BR112014009288A2 - formas sólidas de 1,l-dioxo-4-tiomorfolinil)-[6-[[3(4-fluorofenil)-5-metil-4-isoxazolil]metóxi]-3-piridinil]-metanona - Google Patents
formas sólidas de 1,l-dioxo-4-tiomorfolinil)-[6-[[3(4-fluorofenil)-5-metil-4-isoxazolil]metóxi]-3-piridinil]-metanonaInfo
- Publication number
- BR112014009288A2 BR112014009288A2 BR112014009288A BR112014009288A BR112014009288A2 BR 112014009288 A2 BR112014009288 A2 BR 112014009288A2 BR 112014009288 A BR112014009288 A BR 112014009288A BR 112014009288 A BR112014009288 A BR 112014009288A BR 112014009288 A2 BR112014009288 A2 BR 112014009288A2
- Authority
- BR
- Brazil
- Prior art keywords
- solid forms
- thiomorpholinyl
- dioxo
- isoxazolyl
- pyridinyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/541—Non-condensed thiazines containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Neurosurgery (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Psychiatry (AREA)
- Addiction (AREA)
- Pain & Pain Management (AREA)
- Psychology (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Anesthesiology (AREA)
- Hospice & Palliative Care (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Medicinal Preparation (AREA)
Abstract
resumo patente de invenção: "formas sólidas de 1,l-dioxo-4-tiomorfolinil)-[6-[[3(4-fluorofenil)-5-metil-4-isoxazolil]metóxi]-3-piridinil]-metanona". a presente invenção refere-se a novas formas sólidas do composto da fórmula (i) (i), assim como solvatos, complexos de inclusão com outros compostos adequados, processos para a fabricação das mesmas, composições farmacêuticas contendo estas formas sólidas, e uso das mesmas como medicamentos.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP11185993 | 2011-10-20 | ||
PCT/EP2012/070522 WO2013057124A1 (en) | 2011-10-20 | 2012-10-17 | Solid forms of 1,l-dioxo-4-thiomorpholinyl)-[6-[[3(4-fluorophenyl)-5-methyl-4-isoxazolyl]methoxy]-3-pyridinyl]-methanone |
Publications (2)
Publication Number | Publication Date |
---|---|
BR112014009288A2 true BR112014009288A2 (pt) | 2017-06-13 |
BR112014009288A8 BR112014009288A8 (pt) | 2020-04-22 |
Family
ID=47019027
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112014009288A BR112014009288A8 (pt) | 2011-10-20 | 2012-10-17 | formas sólidas de 1,l-dioxo-4-tiomorfolinil)-[6-[[3(4-fluorofenil)-5-metil-4-isoxazolil]metóxi]-3-piridinil]-metanona, seus usos e seus processos de preparação, e composições farmacêuticas |
Country Status (20)
Country | Link |
---|---|
US (2) | US8785435B2 (pt) |
EP (1) | EP2768821B1 (pt) |
JP (1) | JP5918856B2 (pt) |
KR (1) | KR20140079503A (pt) |
CN (1) | CN103889971B (pt) |
AR (1) | AR088359A1 (pt) |
AU (1) | AU2012318294B2 (pt) |
BR (1) | BR112014009288A8 (pt) |
CA (1) | CA2850441A1 (pt) |
DK (1) | DK2768821T3 (pt) |
ES (1) | ES2606547T3 (pt) |
HK (1) | HK1193611A1 (pt) |
HU (1) | HUE030298T2 (pt) |
IL (1) | IL231532A0 (pt) |
MX (1) | MX341492B (pt) |
PL (1) | PL2768821T3 (pt) |
RU (1) | RU2618524C2 (pt) |
SG (1) | SG11201401591WA (pt) |
SI (1) | SI2768821T1 (pt) |
WO (1) | WO2013057124A1 (pt) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2792360A1 (en) | 2013-04-18 | 2014-10-22 | IP Gesellschaft für Management mbH | (1aR,12bS)-8-cyclohexyl-11-fluoro-N-((1-methylcyclopropyl)sulfonyl)-1a-((3-methyl-3,8-diazabicyclo[3.2.1]oct-8-yl)carbonyl)-1,1a,2,2b-tetrahydrocyclopropa[d]indolo[2,1-a][2]benzazepine-5-carboxamide for use in treating HCV |
