BR112013018924A2 - Colon cancer gene expression signatures and methods of use - Google Patents
Colon cancer gene expression signatures and methods of useInfo
- Publication number
- BR112013018924A2 BR112013018924A2 BR112013018924-0A BR112013018924A BR112013018924A2 BR 112013018924 A2 BR112013018924 A2 BR 112013018924A2 BR 112013018924 A BR112013018924 A BR 112013018924A BR 112013018924 A2 BR112013018924 A2 BR 112013018924A2
- Authority
- BR
- Brazil
- Prior art keywords
- colon cancer
- transcripts
- nucleic acid
- sample
- expression level
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
- C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/575—Immunoassay; Biospecific binding assay; Materials therefor for cancer
- G01N33/57535—Immunoassay; Biospecific binding assay; Materials therefor for cancer of the large intestine, e.g. colon, rectum or anus
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/112—Disease subtyping, staging or classification
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/118—Prognosis of disease development
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/158—Expression markers
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pathology (AREA)
- Analytical Chemistry (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Physics & Mathematics (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Oncology (AREA)
- Hospice & Palliative Care (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Biophysics (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Urology & Nephrology (AREA)
- Medicinal Chemistry (AREA)
- Food Science & Technology (AREA)
- General Physics & Mathematics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Cell Biology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161435922P | 2011-01-25 | 2011-01-25 | |
| US61/435,922 | 2011-01-25 | ||
| PCT/US2012/022594 WO2012103250A2 (en) | 2011-01-25 | 2012-01-25 | Colon cancer gene expression signatures and methods of use |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR112013018924A2 true BR112013018924A2 (en) | 2018-05-08 |
Family
ID=46581385
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112013018924-0A BR112013018924A2 (en) | 2011-01-25 | 2012-01-25 | Colon cancer gene expression signatures and methods of use |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US10196691B2 (https=) |
| EP (1) | EP2668296B1 (https=) |
| JP (1) | JP2014509189A (https=) |
| KR (1) | KR20140006898A (https=) |
| CN (1) | CN103403543B9 (https=) |
| AU (1) | AU2012209074A1 (https=) |
| BR (1) | BR112013018924A2 (https=) |
| CA (1) | CA2825218A1 (https=) |
| EA (1) | EA201391074A1 (https=) |
| IL (1) | IL227643A0 (https=) |
| MX (1) | MX2013008367A (https=) |
| SG (1) | SG192108A1 (https=) |
| WO (1) | WO2012103250A2 (https=) |
| ZA (1) | ZA201305024B (https=) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10787701B2 (en) | 2010-04-05 | 2020-09-29 | Prognosys Biosciences, Inc. | Spatially encoded biological assays |
| US20190300945A1 (en) | 2010-04-05 | 2019-10-03 | Prognosys Biosciences, Inc. | Spatially Encoded Biological Assays |
| WO2011127099A1 (en) | 2010-04-05 | 2011-10-13 | Prognosys Biosciences, Inc. | Spatially encoded biological assays |
| GB201106254D0 (en) | 2011-04-13 | 2011-05-25 | Frisen Jonas | Method and product |
| US20130074201A1 (en) * | 2011-09-16 | 2013-03-21 | The Johns Hopkins University | Cancer-specific genetic rearrangements |
| EP4592400A3 (en) * | 2012-10-17 | 2025-10-29 | 10x Genomics Sweden AB | Methods and product for optimising localised or spatial detection of gene expression in a tissue sample |
| CA2916662C (en) | 2013-06-25 | 2022-03-08 | Prognosys Biosciences, Inc. | Methods and systems for determining spatial patterns of biological targets in a sample |
