BR112014007766B1 - Polipeptídeo glicosilado, método para fabricação do mesmo e composição farmacêutica - Google Patents
Polipeptídeo glicosilado, método para fabricação do mesmo e composição farmacêutica Download PDFInfo
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- BR112014007766B1 BR112014007766B1 BR112014007766-5A BR112014007766A BR112014007766B1 BR 112014007766 B1 BR112014007766 B1 BR 112014007766B1 BR 112014007766 A BR112014007766 A BR 112014007766A BR 112014007766 B1 BR112014007766 B1 BR 112014007766B1
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- fmoc
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- sugar chain
- polypeptide
- glycosylated polypeptide
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- 239000010452 phosphate Substances 0.000 description 1
- 239000008055 phosphate buffer solution Substances 0.000 description 1
- 125000002467 phosphate group Chemical group [H]OP(=O)(O[H])O[*] 0.000 description 1
- 230000026731 phosphorylation Effects 0.000 description 1
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- 239000000256 polyoxyethylene sorbitan monolaurate Substances 0.000 description 1
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- 230000003389 potentiating effect Effects 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 description 1
- 238000010791 quenching Methods 0.000 description 1
- 230000000171 quenching effect Effects 0.000 description 1
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- 125000005629 sialic acid group Chemical group 0.000 description 1
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- 239000001488 sodium phosphate Substances 0.000 description 1
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- 125000001273 sulfonato group Chemical group [O-]S(*)(=O)=O 0.000 description 1
- 150000003462 sulfoxides Chemical class 0.000 description 1
- GFYHSKONPJXCDE-UHFFFAOYSA-N sym-collidine Natural products CC1=CN=C(C)C(C)=C1 GFYHSKONPJXCDE-UHFFFAOYSA-N 0.000 description 1
- WROMPOXWARCANT-UHFFFAOYSA-N tfa trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F.OC(=O)C(F)(F)F WROMPOXWARCANT-UHFFFAOYSA-N 0.000 description 1
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- 238000013519 translation Methods 0.000 description 1
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Images
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/555—Interferons [IFN]
- C07K14/565—IFN-beta
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/21—Interferons [IFN]
- A61K38/215—IFN-beta
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/02—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length in solution
- C07K1/026—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length in solution by fragment condensation in solution
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
- C07K1/1072—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups
- C07K1/1077—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups by covalent attachment of residues other than amino acids or peptide residues, e.g. sugars, polyols, fatty acids
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biochemistry (AREA)
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- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Epidemiology (AREA)
- Analytical Chemistry (AREA)
- Toxicology (AREA)
- Oncology (AREA)
- Virology (AREA)
- Communicable Diseases (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
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| JP2011218793 | 2011-10-01 | ||
| JP2011-218793 | 2011-10-01 | ||
| PCT/JP2012/075262 WO2013047846A1 (ja) | 2011-10-01 | 2012-09-28 | 糖鎖付加ポリペプチドおよび当該ポリペプチドを含む医薬組成物 |
Publications (2)
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|---|---|
| BR112014007766A2 BR112014007766A2 (pt) | 2017-04-04 |
| BR112014007766B1 true BR112014007766B1 (pt) | 2022-05-10 |
Family
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| BR112014007766-5A BR112014007766B1 (pt) | 2011-10-01 | 2012-09-28 | Polipeptídeo glicosilado, método para fabricação do mesmo e composição farmacêutica |
