BR112013028006A2 - método para aumentar a produtividade de células eucarióticas na produção do recombinante fviii - Google Patents
método para aumentar a produtividade de células eucarióticas na produção do recombinante fviiiInfo
- Publication number
- BR112013028006A2 BR112013028006A2 BR112013028006A BR112013028006A BR112013028006A2 BR 112013028006 A2 BR112013028006 A2 BR 112013028006A2 BR 112013028006 A BR112013028006 A BR 112013028006A BR 112013028006 A BR112013028006 A BR 112013028006A BR 112013028006 A2 BR112013028006 A2 BR 112013028006A2
- Authority
- BR
- Brazil
- Prior art keywords
- eukaryotic cell
- cell suspension
- productivity
- increasing
- production
- Prior art date
Links
- 210000003527 eukaryotic cell Anatomy 0.000 title abstract 5
- 238000000034 method Methods 0.000 title abstract 3
- 239000006285 cell suspension Substances 0.000 abstract 4
- 210000004027 cell Anatomy 0.000 abstract 2
- 238000012258 culturing Methods 0.000 abstract 1
- 239000003599 detergent Substances 0.000 abstract 1
- 229960000301 factor viii Drugs 0.000 abstract 1
- 239000001963 growth medium Substances 0.000 abstract 1
- 230000001939 inductive effect Effects 0.000 abstract 1
- 235000015097 nutrients Nutrition 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/005—Glycopeptides, glycoproteins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/745—Blood coagulation or fibrinolysis factors
- C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M1/00—Apparatus for enzymology or microbiology
- C12M1/42—Apparatus for the treatment of microorganisms or enzymes with electrical or wave energy, e.g. magnetism, sonic waves
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N13/00—Treatment of microorganisms or enzymes with electrical or wave energy, e.g. magnetism, sonic waves
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/0018—Culture media for cell or tissue culture
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0684—Cells of the urinary tract or kidneys
- C12N5/0686—Kidney cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2510/00—Genetically modified cells
- C12N2510/02—Cells for production
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2511/00—Cells for large scale production
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2521/00—Culture process characterised by the use of hydrostatic pressure, flow or shear forces
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2527/00—Culture process characterised by the use of mechanical forces, e.g. strain, vibration
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Biomedical Technology (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- General Engineering & Computer Science (AREA)
- Cell Biology (AREA)
- Urology & Nephrology (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- Hematology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Sustainable Development (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Peptides Or Proteins (AREA)
- Enzymes And Modification Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP11166071 | 2011-05-13 | ||
| US201161489406P | 2011-05-24 | 2011-05-24 | |
| PCT/EP2012/058899 WO2012156356A1 (en) | 2011-05-13 | 2012-05-14 | A method of increasing the productivity of eucaryotic cells in the production of recombinant fviii |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR112013028006A2 true BR112013028006A2 (pt) | 2016-09-06 |
