MX341492B - Nuevas formas solidas de 1,1-dioxo-4-tiomorfolinil)-[6-[[3(4-fluor ofenil)-5-metil-4-isoxazolil]metoxi]-3-piridinil]-metanona. - Google Patents
Nuevas formas solidas de 1,1-dioxo-4-tiomorfolinil)-[6-[[3(4-fluor ofenil)-5-metil-4-isoxazolil]metoxi]-3-piridinil]-metanona.Info
- Publication number
- MX341492B MX341492B MX2014004678A MX2014004678A MX341492B MX 341492 B MX341492 B MX 341492B MX 2014004678 A MX2014004678 A MX 2014004678A MX 2014004678 A MX2014004678 A MX 2014004678A MX 341492 B MX341492 B MX 341492B
- Authority
- MX
- Mexico
- Prior art keywords
- solid forms
- methanone
- thiomorpholinyl
- dioxo
- isoxazolyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/541—Non-condensed thiazines containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Neurosurgery (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Psychiatry (AREA)
- Addiction (AREA)
- Psychology (AREA)
- Pain & Pain Management (AREA)
- Cardiology (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Heart & Thoracic Surgery (AREA)
- Anesthesiology (AREA)
- Hospice & Palliative Care (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
La presente invención se refiere a nuevas formas sólidas del compuesto de la fórmula (I) (ver Fórmula) así como a solvatos, complejos de inclusión con otros compuestos idóneos, a procesos de obtención, a composiciones farmacéuticas que contienen estas formas sólidas y a su utilización como medicamentos.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP11185993 | 2011-10-20 | ||
PCT/EP2012/070522 WO2013057124A1 (en) | 2011-10-20 | 2012-10-17 | Solid forms of 1,l-dioxo-4-thiomorpholinyl)-[6-[[3(4-fluorophenyl)-5-methyl-4-isoxazolyl]methoxy]-3-pyridinyl]-methanone |
Publications (2)
Publication Number | Publication Date |
---|---|
MX2014004678A MX2014004678A (es) | 2014-05-28 |
MX341492B true MX341492B (es) | 2016-08-23 |
Family
ID=47019027
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2014004678A MX341492B (es) | 2011-10-20 | 2012-10-17 | Nuevas formas solidas de 1,1-dioxo-4-tiomorfolinil)-[6-[[3(4-fluor ofenil)-5-metil-4-isoxazolil]metoxi]-3-piridinil]-metanona. |
Country Status (20)
Country | Link |
---|---|
US (2) | US8785435B2 (es) |
EP (1) | EP2768821B1 (es) |
JP (1) | JP5918856B2 (es) |
KR (1) | KR20140079503A (es) |
CN (1) | CN103889971B (es) |
AR (1) | AR088359A1 (es) |
AU (1) | AU2012318294B2 (es) |
BR (1) | BR112014009288A8 (es) |
CA (1) | CA2850441A1 (es) |
DK (1) | DK2768821T3 (es) |
ES (1) | ES2606547T3 (es) |
HK (1) | HK1193611A1 (es) |
HU (1) | HUE030298T2 (es) |
IL (1) | IL231532A0 (es) |
MX (1) | MX341492B (es) |
PL (1) | PL2768821T3 (es) |
RU (1) | RU2618524C2 (es) |
SG (1) | SG11201401591WA (es) |
SI (1) | SI2768821T1 (es) |
WO (1) | WO2013057124A1 (es) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2792360A1 (en) | 2013-04-18 | 2014-10-22 | IP Gesellschaft für Management mbH | (1aR,12bS)-8-cyclohexyl-11-fluoro-N-((1-methylcyclopropyl)sulfonyl)-1a-((3-methyl-3,8-diazabicyclo[3.2.1]oct-8-yl)carbonyl)-1,1a,2,2b-tetrahydrocyclopropa[d]indolo[2,1-a][2]benzazepine-5-carboxamide for use in treating HCV |
EP3675845A4 (en) | 2017-08-28 | 2021-05-05 | University of Maryland, Baltimore | NEW GAMMA AMINOBUTIC ACID TYPE A RECEPTOR MODULATORS FOR EMOTIONAL DISORDERS |
CA3102101A1 (en) | 2018-06-13 | 2019-12-19 | F. Hoffmann-La Roche Ag | New isoxazolyl ether derivatives as gaba a alpha5 pam |
