BR112013028536A2 - variantes de albumina - Google Patents
variantes de albuminaInfo
- Publication number
- BR112013028536A2 BR112013028536A2 BR112013028536A BR112013028536A BR112013028536A2 BR 112013028536 A2 BR112013028536 A2 BR 112013028536A2 BR 112013028536 A BR112013028536 A BR 112013028536A BR 112013028536 A BR112013028536 A BR 112013028536A BR 112013028536 A2 BR112013028536 A2 BR 112013028536A2
- Authority
- BR
- Brazil
- Prior art keywords
- albumin
- variants
- albumin variants
- relates
- origin
- Prior art date
Links
- 102000009027 Albumins Human genes 0.000 title abstract 5
- 108010088751 Albumins Proteins 0.000 title abstract 5
- 230000004927 fusion Effects 0.000 abstract 1
- 229920001184 polypeptide Polymers 0.000 abstract 1
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/76—Albumins
- C07K14/765—Serum albumin, e.g. HSA
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Abstract
variantes de albumina a invenção refere-se às variantes de uma albumina de origem tendo meia vida plasmática alterada, em comparação com a albumina de origem. a invenção também diz respeito a polipeptídeos de fusão e conjugados compreendendo a referida variante de albumina.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP11164991 | 2011-05-05 | ||
EP11185064 | 2011-10-13 | ||
EP12160007 | 2012-03-16 | ||
PCT/EP2012/058206 WO2012150319A1 (en) | 2011-05-05 | 2012-05-04 | Albumin variants |
Publications (1)
Publication Number | Publication Date |
---|---|
BR112013028536A2 true BR112013028536A2 (pt) | 2016-11-29 |
Family
ID=46027974
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112013028536A BR112013028536A2 (pt) | 2011-05-05 | 2012-05-04 | variantes de albumina |
Country Status (14)
Country | Link |
---|---|
US (3) | US8822417B2 (pt) |
EP (1) | EP2705051A1 (pt) |
JP (1) | JP6430828B2 (pt) |
KR (1) | KR20140027307A (pt) |
CN (2) | CN110272484A (pt) |
AU (2) | AU2012251583B2 (pt) |
BR (1) | BR112013028536A2 (pt) |
CA (1) | CA2830660A1 (pt) |
GB (1) | GB2491006A (pt) |
IL (1) | IL228737B (pt) |
MX (1) | MX353816B (pt) |
RU (1) | RU2650784C2 (pt) |
WO (1) | WO2012150319A1 (pt) |
ZA (1) | ZA201308255B (pt) |
Families Citing this family (55)
Publication number | Priority date | Publication date | Assignee | Title |
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JP5936112B2 (ja) | 2009-02-11 | 2016-06-15 | アルブミディクス アクティーゼルスカブ | アルブミン変異体及び複合体 |
RU2607374C2 (ru) * | 2009-10-30 | 2017-01-10 | Новозаймс Байофарма Дк А/С | Варианты альбумина |
JP2013519392A (ja) | 2010-02-16 | 2013-05-30 | メディミューン,エルエルシー | Hsa関連組成物および使用方法 |
KR20130070576A (ko) | 2010-04-09 | 2013-06-27 | 노보자임스 바이오파마 디케이 에이/에스 | 알부민 유도체 및 변이체 |
SG10201505218YA (en) | 2010-07-09 | 2015-08-28 | Biogen Hemophilia Inc | Factor ix polypeptides and methods of use thereof |
US9045564B2 (en) | 2011-02-15 | 2015-06-02 | Medimmune, Llc | HSA-related compositions and methods of use |
EP2780364A2 (en) | 2011-11-18 | 2014-09-24 | Eleven Biotherapeutics, Inc. | Proteins with improved half-life and other properties |