Family
ID=45470754
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112013028006A BR112013028006A2 (pt) | 2011-05-13 | 2012-05-14 | método para aumentar a produtividade de células eucarióticas na produção do recombinante fviii |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US9115381B2 (enExample) |
| EP (3) | EP3626737B1 (enExample) |
| JP (1) | JP6178786B2 (enExample) |
| KR (1) | KR101980164B1 (enExample) |
| CN (1) | CN103517919B (enExample) |
| AU (1) | AU2012257736B2 (enExample) |
| BR (1) | BR112013028006A2 (enExample) |
| CA (1) | CA2835053C (enExample) |
| DK (1) | DK3626737T3 (enExample) |
| ES (1) | ES2970057T3 (enExample) |
| IL (1) | IL229058A (enExample) |
| RU (1) | RU2600886C2 (enExample) |
| WO (1) | WO2012156356A1 (enExample) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6591609B2 (en) | 1997-07-15 | 2003-07-15 | New Power Concepts Llc | Regenerator for a Stirling Engine |
| ES2909630T3 (es) | 2014-06-04 | 2022-05-09 | Amgen Inc | Métodos de recolección en cultivos de células de mamífero |
| CN107287265B (zh) * | 2016-03-31 | 2018-09-14 | 正大天晴药业集团南京顺欣制药有限公司 | 一种制备重组人凝血因子ⅷ的方法 |
| CN112469821B (zh) * | 2018-07-26 | 2021-12-14 | 正大天晴药业集团股份有限公司 | 一种制备重组人凝血因子ⅷ的方法 |
| WO2023242238A1 (en) * | 2022-06-15 | 2023-12-21 | UCB Biopharma SRL | Cell culture processes |
| CN120005720B (zh) * | 2025-04-21 | 2025-08-08 | 深圳市茵冠生物科技有限公司 | 一种人工智能的细胞培养监测方法及系统 |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5804420A (en) | 1997-04-18 | 1998-09-08 | Bayer Corporation | Preparation of recombinant Factor VIII in a protein free medium |
| US6358703B1 (en) * | 1998-12-10 | 2002-03-19 | Bayer Corporation | Expression system for factor VIII |
| NZ516400A (en) * | 1999-07-13 | 2004-02-27 | Biovitrum Ab | Stable factor VIII compositions |
| EP1460131A3 (en) | 2000-03-22 | 2005-06-01 | Octagene GmbH | Production of recombinant blood clotting factors in human cell lines |
| CN104593277A (zh) * | 2004-03-05 | 2015-05-06 | 帝斯曼知识产权资产管理有限公司 | 用于通过连续灌注和交互切向流来培养细胞的方法 |
| JP2006296423A (ja) * | 2005-03-24 | 2006-11-02 | Hitachi Ltd | 培養槽の制御装置及び培養装置 |
| EP1707634A1 (en) * | 2005-03-29 | 2006-10-04 | Octapharma AG | Method for isolation of recombinantly produced proteins |
| JP2008534559A (ja) * | 2005-04-01 | 2008-08-28 | ノボ ノルディスク ヘルス ケア アクチェンゲゼルシャフト | 血液凝固ｆｖｉｉｉ類似体 |
| EP1739179A1 (en) | 2005-06-30 | 2007-01-03 | Octapharma AG | Serum-free stable transfection and production of recombinant human proteins in human cell lines |
| PT2634243T (pt) | 2006-07-14 | 2017-12-18 | Patheon Holdings I B V | Método para melhorar a cultura de células |
| CN101490239A (zh) * | 2006-07-14 | 2009-07-22 | 帝斯曼知识产权资产管理有限公司 | 改进的细胞培养方法 |
| WO2009090787A1 (ja) * | 2008-01-15 | 2009-07-23 | Toray Industries, Inc. | 生理活性ペプチドまたはタンパク質製造方法、および組換え動物細胞 |
| SI2300497T1 (sl) * | 2008-06-24 | 2013-02-28 | Octapharma Ag | Postopek za äťiĺˇäťenje koagulacijskega faktorja viii |
| AU2009284113B2 (en) | 2008-08-21 | 2015-05-14 | Octapharma Ag | Recombinantly produced human factor VIII and IX |
| DE102008049120A1 (de) | 2008-09-26 | 2010-04-01 | Bayer Technology Services Gmbh | Verfahren zur Reduzierung von Ablagerungen bei der Kultivierung von Organismen |
| EP2216395A1 (en) | 2009-02-09 | 2010-08-11 | Lonza Biologics plc. | Bioreactor for the cultivation of mammalian cells |
