BR112013020500A2 - anticorpo isolado, recombinante ou purificado - Google Patents
anticorpo isolado, recombinante ou purificadoInfo
- Publication number
- BR112013020500A2 BR112013020500A2 BR112013020500A BR112013020500A BR112013020500A2 BR 112013020500 A2 BR112013020500 A2 BR 112013020500A2 BR 112013020500 A BR112013020500 A BR 112013020500A BR 112013020500 A BR112013020500 A BR 112013020500A BR 112013020500 A2 BR112013020500 A2 BR 112013020500A2
- Authority
- BR
- Brazil
- Prior art keywords
- recombinant
- isolated
- purified antibody
- antibody
- compositions
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/51—Complete heavy chain or Fd fragment, i.e. VH + CH1
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/515—Complete light chain, i.e. VL + CL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/62—DNA sequences coding for fusion proteins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/15011—Lentivirus, not HIV, e.g. FIV, SIV
- C12N2740/15041—Use of virus, viral particle or viral elements as a vector
- C12N2740/15043—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
Abstract
anticorpo isolado, recombinante ou purificado a presente invenção fornece anticorpos específicos para o cfs-1r, composições que compreendem o dito anticorpo e métodos de tratamento que usam tais composições.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US13/026,944 US8470977B2 (en) | 2008-03-14 | 2011-02-14 | Antibody against the CSF-1R |
PCT/EP2012/052043 WO2012110360A1 (en) | 2011-02-14 | 2012-02-07 | Antibody against the csf-1r |
Publications (2)
Publication Number | Publication Date |
---|---|
BR112013020500A2 true BR112013020500A2 (pt) | 2016-10-18 |
BR112013020500A8 BR112013020500A8 (pt) | 2018-01-09 |
Family
ID=45808764
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112013020500A BR112013020500A8 (pt) | 2011-02-14 | 2012-02-07 | anticorpo isolado, recombinante ou purificado |
Country Status (18)
Country | Link |
---|---|
US (3) | US8470977B2 (pt) |
EP (1) | EP2675826B1 (pt) |
JP (1) | JP5996558B2 (pt) |
KR (1) | KR101920946B1 (pt) |
CN (2) | CN104140467B (pt) |
AU (1) | AU2012217303B2 (pt) |
BR (1) | BR112013020500A8 (pt) |
CA (1) | CA2825243A1 (pt) |
DK (1) | DK2675826T3 (pt) |
ES (1) | ES2654551T3 (pt) |
HK (1) | HK1203976A1 (pt) |
HU (1) | HUE035617T2 (pt) |
IL (1) | IL227078A (pt) |
MX (1) | MX347020B (pt) |
RU (1) | RU2621859C2 (pt) |
SG (1) | SG191899A1 (pt) |
WO (1) | WO2012110360A1 (pt) |
ZA (1) | ZA201306869B (pt) |
Families Citing this family (41)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2009224955B2 (en) | 2008-03-14 | 2012-08-09 | Transgene S.A. | Antibody against the CSF-1 R |
US8470977B2 (en) | 2008-03-14 | 2013-06-25 | Transgene S.A. | Antibody against the CSF-1R |
CN102791738B (zh) | 2009-12-10 | 2015-10-07 | 霍夫曼-拉罗奇有限公司 | 优先结合人csf1r胞外域4的抗体及其用途 |
US9169323B2 (en) | 2010-03-05 | 2015-10-27 | Hoffmann-La Roche Inc. | Antibodies against human CSF-1R |
CN102918061B (zh) | 2010-03-05 | 2016-06-08 | 霍夫曼-拉罗奇有限公司 | 针对人csf-1r的抗体及其用途 |
TWI595008B (zh) | 2010-05-04 | 2017-08-11 | 戊瑞治療有限公司 | 與集落刺激因子1受體(csf1r)結合之抗體類 |
ES2618828T3 (es) | 2011-07-18 | 2017-06-22 | The University Of Melbourne | Uso de antagonistas de c-Fms |
SG11201401639QA (en) | 2011-10-21 | 2014-05-29 | Transgene Sa | Modulation of macrophage activation |
EA201700111A1 (ru) | 2011-10-28 | 2018-02-28 | Тева Фармасьютикал Австралия Пти Лтд | Полипептидные конструкции и их применение |
