SG11201401591WA - Solid forms of 1,l-dioxo-4-thiomorpholinyl)-[6-[[3(4-fluorophenyl)-5-methyl-4-isoxazolyl]methoxy]-3-pyridinyl]-methanone - Google Patents

Solid forms of 1,l-dioxo-4-thiomorpholinyl)-[6-[[3(4-fluorophenyl)-5-methyl-4-isoxazolyl]methoxy]-3-pyridinyl]-methanone

Info

Publication number
SG11201401591WA
SG11201401591WA SG11201401591WA SG11201401591WA SG11201401591WA SG 11201401591W A SG11201401591W A SG 11201401591WA SG 11201401591W A SG11201401591W A SG 11201401591WA SG 11201401591W A SG11201401591W A SG 11201401591WA SG 11201401591W A SG11201401591W A SG 11201401591WA
Authority
SG
Singapore
Prior art keywords
methanone
thiomorpholinyl
dioxo
isoxazolyl
pyridinyl
Prior art date
Application number
SG11201401591WA
Inventor
Pascal Dott
Olaf Grassmann
Michael Kammerer
Joachim Manns
Urs Schwitter
Andrew Thomas
Nicole Wyttenbach
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of SG11201401591WA publication Critical patent/SG11201401591WA/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/541Non-condensed thiazines containing further heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/04Centrally acting analgesics, e.g. opioids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16Anti-Parkinson drugs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/18Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/20Hypnotics; Sedatives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/22Anxiolytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/24Antidepressants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/30Drugs for disorders of the nervous system for treating abuse or dependence
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/30Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32Alcohol-abuse
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Psychiatry (AREA)
  • Addiction (AREA)
  • Pain & Pain Management (AREA)
  • Psychology (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Anesthesiology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Medicinal Preparation (AREA)
SG11201401591WA 2011-10-20 2012-10-17 Solid forms of 1,l-dioxo-4-thiomorpholinyl)-[6-[[3(4-fluorophenyl)-5-methyl-4-isoxazolyl]methoxy]-3-pyridinyl]-methanone SG11201401591WA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP11185993 2011-10-20
PCT/EP2012/070522 WO2013057124A1 (en) 2011-10-20 2012-10-17 Solid forms of 1,l-dioxo-4-thiomorpholinyl)-[6-[[3(4-fluorophenyl)-5-methyl-4-isoxazolyl]methoxy]-3-pyridinyl]-methanone

Publications (1)

Publication Number Publication Date
SG11201401591WA true SG11201401591WA (en) 2014-05-29

Family

ID=47019027

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11201401591WA SG11201401591WA (en) 2011-10-20 2012-10-17 Solid forms of 1,l-dioxo-4-thiomorpholinyl)-[6-[[3(4-fluorophenyl)-5-methyl-4-isoxazolyl]methoxy]-3-pyridinyl]-methanone

Country Status (20)

Country Link
US (2) US8785435B2 (en)
EP (1) EP2768821B1 (en)
JP (1) JP5918856B2 (en)
KR (1) KR20140079503A (en)
CN (1) CN103889971B (en)
AR (1) AR088359A1 (en)
AU (1) AU2012318294B2 (en)
BR (1) BR112014009288A8 (en)
CA (1) CA2850441A1 (en)
DK (1) DK2768821T3 (en)
ES (1) ES2606547T3 (en)
HK (1) HK1193611A1 (en)
HU (1) HUE030298T2 (en)
IL (1) IL231532A0 (en)
MX (1) MX341492B (en)
PL (1) PL2768821T3 (en)
RU (1) RU2618524C2 (en)
SG (1) SG11201401591WA (en)
SI (1) SI2768821T1 (en)
WO (1) WO2013057124A1 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2792360A1 (en) 2013-04-18 2014-10-22 IP Gesellschaft für Management mbH (1aR,12bS)-8-cyclohexyl-11-fluoro-N-((1-methylcyclopropyl)sulfonyl)-1a-((3-methyl-3,8-diazabicyclo[3.2.1]oct-8-yl)carbonyl)-1,1a,2,2b-tetrahydrocyclopropa[d]indolo[2,1-a][2]benzazepine-5-carboxamide for use in treating HCV
BR112020004116A2 (en) 2017-08-28 2020-09-01 University Of Maryland, Baltimore new modulators of the type a gamma aminobutyric acid receptor for mood disorders
PE20210555A1 (en) 2018-06-13 2021-03-17 Hoffmann La Roche NEW DERIVATIVES OF ISOXAZOLYL ETHER AS PAM FROM GABA TO ALFA5

