Link
US (2) US20130317050A1 (enExample)
EP (1) EP2793888A4 (enExample)
JP (2) JP2015501849A (enExample)
KR (1) KR20140107540A (enExample)
CN (2) CN110384701A (enExample)
AU (3) AU2012359013A1 (enExample)
BR (1) BR112014014805A2 (enExample)
CA (1) CA2859203C (enExample)
IL (1) IL233266A0 (enExample)
MX (1) MX2014007312A (enExample)
WO (1) WO2013096444A1 (enExample)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI489984B (zh) 2006-08-04 2015-07-01 Wyeth Corp 用於非經腸道傳輸化合物之配方及其用途
WO2015191686A1 (en) * 2014-06-10 2015-12-17 Salix Pharmaceuticals, Inc. Methods of administering methylnaltrexone
WO2016061531A1 (en) * 2014-10-17 2016-04-21 Salix Pharmaceuticals, Inc. Use of methylnaltrexone to attenuate tumor progression
WO2017172816A1 (en) * 2016-03-29 2017-10-05 Colonaryconcepts Llc Formulations for treating constipation
WO2023031955A1 (en) * 2021-08-28 2023-03-09 Redasani Vijayendrakumar Virendrakumar Ji Oral pharmaceutical compositions of methylnaltrexone and salt thereof

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101845047A (zh) * 2009-12-31 2010-09-29 南京臣功制药有限公司 一种溴甲基纳曲酮的制备方法
CN102014907A (zh) * 2008-05-07 2011-04-13 尼克塔治疗公司 外周作用阿片拮抗剂的口服给药
WO2011112816A1 (en) * 2010-03-11 2011-09-15 Wyeth, Llc Oral formulations and lipophilic salts of methylnaltrexone

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS601128A (ja) * 1983-06-15 1985-01-07 Shionogi & Co Ltd 作用持続型セフアクロル製剤
US20030158220A1 (en) * 1997-11-03 2003-08-21 Foss Joseph F. Use of methylnaltrexone and related compounds to treat chronic opioid use side effects
US20050176685A1 (en) * 2002-04-05 2005-08-11 Daifotis Anastasia G. Method for inhibiting bone resorption with an alendronate and vitamin d formulation
SE0303135D0 (sv) * 2003-11-25 2003-11-25 Lipocore Holding Ab Controlled food effect composition
WO2007005780A2 (en) * 2005-07-01 2007-01-11 Dynogen Pharmaceuticals, Inc. Compositions and methods for treating gastrointestinal hypomotility and associated disorders

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102014907A (zh) * 2008-05-07 2011-04-13 尼克塔治疗公司 外周作用阿片拮抗剂的口服给药
CN101845047A (zh) * 2009-12-31 2010-09-29 南京臣功制药有限公司 一种溴甲基纳曲酮的制备方法
WO2011112816A1 (en) * 2010-03-11 2011-09-15 Wyeth, Llc Oral formulations and lipophilic salts of methylnaltrexone

Also Published As

Publication number Publication date
AU2019203694A1 (en) 2019-06-20
NZ625863A (en) 2016-11-25
IL233266A0 (en) 2014-08-31
KR20140107540A (ko) 2014-09-04
JP2019048820A (ja) 2019-03-28
BR112014014805A2 (pt) 2017-06-13
CA2859203A1 (en) 2013-06-27
JP2015501849A (ja) 2015-01-19
EP2793888A4 (en) 2015-10-28
WO2013096444A1 (en) 2013-06-27
CA2859203C (en) 2020-08-25
AU2012359013A1 (en) 2014-06-26
US20190231771A1 (en) 2019-08-01
US20130317050A1 (en) 2013-11-28
AU2017258808A1 (en) 2017-11-23
MX2014007312A (es) 2014-08-27
CN110384701A (zh) 2019-10-29
EP2793888A1 (en) 2014-10-29

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PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
RJ01 Rejection of invention patent application after publication
RJ01 Rejection of invention patent application after publication

Application publication date: 20141231