KR20140113683A (ko) | 2011-12-15 | 2014-09-24 | 에프. 호프만-라 로슈 아게 | 인간 csf-1r에 대한 항체 및 이의 용도 |
US20130302322A1 (en) | 2012-05-11 | 2013-11-14 | Five Prime Therapeutics, Inc. | Methods of treating conditions with antibodies that bind colony stimulating factor 1 receptor (csf1r) |
SG11201501413YA (en) | 2012-08-31 | 2015-03-30 | Five Prime Therapeutics Inc | Methods of treating conditions with antibodies that bind colony stimulating factor 1 receptor (csf1r) |
US9676859B2 (en) | 2012-11-09 | 2017-06-13 | Transgene Sa | In vitro generation of dendritic cells by exposure to an anti-CSF1-R antibody |
WO2014167088A1 (en) | 2013-04-12 | 2014-10-16 | Morphosys Ag | Antibodies targeting m-csf |
US20140314741A1 (en) * | 2013-04-18 | 2014-10-23 | Developmen Center For Biotechnology | Human Antibody against Interleukin-20 and Treatment for Inflammatory Diseases |
AR095882A1 (es) | 2013-04-22 | 2015-11-18 | Hoffmann La Roche | Terapia de combinación de anticuerpos contra csf-1r humano con un agonista de tlr9 |
GB201315487D0 (en) | 2013-08-30 | 2013-10-16 | Ucb Pharma Sa | Antibodies |
GB201315486D0 (en) * | 2013-08-30 | 2013-10-16 | Ucb Pharma Sa | Antibodies |
AR097584A1 (es) | 2013-09-12 | 2016-03-23 | Hoffmann La Roche | Terapia de combinación de anticuerpos contra el csf-1r humano y anticuerpos contra el pd-l1 humano |
CN106795222A (zh) | 2014-06-23 | 2017-05-31 | 戊瑞治疗有限公司 | 用结合集落刺激因子1受体(csf1r)的抗体治疗病状的方法 |
DK3169341T3 (da) | 2014-07-16 | 2019-08-05 | Transgene Sa | Onkolytisk virus til ekspression af immun-checkpoint-modulatorer |
RU2705780C2 (ru) | 2014-07-16 | 2019-11-11 | Трансген Са | Комбинация онколитического вируса с модуляторами иммунологических контрольных точек |
ES2851390T3 (es) | 2014-10-29 | 2021-09-06 | Five Prime Therapeutics Inc | Terapia de combinación para el cáncer |
KR20170096187A (ko) | 2014-12-22 | 2017-08-23 | 파이브 프라임 테라퓨틱스, 인크. | Pvns를 치료하기 위한 항-csf1r 항체 |
RS61531B1 (sr) | 2015-04-13 | 2021-04-29 | Five Prime Therapeutics Inc | Kombinovana terapija za kancer |
WO2016175236A1 (ja) * | 2015-04-28 | 2016-11-03 | 田辺三菱製薬株式会社 | RGMa結合タンパク質及びその使用 |
EA039951B1 (ru) * | 2015-05-27 | 2022-03-31 | Юсб Биофарма Спрл | Ингибитор активности csf-1r, предназначенный для лечения или профилактики эпилепсии или болезни паркинсона, и фармацевтическая композиция на его основе |
EP3349794A4 (en) * | 2015-09-16 | 2019-07-31 | Ablexis, LLC | ANTI-CD115 ANTIBODIES |
US10844395B2 (en) | 2016-06-16 | 2020-11-24 | Farmhannong Co., Ltd. | Methods and compositions for conferring and/or enhancing herbicide tolerance using protoporphyrinogen oxidase or variant thereof |
MX2018016364A (es) | 2016-06-20 | 2019-11-28 | Kymab Ltd | Anticuerpos anti-pd-l1. |
EP3486254A4 (en) * | 2016-07-05 | 2019-12-18 | Ibentrus, Inc. | COMPOSITION FOR THE TREATMENT OF CANCER FOR INHIBITING TUMOR ANGIOGENESIS, CONTAINING A VEGF DEEP-BLOCKING AGENT, AND METHOD FOR PREPARING THE SAME |
JP7138094B2 (ja) | 2016-08-25 | 2022-09-15 | エフ・ホフマン-ラ・ロシュ・アクチェンゲゼルシャフト | マクロファージ活性化剤と組み合わせた抗csf-1r抗体の間欠投与 |
JP7304287B2 (ja) | 2016-12-22 | 2023-07-06 | エフ・ホフマン-ラ・ロシュ・アクチェンゲゼルシャフト | 抗pd-l1/pd1治療の不成功後の、抗pd-l1抗体との組み合わせでの抗csf-1r抗体を用いた腫瘍の治療 |
EP3522925A4 (en) * | 2017-01-10 | 2020-06-10 | National Yang-Ming University | METHOD FOR TREATING CANCER METASTASES AND COMPOSITION THEREOF |
JP2020535119A (ja) | 2017-09-13 | 2020-12-03 | ファイヴ プライム セラピューティクス インク | 膵臓がんの抗csf1rおよび抗pd−1抗体組合せ併用療法 |
