BR112014011514A2 - dispositivo para detectar uma molécula-alvo dentro de uma amostra, método de detectar a presença ou a quantidade de uma molécula-alvo dentro de uma amostra e uso de uma partícula - Google Patents

dispositivo para detectar uma molécula-alvo dentro de uma amostra, método de detectar a presença ou a quantidade de uma molécula-alvo dentro de uma amostra e uso de uma partícula

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Publication number
BR112014011514A2
BR112014011514A2 BR112014011514A BR112014011514A BR112014011514A2 BR 112014011514 A2 BR112014011514 A2 BR 112014011514A2 BR 112014011514 A BR112014011514 A BR 112014011514A BR 112014011514 A BR112014011514 A BR 112014011514A BR 112014011514 A2 BR112014011514 A2 BR 112014011514A2
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BR
Brazil
Prior art keywords
sample
particle
target molecule
detecting
molecule
Prior art date
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BR112014011514A
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English (en)
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BR112014011514B8 (pt
BR112014011514B1 (pt
Inventor
Koets Maatje
Hendrik Evers Toon
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Koninklijke Philips Nv
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Application filed by Koninklijke Philips Nv filed Critical Koninklijke Philips Nv
Publication of BR112014011514A2 publication Critical patent/BR112014011514A2/pt
Publication of BR112014011514B1 publication Critical patent/BR112014011514B1/pt
Publication of BR112014011514B8 publication Critical patent/BR112014011514B8/pt

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54393—Improving reaction conditions or stability, e.g. by coating or irradiation of surface, by reduction of non-specific binding, by promotion of specific binding
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/55—Specular reflectivity
    • G01N21/552—Attenuated total reflection
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
    • G01N33/54326—Magnetic particles
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54353—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals with ligand attached to the carrier via a chemical coupling agent
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/551—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being inorganic
    • G01N33/553—Metal or metal coated
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6887—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids from muscle, cartilage or connective tissue
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/575—Hormones
    • G01N2333/58—Atrial natriuretic factor complex; Atriopeptin; Atrial natriuretic peptide [ANP]; Brain natriuretic peptide [BNP, proBNP]; Cardionatrin; Cardiodilatin

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Endocrinology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Inorganic Chemistry (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analyzing Materials By The Use Of Ultrasonic Waves (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)

Abstract

resumo dispositivo para detectar uma molécula-alvo dentro de uma amostra, método de detectar a presença ou a quantidade de uma molécula-alvo dentro de uma amostra e uso de uma partícula a presente invenção refere-se a um dispositivo para detectar uma molécula alvo dentro de uma amostra compreendendo um recipiente de amostra para a medição da molécula alvo dentro de uma amostra, uma primeira partícula, em que a dita primeira partícula é funcionalizada com uma primeira molécula de ligação capaz de se ligar especificamente à dita molécula alvo, e uma estrutura de superfície compreendendo uma segunda molécula de ligação, em que a dita estrutura de superfície cobre um sensor plano ou está presente em uma segunda partícula, em que a dita primeira partícula é capaz de se ligar à dita segunda molécula de ligação da estrutura de superfície diretamente ou indiretamente; em que a dita primeira e/ou segunda molécula de ligação é indiretamente fixada à superfície de partícula da dita primeira e/ou segunda partícula e/ou à superfície de sensor plano através de uma molécula ligante rígida e longa; em que o comprimento e a consistência da dita molécula ligante são selecionados de modo a resultar em um comprimento de extensão médio do dito ligante maior que 60 nm; e em que o número de aglomerados de partículas ou de partículas ligadas é diretamente ou inversamente relacionado à quantidade de moléculas alvo presentes na amostra. em um aspecto adicional, a presente invenção refere-se a um método de detectar a presença ou a quantidade de uma molécula alvo dentro de uma amostra. a presente invenção também descreve o uso de uma partícula de acordo com a invenção para detectar uma molécula alvo dentro de uma amostra. 1/2
BR112014011514A 2011-11-16 2013-11-13 Sistema para detectar uma molécula-alvo dentro de uma solução e método de detectar a presença ou a quantidade de uma molécula-alvo dentro de uma amostra disposta em um recipiente da amostra BR112014011514B8 (pt)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201161560441P 2011-11-16 2011-11-16
US61/560,441 2011-11-16
EP11191454.5A EP2594942A1 (en) 2011-11-16 2011-12-01 Long rigid spacers to enhance binding kinetics in immunoassays
EP11191454.5 2011-12-01
PCT/IB2012/056378 WO2013072842A1 (en) 2011-11-16 2012-11-13 Long rigid spacers to enhance binding kinetics in immunoassays

Publications (3)

Publication Number Publication Date
BR112014011514A2 true BR112014011514A2 (pt) 2017-05-16
BR112014011514B1 BR112014011514B1 (pt) 2020-09-15
BR112014011514B8 BR112014011514B8 (pt) 2022-12-20

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
BR112014011514A BR112014011514B8 (pt) 2011-11-16 2013-11-13 Sistema para detectar uma molécula-alvo dentro de uma solução e método de detectar a presença ou a quantidade de uma molécula-alvo dentro de uma amostra disposta em um recipiente da amostra

Country Status (10)

Country Link
US (1) US10942178B2 (pt)
EP (2) EP2594942A1 (pt)
JP (1) JP6173332B2 (pt)
CN (1) CN103946686B (pt)
BR (1) BR112014011514B8 (pt)
DK (1) DK2745091T3 (pt)
ES (1) ES2555904T3 (pt)
PL (1) PL2745091T3 (pt)
RU (1) RU2641032C2 (pt)
WO (1) WO2013072842A1 (pt)

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Publication number Publication date
US20150177239A1 (en) 2015-06-25
CN103946686A (zh) 2014-07-23
EP2594942A1 (en) 2013-05-22
WO2013072842A1 (en) 2013-05-23
EP2745091B1 (en) 2015-10-21
JP6173332B2 (ja) 2017-08-02
JP2014533831A (ja) 2014-12-15
CN103946686B (zh) 2017-03-15
WO2013072842A8 (en) 2014-05-30
EP2745091A1 (en) 2014-06-25
US10942178B2 (en) 2021-03-09
BR112014011514B8 (pt) 2022-12-20
RU2014124190A (ru) 2015-12-27
BR112014011514B1 (pt) 2020-09-15
RU2641032C2 (ru) 2018-01-15
ES2555904T3 (es) 2016-01-11
PL2745091T3 (pl) 2016-04-29
DK2745091T3 (en) 2015-12-14

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