KR20200044906A (ko) * | 2017-08-28 | 2020-04-29 | 유니버시티 오브 매릴랜드, 발티모어 | 기분장애를 위한 신규한 감마 아미노부티르산 타입 a 수용체 모듈레이터 |
JP7478676B2 (ja) | 2018-06-13 | 2024-05-07 | エフ. ホフマン-ラ ロシュ アーゲー | Gaba a alpha5 pamとしての新規イソオキサゾリルエーテル誘導体 |
Family Cites Families (40)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE352505C (de) | 1918-03-01 | 1922-04-27 | Metallbank | Verfahren zur Verarbeitung von Salmiakschlacken |
DE3525205A1 (de) | 1984-09-11 | 1986-03-20 | Hoechst Ag, 6230 Frankfurt | Pflanzenschuetzende mittel auf basis von 1,2,4-triazolderivaten sowie neue derivate des 1,2,4-triazols |
GB9808663D0 (en) | 1998-04-23 | 1998-06-24 | Merck Sharp & Dohme | Therapeutic agents |
US6262098B1 (en) | 1998-08-07 | 2001-07-17 | Chiron Corporation | Estrogen receptor modulators |
US6297256B1 (en) | 1999-06-15 | 2001-10-02 | Neurogen Corporation | Aryl and heteroaryl substituted pyridino derivatives GABA brain receptor ligands |
US6660753B2 (en) | 1999-08-19 | 2003-12-09 | Nps Pharmaceuticals, Inc. | Heteropolycyclic compounds and their use as metabotropic glutamate receptor antagonists |
IT1314191B1 (it) | 1999-10-18 | 2002-12-06 | Recordati Chem Pharm | Derivati isossazolcarbossamidici |
CA2388593A1 (en) | 1999-11-12 | 2001-05-17 | Neurogen Corporation | Bicyclic and tricyclic heteroaromatic compounds |
PA8535601A1 (es) | 2000-12-21 | 2002-11-28 | Pfizer | Derivados benzimidazol y piridilimidazol como ligandos para gabaa |
GB0108475D0 (en) | 2001-04-04 | 2001-05-23 | Merck Sharp & Dohme | New compounds |
JP2004536104A (ja) | 2001-07-05 | 2004-12-02 | シナプティック・ファーマスーティカル・コーポレーション | Mch選択的アンタゴニストとしての置換されたアニリン−ピペリジン誘導体 |
EP1285914B1 (en) | 2001-08-13 | 2007-12-19 | PheneX Pharmaceuticals AG | Nr1h4 nuclear receptor binding compounds |
DE60225174T2 (de) | 2001-11-20 | 2009-02-12 | Eli Lilly And Co., Indianapolis | Beta-3 adrenergische agonisten |
GB0128160D0 (en) | 2001-11-23 | 2002-01-16 | Merck Sharp & Dohme | Novel compounds |
GB0128499D0 (en) | 2001-11-28 | 2002-01-23 | Merck Sharp & Dohme | Therapeutic agents |
JP2006515838A (ja) | 2002-11-22 | 2006-06-08 | スミスクライン ビーチャム コーポレーション | ファルネソイドx受容体アゴニスト |
GB0318447D0 (en) | 2003-08-05 | 2003-09-10 | Merck Sharp & Dohme | Therapeutic agents |
US7820705B2 (en) | 2004-05-14 | 2010-10-26 | Irm Llc | Compounds and compositions as PPAR modulators |
EP1756086B1 (en) | 2004-06-01 | 2008-06-04 | F.Hoffmann-La Roche Ag | Pyridin-4-yl-ethynyl-imidazoles and pyrazoles as mglu5 receptor antagonists |
JP2008502687A (ja) | 2004-06-14 | 2008-01-31 | タケダ サン ディエゴ インコーポレイテッド | キナーゼ阻害剤 |
EP1802566B1 (en) | 2004-10-01 | 2008-11-26 | F. Hoffmann-Roche AG | Hexafluoroisopropanol substituted ether derivatives |
WO2006044617A1 (en) | 2004-10-15 | 2006-04-27 | The Scripps Research Institute | Oxadiazole ketone inhibitors of fatty acid amide hydrolase |
US20070060589A1 (en) | 2004-12-21 | 2007-03-15 | Purandare Ashok V | Inhibitors of protein arginine methyl transferases |
WO2006095822A1 (ja) | 2005-03-11 | 2006-09-14 | Ono Pharmaceutical Co., Ltd. | スルホンアミド化合物およびその医薬 |
DE602006017694D1 (de) | 2005-06-27 | 2010-12-02 | Bristol Myers Squibb Co | C-verknüpfte zyklische antagonisten des p2y1-rezeptors mit eignung bei der behandlung thrombotischer leiden |
WO2007009275A1 (de) | 2005-07-20 | 2007-01-25 | Prospective Concepts Ag | Pneumatische kissenstrukturen |
EP1931661B1 (en) | 2005-09-19 | 2008-11-19 | F.Hoffmann-La Roche Ag | Isoxazolo derivatives as gaba a alpha5 inverse agonists |