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DE352505C (de) | 1918-03-01 | 1922-04-27 | Metallbank | Verfahren zur Verarbeitung von Salmiakschlacken |
DE3525205A1 (de) | 1984-09-11 | 1986-03-20 | Hoechst Ag, 6230 Frankfurt | Pflanzenschuetzende mittel auf basis von 1,2,4-triazolderivaten sowie neue derivate des 1,2,4-triazols |
GB9808663D0 (en) | 1998-04-23 | 1998-06-24 | Merck Sharp & Dohme | Therapeutic agents |
AU5467699A (en) | 1998-08-07 | 2000-02-28 | Chiron Corporation | Substituted isoxazole as estrogen receptor modulators |
US6297256B1 (en) | 1999-06-15 | 2001-10-02 | Neurogen Corporation | Aryl and heteroaryl substituted pyridino derivatives GABA brain receptor ligands |
US6660753B2 (en) | 1999-08-19 | 2003-12-09 | Nps Pharmaceuticals, Inc. | Heteropolycyclic compounds and their use as metabotropic glutamate receptor antagonists |
IT1314191B1 (it) | 1999-10-18 | 2002-12-06 | Recordati Chem Pharm | Derivati isossazolcarbossamidici |
ES2195943T3 (es) | 1999-11-12 | 2003-12-16 | Neurogen Corp | Compuestos heteroaromaticos biciclicos y triciclicos. |
PA8535601A1 (es) | 2000-12-21 | 2002-11-28 | Pfizer | Derivados benzimidazol y piridilimidazol como ligandos para gabaa |
GB0108475D0 (en) | 2001-04-04 | 2001-05-23 | Merck Sharp & Dohme | New compounds |
EA005934B1 (ru) | 2001-07-05 | 2005-08-25 | Х. Лундбекк А/С | Замещённые анилиновые пиперидины в качестве селективных антагонистов мсн |
DE60131967D1 (de) | 2001-08-13 | 2008-01-31 | Phenex Pharmaceuticals Ag | Nr1h4-kern-rezeptor-bindende verbindungen |
AU2002353844A1 (en) | 2001-11-20 | 2003-06-10 | Eli Lilly And Company | Beta 3 adrenergic agonists |
GB0128160D0 (en) | 2001-11-23 | 2002-01-16 | Merck Sharp & Dohme | Novel compounds |
GB0128499D0 (en) | 2001-11-28 | 2002-01-23 | Merck Sharp & Dohme | Therapeutic agents |
WO2004048349A1 (en) | 2002-11-22 | 2004-06-10 | Smithkline Beecham Corporation | Farnesoid x receptor agonists |
GB0318447D0 (en) | 2003-08-05 | 2003-09-10 | Merck Sharp & Dohme | Therapeutic agents |
EP1745027A4 (en) | 2004-05-14 | 2009-06-03 | Irm Llc | COMPOUNDS AND COMPOSITIONS AS PPAR MODULATORS |
DE602005007350D1 (de) | 2004-06-01 | 2008-07-17 | Hoffmann La Roche | Pyridin-4-yl-ethynylimidazole und -pyrazole als antagonisten des mglu5-rezeptors |
JP2008502687A (ja) | 2004-06-14 | 2008-01-31 | タケダ サン ディエゴ インコーポレイテッド | キナーゼ阻害剤 |
ES2315912T3 (es) | 2004-10-01 | 2009-04-01 | F. Hoffmann-La Roche Ag | Derivados de eter sustituido por hexafluorisopropanol. |
EP1812427A4 (en) | 2004-10-15 | 2009-10-14 | Scripps Research Inst | FATTY ACID AMIDE HYDROLASE OXADIAZOLE KETONE INHIBITORS |
US20070060589A1 (en) | 2004-12-21 | 2007-03-15 | Purandare Ashok V | Inhibitors of protein arginine methyl transferases |
WO2006095822A1 (ja) | 2005-03-11 | 2006-09-14 | Ono Pharmaceutical Co., Ltd. | スルホンアミド化合物およびその医薬 |
EP1899299B1 (en) | 2005-06-27 | 2010-10-20 | Bristol-Myers Squibb Company | C-linked cyclic antagonists of p2y1 receptor useful in the treatment of thrombotic conditions |
ATE484416T1 (de) | 2005-07-20 | 2010-10-15 | Prospective Concepts Ag | Pneumatisch verstellbare seitenwangen für fahrzeugsitze |
BRPI0616184A2 (pt) | 2005-09-19 | 2011-06-07 | Hoffmann La Roche | derivados de isoxazolo como agonistas inversos gaba a alfa 5, processo para a preparação dos mesmos, medicamento e uso dos referidos derivados |
JP2009511533A (ja) | 2005-10-11 | 2009-03-19 | エフ.ホフマン−ラ ロシュ アーゲー | イソオキサゾール誘導体 |
WO2007052843A1 (ja) | 2005-11-04 | 2007-05-10 | Takeda Pharmaceutical Company Limited | 複素環アミド化合物およびその用途 |
