UY34017A - Proteínas de fusión y vacunas de combinación - Google Patents

Proteínas de fusión y vacunas de combinación

Info

Publication number
UY34017A
UY34017A UY0001034017A UY34017A UY34017A UY 34017 A UY34017 A UY 34017A UY 0001034017 A UY0001034017 A UY 0001034017A UY 34017 A UY34017 A UY 34017A UY 34017 A UY34017 A UY 34017A
Authority
UY
Uruguay
Prior art keywords
fusion proteins
combination vaccines
vaccines
combination
fusion
Prior art date
Application number
UY0001034017A
Other languages
English (en)
Inventor
Blais Normand
Labbe Steve
Poolman Jan
Original Assignee
Glaxosmithkline Biolog Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=47008755&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=UY34017(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Glaxosmithkline Biolog Sa filed Critical Glaxosmithkline Biolog Sa
Publication of UY34017A publication Critical patent/UY34017A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/285—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Pasteurellaceae (F), e.g. Haemophilus influenza
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0011—Cancer antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/102—Pasteurellales, e.g. Actinobacillus, Pasteurella; Haemophilus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/145—Orthomyxoviridae, e.g. influenza virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/385—Haptens or antigens, bound to carriers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70—Vectors or expression systems specially adapted for E. coli
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
    • A61K2039/541—Mucosal route
    • A61K2039/543—Mucosal route intranasal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55544—Bacterial toxins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55566—Emulsions, e.g. Freund's adjuvant, MF59
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
    • A61K2039/575—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2 humoral response
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/70—Multivalent vaccine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/20—Fusion polypeptide containing a tag with affinity for a non-protein ligand
    • C07K2319/21—Fusion polypeptide containing a tag with affinity for a non-protein ligand containing a His-tag
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/40—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/50—Fusion polypeptide containing protease site
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Biophysics (AREA)
  • Communicable Diseases (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Virology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Pulmonology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

La presente invención se refiere a composiciones que comprenden Proteína E y Pilina A de Haemophilus influenzae. De una manera más particular, la presente solicitud se refiere a proteínas de fusión y a composiciones inmunogénicas que comprenden Proteína E y PilA, a vacunas que comprenden estas composiciones inmunogénicas, y a los usos terapéuticos de las mismas.
UY0001034017A 2011-04-13 2012-04-12 Proteínas de fusión y vacunas de combinación UY34017A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161474779P 2011-04-13 2011-04-13
US201161534012P 2011-09-13 2011-09-13

Publications (1)

Publication Number Publication Date
UY34017A true UY34017A (es) 2012-11-30

Family

ID=47008755

Family Applications (1)

Application Number Title Priority Date Filing Date
UY0001034017A UY34017A (es) 2011-04-13 2012-04-12 Proteínas de fusión y vacunas de combinación

Country Status (34)