ES2664328T3 (es) | 2012-03-16 | 2018-04-19 | Albumedix A/S | Variantes de albúmina |
US20140128326A1 (en) * | 2012-11-08 | 2014-05-08 | Novozymes Biopharma Dk A/S | Albumin variants |
CN105007722A (zh) | 2013-02-16 | 2015-10-28 | 诺维信生物制药丹麦公司 | 药代动力学动物模型 |
TWI745671B (zh) | 2013-03-15 | 2021-11-11 | 美商百歐維拉提夫治療公司 | 因子ix多肽調配物 |
EP3044232A1 (en) * | 2013-09-13 | 2016-07-20 | Novozymes Biopharma DK A/S | Albumin variants |
JP6306700B2 (ja) | 2013-11-01 | 2018-04-04 | ユニバーシティ オブ オスロUniversity of Oslo | アルブミン改変体及びその使用 |
JP6672175B2 (ja) * | 2014-05-07 | 2020-03-25 | ノヴォ ノルディスク アー/エス | Glp−1及び抗il−21を使用した1型糖尿病の治療 |
TW201609812A (zh) | 2014-07-31 | 2016-03-16 | 安美基研究(慕尼黑)公司 | 最佳化之跨物種特異性雙特異性單鏈抗體構築體 |
TW202311292A (zh) | 2015-04-17 | 2023-03-16 | 德商安美基研究(慕尼黑)公司 | Cdh3與cd3之雙特異性抗體構築體 |
JP2018517708A (ja) | 2015-06-05 | 2018-07-05 | ニューヨーク・ユニバーシティ | 抗ブドウ球菌生物学的薬剤のための組成物及び方法 |
TW202346349A (zh) | 2015-07-31 | 2023-12-01 | 德商安美基研究(慕尼黑)公司 | Dll3及cd3抗體構築體 |
TWI829617B (zh) | 2015-07-31 | 2024-01-21 | 德商安美基研究(慕尼黑)公司 | Flt3及cd3抗體構築體 |
TWI744242B (zh) | 2015-07-31 | 2021-11-01 | 德商安美基研究(慕尼黑)公司 | Egfrviii及cd3抗體構築體 |
TWI717375B (zh) | 2015-07-31 | 2021-02-01 | 德商安美基研究(慕尼黑)公司 | Cd70及cd3抗體構築體 |
TWI796283B (zh) | 2015-07-31 | 2023-03-21 | 德商安美基研究(慕尼黑)公司 | Msln及cd3抗體構築體 |
MX2018001825A (es) * | 2015-08-20 | 2018-05-07 | Albumedix As | Variantes y conjugados de albumina. |
WO2017112847A1 (en) | 2015-12-22 | 2017-06-29 | Albumedix A/S | Improved protein expression strains |
MA43571A (fr) | 2015-12-23 | 2018-11-14 | Biogen Ma Inc | Protéines contenant un domaine riche en cystéine 2 dkk2 et leurs utilisations |
WO2017117631A1 (en) | 2016-01-07 | 2017-07-13 | Csl Limited | Mutated truncated von willebrand factor |
EA039859B1 (ru) | 2016-02-03 | 2022-03-21 | Эмджен Рисерч (Мюник) Гмбх | Биспецифические конструкты антител, связывающие egfrviii и cd3 |
US11110122B2 (en) | 2016-06-03 | 2021-09-07 | New York University | Methods and reagents for modulating macrophage phenotype |
WO2018082758A1 (en) | 2016-11-04 | 2018-05-11 | Aarhus Universitet | Identification and treatment of tumors characterized by an overexpression of the neonatal fc receptor |
WO2018096396A1 (en) * | 2016-11-22 | 2018-05-31 | University Of Oslo | Albumin variants and uses thereof |
AU2017366674A1 (en) | 2016-12-02 | 2019-06-20 | The Texas A&M University System | Fusion proteins for selectively depleting antigen-specific antibodies |
BR112019012538A2 (pt) | 2016-12-21 | 2019-11-12 | Prometic Pharma Smt Ltd | métodos e composições para prevenir ou minimizar a transição epitelial-mesenquimal |
CN111032871A (zh) | 2017-06-20 | 2020-04-17 | 阿尔布梅迪克斯医疗有限公司 | 改良的表达蛋白质的菌株 |
DK3641800T3 (da) | 2017-06-22 | 2024-01-02 | CSL Behring Lengnau AG | Modulation af fviii immunogenicitet ved trunkeret vwf |
JP7079171B2 (ja) | 2017-08-03 | 2022-06-01 | アムジエン・インコーポレーテツド | インターロイキン-21ムテイン及び治療方法 |
CA3075046A1 (en) | 2017-09-08 | 2019-03-14 | Amgen Inc. | Inhibitors of kras g12c and methods of using the same |