CN109096397B (zh) * | 2018-07-18 | 2019-04-16 | 博奥信生物技术(南京)有限公司 | 一种抗人csf-1r单克隆抗体及应用 |
US20220064310A1 (en) * | 2018-12-13 | 2022-03-03 | Development Center For Biotechnology | Anti-human csf-1r antibody and uses thereof |
AU2020283742A1 (en) | 2019-05-24 | 2021-09-16 | Elixiron Immunotherapeutics (hong Kong) Limited | Anti-CSF1R antibodies, IL10 fusion proteins, and uses thereof |
WO2021058718A1 (en) | 2019-09-26 | 2021-04-01 | Roche Diagnostics Gmbh | Anti-csf-1r antibody |
RU2751249C1 (ru) * | 2020-10-28 | 2021-07-12 | Закрытое Акционерное Общество "Биокад" | Моноклональное антитело, которое специфически связывается с csf-1r |
CN114907489A (zh) * | 2022-04-24 | 2022-08-16 | 首都医科大学附属北京天坛医院 | 一种可诱导嵌合抗原受体及其应用 |
Family Cites Families (28)
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US245471A (en) * | 1881-08-09 | fabwell | ||
US59113A (en) * | 1866-10-23 | Improvement in horse-rakes | ||
US317403A (en) * | 1885-05-05 | Seal-lock for car-doors | ||
US4603112A (en) | 1981-12-24 | 1986-07-29 | Health Research, Incorporated | Modified vaccinia virus |
FR2583429B1 (fr) | 1985-06-18 | 1989-11-03 | Transgene Sa | Vecteur d'expression de l'interferon u dans les cellules de mammifere, procede pour sa mise en oeuvre et produit obtenu et composition pharmaceutique contenant l'interferon u |
US5710158A (en) | 1991-05-10 | 1998-01-20 | Rhone-Poulenc Rorer Pharmaceuticals Inc. | Aryl and heteroaryl quinazoline compounds which inhibit EGF and/or PDGF receptor tyrosine kinase |
JPH0517367A (ja) | 1991-07-08 | 1993-01-26 | Green Cross Corp:The | 骨粗鬆症治療剤 |
US6005079A (en) | 1992-08-21 | 1999-12-21 | Vrije Universiteit Brussels | Immunoglobulins devoid of light chains |
US5747323A (en) | 1992-12-31 | 1998-05-05 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Retroviral vectors comprising a VL30-derived psi region |
DE69426841T2 (de) | 1993-02-16 | 2001-09-06 | Onyx Pharma Inc | Cytopatische Viren zur Therapie und Prophylaxe der Neoplasie |
FR2705686B1 (fr) | 1993-05-28 | 1995-08-18 | Transgene Sa | Nouveaux adénovirus défectifs et lignées de complémentation correspondantes. |
US6107045A (en) * | 1994-06-30 | 2000-08-22 | Oklahoma Medical Research Foundation | Antibodies to lipoproteins and apolipoproteins and methods of use thereof |
FR2727689A1 (fr) | 1994-12-01 | 1996-06-07 | Transgene Sa | Nouveau procede de preparation d'un vecteur viral |
FR2737222B1 (fr) | 1995-07-24 | 1997-10-17 | Transgene Sa | Nouveaux vecteurs viraux et lignee pour la therapie genique |
FR2759382A1 (fr) | 1997-02-10 | 1998-08-14 | Transgene Sa | Nouveaux composes et compositions les contenant utilisables pour le transfert d'au moins une substance therapeutiquement active, notamment un polynucleotide, dans une cellule cible et utilisation en therapie genique |
US7083950B2 (en) | 1998-09-25 | 2006-08-01 | Regeneron Pharmaceuticals, Inc. | High affinity fusion proteins and therapeutic and diagnostic methods for use |
CA2296792A1 (en) * | 1999-02-26 | 2000-08-26 | Genset S.A. | Expressed sequence tags and encoded human proteins |
WO2001030381A2 (de) | 1999-10-28 | 2001-05-03 | Hofbauer, Reinhold | Verwendung von csf-1-inhibitoren |
EP1463757A2 (fr) | 2002-01-03 | 2004-10-06 | Transgene | Antisens diriges contre le csf-1 humain |
AR045563A1 (es) | 2003-09-10 | 2005-11-02 | Warner Lambert Co | Anticuerpos dirigidos a m-csf |
EP1704166B1 (en) | 2004-01-07 | 2015-04-29 | Novartis Vaccines and Diagnostics, Inc. | M-csf-specific monoclonal antibody and uses thereof |