Country Link
US (7) US8945577B2 (es)
EP (2) EP2707393B1 (es)
JP (1) JP6196963B2 (es)
KR (1) KR101999673B1 (es)
CN (3) CN103476799A (es)
AR (1) AR086078A1 (es)
AU (1) AU2012243412C1 (es)
BR (1) BR112013026175B1 (es)
CA (1) CA2830786C (es)
CL (1) CL2013002937A1 (es)
CO (1) CO6781540A2 (es)
CR (1) CR20130529A (es)
CY (2) CY1120319T1 (es)
DK (2) DK3321287T3 (es)
DO (1) DOP2013000235A (es)
EA (1) EA031580B1 (es)
ES (2) ES2658512T3 (es)
HR (2) HRP20180216T1 (es)
HU (2) HUE036983T2 (es)
IL (2) IL271862B (es)
LT (2) LT3321287T (es)
MA (1) MA35110B1 (es)
ME (1) ME02995B (es)
MX (1) MX350013B (es)
PE (1) PE20140986A1 (es)
PL (2) PL2707393T3 (es)
PT (2) PT3321287T (es)
RS (1) RS56903B1 (es)
SG (2) SG193906A1 (es)
SI (2) SI2707393T1 (es)
TW (1) TW201302779A (es)
UY (1) UY34017A (es)
WO (1) WO2012139225A1 (es)
ZA (1) ZA201307118B (es)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW201302779A (zh) 2011-04-13 2013-01-16 Glaxosmithkline Biolog Sa 融合蛋白質及組合疫苗
GB201218660D0 (en) 2012-10-17 2012-11-28 Glaxosmithkline Biolog Sa Immunogenic composition
EP2908854A2 (en) * 2012-10-17 2015-08-26 GlaxoSmithKline Biologicals S.A. Immunogenic composition
CN107072239A (zh) 2013-09-30 2017-08-18 岛修道院食品有限公司 可咀嚼产品和用于制备其的方法
TW201620927A (zh) 2014-02-24 2016-06-16 葛蘭素史密斯克藍生物品公司 Ｕｓｐａ２蛋白質構築體及其用途
US10648966B2 (en) * 2015-01-16 2020-05-12 University Of Kentucky Research Foundation Lipid bilayer-integrated SPP1 connector protein nanopore and SPP1 connector protein variants for use as lipid bilayer-integrated nanopore
CN105175549B (zh) * 2015-09-30 2019-08-16 康希诺生物股份公司 一种流感嗜血杆菌融合蛋白及其构建方法与应用
GB201621686D0 (en) 2016-12-20 2017-02-01 Glaxosmithkline Biologicals Sa Novel methods for inducing an immune response
WO2018178265A1 (en) 2017-03-31 2018-10-04 Glaxosmithkline Intellectual Property Development Limited Immunogenic composition, use and method of treatment
BR112019020209A2 (pt) * 2017-03-31 2020-06-02 Glaxosmithkline Intellectual Property Development Limited Composição imunogênica, uso de uma composição imunogênica, método de tratamento ou prevenção de uma recorrência de uma exacerbação aguda de doença pulmonar obstrutiva crônica, e, terapia de combinação.
JP7291633B2 (ja) 2017-05-30 2023-06-15 グラクソスミスクライン バイオロジカルズ ソシエテ アノニム アジュバントを製造する方法
BR112020001768A2 (pt) 2017-08-14 2020-09-29 Glaxosmithkline Biologicals S.A. método de reforçar uma resposta imune pré-existente contra haemophilus influenzae e moraxella catarrhalis não tipáveis em um indivíduo, e, protocolo de vacinação.
CN107602697B (zh) * 2017-08-29 2020-05-05 杭州医学院 一种治疗流感嗜血杆菌引起鼻窦炎的血清及该血清的应用
CA3083078A1 (en) 2017-12-01 2019-06-06 Glaxosmithkline Biologicals Sa Saponin purification
CN112703006A (zh) * 2018-06-19 2021-04-23 葛兰素史密丝克莱恩生物有限公司 免疫原性组合物
MX2021001479A (es) 2018-08-07 2021-04-28 Glaxosmithkline Biologicals Sa Novedosos procesos y vacunas.
US20220339282A1 (en) 2018-11-29 2022-10-27 Glaxosmithkline Biologicals Sa Methods for manufacturing an adjuvant
CN110540597B (zh) * 2018-12-20 2021-04-30 湖北工业大学 基于流感嗜血杆菌表面蛋白的乳胶微球免疫层析试纸的制备方法
CN110540598B (zh) * 2018-12-20 2021-04-30 湖北工业大学 基于流感嗜血杆菌表面蛋白抗体的流感嗜血杆菌Elisa检测试剂盒及制备方法
US20220143168A1 (en) 2019-02-27 2022-05-12 Evaxion Biotech A/S Vaccines targeting H. influenzae
US20220221455A1 (en) 2019-04-18 2022-07-14 Glaxosmithkline Biologicals Sa Antigen binding proteins and assays
US20220235095A1 (en) 2019-06-05 2022-07-28 Glaxosmithkline Biologicals Sa Saponin purification
CA3148928A1 (en) * 2019-08-05 2021-02-11 Glaxosmithkline Biologicals Sa Process for preparing a composition comprising a protein d polypeptide
WO2021023691A1 (en) 2019-08-05 2021-02-11 Glaxosmithkline Biologicals Sa Immunogenic composition
JP2024510717A (ja) 2021-02-22 2024-03-11 グラクソスミスクライン バイオロジカルズ ソシエテ アノニム 免疫原性組成物、使用及び方法
KR20220142219A (ko) * 2021-04-14 2022-10-21 한국생명공학연구원 장내 미생물에서 단백질 분비를 유도하는 신호서열
WO2024017827A1 (en) 2022-07-19 2024-01-25 Glaxosmithkline Biologicals Sa Continuous process for vaccine production