CN101316838B (zh) * | 2005-11-30 | 2013-01-30 | 霍夫曼-拉罗奇有限公司 | 用作h3调节剂的1,1-二氧代-硫代吗啉基吲哚基甲酮衍生物 |
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CN101374834B (zh) | 2006-02-03 | 2011-12-14 | 伊莱利利公司 | 用于调节fxr的化合物和方法 |
JP2007230909A (ja) | 2006-03-01 | 2007-09-13 | Univ Of Tokyo | 置換イソキサゾール誘導体 |
AU2007267183B2 (en) | 2006-05-31 | 2011-10-20 | F. Hoffmann-La Roche Ag | Aryl-4-ethynyl-isoxazole derivatives |
EP1894928A1 (en) | 2006-08-29 | 2008-03-05 | PheneX Pharmaceuticals AG | Heterocyclic fxr binding compounds |
EP1894924A1 (en) | 2006-08-29 | 2008-03-05 | Phenex Pharmaceuticals AG | Heterocyclic FXR binding compounds |
JP2010524953A (ja) | 2007-04-17 | 2010-07-22 | ブリストル−マイヤーズ スクイブ カンパニー | 縮合ヘテロ環11−β−ヒドロキシステロイドデヒドロゲナーゼI型阻害剤 |
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DK2767536T3 (en) | 2007-12-04 | 2015-10-19 | Hoffmann La Roche | Isoxazolo-pyridine derivatives |
-
2012
- 2012-10-12 US US13/650,159 patent/US8785435B2/en active Active
- 2012-10-17 AU AU2012318294A patent/AU2012318294B2/en not_active Ceased
- 2012-10-17 WO PCT/EP2012/070522 patent/WO2013057124A1/en active Application Filing
- 2012-10-17 BR BR112014009288A patent/BR112014009288A8/pt not_active IP Right Cessation
- 2012-10-17 HU HUE12772789A patent/HUE030298T2/en unknown
- 2012-10-17 MX MX2014004678A patent/MX341492B/es active IP Right Grant
- 2012-10-17 AR ARP120103860A patent/AR088359A1/es unknown
- 2012-10-17 SI SI201230792A patent/SI2768821T1/sl unknown
- 2012-10-17 JP JP2014536209A patent/JP5918856B2/ja active Active
- 2012-10-17 RU RU2014118968A patent/RU2618524C2/ru not_active IP Right Cessation
- 2012-10-17 PL PL12772789T patent/PL2768821T3/pl unknown
- 2012-10-17 CA CA2850441A patent/CA2850441A1/en not_active Abandoned
- 2012-10-17 SG SG11201401591WA patent/SG11201401591WA/en unknown
- 2012-10-17 DK DK12772789.9T patent/DK2768821T3/en active
- 2012-10-17 CN CN201280051089.3A patent/CN103889971B/zh active Active
- 2012-10-17 ES ES12772789.9T patent/ES2606547T3/es active Active
- 2012-10-17 KR KR1020147013555A patent/KR20140079503A/ko active Search and Examination
- 2012-10-17 EP EP12772789.9A patent/EP2768821B1/en active Active
-
2014
- 2014-03-13 IL IL231532A patent/IL231532A0/en active IP Right Grant
- 2014-06-04 US US14/295,535 patent/US8975397B2/en active Active
- 2014-07-09 HK HK14106993.8A patent/HK1193611A1/zh unknown
Also Published As
Publication number | Publication date |
---|---|
AU2012318294B2 (en) | 2015-10-01 |
BR112014009288A2 (pt) | 2017-06-13 |
JP2014530832A (ja) | 2014-11-20 |
SI2768821T1 (sl) | 2017-01-31 |
AR088359A1 (es) | 2014-05-28 |
IL231532A0 (en) | 2014-04-30 |
AU2012318294A1 (en) | 2013-05-09 |
BR112014009288A8 (pt) | 2020-04-22 |
MX2014004678A (es) | 2014-05-28 |
DK2768821T3 (en) | 2017-01-23 |
ES2606547T3 (es) | 2017-03-24 |
PL2768821T3 (pl) | 2017-05-31 |
JP5918856B2 (ja) | 2016-05-18 |
CN103889971A (zh) | 2014-06-25 |
EP2768821B1 (en) | 2016-11-16 |
RU2618524C2 (ru) | 2017-05-04 |
CN103889971B (zh) | 2016-08-31 |
HUE030298T2 (en) | 2017-04-28 |
SG11201401591WA (en) | 2014-05-29 |
RU2014118968A (ru) | 2015-11-27 |
WO2013057124A1 (en) | 2013-04-25 |
NZ622215A (en) | 2016-06-24 |
US8785435B2 (en) | 2014-07-22 |
HK1193611A1 (zh) | 2014-09-26 |
US20130172329A1 (en) | 2013-07-04 |
EP2768821A1 (en) | 2014-08-27 |
US20140329806A1 (en) | 2014-11-06 |
CA2850441A1 (en) | 2013-04-25 |
KR20140079503A (ko) | 2014-06-26 |
US8975397B2 (en) | 2015-03-10 |
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