BR112013017264A2 - processo de síntese da agomelatina - Google Patents

processo de síntese da agomelatina

Info

Publication number
BR112013017264A2
BR112013017264A2 BR112013017264A BR112013017264A BR112013017264A2 BR 112013017264 A2 BR112013017264 A2 BR 112013017264A2 BR 112013017264 A BR112013017264 A BR 112013017264A BR 112013017264 A BR112013017264 A BR 112013017264A BR 112013017264 A2 BR112013017264 A2 BR 112013017264A2
Authority
BR
Brazil
Prior art keywords
synthesis process
agomelatine
agomelatine synthesis
compound
formula
Prior art date
Application number
BR112013017264A
Other languages
English (en)
Inventor
Béatrice Sire
Mehdi Boumediene
Samir Zard
Original Assignee
Servier Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=44121614&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BR112013017264(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Servier Lab filed Critical Servier Lab
Publication of BR112013017264A2 publication Critical patent/BR112013017264A2/pt

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00Preparation of carboxylic acid amides
    • C07C231/14Preparation of carboxylic acid amides by formation of carboxamide groups together with reactions not involving the carboxamide groups
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • A61P15/18Feminine contraceptives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/06Antimigraine agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16Anti-Parkinson drugs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00Preparation of carboxylic acid amides
    • C07C231/10Preparation of carboxylic acid amides from compounds not provided for in groups C07C231/02 - C07C231/08
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00Preparation of carboxylic acid amides
    • C07C231/12Preparation of carboxylic acid amides by reactions not involving the formation of carboxamide groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44Iso-indoles; Hydrogenated iso-indoles
    • C07D209/48Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00Systems containing two condensed rings
    • C07C2602/02Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04One of the condensed rings being a six-membered aromatic ring
    • C07C2602/10One of the condensed rings being a six-membered aromatic ring the other ring being six-membered, e.g. tetraline

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Hospice & Palliative Care (AREA)
  • Cardiology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Psychology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Gynecology & Obstetrics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Indole Compounds (AREA)
  • Inorganic Compounds Of Heavy Metals (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Catalysts (AREA)

Abstract

processo de síntese da agomelatina a presente invenção refere-se a um processo de síntese industrial do composto de fórmula (i).
BR112013017264A 2011-01-05 2012-01-04 processo de síntese da agomelatina BR112013017264A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR1100023A FR2970001B1 (fr) 2011-01-05 2011-01-05 Nouveau procede de synthese de l'agomelatine
PCT/FR2012/000004 WO2012093225A1 (fr) 2011-01-05 2012-01-04 Nouveau procede de synthese de l'agomelatine

Publications (1)

Publication Number Publication Date
BR112013017264A2 true BR112013017264A2 (pt) 2016-10-25

Family

ID=44121614

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112013017264A BR112013017264A2 (pt) 2011-01-05 2012-01-04 processo de síntese da agomelatina

Country Status (42)

Country Link
US (1) US8871975B2 (pt)
EP (1) EP2661423B1 (pt)
JP (1) JP5837615B2 (pt)
KR (1) KR101544129B1 (pt)
CN (1) CN103298779B (pt)
AP (1) AP3399A (pt)
AR (1) AR084779A1 (pt)
AU (1) AU2012204817B2 (pt)
BR (1) BR112013017264A2 (pt)
CA (1) CA2823584C (pt)
CL (1) CL2013001881A1 (pt)
CO (1) CO6731102A2 (pt)
CR (1) CR20130300A (pt)
CU (1) CU24291B1 (pt)
CY (1) CY1116366T1 (pt)
DK (1) DK2661423T3 (pt)
EA (1) EA024126B1 (pt)
ES (1) ES2539173T3 (pt)
FR (1) FR2970001B1 (pt)
GE (1) GEP201606576B (pt)
GT (1) GT201300176A (pt)
HK (1) HK1189217A1 (pt)
HR (1) HRP20150504T1 (pt)
IL (1) IL227282A (pt)
JO (1) JO3085B1 (pt)
ME (1) ME02109B (pt)
MX (1) MX2013007838A (pt)
MY (1) MY162973A (pt)
NI (1) NI201300061A (pt)
PE (1) PE20140169A1 (pt)
PL (1) PL2661423T3 (pt)
PT (1) PT2661423E (pt)
RS (1) RS53958B1 (pt)
SA (1) SA112330135B1 (pt)
SG (1) SG191191A1 (pt)
SI (1) SI2661423T1 (pt)
TN (1) TN2013000273A1 (pt)
TW (1) TWI534127B (pt)
UA (1) UA104123C2 (pt)
UY (1) UY33847A (pt)
WO (1) WO2012093225A1 (pt)
ZA (1) ZA201305026B (pt)