Family Cites Families (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE454403B (sv) 1984-05-30 1988-05-02 Alfa Laval Agri Int Anvendning av ett cellyteprotein med fibronektin-, fibrinogen-, kollagen-, och/eller lamininbindande egenskaper vid framstellning av sarbehandlingsmedel
US4912094B1 (en) 1988-06-29 1994-02-15 Ribi Immunochem Research Inc. Modified lipopolysaccharides and process of preparation
KR100188323B1 (ko) 1989-03-09 1999-06-01 이곤 이이 버어그 비타입성 헤모필루스 인플렌자에 대한 백신
SE466259B (sv) 1990-05-31 1992-01-20 Arne Forsgren Protein d - ett igd-bindande protein fraan haemophilus influenzae, samt anvaendning av detta foer analys, vacciner och uppreningsaendamaal
ES2143716T3 (es) 1992-06-25 2000-05-16 Smithkline Beecham Biolog Composicion de vacuna que contiene adyuvantes.
SG48309A1 (en) 1993-03-23 1998-04-17 Smithkline Beecham Biolog Vaccine compositions containing 3-0 deacylated monophosphoryl lipid a
GB9326253D0 (en) 1993-12-23 1994-02-23 Smithkline Beecham Biolog Vaccines
EP1167377B2 (en) 1994-07-15 2012-08-08 University of Iowa Research Foundation Immunomodulatory oligonucleotides
UA56132C2 (uk) 1995-04-25 2003-05-15 Смітклайн Бічем Байолоджікалс С.А. Композиція вакцини (варіанти), спосіб стабілізації qs21 відносно гідролізу (варіанти), спосіб приготування композиції вакцини
US6440425B1 (en) 1995-05-01 2002-08-27 Aventis Pasteur Limited High molecular weight major outer membrane protein of moraxella
SK176197A3 (en) 1995-06-23 1998-07-08 Smithkline Beecham Biolog A vaccine composition comprising a polysaccharide conjugate antigen adsorbed onto aluminium phosphate
EP0948625B1 (en) 1996-12-20 2011-01-26 The Board Of Regents, The University Of Texas System Uspa1 and uspa2 antigens of moraxella catarrhalis
ES2298269T3 (es) 2000-09-26 2008-05-16 Idera Pharmaceuticals, Inc. Modulacion de la actividad inmunoestimulante de analogos oligonucleotidicos inmunoestimulantes mediante cambios quimicos posicionales.
DK2270171T5 (da) 2000-10-02 2013-11-18 Id Biomedical Corp Quebec Haemophilus influenzae-antigener og tilsvarende DNA-fragmenter
US6942802B2 (en) 2001-04-13 2005-09-13 Wyeth Holdings Corporation Removal of bacterial endotoxin in a protein solution by immobilized metal affinity chromatography
WO2003035836A2 (en) 2001-10-24 2003-05-01 Hybridon Inc. Modulation of immunostimulatory properties of oligonucleotide-based compounds by optimal presentation of 5' ends
GB0222764D0 (en) 2002-10-02 2002-11-06 Univ Bristol Therapeutic peptide
CN1894581B (zh) 2003-07-09 2012-02-01 生命技术公司 检测蛋白-蛋白相互作用的方法
GB0410866D0 (en) 2004-05-14 2004-06-16 Chiron Srl Haemophilius influenzae
WO2006119983A2 (en) * 2005-05-12 2006-11-16 Novartis Ag Genes and proteins of brachyspira hyodysenteriae and use of same for diagnosis and therapy
JP5042218B2 (ja) * 2005-07-08 2012-10-03 ユニバーシティ・オブ・チューリッヒ 融合ポリペプチドの翻訳と同時のトランスロケーションを使用するファージディスプレイ
WO2007008527A2 (en) 2005-07-08 2007-01-18 Children's Hospital Inc. Chimeric vaccine for haemophilus influenzae-induced disease
AU2006277076B2 (en) 2005-08-10 2012-03-29 Arne Forsgren Ab Interaction of Moraxella catarrhalis with epithelial cells, extracellular matrix proteins and the complement system
ZA200805602B (en) * 2006-01-17 2009-12-30 Arne Forsgren A novel surface exposed haemophilus influenzae protein (protein E; pE)
GB2444903A (en) * 2006-12-21 2008-06-25 Secr Defence Live Francisella vaccine, inactivated at gene FTT1564
WO2009154025A1 (ja) 2008-06-20 2009-12-23 国立大学法人岡山大学 酸化LDL/β2GPI複合体に対する抗体及びその用途
TW201302779A (zh) 2011-04-13 2013-01-16 Glaxosmithkline Biolog Sa 融合蛋白質及組合疫苗