| US8580554B2 (en) | 2009-07-31 | 2013-11-12 | Baxter International Inc. | Method of producing a polypeptide or virus of interest in a continuous cell culture |
-
2012
- 2012-05-14 KR KR1020137029808A patent/KR101980164B1/ko not_active Expired - Fee Related
- 2012-05-14 EP EP19209635.2A patent/EP3626737B1/en active Active
- 2012-05-14 US US14/113,923 patent/US9115381B2/en active Active
- 2012-05-14 AU AU2012257736A patent/AU2012257736B2/en active Active
- 2012-05-14 CN CN201280021390.XA patent/CN103517919B/zh active Active
- 2012-05-14 WO PCT/EP2012/058899 patent/WO2012156356A1/en not_active Ceased
- 2012-05-14 ES ES19209635T patent/ES2970057T3/es active Active
- 2012-05-14 DK DK19209635.2T patent/DK3626737T3/da active
- 2012-05-14 EP EP12721821.2A patent/EP2707387B1/en not_active Revoked
- 2012-05-14 RU RU2013155382/10A patent/RU2600886C2/ru active
- 2012-05-14 JP JP2014510762A patent/JP6178786B2/ja active Active
- 2012-05-14 BR BR112013028006A patent/BR112013028006A2/pt not_active Application Discontinuation
- 2012-05-14 CA CA2835053A patent/CA2835053C/en not_active Expired - Fee Related
- 2012-05-14 EP EP23211876.0A patent/EP4353743A3/en not_active Withdrawn
-
2013
- 2013-10-24 IL IL229058A patent/IL229058A/en active IP Right Grant
Also Published As
| Publication number | Publication date |
|---|---|
| CN103517919A (zh) | 2014-01-15 |
| US20140051123A1 (en) | 2014-02-20 |
| US9115381B2 (en) | 2015-08-25 |
| AU2012257736B2 (en) | 2015-12-10 |
| RU2600886C2 (ru) | 2016-10-27 |
| EP3626737B1 (en) | 2023-11-29 |
| KR20140021009A (ko) | 2014-02-19 |
| EP4353743A2 (en) | 2024-04-17 |
| ES2970057T3 (es) | 2024-05-24 |
| IL229058A (en) | 2017-03-30 |
| EP4353743A3 (en) | 2024-07-17 |
| WO2012156356A1 (en) | 2012-11-22 |
| CN103517919B (zh) | 2016-11-16 |
| KR101980164B1 (ko) | 2019-05-20 |
| JP2014513545A (ja) | 2014-06-05 |
| JP6178786B2 (ja) | 2017-08-09 |
| IL229058A0 (en) | 2013-12-31 |
| EP2707387B1 (en) | 2019-12-25 |
| RU2013155382A (ru) | 2015-06-20 |
| DK3626737T3 (da) | 2024-02-05 |
| EP3626737A1 (en) | 2020-03-25 |
| EP2707387A1 (en) | 2014-03-19 |
| CA2835053C (en) | 2020-07-07 |
| CA2835053A1 (en) | 2012-11-22 |
| AU2012257736A1 (en) | 2013-10-10 |
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Legal Events
| Date | Code | Title | Description |
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| B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] |
Free format text: DE ACORDO COM O ARTIGO 229-C DA LEI NAO 10196/2001, QUE MODIFICOU A LEI NAO 9279/96, A CONCESSAO DA PATENTE ESTA CONDICIONADA A ANUAANCIA PRA VIA DA ANVISA. CONSIDERANDO A APROVAA AO DOS TERMOS DO PARECER NAO 337/PGF/EA/2010, BEM COMO A PORTARIA INTERMINISTERIAL NAO 1065 DE 24/05/2012, ENCAMINHA-SE O PRESENTE PEDIDO PARA AS PROVIDAANCIAS CABA-VEIS. |
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| B07G | Grant request does not fulfill article 229-c lpi (prior consent of anvisa) [chapter 7.7 patent gazette] |
Free format text: NOTIFICACAO DE DEVOLUCAO DO PEDIDO EM FUNCAO DA REVOGACAO DO ART. 229-C DA LEI NO 9.279, DE 1996, POR FORCA DA LEI NO 14.195, DE 2021 |
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| B06U | Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette] | ||
| B11B | Dismissal acc. art. 36, par 1 of ipl - no reply within 90 days to fullfil the necessary requirements | ||
| B15V | Prolongation of time limit allowed |