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| EP (1) | EP2762489B1 (enExample) |
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| AU (1) | AU2012317325B2 (enExample) |
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| CA (1) | CA2850469C (enExample) |
| DK (1) | DK2762489T3 (enExample) |
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| SG (2) | SG11201401071YA (enExample) |
| TW (1) | TWI633115B (enExample) |
| WO (1) | WO2013047846A1 (enExample) |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101979045B1 (ko) | 2011-10-01 | 2019-05-15 | 가부시키가이샤 도우사 고가쿠 겐큐쇼 | 당쇄 부가 폴리펩티드 및 상기 폴리펩티드를 포함하는 의약 조성물 |
| DK2982686T3 (en) | 2013-03-29 | 2018-10-08 | Glytech Inc | POLYPEPTIDE WITH SIALYLED SUGAR CHAIN CONNECTED |
| CN114685645B (zh) * | 2020-12-30 | 2025-03-21 | 深圳翰宇药业股份有限公司 | 一种索玛鲁肽的合成方法 |
Family Cites Families (39)
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| EP0237019A3 (en) * | 1986-03-14 | 1988-03-09 | Toray Industries, Inc. | Interferon conjugate and production thereof using recombinant gene |
| ES2218806T3 (es) | 1997-01-16 | 2004-11-16 | Neose Technologies, Inc. | Sialilacion practica in vitro de glicoproteinas recombinantes. |
| DE19717864C2 (de) | 1997-04-23 | 2001-05-17 | Fraunhofer Ges Forschung | Humanes rekombinantes Interferon-beta, Verfahren zu seiner Herstellung und seine Verwendung |
| BR9910023A (pt) * | 1998-04-28 | 2000-12-26 | Applied Research Systems | Conjugados de poliol-ifn-beta |
| EE05111B1 (et) * | 1998-10-16 | 2008-12-15 | Biogen, Incorporated | Interferoon-beetaga sulandatud valgud ja nende kasutamine |
| HU229888B1 (en) | 1998-10-16 | 2014-11-28 | Biogen Idec Ma Inc Cambridge | Polymer conjugates of interferon betha-1a and uses |
| US6514729B1 (en) | 1999-05-12 | 2003-02-04 | Xencor, Inc. | Recombinant interferon-beta muteins |
| DE60037978T2 (de) * | 1999-12-08 | 2008-05-21 | Amgen Inc., Thousand Oaks | Interferon ähnliche moleküle, und deren verwendungen |
| US7795002B2 (en) * | 2000-06-28 | 2010-09-14 | Glycofi, Inc. | Production of galactosylated glycoproteins in lower eukaryotes |
| AU2001273385B2 (en) | 2000-09-08 | 2005-04-07 | Gryphon Therapeutics, Inc. | Polymer-modified synthetic proteins |
| JP2004534523A (ja) | 2001-02-27 | 2004-11-18 | マキシゲン・エイピーエス | 新規なインターフェロンβ様分子 |
| CA2441095A1 (en) | 2001-03-15 | 2002-09-26 | Merck Patent Gesellschaft Mit Beschraenkter Haftung | Modified interferon beta with reduced immunogenicity |
| US7226903B2 (en) * | 2001-10-10 | 2007-06-05 | Neose Technologies, Inc. | Interferon beta: remodeling and glycoconjugation of interferon beta |
| EP2305312B1 (en) * | 2001-10-10 | 2015-03-04 | ratiopharm GmbH | Remodelling and glycoconjugation of follicle-stimulating hormone (FSH) |
| CA2469487A1 (en) | 2001-12-11 | 2003-07-03 | Aventis Pasteur | Mutated hiv tat |
| MXPA04008798A (es) | 2002-03-12 | 2004-11-26 | Maxygen Aps | Moleculas semejantes a interferon beta para el tratamiento de evento cerebrovascular. |
| US7943763B2 (en) | 2002-07-05 | 2011-05-17 | Otsuka Chemical Holdings Co., Ltd. | Process for preparing glycopeptides having asparagine-linked oligosaccharides, and the glycopeptides |
| AU2003254641A1 (en) | 2002-08-28 | 2004-03-19 | Maxygen Aps | Interferon beta-like molecules for treatment of cancer |
| PL377612A1 (pl) * | 2002-09-27 | 2006-02-06 | Biogen Idec Ma Inc. | Terapie przewlekłej zapalnej polineuropatii demielinizacyjnej z użyciem interferonu-ß |
| AU2003277088A1 (en) | 2002-10-01 | 2004-04-23 | Xencor, Inc | Interferon variants with improved properties |
| AU2003292792A1 (en) | 2002-12-26 | 2004-07-22 | Kajihara, Yasuhiro | Sugar-chain asparagine derivatives and processes for the preparation thereof |
| EP1666496B1 (en) | 2003-08-25 | 2014-03-12 | Toray Industries, Inc. | Interferon-beta composite |
| JP2007526317A (ja) | 2004-03-01 | 2007-09-13 | エンゾン ファーマスーティカルズ インコーポレイテッド | インターフェロン−ベータ・ポリマー結合体 |
| EP1789074A4 (en) | 2004-08-09 | 2009-08-12 | Alios Biopharma Inc | PROTEASE-RESISTANT HYPERGLYCOSYL SYNTHETIC POLYPEPTIDE VARIANTS, ORAL FORMULATIONS AND METHODS OF USING THE SAME |
