WO2012050365A3 - 교모세포종의 진단 또는 예후 예측용 바이오 마커 및 그 용도 - Google Patents

교모세포종의 진단 또는 예후 예측용 바이오 마커 및 그 용도 Download PDF

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WO2012050365A3
WO2012050365A3 PCT/KR2011/007592 KR2011007592W WO2012050365A3 WO 2012050365 A3 WO2012050365 A3 WO 2012050365A3 KR 2011007592 W KR2011007592 W KR 2011007592W WO 2012050365 A3 WO2012050365 A3 WO 2012050365A3
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glioblastoma
prognosis
biomarker
predicting
diagnosing
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PCT/KR2011/007592
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French (fr)
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WO2012050365A9 (ko
WO2012050365A2 (ko
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남도현
김종현
박관
신형진
홍승철
이정일
공두식
설호준
서연림
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사회복지법인 삼성생명공익재단
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Publication of WO2012050365A2 publication Critical patent/WO2012050365A2/ko
Publication of WO2012050365A9 publication Critical patent/WO2012050365A9/ko
Publication of WO2012050365A3 publication Critical patent/WO2012050365A3/ko

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57407—Specifically defined cancers
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    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/112—Disease subtyping, staging or classification
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    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/118—Prognosis of disease development
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers

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  • Health & Medical Sciences (AREA)
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  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
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  • Analytical Chemistry (AREA)
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  • Cell Biology (AREA)
  • Organic Chemistry (AREA)
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  • General Physics & Mathematics (AREA)
  • Oncology (AREA)
  • Hospice & Palliative Care (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

본 발명은 교모세포종의 진단 또는 예후 예측을 위한 바이오 마커 및 그 용도에 관한 것으로, 더욱 자세하게는 survivin, cyclinE, DCC, TGF-β, CDC25B, Histone H1, p-EGFR, p-VEGFR2/3 및 p16 로 구성된 군에서 선택되는 단백질을 교모세포종의 진단 또는 예후 예측을 위한 바이오 마커로 활용하여, 교모세포종의 진단 또는 예후 예측에 필요한 정보를 제공하기 위해 상기 단백질의 발현량을 측정하는 단계를 포함하는 단백질의 분석방법에 관한 것이다. 본 발명의 분석을 통해 발굴된 단백질들은 교모세포종 환자의 예후 예측에 적용가능 함으로 이를 이용한 교모세포종 예후 진단용 키트를 제공할 수 있고, 발굴된 단백질들을 대상으로 한 새로운 개념의 표적 치료법 및 항암제 개발에 응용될 수 있어 유용하다. 또한, 이에 따라 관련 산업 분야에 큰 파급효과를 가져올 수 있어 유용하다.
PCT/KR2011/007592 2010-10-13 2011-10-12 교모세포종의 진단 또는 예후 예측용 바이오 마커 및 그 용도 WO2012050365A2 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR10-2010-0100050 2010-10-13
KR1020100100050A KR101760464B1 (ko) 2010-10-13 2010-10-13 교모세포종의 진단 또는 예후 예측용 바이오 마커 및 그 용도

Publications (3)

Publication Number Publication Date
WO2012050365A2 WO2012050365A2 (ko) 2012-04-19
WO2012050365A9 WO2012050365A9 (ko) 2012-06-28
WO2012050365A3 true WO2012050365A3 (ko) 2012-11-01

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PCT/KR2011/007592 WO2012050365A2 (ko) 2010-10-13 2011-10-12 교모세포종의 진단 또는 예후 예측용 바이오 마커 및 그 용도

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KR (1) KR101760464B1 (ko)
WO (1) WO2012050365A2 (ko)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101692044B1 (ko) * 2014-12-05 2017-01-04 사회복지법인 삼성생명공익재단 교모세포종에서 표피 성장인자 수용체 억제제의 치료 효과를 예측하는 방법
US20180133327A1 (en) * 2015-03-16 2018-05-17 Amal Therapeutics Sa Cell Penetrating Peptides and Complexes Comprising the Same
CN108139405B (zh) * 2015-10-22 2022-06-10 巴斯利尔药物国际股份公司 Eb1作为药物应答的生物标记物的用途
JP7346291B2 (ja) 2016-09-21 2023-09-19 アマル セラピューティクス エスエー 癌を治療するための細胞透過性ペプチド、マルチエピトープ、及びｔｌｒペプチドアゴニストを含む融合体
KR102320436B1 (ko) * 2020-01-13 2021-11-03 주식회사 메타큐라 교모종줄기세포 엑소좀 유래 펩타이드를 포함하는 교모세포종의 진단용 바이오마커 조성물
CN111454254B (zh) * 2020-04-26 2023-06-02 云白药征武科技(上海)有限公司 一种具有含氟取代基的苯并咪唑衍生物的制备及其应用
CN114075604B (zh) * 2022-01-18 2022-04-08 天津医科大学总医院 胶质母细胞瘤预后预测评分模型及其在指导临床精准诊疗中的应用
KR20230144764A (ko) * 2022-04-08 2023-10-17 연세대학교 산학협력단 유전자로 정의된 암기원세포, 및 이의 분류방법
KR20230144759A (ko) * 2022-04-08 2023-10-17 연세대학교 산학협력단 유전자로 정의된 암기원세포, 및 이의 분류방법

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
BLUM R. ET AL.: "Suppression of survivin expression in glioblastoma cells by the Ras inhibitor farnesylthiosalicylic acid promotes caspase-dependent apoptosis.", MOLECULAR CANCER THERAPEUTICS., vol. 5, no. 9, September 2006 (2006-09-01), pages 2737 - 2347 *
GEORGE J. ET AL.: "Survivin knockdown and concurrent 4-HPR treatment controlled human glioblastoma in vitro and in vivo.", NEURO-ONCOLOGY., vol. 12, no. 11, 2 August 2010 (2010-08-02), pages 1088 - 1101 *
QUICK Q. A. ET AL.: "Epothilone B induces glioblastoma cell death via survivin down-regulation.", EXPERIMENTAL ONCOLOGY., vol. 30, no. 3, September 2008 (2008-09-01), pages 195 - 201 *
UEMATSU, M. ET AL.: "Prognostic significance of the immunohistochemical index of survivin in glioma: a comparative study with the MIB-1 index.", JOURNAL OF NEUROONCOLOGY., vol. 72, no. 3, May 2005 (2005-05-01), pages 231 - 238 *

Also Published As

Publication number Publication date
KR20120038339A (ko) 2012-04-23
KR101760464B1 (ko) 2017-07-24
WO2012050365A9 (ko) 2012-06-28
WO2012050365A2 (ko) 2012-04-19

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