EP1937674A1 (en) | 2005-10-11 | 2008-07-02 | F.Hoffmann-La Roche Ag | Isoxazole derivatives |
WO2007052843A1 (ja) | 2005-11-04 | 2007-05-10 | Takeda Pharmaceutical Company Limited | 複素環アミド化合物およびその用途 |
WO2007062997A1 (en) * | 2005-11-30 | 2007-06-07 | F. Hoffmann-La Roche Ag | 1,1-dioxo-thiomorpholinyl indolyl methanone derivatives for use as h3 modulators |
JP5081161B2 (ja) | 2005-12-19 | 2012-11-21 | スミスクライン ビーチャム コーポレーション | ファルネソイドx受容体アゴニスト |
WO2007071476A1 (en) * | 2005-12-20 | 2007-06-28 | International Business Machines Corporation | Method, system and computer program for distributing software products based on an e-mail service |
AU2007212126B2 (en) | 2006-02-03 | 2012-07-19 | Eli Lilly And Company | Compounds and methods for modulating FX-receptors |
JP2007230909A (ja) | 2006-03-01 | 2007-09-13 | Univ Of Tokyo | 置換イソキサゾール誘導体 |
WO2007137954A1 (en) | 2006-05-31 | 2007-12-06 | F. Hoffmann-La Roche Ag | Aryl-4-ethynyl-isoxazole derivatives |
EP1894928A1 (en) | 2006-08-29 | 2008-03-05 | PheneX Pharmaceuticals AG | Heterocyclic fxr binding compounds |
EP1894924A1 (en) | 2006-08-29 | 2008-03-05 | Phenex Pharmaceuticals AG | Heterocyclic FXR binding compounds |
WO2008130951A1 (en) | 2007-04-17 | 2008-10-30 | Bristol-Myers Squibb Company | Fused heterocyclic 11-beta-hydroxysteroid dehydrogenase type i inhibitors |
RS53877B1 (en) | 2007-12-04 | 2015-08-31 | F. Hoffmann-La Roche Ag. | IZOKSAZOL-PYRIDINE DERIVATIVES |
US7618973B2 (en) | 2007-12-04 | 2009-11-17 | Hoffmann-La Roche Inc. | Isoxazolo-pyrazine derivatives |
-
2012
- 2012-10-12 US US13/650,159 patent/US8785435B2/en active Active
- 2012-10-17 RU RU2014118968A patent/RU2618524C2/ru not_active IP Right Cessation
- 2012-10-17 ES ES12772789.9T patent/ES2606547T3/es active Active
- 2012-10-17 PL PL12772789T patent/PL2768821T3/pl unknown
- 2012-10-17 SG SG11201401591WA patent/SG11201401591WA/en unknown
- 2012-10-17 HU HUE12772789A patent/HUE030298T2/en unknown
- 2012-10-17 AU AU2012318294A patent/AU2012318294B2/en not_active Ceased
- 2012-10-17 JP JP2014536209A patent/JP5918856B2/ja active Active
- 2012-10-17 EP EP12772789.9A patent/EP2768821B1/en active Active
- 2012-10-17 KR KR1020147013555A patent/KR20140079503A/ko active Search and Examination
- 2012-10-17 MX MX2014004678A patent/MX341492B/es active IP Right Grant
- 2012-10-17 AR ARP120103860A patent/AR088359A1/es unknown
- 2012-10-17 BR BR112014009288A patent/BR112014009288A8/pt not_active IP Right Cessation
- 2012-10-17 CA CA2850441A patent/CA2850441A1/en not_active Abandoned
- 2012-10-17 CN CN201280051089.3A patent/CN103889971B/zh active Active
- 2012-10-17 SI SI201230792A patent/SI2768821T1/sl unknown
- 2012-10-17 DK DK12772789.9T patent/DK2768821T3/en active
- 2012-10-17 WO PCT/EP2012/070522 patent/WO2013057124A1/en active Application Filing
-
2014
- 2014-03-13 IL IL231532A patent/IL231532A0/en active IP Right Grant
- 2014-06-04 US US14/295,535 patent/US8975397B2/en active Active
- 2014-07-09 HK HK14106993.8A patent/HK1193611A1/zh unknown
Also Published As
Publication number | Publication date |
---|---|
HK1193611A1 (zh) | 2014-09-26 |
MX2014004678A (es) | 2014-05-28 |
NZ622215A (en) | 2016-06-24 |
RU2618524C2 (ru) | 2017-05-04 |
EP2768821A1 (en) | 2014-08-27 |
US20130172329A1 (en) | 2013-07-04 |
SG11201401591WA (en) | 2014-05-29 |
US20140329806A1 (en) | 2014-11-06 |
