AP3399A - New process for the synthesis of agomelatine - Google Patents

New process for the synthesis of agomelatine

Info

Publication number
AP3399A
AP3399A AP2013007024A AP2013007024A AP3399A AP 3399 A AP3399 A AP 3399A AP 2013007024 A AP2013007024 A AP 2013007024A AP 2013007024 A AP2013007024 A AP 2013007024A AP 3399 A AP3399 A AP 3399A
Authority
AP
ARIPO
Prior art keywords
agomelatine
synthesis
new process
new
Prior art date
Application number
AP2013007024A
Other languages
English (en)
Other versions
AP2013007024A0 (en
Inventor
Samir Zard
Mehdi Boumediene
Beatrice Sire
Original Assignee
Servier Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=44121614&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AP3399(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Servier Lab filed Critical Servier Lab
Publication of AP2013007024A0 publication Critical patent/AP2013007024A0/xx
Application granted granted Critical
Publication of AP3399A publication Critical patent/AP3399A/xx

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00Preparation of carboxylic acid amides
    • C07C231/14Preparation of carboxylic acid amides by formation of carboxamide groups together with reactions not involving the carboxamide groups
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • A61P15/18Feminine contraceptives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/06Antimigraine agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16Anti-Parkinson drugs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00Preparation of carboxylic acid amides
    • C07C231/10Preparation of carboxylic acid amides from compounds not provided for in groups C07C231/02 - C07C231/08
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00Preparation of carboxylic acid amides
    • C07C231/12Preparation of carboxylic acid amides by reactions not involving the formation of carboxamide groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44Iso-indoles; Hydrogenated iso-indoles
    • C07D209/48Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00Systems containing two condensed rings
    • C07C2602/02Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04One of the condensed rings being a six-membered aromatic ring
    • C07C2602/10One of the condensed rings being a six-membered aromatic ring the other ring being six-membered, e.g. tetraline

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Hospice & Palliative Care (AREA)
  • Cardiology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Psychology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Gynecology & Obstetrics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Indole Compounds (AREA)
  • Inorganic Compounds Of Heavy Metals (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Catalysts (AREA)
AP2013007024A 2011-01-05 2012-01-04 New process for the synthesis of agomelatine AP3399A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR1100023A FR2970001B1 (fr) 2011-01-05 2011-01-05 Nouveau procede de synthese de l'agomelatine
PCT/FR2012/000004 WO2012093225A1 (fr) 2011-01-05 2012-01-04 Nouveau procede de synthese de l'agomelatine

Publications (2)

Publication Number Publication Date
AP2013007024A0 AP2013007024A0 (en) 2013-07-31
AP3399A true AP3399A (en) 2015-08-31

Family

ID=44121614

Family Applications (1)

Application Number Title Priority Date Filing Date
AP2013007024A AP3399A (en) 2011-01-05 2012-01-04 New process for the synthesis of agomelatine

Country Status (42)

Country Link
US (1) US8871975B2 (xx)
EP (1) EP2661423B1 (xx)
JP (1) JP5837615B2 (xx)
KR (1) KR101544129B1 (xx)
CN (1) CN103298779B (xx)
AP (1) AP3399A (xx)
AR (1) AR084779A1 (xx)
AU (1) AU2012204817B2 (xx)
BR (1) BR112013017264A2 (xx)
CA (1) CA2823584C (xx)
CL (1) CL2013001881A1 (xx)
CO (1) CO6731102A2 (xx)
CR (1) CR20130300A (xx)
CU (1) CU24291B1 (xx)
CY (1) CY1116366T1 (xx)
DK (1) DK2661423T3 (xx)
EA (1) EA024126B1 (xx)
ES (1) ES2539173T3 (xx)
FR (1) FR2970001B1 (xx)
GE (1) GEP201606576B (xx)
GT (1) GT201300176A (xx)
HK (1) HK1189217A1 (xx)
HR (1) HRP20150504T1 (xx)
IL (1) IL227282A (xx)
JO (1) JO3085B1 (xx)
ME (1) ME02109B (xx)
MX (1) MX2013007838A (xx)
MY (1) MY162973A (xx)
NI (1) NI201300061A (xx)
PE (1) PE20140169A1 (xx)
PL (1) PL2661423T3 (xx)
PT (1) PT2661423E (xx)
RS (1) RS53958B1 (xx)
SA (1) SA112330135B1 (xx)
SG (1) SG191191A1 (xx)
SI (1) SI2661423T1 (xx)
TN (1) TN2013000273A1 (xx)
TW (1) TWI534127B (xx)
UA (1) UA104123C2 (xx)
UY (1) UY33847A (xx)
WO (1) WO2012093225A1 (xx)
ZA (1) ZA201305026B (xx)