CN109553684A (zh) * | 2017-09-25 | 2019-04-02 | 中国科学院过程工程研究所 | 一种纳米载体蛋白及其制备方法和应用 |
EP3697812A4 (en) * | 2017-10-18 | 2021-09-22 | CSL Limited | HUMAN SERIAL ALBUMIN VARIANTS AND THEIR USES |
JOP20200172A1 (ar) | 2018-01-12 | 2020-07-12 | Amgen Inc | الأجسام المضادة لـ pd-1 وطرق العلاج |
AR114541A1 (es) | 2018-08-03 | 2020-09-16 | Amgen Res Munich Gmbh | Constructos de anticuerpos para cldn18.2 y cd3 |
US20210187100A1 (en) | 2018-09-06 | 2021-06-24 | Bavarian Nordic A/S | Storage Improved Poxvirus Compositions |
CA3117409A1 (en) | 2018-10-29 | 2020-05-07 | Biogen Ma Inc. | Humanized and stabilized fc5 variants for enhancement of blood brain barrier transport |
PE20220401A1 (es) | 2019-09-06 | 2022-03-22 | Novartis Ag | Proteinas de fusion terapeuticas |
EP3819007A1 (en) | 2019-11-11 | 2021-05-12 | Amgen Research (Munich) GmbH | Dosing regimen for anti-bcma agents |
US20230000774A1 (en) | 2019-12-04 | 2023-01-05 | Albumedix Limited | Methods and compositions produced thereby |
EP4093771A1 (en) | 2020-01-22 | 2022-11-30 | Amgen Research (Munich) GmbH | Combinations of antibody constructs and inhibitors of cytokine release syndrome and uses thereof |
EP4117722A1 (en) | 2020-03-12 | 2023-01-18 | Bavarian Nordic A/S | Compositions improving poxvirus stability |
WO2021183861A1 (en) | 2020-03-12 | 2021-09-16 | Amgen Inc. | Method for treatment and prophylaxis of crs in patients comprising a combination of bispecifc antibodies binding to cds x cancer cell and tnfalpha or il-6 inhibitor |
AU2021275049A1 (en) | 2020-05-19 | 2022-12-22 | Amgen Inc. | MAGEB2 binding constructs |
AU2021374036A1 (en) | 2020-11-06 | 2023-06-08 | Amgen Inc. | Polypeptide constructs selectively binding to cldn6 and cd3 |
CA3199931A1 (en) | 2020-11-06 | 2022-05-12 | Amgen Inc. | Polypeptide constructs binding to cd3 |
TW202233678A (zh) | 2020-11-06 | 2022-09-01 | 德商安美基研究(慕尼黑)公司 | 具有增強的剪切特徵的多肽 |
WO2022103781A1 (en) | 2020-11-10 | 2022-05-19 | Amgen Inc. | Methods for administering a bcma x cd3 binding molecule |
WO2024025958A1 (en) * | 2022-07-27 | 2024-02-01 | Terraferma Foods, Inc. | Compositions and methods for producing protein |
WO2024089258A1 (en) | 2022-10-28 | 2024-05-02 | Aarhus Universitet | Albumin conjugated to cpg oligodeoxynucleotides as super-boosters of immune response |
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AU613030B2 (en) | 1987-04-09 | 1991-07-25 | Novozymes Delta Limited | Yeast vector |
US5223409A (en) | 1988-09-02 | 1993-06-29 | Protein Engineering Corp. | Directed evolution of novel binding proteins |
IL99552A0 (en) | 1990-09-28 | 1992-08-18 | Ixsys Inc | Compositions containing procaryotic cells,a kit for the preparation of vectors useful for the coexpression of two or more dna sequences and methods for the use thereof |
CA2058820C (en) | 1991-04-25 | 2003-07-15 | Kotikanyad Sreekrishna | Expression cassettes and vectors for the secretion of human serum albumin in pichia pastoris cells |
DE4343591A1 (de) | 1993-12-21 | 1995-06-22 | Evotec Biosystems Gmbh | Verfahren zum evolutiven Design und Synthese funktionaler Polymere auf der Basis von Formenelementen und Formencodes |