Family Cites Families (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE352505C (en) 1918-03-01 1922-04-27 Metallbank Method for processing ammonia slag
DE3525205A1 (en) 1984-09-11 1986-03-20 Hoechst Ag, 6230 Frankfurt PLANT PROTECTIVE AGENTS BASED ON 1,2,4-TRIAZOLE DERIVATIVES AND NEW DERIVATIVES OF 1,2,4-TRIAZOLE
GB9808663D0 (en) 1998-04-23 1998-06-24 Merck Sharp & Dohme Therapeutic agents
ES2255294T3 (en) 1998-08-07 2006-06-16 Chiron Corporation ISOXAZOL DERIVATIVES REPLACED AS MODULATORS OF THE STROGEN RECEPTOR.
US6297256B1 (en) 1999-06-15 2001-10-02 Neurogen Corporation Aryl and heteroaryl substituted pyridino derivatives GABA brain receptor ligands
US6660753B2 (en) 1999-08-19 2003-12-09 Nps Pharmaceuticals, Inc. Heteropolycyclic compounds and their use as metabotropic glutamate receptor antagonists
IT1314191B1 (en) 1999-10-18 2002-12-06 Recordati Chem Pharm ISOSSAZOLCARBOSSAMIDIC DERIVATIVES
AU1481701A (en) 1999-11-12 2001-06-06 Neurogen Corporation Bicyclic and tricyclic heteroaromatic compounds
PA8535601A1 (en) 2000-12-21 2002-11-28 Pfizer BENZIMIDAZOL AND PIRIDILIMIDAZOL DERIVATIVES AS LIGANDOS FOR GABAA
GB0108475D0 (en) 2001-04-04 2001-05-23 Merck Sharp & Dohme New compounds
EA005934B1 (en) 2001-07-05 2005-08-25 Х. Лундбекк А/С Substituted anilinic piperidines as mch selective antagonists
DE60131967D1 (en) 2001-08-13 2008-01-31 Phenex Pharmaceuticals Ag Nr1h4 nuclear receptor binding compounds
ES2299618T3 (en) 2001-11-20 2008-06-01 Eli Lilly And Company BETA-3-ADRENERGIC AGONISTS.
GB0128160D0 (en) 2001-11-23 2002-01-16 Merck Sharp & Dohme Novel compounds
GB0128499D0 (en) 2001-11-28 2002-01-23 Merck Sharp & Dohme Therapeutic agents
EP1562915A1 (en) 2002-11-22 2005-08-17 SmithKline Beecham Corporation Farnesoid x receptor agonists
GB0318447D0 (en) 2003-08-05 2003-09-10 Merck Sharp & Dohme Therapeutic agents
RU2408589C2 (en) 2004-05-14 2011-01-10 Айрм Ллк Compounds and compositions as modulators of ppar-receptors activated by peroxisome proliferator
MXPA06013603A (en) 2004-06-01 2007-02-08 Hoffmann La Roche Pyridin-4-yl-ethynyl-imidazoles and pyrazoles as mglu5 receptor antagonists.
JP2008502687A (en) 2004-06-14 2008-01-31 タケダ サン ディエゴ インコーポレイテッド Kinase inhibitor
MX2007003648A (en) 2004-10-01 2007-06-11 Hoffmann La Roche Hexafluoroisopropanol substituted ether derivatives.
WO2006044617A1 (en) 2004-10-15 2006-04-27 The Scripps Research Institute Oxadiazole ketone inhibitors of fatty acid amide hydrolase
US20070060589A1 (en) 2004-12-21 2007-03-15 Purandare Ashok V Inhibitors of protein arginine methyl transferases
WO2006095822A1 (en) 2005-03-11 2006-09-14 Ono Pharmaceutical Co., Ltd. Sulfonamide compound and pharmaceutical thereof
WO2007002635A2 (en) 2005-06-27 2007-01-04 Bristol-Myers Squibb Company C-linked cyclic antagonists of p2y1 receptor useful in the treatment of thrombotic conditions
EP1904338B1 (en) 2005-07-20 2011-11-09 Prospective Concepts AG Pneumatic cushion structure
EP1931661B1 (en) 2005-09-19 2008-11-19 F.Hoffmann-La Roche Ag Isoxazolo derivatives as gaba a alpha5 inverse agonists
JP2009511533A (en) 2005-10-11 2009-03-19 エフ.ホフマン−ラ ロシュ アーゲー Isoxazole derivatives
WO2007052843A1 (en) 2005-11-04 2007-05-10 Takeda Pharmaceutical Company Limited Heterocyclic amide compound and use thereof
ATE507222T1 (en) * 2005-11-30 2011-05-15 Hoffmann La Roche 1,1-DIOXO-THIOMORPHOLINYL-INDOLYL-METHANONE DERIVATIVES FOR USE AS H3 MODULATORS
ATE526318T1 (en) 2005-12-19 2011-10-15 Glaxosmithkline Llc FARNESOID-X RECEPTOR AGONISTS
WO2007071476A1 (en) * 2005-12-20 2007-06-28 International Business Machines Corporation Method, system and computer program for distributing software products based on an e-mail service
JP5301286B2 (en) 2006-02-03 2013-09-25 イーライ リリー アンド カンパニー Compounds and methods for modulating FX receptors
JP2007230909A (en) 2006-03-01 2007-09-13 Univ Of Tokyo Substituted isoxazole derivative
EP2029559B1 (en) 2006-05-31 2009-08-05 F. Hoffmann-Roche AG Aryl-4-ethynyl-isoxazole derivatives
EP1894924A1 (en) 2006-08-29 2008-03-05 Phenex Pharmaceuticals AG Heterocyclic FXR binding compounds
EP1894928A1 (en) 2006-08-29 2008-03-05 PheneX Pharmaceuticals AG Heterocyclic fxr binding compounds
WO2008130951A1 (en) 2007-04-17 2008-10-30 Bristol-Myers Squibb Company Fused heterocyclic 11-beta-hydroxysteroid dehydrogenase type i inhibitors
US7618973B2 (en) 2007-12-04 2009-11-17 Hoffmann-La Roche Inc. Isoxazolo-pyrazine derivatives
AU2008333326B2 (en) 2007-12-04 2013-05-30 F. Hoffmann-La Roche Ag Isoxazolo-pyridine derivatives