CN103889971B (zh) | 2016-08-31 |
JP5918856B2 (ja) | 2016-05-18 |
EP2768821B1 (en) | 2016-11-16 |
ES2606547T3 (es) | 2017-03-24 |
SI2768821T1 (sl) | 2017-01-31 |
US8785435B2 (en) | 2014-07-22 |
US8975397B2 (en) | 2015-03-10 |
DK2768821T3 (en) | 2017-01-23 |
CN103889971A (zh) | 2014-06-25 |
HUE030298T2 (en) | 2017-04-28 |
AR088359A1 (es) | 2014-05-28 |
PL2768821T3 (pl) | 2017-05-31 |
CA2850441A1 (en) | 2013-04-25 |
BR112014009288A8 (pt) | 2020-04-22 |
WO2013057124A1 (en) | 2013-04-25 |
AU2012318294A1 (en) | 2013-05-09 |
MX341492B (es) | 2016-08-23 |
KR20140079503A (ko) | 2014-06-26 |
RU2014118968A (ru) | 2015-11-27 |
JP2014530832A (ja) | 2014-11-20 |
IL231532A0 (en) | 2014-04-30 |
AU2012318294B2 (en) | 2015-10-01 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CY1116439T1 (el) | Τριαζολοπυριδινες | |
EA201001205A1 (ru) | Соединения, содержащие циклобутоксигруппу | |
EA201491060A1 (ru) | Новые производные трифторметилоксадиазола и их применение для лечения заболевания | |
PH12014501514A1 (en) | New azetidine derivatives, pharmaceutical compositions and uses thereof | |
CO6480975A2 (es) | Mimetico de smac | |
EA201190235A1 (ru) | Замещенные 1-цианоэтилгетероциклилкарбоксамидные соединения 750 | |
MX2015008628A (es) | Derivados de acido boronico y usos terapeuticos de los mismos. | |
EA201170772A1 (ru) | Органические соединения | |
EA201200471A1 (ru) | Простые эфирные производные бициклических гетероарилов | |
GEP20146146B (en) | Pyrrolopyrimidine compounds as inhibitors of cdk4/6 | |
UA109010C2 (en) | MORPHOLINOPYRIMIDINES AND THEIR APPLICATIONS IN THERAPY | |
EA201001683A1 (ru) | Производные фенил- или пиридинилзамещенных индазолов | |
MX2011008864A (es) | Tetrahidroazolopirazinas sulfoniladas y su uso como productos medicinales. | |
BR112016010080A8 (pt) | compostos de pirazolopirimidina, composição farmacêutica e seu uso | |
EA201390381A1 (ru) | Триазиноксадиазолы | |
MA33939B1 (fr) | 5-alcynyl-pyrimidines | |
EA201591195A1 (ru) | Новые хинолоновые производные | |
PH12015501609A1 (en) | Phenicol antibacterials | |
BR112015018504A2 (pt) | moduladores de flap | |
EA201201658A1 (ru) | Производные пиперидина и их применение для лечения метаболических нарушений | |
MX2014004858A (es) | Compuestos de 3,4-diamino-3-ciclobuten-1,2-diona disustituidos utiles en el tratamiento de patologias mediadas por quimiocinas. | |
WO2013061004A8 (fr) | Nouveaux composés di-substitués de la diamino-3,4-cyclobutène-3-dione-1,2 utiles dans le traitement de pathologies médiées par des chimiokines | |
BR112013019160A2 (pt) | novos compostos, composição farmacêutica, uso, processos e métodos | |
TW200738627A (en) | Trialkylsilyl-indoles | |
EA201490630A1 (ru) | 6-замещенные 3-(хинолин-6-илтио)[1,2,4]триазоло[4,3-a]пиридины в качестве ингибиторов c-met тирозинкиназы |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] | ||
B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
B07E | Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] |
Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI |
|
B06U | Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette] | ||
B350 | Update of information on the portal [chapter 15.35 patent gazette] | ||
B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 9A ANUIDADE. |
|
B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2640 DE 10-08-2021 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013. |