US5605793A (en) | 1994-02-17 | 1997-02-25 | Affymax Technologies N.V. | Methods for in vitro recombination |
GB9404270D0 (en) | 1994-03-05 | 1994-04-20 | Delta Biotechnology Ltd | Yeast strains and modified albumins |
GB9526733D0 (en) * | 1995-12-30 | 1996-02-28 | Delta Biotechnology Ltd | Fusion proteins |
US6274305B1 (en) * | 1996-12-19 | 2001-08-14 | Tufts University | Inhibiting proliferation of cancer cells |
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WO2002016411A2 (en) * | 2000-08-18 | 2002-02-28 | Human Genome Sciences, Inc. | Binding polypeptides and methods based thereon |
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ATE375388T1 (de) | 2001-07-27 | 2007-10-15 | Us Gov Health & Human Serv | Systeme zur stellengerichteten in-vivo-mutagenese mit oligonukleotiden |
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ES2500918T3 (es) | 2001-12-21 | 2014-10-01 | Human Genome Sciences, Inc. | Proteínas de fusión de albúmina e interferón beta |
AU2003244516A1 (en) | 2002-02-07 | 2003-09-02 | Novozymes Delta Limited | Hiv inhibiting proteins |
GB0217347D0 (en) | 2002-07-26 | 2002-09-04 | Univ Edinburgh | Novel albumins |
CA2513213C (en) | 2003-01-22 | 2013-07-30 | Human Genome Sciences, Inc. | Albumin fusion proteins |
DE602004017290D1 (de) | 2003-02-17 | 2008-12-04 | Novozymes Biopharma Uk Ltd | Konjugate für medizinische abbildungen umfassend träger, targeting-anteile und kontrastmittel |
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US20060051859A1 (en) * | 2004-09-09 | 2006-03-09 | Yan Fu | Long acting human interferon analogs |
EP2169067A1 (en) | 2004-12-22 | 2010-03-31 | Novozymes A/S | Recombinant production of serum albumin |
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GB0607798D0 (en) * | 2006-04-20 | 2006-05-31 | Alligator Bioscience Ab | Novel polypeptides and use thereof |
AU2007274035A1 (en) | 2006-07-13 | 2008-01-17 | Novozymes Biopharma Dk A/S | Process for preparing particles of proteinaceous material |
CN104193815A (zh) * | 2006-09-08 | 2014-12-10 | Ambrx公司 | 经修饰的人类血浆多肽或Fc骨架和其用途 |
EP2201036A1 (en) | 2007-08-08 | 2010-06-30 | Novozymes Biopharma DK A/S | Transferrin variants and conjugates |
AU2009234253C1 (en) * | 2008-04-11 | 2015-05-07 | Merrimack Pharmaceuticals, Inc. | Human serum albumin linkers and conjugates thereof |
JP5677972B2 (ja) | 2008-11-18 | 2015-02-25 | メリマック ファーマシューティカルズ インコーポレーティッド | ヒト血清アルブミンリンカーおよびそのコンジュゲート |
CN102307905B (zh) | 2008-12-10 | 2015-11-25 | 斯克利普斯研究院 | 利用化学反应性非天然氨基酸产生载体-肽偶联物 |
JP5936112B2 (ja) * | 2009-02-11 | 2016-06-15 | アルブミディクス アクティーゼルスカブ | アルブミン変異体及び複合体 |
CN102458442B (zh) | 2009-04-08 | 2016-06-29 | 加利福尼亚大学董事会 | 具有受控血清药代动力学的人蛋白支架 |
WO2010138814A2 (en) | 2009-05-29 | 2010-12-02 | The Brigham And Women's Hospital, Inc. | Disrupting fcrn-albumin interactions |
AR077764A1 (es) | 2009-07-20 | 2011-09-21 | Univ Nat Cheng Kung | Polipeptidos selectivos para integrina alfavbeta 3 conjugados a una variante de seroalbumina humana (hsa) y usos farmaceuticos de los mismos |