ATE504599T1 (de) | 2004-01-16 | 2011-04-15 | Regeneron Pharma | Zur aktivierung von rezeptoren fähige fusionspolypeptide |
AU2007284651B2 (en) * | 2006-08-09 | 2014-03-20 | Institute For Systems Biology | Organ-specific proteins and methods of their use |
ES2650224T3 (es) * | 2007-08-21 | 2018-01-17 | Amgen, Inc. | Proteínas de unión al antígeno C-FMS humano |
AU2009224955B2 (en) * | 2008-03-14 | 2012-08-09 | Transgene S.A. | Antibody against the CSF-1 R |
US8470977B2 (en) * | 2008-03-14 | 2013-06-25 | Transgene S.A. | Antibody against the CSF-1R |
SG11201401639QA (en) * | 2011-10-21 | 2014-05-29 | Transgene Sa | Modulation of macrophage activation |
US9676859B2 (en) * | 2012-11-09 | 2017-06-13 | Transgene Sa | In vitro generation of dendritic cells by exposure to an anti-CSF1-R antibody |
-
2011
- 2011-02-14 US US13/026,944 patent/US8470977B2/en active Active
-
2012
- 2012-02-07 HU HUE12707246A patent/HUE035617T2/en unknown
- 2012-02-07 EP EP12707246.0A patent/EP2675826B1/en active Active
- 2012-02-07 MX MX2013009362A patent/MX347020B/es active IP Right Grant
- 2012-02-07 DK DK12707246.0T patent/DK2675826T3/en active
- 2012-02-07 CA CA2825243A patent/CA2825243A1/en not_active Abandoned
- 2012-02-07 WO PCT/EP2012/052043 patent/WO2012110360A1/en active Application Filing
- 2012-02-07 CN CN201410224979.0A patent/CN104140467B/zh not_active Expired - Fee Related
- 2012-02-07 SG SG2013052584A patent/SG191899A1/en unknown
- 2012-02-07 JP JP2013552940A patent/JP5996558B2/ja not_active Expired - Fee Related
- 2012-02-07 KR KR1020137021322A patent/KR101920946B1/ko active IP Right Grant
- 2012-02-07 RU RU2013141956A patent/RU2621859C2/ru active
- 2012-02-07 BR BR112013020500A patent/BR112013020500A8/pt not_active IP Right Cessation
- 2012-02-07 AU AU2012217303A patent/AU2012217303B2/en not_active Ceased
- 2012-02-07 CN CN201280008872.1A patent/CN103476794B/zh not_active Expired - Fee Related
- 2012-02-07 ES ES12707246.0T patent/ES2654551T3/es active Active
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2013
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2015
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2016
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CN104140467B (zh) | 2017-05-31 |
AU2012217303A1 (en) | 2013-07-11 |
KR20140032992A (ko) | 2014-03-17 |
US9428584B2 (en) | 2016-08-30 |
JP5996558B2 (ja) | 2016-09-21 |
NZ612038A (en) | 2014-09-26 |
HUE035617T2 (en) | 2018-05-28 |
US8470977B2 (en) | 2013-06-25 |
EP2675826A1 (en) | 2013-12-25 |
AU2012217303B2 (en) | 2016-10-20 |
US20110178278A1 (en) | 2011-07-21 |
EP2675826B1 (en) | 2017-11-01 |
RU2621859C2 (ru) | 2017-06-07 |
JP2014506572A (ja) | 2014-03-17 |
KR101920946B1 (ko) | 2018-11-21 |
SG191899A1 (en) | 2013-08-30 |
CA2825243A1 (en) | 2012-08-23 |
DK2675826T3 (en) | 2018-01-22 |
RU2013141956A (ru) | 2015-03-27 |
US20170002081A1 (en) | 2017-01-05 |
WO2012110360A1 (en) | 2012-08-23 |
ES2654551T3 (es) | 2018-02-14 |
ZA201306869B (en) | 2014-05-28 |
IL227078A (en) | 2017-06-29 |
HK1203976A1 (en) | 2015-11-06 |
MX347020B (es) | 2017-04-06 |
CN104140467A (zh) | 2014-11-12 |
CN103476794B (zh) | 2017-05-03 |
BR112013020500A8 (pt) | 2018-01-09 |
MX2013009362A (es) | 2014-04-25 |
CN103476794A (zh) | 2013-12-25 |
US9982055B2 (en) | 2018-05-29 |
US20130289250A1 (en) | 2013-10-31 |
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