| RU2392963C2 (ru) * | 2004-08-09 | 2010-06-27 | Элиоз Байофарма, Инк. | Синтетические варианты гипергликозилированного протеазо-резистентного полипептида, пероральные композиции и способы применения таких вариантов |
| KR100781666B1 (ko) | 2004-11-02 | 2007-12-03 | 신영기 | 인간 인터페론-베타 변이체 |
| SG155183A1 (en) * | 2005-08-26 | 2009-09-30 | Ares Trading Sa | Process for the preparation of glycosylated interferon beta |
| WO2007110231A2 (en) * | 2006-03-28 | 2007-10-04 | Nautilus Biotech, S.A. | MODIFIED INTERFERON-β (IFN-β) POLYPEPTIDES |
| US20080096819A1 (en) | 2006-05-02 | 2008-04-24 | Allozyne, Inc. | Amino acid substituted molecules |
| TWI423821B (zh) | 2007-06-19 | 2014-01-21 | Glucose-containing glucagon-like peptide-1 peptide | |
| AU2008283317B2 (en) | 2007-07-31 | 2012-08-02 | Glytech, Inc. | Method for producing peptide |
| JP2009242372A (ja) | 2008-03-11 | 2009-10-22 | Yokohama City Univ | 均一な糖鎖構造を有するエリスロポエチン誘導体 |
| JP5604297B2 (ja) | 2008-06-17 | 2014-10-08 | 株式会社糖鎖工学研究所 | 糖鎖付加ｇｌｐ−１ペプチド |
| CA2733362C (en) | 2008-08-08 | 2016-10-18 | Universiteit Gent | Cells producing glycoproteins having altered glycosylation patterns and methods and use thereof |
| KR20110067097A (ko) * | 2008-08-19 | 2011-06-21 | 오츠카 가가쿠 가부시키가이샤 | 당단백질의 제조방법 및 스크리닝 방법 |
| WO2012051615A1 (en) | 2010-10-15 | 2012-04-19 | Transgenrx, Inc. | Novel vectors for production of glycosylated interferon |
| SG193377A1 (en) | 2011-03-10 | 2013-10-30 | Glytech Inc | Method for producing glycopeptide having sialyl sugar chain, sialyl sugar chain-added amino acid derivative to be used in same, and glycopeptide |
| ES2774284T3 (es) | 2011-06-29 | 2020-07-20 | Kyowa Kirin Co Ltd | Método para purificar antitrombina |
| KR101979045B1 (ko) | 2011-10-01 | 2019-05-15 | 가부시키가이샤 도우사 고가쿠 겐큐쇼 | 당쇄 부가 폴리펩티드 및 상기 폴리펩티드를 포함하는 의약 조성물 |
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| SG10201602076QA (en) | 2016-04-28 |
| CA2850469C (en) | 2020-07-07 |
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| US10358470B2 (en) | 2019-07-23 |
| RU2014116550A (ru) | 2015-10-27 |
| KR101979045B1 (ko) | 2019-05-15 |
| RU2636456C2 (ru) | 2017-11-23 |
| MY168902A (en) | 2018-12-04 |
| BR112014007766A2 (pt) | 2017-04-04 |
| DK2762489T3 (en) | 2018-07-02 |
| CN104080803B (zh) | 2020-08-04 |
| JP6153470B2 (ja) | 2017-06-28 |
| CN109134642A (zh) | 2019-01-04 |
| AU2012317325B2 (en) | 2016-10-06 |
| EP2762489B1 (en) | 2018-03-28 |
| EP2762489A1 (en) | 2014-08-06 |
| US20140369964A1 (en) | 2014-12-18 |
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| SG11201401071YA (en) | 2014-08-28 |
| CA2850469A1 (en) | 2013-04-04 |
| TW201321404A (zh) | 2013-06-01 |
| KR20140095051A (ko) | 2014-07-31 |
| PH12014500694B1 (en) | 2020-01-31 |
| WO2013047846A1 (ja) | 2013-04-04 |
| TWI633115B (zh) | 2018-08-21 |
| JPWO2013047846A1 (ja) | 2015-03-30 |
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Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI |
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| B06U | Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette] | ||
| B06A | Patent application procedure suspended [chapter 6.1 patent gazette] | ||
| B09A | Decision: intention to grant [chapter 9.1 patent gazette] | ||
| B16A | Patent or certificate of addition of invention granted [chapter 16.1 patent gazette] |
Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 28/09/2012, OBSERVADAS AS CONDICOES LEGAIS |
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| B21F | Lapse acc. art. 78, item iv - on non-payment of the annual fees in time |
Free format text: REFERENTE A 12A ANUIDADE. |
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| B24J | Lapse because of non-payment of annual fees (definitively: art 78 iv lpi, resolution 113/2013 art. 12) |
Free format text: EM VIRTUDE DA EXTINCAO PUBLICADA NA RPI 2794 DE 23-07-2024 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDA A EXTINCAO DA PATENTE E SEUS CERTIFICADOS, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013. |