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0447285A1 (fr) * 1990-02-27 1991-09-18 Adir Et Compagnie Nouveaux dérivés à structure naphtalénique, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent
EP1564202A1 (fr) * 2004-02-13 2005-08-17 Les Laboratoires Servier Nouveau procédé de synthèse et nouvelle forme cristalline de l'agomelatine ainsi que les compositions pharmaceutiques qui la contiennent
EP2151428A1 (fr) * 2008-08-05 2010-02-10 Les Laboratoires Servier Nouveau procédé de synthèse de l'agomélatine

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0447285A1 (fr) * 1990-02-27 1991-09-18 Adir Et Compagnie Nouveaux dérivés à structure naphtalénique, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent
EP1564202A1 (fr) * 2004-02-13 2005-08-17 Les Laboratoires Servier Nouveau procédé de synthèse et nouvelle forme cristalline de l'agomelatine ainsi que les compositions pharmaceutiques qui la contiennent
EP2151428A1 (fr) * 2008-08-05 2010-02-10 Les Laboratoires Servier Nouveau procédé de synthèse de l'agomélatine

Also Published As

Publication number Publication date
CN103298779A (zh) 2013-09-11
BR112013017264A2 (pt) 2016-10-25
FR2970001B1 (fr) 2013-01-04
HRP20150504T1 (hr) 2015-06-05
DK2661423T3 (da) 2015-06-22
CU20130087A7 (es) 2013-08-29
ZA201305026B (en) 2014-03-26
TN2013000273A1 (fr) 2014-11-10
CU24291B1 (es) 2017-12-08
JP5837615B2 (ja) 2015-12-24
SG191191A1 (en) 2013-07-31
UA104123C2 (uk) 2013-12-25
MX2013007838A (es) 2013-09-06
CA2823584A1 (fr) 2012-07-12
AP2013007024A0 (en) 2013-07-31
CR20130300A (es) 2013-08-09
IL227282A (en) 2015-06-30
US8871975B2 (en) 2014-10-28
HK1189217A1 (en) 2014-05-30
EA201300793A1 (ru) 2013-12-30
CO6731102A2 (es) 2013-08-15
NI201300061A (es) 2013-12-11
PL2661423T3 (pl) 2015-07-31
WO2012093225A1 (fr) 2012-07-12
CA2823584C (fr) 2015-09-01
SA112330135B1 (ar) 2014-08-31
SI2661423T1 (sl) 2015-10-30
CL2013001881A1 (es) 2013-12-06
PE20140169A1 (es) 2014-02-15
CN103298779B (zh) 2015-01-28
AR084779A1 (es) 2013-06-26
GEP201606576B (en) 2016-11-25
ES2539173T3 (es) 2015-06-26
AU2012204817A1 (en) 2013-07-11
CY1116366T1 (el) 2017-02-08
GT201300176A (es) 2014-12-30
EP2661423B1 (fr) 2015-03-11
JO3085B1 (ar) 2017-03-15
KR20130115344A (ko) 2013-10-21
KR101544129B1 (ko) 2015-08-12
US20130289308A1 (en) 2013-10-31
TW201309624A (zh) 2013-03-01
IL227282A0 (en) 2013-09-30
EA024126B1 (ru) 2016-08-31
PT2661423E (pt) 2015-05-18
UY33847A (es) 2012-07-31
AU2012204817B2 (en) 2015-08-27
NZ612163A (en) 2015-09-25
RS53958B1 (en) 2015-08-31
FR2970001A1 (fr) 2012-07-06
MY162973A (en) 2017-07-31
JP2014509308A (ja) 2014-04-17
TWI534127B (zh) 2016-05-21
ME02109B (me) 2015-10-20
EP2661423A1 (fr) 2013-11-13

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