Also Published As

Publication number Publication date
LT2707393T (lt) 2018-03-12
NZ615328A (en) 2015-10-30
PL3321287T3 (pl) 2020-07-27
US20170029472A1 (en) 2017-02-02
ES2658512T3 (es) 2018-03-12
US20150175670A1 (en) 2015-06-25
MX2013011939A (es) 2014-03-27
EP3321287B1 (en) 2020-02-26
DK3321287T3 (da) 2020-05-04
PT2707393T (pt) 2018-02-09
ES2776369T3 (es) 2020-07-30
HUE036983T2 (hu) 2018-08-28
DOP2013000235A (es) 2014-03-16
EP3321287A1 (en) 2018-05-16
KR101999673B1 (ko) 2019-07-12
US10023616B2 (en) 2018-07-17
PL2707393T3 (pl) 2018-05-30
WO2012139225A1 (en) 2012-10-18
CN107383201A (zh) 2017-11-24
AU2012243412C1 (en) 2015-12-10
AR086078A1 (es) 2013-11-20
US20150166613A1 (en) 2015-06-18
PT3321287T (pt) 2020-05-22
AU2012243412B2 (en) 2015-05-14
ME02995B (me) 2018-10-20
CY1120319T1 (el) 2019-07-10
CO6781540A2 (es) 2013-10-31
SI3321287T1 (sl) 2020-07-31
HRP20180216T1 (hr) 2018-03-09
EA031580B1 (ru) 2019-01-31
MA35110B1 (fr) 2014-05-02
US20200331972A1 (en) 2020-10-22
HUE048848T2 (hu) 2020-08-28
IL228344A0 (en) 2013-12-31
SG193906A1 (en) 2013-11-29
EP2707393B1 (en) 2017-12-20
TW201302779A (zh) 2013-01-16
IL228344B (en) 2020-01-30
ZA201307118B (en) 2022-03-30
EP2707393A1 (en) 2014-03-19
AU2012243412A1 (en) 2013-04-18
CN107522788A (zh) 2017-12-29
CY1122824T1 (el) 2021-05-05
US20140056934A1 (en) 2014-02-27
RS56903B1 (sr) 2018-05-31
US10730917B2 (en) 2020-08-04
JP2014512365A (ja) 2014-05-22
JP6196963B2 (ja) 2017-09-13
US11198707B2 (en) 2021-12-14
MX350013B (es) 2017-08-23
US20180222946A1 (en) 2018-08-09
LT3321287T (lt) 2020-06-10
EA201391240A1 (ru) 2014-04-30
BR112013026175A2 (pt) 2016-11-29
SG10201602549WA (en) 2016-05-30
CL2013002937A1 (es) 2014-07-25
US9409957B2 (en) 2016-08-09
HRP20200466T1 (hr) 2020-06-26
CA2830786A1 (en) 2012-10-18
US8945577B2 (en) 2015-02-03
CR20130529A (es) 2014-03-05
IL271862B (en) 2022-07-01
US10214569B2 (en) 2019-02-26
IL271862A (en) 2020-02-27
BR112013026175B1 (pt) 2020-05-12
KR20140026483A (ko) 2014-03-05
SI2707393T1 (en) 2018-03-30
US20160250313A1 (en) 2016-09-01
PE20140986A1 (es) 2014-08-20
CA2830786C (en) 2021-10-26
US9296794B2 (en) 2016-03-29
CN103476799A (zh) 2013-12-25
DK2707393T3 (da) 2018-01-29
EP2707393A4 (en) 2014-11-05