| US9652722B1 (en) * | 2013-12-05 | 2017-05-16 | The Mathworks, Inc. | Methods and systems for robust supervised machine learning |
| CA2939697A1 (en) * | 2014-02-17 | 2015-08-20 | Ventana Medical Systems, Inc. | G-alpha, interacting vesicle associated protein (giv) as a predictive marker in stage ii colorectal cancer |
| EP3129509B1 (en) * | 2014-04-10 | 2020-06-17 | Bio-Marcare Technologies Ltd. | Methods and kits for identifying pre-cancerous colorectal polyps and colorectal cancer |
| EP3901282B1 (en) | 2015-04-10 | 2023-06-28 | Spatial Transcriptomics AB | Spatially distinguished, multiplex nucleic acid analysis of biological specimens |
| CN108020672A (zh) * | 2016-11-03 | 2018-05-11 | 中国医学科学院基础医学研究所 | 检测rhbdd1蛋白的elisa方法及试剂盒 |
| US20200088748A1 (en) * | 2016-12-08 | 2020-03-19 | Dana-Farber Cancer Institute, Inc. | Metabolic profiling of fixed samples |
| CN107158388B (zh) * | 2017-07-11 | 2021-03-23 | 上海市第一人民医院 | MIIP pS303阻断剂在制备抗肿瘤药物中的应用 |
| IL276089B2 (en) * | 2018-01-22 | 2024-07-01 | Liquid Biopsy Res Llc | Methods for colon cancer detection and treatment monitoring |
| AU2019252672B2 (en) | 2018-04-12 | 2025-08-14 | Board Of Regents, The University Of Texas System | Biomarker for detecting cancer |
| JP2020028278A (ja) * | 2018-08-24 | 2020-02-27 | 国立大学法人九州大学 | 被検体に生じるイベントを予測するための判別器の生成方法、及び前記判別器を用いた被検体の層別化方法 |
| CN111321220A (zh) * | 2018-12-14 | 2020-06-23 | 中国医学科学院肿瘤医院 | 用于检测直肠癌放化疗敏感性的组合物、微阵列和计算机系统 |
| CN110079607B (zh) * | 2019-04-04 | 2022-08-02 | 陕西师范大学 | 一种引物组、检测血液样品种属的方法及应用 |
| WO2020243579A1 (en) | 2019-05-30 | 2020-12-03 | 10X Genomics, Inc. | Methods of detecting spatial heterogeneity of a biological sample |
| AU2021283174A1 (en) | 2020-06-02 | 2023-01-05 | 10X Genomics, Inc. | Nucleic acid library methods |
| EP4600376A3 (en) | 2020-06-02 | 2025-10-22 | 10X Genomics, Inc. | Spatial transcriptomics for antigen-receptors |
| EP4421186B1 (en) | 2020-06-08 | 2025-08-13 | 10X Genomics, Inc. | Methods of determining a surgical margin and methods of use thereof |
| US20230235408A1 (en) * | 2020-06-30 | 2023-07-27 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for predicting the risk of recurrence and/or death of patients suffering from a solid cancer after preoperative adjuvant therapies |
| CN111951883A (zh) * | 2020-08-04 | 2020-11-17 | 广东省第二人民医院（广东省卫生应急医院） | 一种特征mRNA表达谱组合及结肠癌早期预测方法 |
| CA3216539A1 (en) * | 2021-04-14 | 2022-10-20 | Amgen Inc. | Automated outlier removal for multivariate modeling |
| CN115786518A (zh) * | 2022-11-29 | 2023-03-14 | 广东医科大学附属医院 | 嗅素结构域家族蛋白4（olfm4）在结肠癌检测产品中的应用 |
| EP4689188A2 (en) * | 2023-03-27 | 2026-02-11 | Immunis.AI, Inc. | Active surveillance and risk stratification for prostate cancer |
| CN119372311A (zh) * | 2024-09-30 | 2025-01-28 | 东南大学 | 基于成纤维细胞相关基因的结肠癌预后和治疗抵抗预测模型的构建方法和应用 |
| CN120009551B (zh) * | 2025-02-27 | 2025-08-15 | 西南医科大学 | 剪接因子wbp11及其抑制剂的用途、预防或治疗结直肠癌的药物 |
Family Cites Families (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1985001051A1 (en) | 1983-09-02 | 1985-03-14 | Molecular Biosystems, Inc. | Oligonucleotide polymeric support system |
| CA1323293C (en) | 1987-12-11 | 1993-10-19 | Keith C. Backman | Assay using template-dependent nucleic acid probe reorganization |
| GB8810400D0 (en) | 1988-05-03 | 1988-06-08 | Southern E | Analysing polynucleotide sequences |
| ATE138106T1 (de) | 1988-07-20 | 1996-06-15 | David Segev | Verfahren zur amplifizierung und zum nachweis von nukleinsäuresequenzen |
| US5219727A (en) | 1989-08-21 | 1993-06-15 | Hoffmann-Laroche Inc. | Quantitation of nucleic acids using the polymerase chain reaction |
| US5427930A (en) | 1990-01-26 | 1995-06-27 | Abbott Laboratories | Amplification of target nucleic acids using gap filling ligase chain reaction |
