BR112014012100B1 - Processo para produzir uma composição de enzima da família s8/s53 e usos das referidas enzimas e composição - Google Patents

Processo para produzir uma composição de enzima da família s8/s53 e usos das referidas enzimas e composição Download PDF

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Publication number
BR112014012100B1
BR112014012100B1 BR112014012100-1A BR112014012100A BR112014012100B1 BR 112014012100 B1 BR112014012100 B1 BR 112014012100B1 BR 112014012100 A BR112014012100 A BR 112014012100A BR 112014012100 B1 BR112014012100 B1 BR 112014012100B1
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BR
Brazil
Prior art keywords
endopep
seq
endopeptidase
family
gluten
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BR112014012100-1A
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English (en)
Portuguese (pt)
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BR112014012100A2 (pt
Inventor
Linda Cavaletti
Lucia Carrano
Monica Abbondi
Mara Brunati
Anna Taravella
Original Assignee
Fondazione Istituto Insubrico Di Ricerca Per La Vita
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Publication of BR112014012100A2 publication Critical patent/BR112014012100A2/pt
Publication of BR112014012100B1 publication Critical patent/BR112014012100B1/pt

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/482—Serine endopeptidases (3.4.21)
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23J—PROTEIN COMPOSITIONS FOR FOODSTUFFS; WORKING-UP PROTEINS FOR FOODSTUFFS; PHOSPHATIDE COMPOSITIONS FOR FOODSTUFFS
    • A23J3/00—Working-up of proteins for foodstuffs
    • A23J3/30—Working-up of proteins for foodstuffs by hydrolysis
    • A23J3/32—Working-up of proteins for foodstuffs by hydrolysis using chemical agents
    • A23J3/34—Working-up of proteins for foodstuffs by hydrolysis using chemical agents using enzymes
    • A23J3/346—Working-up of proteins for foodstuffs by hydrolysis using chemical agents using enzymes of vegetable proteins
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Preparation or treatment thereof
    • A23L2/52—Adding ingredients
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/52—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from bacteria or Archaea
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21026—Prolyl oligopeptidase (3.4.21.26), i.e. proline-specific endopeptidase

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Immunology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Food Science & Technology (AREA)
  • Polymers & Plastics (AREA)
  • Nutrition Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Wood Science & Technology (AREA)
  • Epidemiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Mycology (AREA)
  • Dermatology (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
BR112014012100-1A 2011-12-06 2012-11-05 Processo para produzir uma composição de enzima da família s8/s53 e usos das referidas enzimas e composição BR112014012100B1 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP11425291.9 2011-12-06
EP11425291 2011-12-06
PCT/EP2012/071816 WO2013083338A1 (en) 2011-12-06 2012-11-05 New proteases able to hydrolyze gluten peptides and proteins at acidic ph, from the actinomycete actinoallomurus

Publications (2)

Publication Number Publication Date
BR112014012100A2 BR112014012100A2 (pt) 2020-10-27
BR112014012100B1 true BR112014012100B1 (pt) 2023-04-18

Family

ID=47137719

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112014012100-1A BR112014012100B1 (pt) 2011-12-06 2012-11-05 Processo para produzir uma composição de enzima da família s8/s53 e usos das referidas enzimas e composição

Country Status (11)

Country Link
US (2) US20140356345A1 (https=)
EP (1) EP2788018B1 (https=)
JP (1) JP6203743B2 (https=)
CN (1) CN104039345B (https=)
AU (1) AU2012348782B2 (https=)
BR (1) BR112014012100B1 (https=)
CA (1) CA2852365C (https=)
EA (1) EA028228B1 (https=)
ES (1) ES2595500T3 (https=)
IN (1) IN2014CN04131A (https=)
WO (1) WO2013083338A1 (https=)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6342802B2 (ja) 2011-08-10 2018-06-13 ザ ユニバーシティ オブ ワシントン スルー イッツ センター フォー コマーシャライゼーションＴｈｅ Ｕｎｉｖｅｒｓｉｔｙ Ｏｆ Ｗａｓｈｉｎｇｔｏｎ Ｔｈｒｏｕｇｈ Ｉｔｓ Ｃｅｎｔｅｒ Ｆｏｒ Ｃｏｍｍｅｒｃｉａｌｉｚａｔｉｏｎ セリアックスプルー病を治療するための組成物および方法
WO2015023728A1 (en) * 2013-08-14 2015-02-19 University Of Washington Through Its Center For Commercialization Compositions and methods for treating celiac sprue disease
US9867872B2 (en) 2013-09-05 2018-01-16 Dsm Ip Assets B.V. Use of an acidic soft drink to enhance the efficacy of a gluten-digesting enzyme
CN105899543A (zh) * 2013-11-26 2016-08-24 诺维信公司 研磨方法
WO2016062855A1 (en) * 2014-10-24 2016-04-28 Dupont Nutrition Biosciences Aps Proline tolerant tripeptidyl peptidases and uses thereof
HK1245129A1 (zh) 2015-06-08 2018-08-24 University Of Washington 治疗腹腔疾病的组合物及方法
US11124785B2 (en) 2016-02-11 2021-09-21 Trustees Of Boston University Rothia subtilisins, S8A family proteases, as therapeutic enzymes for application in gluten intolerance disorders
IT201900012942A1 (it) 2019-07-25 2021-01-25 Nemysis Ltd Metodo per la produzione di una composizione enzimatica comprendente una endopeptidasi ricombinante
AU2020318422B2 (en) * 2019-07-25 2026-03-19 Nemysis Limited Method for the production of an enzymatic composition comprising a recombinant endopeptidase
CN111172138B (zh) * 2020-02-14 2022-03-25 江南大学 一种蛋白水解酶及其在蛋白肽生产中的应用
IT202100018254A1 (it) 2021-07-12 2023-01-12 Nemysis Ltd New systems for producing recombinant proteins/ nuovi sistemi di produzione di proteine ricombinanti
CN114438044B (zh) * 2022-01-14 2024-03-29 南昌大学 一种高效降解麸质蛋白的多酶复合体及其应用
WO2024233959A1 (en) * 2023-05-11 2024-11-14 Digestiva, Inc. Wine dehazing methods and compositions
WO2025067635A1 (en) * 2023-09-26 2025-04-03 Amyra Biotech Ag Pharmaceutical compositions comprising exopeptidases and uses thereof