Also Published As

Publication number Publication date
AR088359A1 (en) 2014-05-28
AU2012318294A1 (en) 2013-05-09
RU2014118968A (en) 2015-11-27
JP2014530832A (en) 2014-11-20
DK2768821T3 (en) 2017-01-23
AU2012318294B2 (en) 2015-10-01
HUE030298T2 (en) 2017-04-28
RU2618524C2 (en) 2017-05-04
IL231532A0 (en) 2014-04-30
ES2606547T3 (en) 2017-03-24
CA2850441A1 (en) 2013-04-25
BR112014009288A8 (en) 2020-04-22
SI2768821T1 (en) 2017-01-31
BR112014009288A2 (en) 2017-06-13
CN103889971B (en) 2016-08-31
WO2013057124A1 (en) 2013-04-25
EP2768821B1 (en) 2016-11-16
NZ622215A (en) 2016-06-24
US20140329806A1 (en) 2014-11-06
MX341492B (en) 2016-08-23
HK1193611A1 (en) 2014-09-26
US20130172329A1 (en) 2013-07-04
CN103889971A (en) 2014-06-25
US8975397B2 (en) 2015-03-10
US8785435B2 (en) 2014-07-22
JP5918856B2 (en) 2016-05-18
KR20140079503A (en) 2014-06-26
PL2768821T3 (en) 2017-05-31
MX2014004678A (en) 2014-05-28
EP2768821A1 (en) 2014-08-27

Similar Documents

Publication Publication Date Title
HK1196371A1 (en) Substituted imidazopyridinyl aminopyridine compounds
IL235745A (en) 2-aminopyridine derivatives
EP2671582A4 (en) Ring-fused heterocyclic derivative
ZA201201125B (en) Pyridin-4-yl derivatives
EP2703394A4 (en) Novel 3-hydroxyisothiazole 1-oxide derivative
HK1188145A1 (en) Novel fused pyridine compounds as casein kinase inhibitors
HK1202288A1 (en) 2-oxo-oxazolidin-3,5-diyl antibiotic derivatives 2---35-
HK1198586A1 (en) 6-difluoromethyl-5,6-dihydro-2h-[1,4]oxazin-3-amine derivatives 6--56--2h-[14]-3-
IL232717A0 (en) 3-cyanoaryl-1h-pyrrolo[2,3-b]pyridine derivatives
EP2524917A4 (en) Fused pyridine derivatives
PT2771327T (en) Novel pyrazine derivatives
EP2668186A4 (en) Pharmaceutical composition comprising pyridone derivatives
EP2558094A4 (en) Pyridone derivatives
HK1187336A1 (en) Pharmaceutical composition comprising pyridone derivatives
HK1193611A1 (en) Solid forms of 1,1-dioxo-4-thiomorpholinyl)-[6-[[3(4-fluorophenyl)-5- methyl-4-isoxazolyl]methoxy]-3-pyridinyl]-methanone (1l--4-)-[6-[[3(4-)-5--4-]]-3- ]-
AU2011901088A0 (en) Door Track
GB201119592D0 (en) Novel heteroaromatic Derivatives I