Similar Documents

Publication Publication Date Title
UY34017A (es) Proteínas de fusión y vacunas de combinación
HK1251589A1 (zh) 靶向/免疫調節性融合蛋白及其製造方法
HK1208827A1 (en) Interleukin-2 fusion proteins and uses thereof -2
CO7020851A2 (es) Proteínas y péptidos modificados
EP2778507A4 (en) WHITE LIGHT SOURCE AND WHITE LIGHT SOURCE SYSTEM THEREWITH
EP2902844A4 (en) LIGHT SOURCE SYSTEM AND RELATED PROJECTION SYSTEM
EP2701213A4 (en) WHITE LIGHT SOURCE AND SYSTEM USING SAME
BR112015003838A2 (pt) formulações de anticorpo e proteína
EP2674662A4 (en) WHITE LIGHT SOURCE AND WHITE LIGHT SOURCE SYSTEM THEREWITH
CO7020859A2 (es) Anticuerpos anti-cd134 (ox40) y usos de los mismos
CO6980627A2 (es) Anticuerpos anti-pfh-tau y sus usos
DK2890402T3 (da) Modificerede aminosyrer omfattende en azidogruppe
EP2772952A4 (en) WHITE LIGHT SOURCE AND WHITE LIGHT SOURCE SYSTEM THEREWITH
DK2844286T3 (da) Lyofiliserede og vandige anti-CD40-antistofformuleringer
EP2877854A4 (en) FUSION PROTEINS AND METHOD THEREFOR
EP2793079A4 (en) LIGHT SOURCE SYSTEM AND PROJECTION DEVICE
BR112014012137A2 (pt) anticorpos anti-fgfr2 e suas utilizações
EP2767859A4 (en) LIGHT SOURCE SYSTEM AND LASER LIGHT SOURCE
EP2793078A4 (en) LIGHT SOURCE SYSTEM AND PROJECTION DEVICE
CO6870003A2 (es) Vacunas bovinas y métodos
EP2772953A4 (en) WHITE LIGHT SOURCE AND WHITE LIGHT SOURCE SYSTEM USING A WHITE LIGHT SOURCE
CO6940376A2 (es) Anticuerpos anti-psgl-1 y usos de los mismos
CO7020877A2 (es) Anticuerpos anti-asic1 y usos de los mismos
EP2770372A4 (en) LIGHT SOURCE SYSTEM AND PROJECTION SYSTEM COMPRISING SAME
DK3173102T3 (da) FGFR-FC-fusionsprotein og anvendelse deraf

Legal Events

Date Code Title Description
109 Application deemed to be withdrawn

Effective date: 20201019