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3104935B2 (ja) 1992-05-28 2000-10-30 株式会社ブリヂストン 空気入りタイヤ
DE60336754D1 (de) * 2002-02-14 2011-05-26 Univ R Enzymbehandlung von nahrungsmitteln für zöliakie-sprue
US7320788B2 (en) 2002-02-14 2008-01-22 The Board Of Trustees Of The Leland Stanford Junior University Enzyme treatment of foodstuffs for Celiac Sprue
US7265093B2 (en) * 2002-05-14 2007-09-04 The Board Of Trustees Of The Leland Stanford Junior University Drug therapy for Celiac Sprue
WO2005019251A2 (en) 2003-08-25 2005-03-03 Funzyme Biotechnologies Sa Novel fungal proteins and nucleic acids encoding same
DK1663298T3 (da) 2003-09-23 2019-10-14 Dsm Ip Assets Bv Anvendelse af prolinspecifikke endoproteaser til hydrolyse af peptider og proteiner
NL1027650C1 (nl) 2004-12-03 2006-06-07 Leonardus Antonius Luttikhold Transporthulpmiddel voor deuren en panelen.
EP1985698A1 (en) * 2007-04-25 2008-10-29 Nestec S.A. Peptidases from basidiomycetes
AU2010334383B2 (en) * 2009-12-21 2014-10-02 Centre Hospitalier Universitaire Vaudois (Chuv) Synergic action of a prolyl protease and tripeptidyl proteases
JP2013518589A (ja) * 2010-02-02 2013-05-23 アマノ エンザイム ユーエスエー，リミテッド グルテン不耐性に対するプロテアーゼの使用
EP2555792A4 (en) * 2010-03-30 2013-11-06 Alvine Pharmaceuticals Inc PROTEASES DEGRADING GLUTEN
JP2011211997A (ja) * 2010-04-02 2011-10-27 Astellas Pharma Inc アントラサイクリン化合物を生産する微生物

Also Published As

Publication number Publication date
EP2788018B1 (en) 2016-06-29
JP2015500641A (ja) 2015-01-08
IN2014CN04131A (https=) 2015-07-17
BR112014012100A2 (pt) 2020-10-27
WO2013083338A1 (en) 2013-06-13
EA028228B1 (ru) 2017-10-31
CN104039345B (zh) 2016-11-09
CA2852365C (en) 2021-01-26
JP6203743B2 (ja) 2017-09-27
US20140356345A1 (en) 2014-12-04
ES2595500T3 (es) 2016-12-30
CN104039345A (zh) 2014-09-10
EA201491117A1 (ru) 2014-09-30
AU2012348782A1 (en) 2014-05-15
CA2852365A1 (en) 2013-06-13
HK1198244A1 (en) 2015-03-20
US10201593B2 (en) 2019-02-12
US20160114009A1 (en) 2016-04-28
AU2012348782B2 (en) 2017-10-26
EP2788018A1 (en) 2014-10-15

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B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]

Free format text: DE ACORDO COM O ARTIGO 229-C DA LEI NO 10196/2001, QUE MODIFICOU A LEI NO 9279/96, A CONCESSAO DA PATENTE ESTA CONDICIONADA A ANUENCIA PREVIA DA ANVISA. CONSIDERANDO A APROVACAO DOS TERMOS DO PARECER NO 337/PGF/EA/2010, BEM COMO A PORTARIA INTERMINISTERIAL NO 1065 DE 24/05/2012, ENCAMINHA-SE O PRESENTE PEDIDO PARA AS PROVIDENCIAS CABIVEIS.

B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
B06U Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]
B350 Update of information on the portal [chapter 15.35 patent gazette]
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 05/11/2012, OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF, QUE DETERMINA A ALTERACAO DO PRAZO DE CONCESSAO.