| US5554501A (en) | 1992-10-29 | 1996-09-10 | Beckman Instruments, Inc. | Biopolymer synthesis using surface activated biaxially oriented polypropylene |
| US5538848A (en) | 1994-11-16 | 1996-07-23 | Applied Biosystems Division, Perkin-Elmer Corp. | Method for detecting nucleic acid amplification using self-quenching fluorescence probe |
| US5648211A (en) | 1994-04-18 | 1997-07-15 | Becton, Dickinson And Company | Strand displacement amplification using thermophilic enzymes |
| EP0758403B1 (en) | 1994-05-05 | 1998-06-24 | Beckman Instruments, Inc. | Oligonucleotide repeat arrays |
| ES2168380T3 (es) | 1994-07-15 | 2002-06-16 | Organon Teknika Bv | Utilizacion de arn polimerasa para mejorar un procedimiento de amplificacion de acido nucleico. |
| AT402203B (de) | 1995-06-13 | 1997-03-25 | Himmler Gottfried Dipl Ing Dr | Verfahren zur transkriptionsfreien amplifizierung von nucleinsäuren |
| US5716784A (en) | 1996-02-05 | 1998-02-10 | The Perkin-Elmer Corporation | Fluorescence detection assay for homogeneous PCR hybridization systems |
| EP2369007B1 (en) | 1996-05-29 | 2015-07-29 | Cornell Research Foundation, Inc. | Detection of nucleic acid sequence differences using coupled ligase detection and polymerase chain reactions |
| US5985567A (en) | 1997-08-15 | 1999-11-16 | Beckman Coulter, Inc. | Hybridization detection by pretreating bound single-stranded probes |
| US6013789A (en) | 1998-02-20 | 2000-01-11 | Beckman Coulter, Inc. | Covalent attachment of biomolecules to derivatized polypropylene supports |
| US20010055596A1 (en) | 2000-03-24 | 2001-12-27 | Meagher Madeleine Joy | Compositions and methods for therapy and diagnosis of colon cancer |
| AU2003209340A1 (en) * | 2002-01-18 | 2003-09-02 | Bristol-Myers Squibb Company | Predictor sets for tyrosine kinase pathways |
| US7250496B2 (en) | 2002-11-14 | 2007-07-31 | Rosetta Genomics Ltd. | Bioinformatically detectable group of novel regulatory genes and uses thereof |
| AU2003295600A1 (en) | 2002-11-14 | 2004-06-15 | Dharmacon, Inc. | Functional and hyperfunctional sirna |
| CA2514187A1 (en) | 2003-01-24 | 2004-08-12 | Bayer Pharmaceuticals Corporation | Expression profiles for colon cancer and methods of use |
| WO2005054508A2 (en) | 2003-12-01 | 2005-06-16 | Ipsogen | Gene expression profiling of colon cancer by dna microarrays and correlation with survival and histoclinical parameters |
| KR20070052694A (ko) | 2004-01-09 | 2007-05-22 | 더 리젠트스 오브 더 유니이버시티 오브 캘리포니아 | 유전자 발현을 위한 세포-유형-특이적 패턴 |
| US20060195266A1 (en) | 2005-02-25 | 2006-08-31 | Yeatman Timothy J | Methods for predicting cancer outcome and gene signatures for use therein |
| WO2005083128A2 (en) | 2004-02-25 | 2005-09-09 | University Of South Florida | Methods for predicting cancer outcome and gene signatures for use therein |
| CA2569079A1 (en) | 2004-06-03 | 2005-12-15 | The Johns Hopkins University | Methods of screening for cell proliferation or neoplastic disorders |
| EP1815021A2 (en) | 2004-11-03 | 2007-08-08 | Almac Diagnostics Limited | Transcriptome microarray technology and methods of using the same |
| TW200730825A (en) | 2005-10-21 | 2007-08-16 | Genenews Inc | Method and apparatus for correlating levels of biomarker products with disease |
| NZ593226A (en) * | 2006-01-11 | 2012-10-26 | Genomic Health Inc | Gene expression markers (efnb2) for colorectal cancer prognosis |
| US20100009905A1 (en) * | 2006-03-24 | 2010-01-14 | Macina Roberto A | Compositions and Methods for Detection, Prognosis and Treatment of Colon Cancer |
| US20100261169A1 (en) | 2007-01-29 | 2010-10-14 | Shira Wallach | Novel nucleotide and amino acid sequences, and methods of use thereof for diagnosis |