RU2607374C2 (ru) * | 2009-10-30 | 2017-01-10 | Новозаймс Байофарма Дк А/С | Варианты альбумина |
WO2011054148A1 (zh) | 2009-11-06 | 2011-05-12 | 华为技术有限公司 | 一种资源配置方法和装置 |
JP2013519392A (ja) | 2010-02-16 | 2013-05-30 | メディミューン,エルエルシー | Hsa関連組成物および使用方法 |
KR20130070576A (ko) | 2010-04-09 | 2013-06-27 | 노보자임스 바이오파마 디케이 에이/에스 | 알부민 유도체 및 변이체 |
US9238080B2 (en) | 2010-05-21 | 2016-01-19 | Merrimack Pharmaceuticals, Inc. | Bi-specific fusion proteins |
WO2011161127A1 (en) | 2010-06-21 | 2011-12-29 | Medimmune, Llc | Protease variants of human neprilysin |
EP2635598A1 (en) * | 2010-11-01 | 2013-09-11 | Novozymes Biopharma DK A/S | Albumin variants |
-
2012
- 2012-05-04 RU RU2013153816A patent/RU2650784C2/ru not_active IP Right Cessation
- 2012-05-04 BR BR112013028536A patent/BR112013028536A2/pt not_active Application Discontinuation
- 2012-05-04 CA CA2830660A patent/CA2830660A1/en not_active Abandoned
- 2012-05-04 KR KR1020137031062A patent/KR20140027307A/ko active IP Right Grant
- 2012-05-04 GB GB1207836.6A patent/GB2491006A/en not_active Withdrawn
- 2012-05-04 US US13/463,944 patent/US8822417B2/en active Active
- 2012-05-04 CN CN201811052791.7A patent/CN110272484A/zh active Pending
- 2012-05-04 JP JP2014508813A patent/JP6430828B2/ja active Active
- 2012-05-04 AU AU2012251583A patent/AU2012251583B2/en not_active Ceased
- 2012-05-04 MX MX2013012358A patent/MX353816B/es active IP Right Grant
- 2012-05-04 CN CN201280033529.2A patent/CN104011072B/zh not_active Expired - Fee Related
- 2012-05-04 WO PCT/EP2012/058206 patent/WO2012150319A1/en active Application Filing
- 2012-05-04 EP EP12718995.9A patent/EP2705051A1/en not_active Withdrawn
-
2013
- 2013-10-06 IL IL228737A patent/IL228737B/en active IP Right Grant
- 2013-11-04 ZA ZA2013/08255A patent/ZA201308255B/en unknown
-
2014
- 2014-07-02 US US14/322,547 patent/US20140315816A1/en not_active Abandoned
-
2017
- 2017-09-05 AU AU2017225014A patent/AU2017225014A1/en not_active Abandoned
-
2019
- 2019-10-22 US US16/660,618 patent/US20200102368A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
KR20140027307A (ko) | 2014-03-06 |
US20120322739A1 (en) | 2012-12-20 |
RU2650784C2 (ru) | 2018-04-17 |
CN110272484A (zh) | 2019-09-24 |
GB201207836D0 (en) | 2012-06-20 |
US8822417B2 (en) | 2014-09-02 |
JP6430828B2 (ja) | 2018-11-28 |
GB2491006A (en) | 2012-11-21 |
US20200102368A1 (en) | 2020-04-02 |
WO2012150319A1 (en) | 2012-11-08 |
EP2705051A1 (en) | 2014-03-12 |
MX353816B (es) | 2018-01-30 |
JP2014515614A (ja) | 2014-07-03 |
US20140315816A1 (en) | 2014-10-23 |
RU2013153816A (ru) | 2015-06-10 |
CN104011072B (zh) | 2018-10-12 |
AU2017225014A1 (en) | 2017-09-28 |
CN104011072A (zh) | 2014-08-27 |
IL228737B (en) | 2019-03-31 |
CA2830660A1 (en) | 2012-11-08 |
IL228737A0 (en) | 2013-12-31 |
MX2013012358A (es) | 2014-04-25 |
AU2012251583B2 (en) | 2017-06-08 |
AU2012251583A1 (en) | 2013-10-10 |
ZA201308255B (en) | 2018-11-28 |
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