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2658818B1 (fr) * 1990-02-27 1993-12-31 Adir Cie Nouveaux derives a structure naphtalenique, leur procede de preparation et les compositions pharmaceutiques qui les contiennent.
FR2866335B1 (fr) 2004-02-13 2006-05-26 Servier Lab Nouveau procede de synthese de l'agomelatine
FR2934859B1 (fr) * 2008-08-05 2010-08-13 Servier Lab Nouveau procede de synthese de l'agomelatine

Also Published As

Publication number Publication date
ME02109B (me) 2015-10-20
UA104123C2 (uk) 2013-12-25
TN2013000273A1 (fr) 2014-11-10
EP2661423B1 (fr) 2015-03-11
KR101544129B1 (ko) 2015-08-12
CL2013001881A1 (es) 2013-12-06
AP3399A (en) 2015-08-31
MY162973A (en) 2017-07-31
EA024126B1 (ru) 2016-08-31
CN103298779B (zh) 2015-01-28
RS53958B1 (en) 2015-08-31
TWI534127B (zh) 2016-05-21
AP2013007024A0 (en) 2013-07-31
PE20140169A1 (es) 2014-02-15
ZA201305026B (en) 2014-03-26
ES2539173T3 (es) 2015-06-26
FR2970001B1 (fr) 2013-01-04
NZ612163A (en) 2015-09-25
HK1189217A1 (en) 2014-05-30
PT2661423E (pt) 2015-05-18
KR20130115344A (ko) 2013-10-21
JO3085B1 (ar) 2017-03-15
AU2012204817A1 (en) 2013-07-11
PL2661423T3 (pl) 2015-07-31
TW201309624A (zh) 2013-03-01
JP5837615B2 (ja) 2015-12-24
SG191191A1 (en) 2013-07-31
CY1116366T1 (el) 2017-02-08
DK2661423T3 (da) 2015-06-22
NI201300061A (es) 2013-12-11
SA112330135B1 (ar) 2014-08-31
AR084779A1 (es) 2013-06-26
CN103298779A (zh) 2013-09-11
EA201300793A1 (ru) 2013-12-30
GEP201606576B (en) 2016-11-25
HRP20150504T1 (hr) 2015-06-05
IL227282A (en) 2015-06-30
CO6731102A2 (es) 2013-08-15
MX2013007838A (es) 2013-09-06
WO2012093225A1 (fr) 2012-07-12
SI2661423T1 (sl) 2015-10-30
US20130289308A1 (en) 2013-10-31
CR20130300A (es) 2013-08-09
CU20130087A7 (es) 2013-08-29
GT201300176A (es) 2014-12-30
CA2823584A1 (fr) 2012-07-12
EP2661423A1 (fr) 2013-11-13
CU24291B1 (es) 2017-12-08
FR2970001A1 (fr) 2012-07-06
US8871975B2 (en) 2014-10-28
UY33847A (es) 2012-07-31
AU2012204817B2 (en) 2015-08-27
CA2823584C (fr) 2015-09-01
IL227282A0 (en) 2013-09-30
JP2014509308A (ja) 2014-04-17

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Legal Events

Date Code Title Description
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]

Free format text: DE ACORDO COM O ARTIGO 229-C DA LEI NO 10196/2001, QUE MODIFICOU A LEI NO 9279/96, A CONCESSAO DA PATENTE ESTA CONDICIONADA A ANUENCIA PREVIA DA ANVISA. CONSIDERANDO A APROVACAO DOS TERMOS DO PARECER NO 337/PGF/EA/2010, BEM COMO A PORTARIA INTERMINISTERIAL NO 1065 DE 24/05/2012, ENCAMINHA-SE O PRESENTE PEDIDO PARA AS PROVIDENCIAS CABIVEIS.

B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 8A ANUIDADE.

B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2547 DE 29-10-2019 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.