| NZ562237A (en) * | 2007-10-05 | 2011-02-25 | Pacific Edge Biotechnology Ltd | Proliferation signature and prognosis for gastrointestinal cancer |
| JP5588970B2 (ja) | 2008-05-27 | 2014-09-10 | ダコ・デンマーク・エー／エス | ハイブリダイゼーション組成物及び方法 |
| WO2010060055A1 (en) | 2008-11-21 | 2010-05-27 | Duke University | Predicting cancer risk and treatment success |
-
2012
- 2012-01-25 KR KR1020137021973A patent/KR20140006898A/ko not_active Withdrawn
- 2012-01-25 AU AU2012209074A patent/AU2012209074A1/en not_active Abandoned
- 2012-01-25 EA EA201391074A patent/EA201391074A1/ru unknown
- 2012-01-25 JP JP2013551314A patent/JP2014509189A/ja active Pending
- 2012-01-25 WO PCT/US2012/022594 patent/WO2012103250A2/en not_active Ceased
- 2012-01-25 SG SG2013056254A patent/SG192108A1/en unknown
- 2012-01-25 BR BR112013018924-0A patent/BR112013018924A2/en not_active IP Right Cessation
- 2012-01-25 EP EP12739742.0A patent/EP2668296B1/en not_active Not-in-force
- 2012-01-25 MX MX2013008367A patent/MX2013008367A/es unknown
- 2012-01-25 CA CA2825218A patent/CA2825218A1/en not_active Abandoned
- 2012-01-25 CN CN201280010123.2A patent/CN103403543B9/zh not_active Expired - Fee Related
- 2012-01-25 US US13/981,601 patent/US10196691B2/en not_active Expired - Fee Related
-
2013
- 2013-07-04 ZA ZA2013/05024A patent/ZA201305024B/en unknown
- 2013-07-24 IL IL227643A patent/IL227643A0/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EA201391074A1 (ru) | 2013-12-30 |
| CN103403543B9 (zh) | 2017-05-17 |
| CN103403543B (zh) | 2016-11-09 |
| JP2014509189A (ja) | 2014-04-17 |
| SG192108A1 (en) | 2013-08-30 |
| MX2013008367A (es) | 2013-08-12 |
| US10196691B2 (en) | 2019-02-05 |
| NZ612471A (en) | 2015-11-27 |
| EP2668296A2 (en) | 2013-12-04 |
| US20140094379A1 (en) | 2014-04-03 |
| CN103403543A (zh) | 2013-11-20 |
| EP2668296B1 (en) | 2018-08-15 |
| EP2668296A4 (en) | 2015-09-02 |
| WO2012103250A3 (en) | 2012-10-11 |
| IL227643A0 (en) | 2013-09-30 |
| WO2012103250A2 (en) | 2012-08-02 |
| CA2825218A1 (en) | 2012-08-02 |
| AU2012209074A1 (en) | 2013-07-11 |
| KR20140006898A (ko) | 2014-01-16 |
| ZA201305024B (en) | 2014-03-26 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US10196691B2 (en) | Colon cancer gene expression signatures and methods of use | |
| EP3094747B1 (en) | Gene expression panel for prognosis of prostate cancer recurrence | |
| JP6404304B2 (ja) | メラノーマ癌の予後予測 | |
| US20080058432A1 (en) | Molecular assay to predict recurrence of Duke's B colon cancer | |
| CA2859663A1 (en) | Identification of multigene biomarkers | |
| CN104603292A (zh) | 用于提供前列腺癌的临床评估的方法、试剂盒和组合物 | |
| EP2524051A2 (en) | Diagnostic gene expression platform | |
| EP3472361A1 (en) | Compositions and methods for diagnosing lung cancers using gene expression profiles | |
| KR20180009762A (ko) | 폐암을 진단하거나 검출하기 위한 방법 및 조성물 | |
| CN101960022A (zh) | Ⅱ期和ⅲ期结肠癌的分子分期和预后 | |
| US20250137066A1 (en) | Compostions and methods for diagnosing lung cancers using gene expression profiles | |
| WO2013109613A1 (en) | Gene signature is associated with early stage rectal cancer recurrence | |
| EP1683862B1 (en) | Microarray for assessing neuroblastoma prognosis and method of assessing neuroblastoma prognosis | |
| NZ612471B2 (en) | Colon cancer gene expression signatures and methods of use | |
| CN110079601B (zh) | 放射性相关疾病诊疗标志物及其应用 | |
| HK1231515B (en) | Gene expression panel for prognosis of prostate cancer recurrence | |
| HK1191675A (en) | Prognostic signature for colorectal cancer recurrence |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 7A ANUIDADE. |
|
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO ARQUIVAMENTO PUBLICADO NA RPI 2498 DE 21/11/2018. |
|
| B350 | Update of information on the portal [chapter 15.35 patent gazette] |