BR112013008822A8 - Novas fucosiltransferases e suas aplicações - Google Patents

Novas fucosiltransferases e suas aplicações

Info

Publication number
BR112013008822A8
BR112013008822A8 BR112013008822A BR112013008822A BR112013008822A8 BR 112013008822 A8 BR112013008822 A8 BR 112013008822A8 BR 112013008822 A BR112013008822 A BR 112013008822A BR 112013008822 A BR112013008822 A BR 112013008822A BR 112013008822 A8 BR112013008822 A8 BR 112013008822A8
Authority
BR
Brazil
Prior art keywords
new
applications
fucosyltransperases
fucosyltransferases
glyco
Prior art date
Application number
BR112013008822A
Other languages
English (en)
Other versions
BR112013008822A2 (pt
Inventor
Parkot Julia
Huefner Eric
Jennewein Stefan
Elling Lothar
Engels Leonie
Original Assignee
Jennewein Biotechnologie Gmbh
Chr Hansen Hmo Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Jennewein Biotechnologie Gmbh, Chr Hansen Hmo Gmbh filed Critical Jennewein Biotechnologie Gmbh
Publication of BR112013008822A2 publication Critical patent/BR112013008822A2/pt
Publication of BR112013008822A8 publication Critical patent/BR112013008822A8/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1048—Glycosyltransferases (2.4)
    • C12N9/1051—Hexosyltransferases (2.4.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/18—Preparation of compounds containing saccharide radicals produced by the action of a glycosyl transferase, e.g. alpha-, beta- or gamma-cyclodextrins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/44—Preparation of O-glycosides, e.g. glucosides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/005—Glycopeptides, glycoproteins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y204/00—Glycosyltransferases (2.4)
    • C12Y204/01—Hexosyltransferases (2.4.1)
    • C12Y204/01214—Glycoprotein 3-alpha-L-fucosyltransferase (2.4.1.214)
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/52—Improvements relating to the production of bulk chemicals using catalysts, e.g. selective catalysts

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

NOVAS FUCOSIL TRANSFERASES E SUAS APLICAÇÕES. A presente invenção se refere ao ácido nucleico e sequências aminoácidas da Akkermansia muciniphila e da Bacteroides fragilis, que codificam/representam novas alfa-1,3-fucosiltransferases. A invenção também provê o uso e métodos para o uso das alfa-1,3-fucosiltransferases para geração de produtos fucosilados, como oligossacarídeos, (glico)proteínas, ou (glico)lipídios, em particular de 3-fucosilactose.
BR112013008822A 2010-10-11 2011-10-07 Novas fucosiltransferases e suas aplicações BR112013008822A8 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP10187167.1A EP2439264B1 (en) 2010-10-11 2010-10-11 Novel fucosyltransferases and their applications
PCT/EP2011/067538 WO2012049083A2 (en) 2010-10-11 2011-10-07 Novel fucosyltransferases and their applications

Publications (2)

Publication Number Publication Date
BR112013008822A2 BR112013008822A2 (pt) 2017-09-19
BR112013008822A8 true BR112013008822A8 (pt) 2023-01-31

Family

ID=43244921

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112013008822A BR112013008822A8 (pt) 2010-10-11 2011-10-07 Novas fucosiltransferases e suas aplicações

Country Status (15)

Country Link
US (1) US9441211B2 (pt)
EP (2) EP2439264B1 (pt)
JP (1) JP6097691B2 (pt)
CN (1) CN103201380B (pt)
AU (1) AU2011315656B2 (pt)
BR (1) BR112013008822A8 (pt)
DK (2) DK2439264T3 (pt)
ES (1) ES2663627T3 (pt)
MX (1) MX344691B (pt)
MY (1) MY189569A (pt)
NZ (1) NZ609127A (pt)
PL (1) PL2944690T3 (pt)
RU (1) RU2642307C2 (pt)
SG (1) SG189300A1 (pt)
WO (1) WO2012049083A2 (pt)

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CN110201003A (zh) 2012-02-29 2019-09-06 伊西康内外科公司 微生物区系的组合物及与其相关的方法
EP3572521A1 (en) 2013-09-10 2019-11-27 Jennewein Biotechnologie GmbH Production of oligosaccharides
PL2896628T3 (pl) 2014-01-20 2019-03-29 Jennewein Biotechnologie Gmbh Sposób wydajnego oczyszczania obojętnych oligosacharydów ludzkiego mleka (HMO) z fermentacji mikrobiologicznej
ES2715010T3 (es) 2014-03-31 2019-05-31 Jennewein Biotechnologie Gmbh Fermentación total de oligosacáridos
KR101718681B1 (ko) 2014-06-23 2017-03-22 서울대학교산학협력단 가용성 단백질 발현량 및 활성이 증대된 헬리코박터 파일로리 유래 α-1,3 푸코실 전달효소의 유전자와 단백질 및 α-1,3 푸코실올리고당 생산에의 응용
JP6737788B2 (ja) * 2014-09-09 2020-08-12 グリコシン リミテッド ライアビリティー カンパニー フコシル化オリゴ糖の生産において使用するためのα（１，３）フコシルトランスフェラーゼ
US9616114B1 (en) 2014-09-18 2017-04-11 David Gordon Bermudes Modified bacteria having improved pharmacokinetics and tumor colonization enhancing antitumor activity
GB2551642B (en) 2014-10-31 2020-09-23 Pendulum Therapeutics Inc Methods and compositions relating to microbial treatment and diagnosis of disorders
EP3050973A1 (en) * 2015-01-30 2016-08-03 Jennewein Biotechnologie GmbH Fermentation process for producing monosaccharides in free form from nucleotide-activated sugars
KR101794971B1 (ko) * 2016-02-02 2017-11-08 서울대학교 산학협력단 α-1,3-푸코실락토오즈의 대량 생산 방법
CN105695537B (zh) * 2016-02-29 2019-11-19 福建农林大学 一种降血糖及调节肠道菌群的糖基化浒苔寡糖制备方法
PL3315610T3 (pl) 2016-10-29 2021-06-14 Jennewein Biotechnologie Gmbh Sposób wytwarzania fukozylowanych oligosacharydów
US11129906B1 (en) 2016-12-07 2021-09-28 David Gordon Bermudes Chimeric protein toxins for expression by therapeutic bacteria
US11180535B1 (en) 2016-12-07 2021-11-23 David Gordon Bermudes Saccharide binding, tumor penetration, and cytotoxic antitumor chimeric peptides from therapeutic bacteria
CN106434590A (zh) * 2016-12-13 2017-02-22 福建农林大学 一种岩藻糖基转移酶及其基因工程菌和应用
CN106434591A (zh) * 2016-12-13 2017-02-22 福建农林大学 一种岩藻糖基转移酶及其应用
KR101794972B1 (ko) * 2017-01-26 2017-11-08 서울대학교 산학협력단 α-1,3-푸코실락토오즈의 대량 생산 방법
EP3613858B1 (en) * 2017-04-21 2024-03-13 Seoul National University R&DB Foundation Method for producing 3'-fucosyllactose using corynebacterium glutamicum
EP3425052A1 (en) 2017-07-07 2019-01-09 Jennewein Biotechnologie GmbH Fucosyltransferases and their use in producing fucosylated oligosaccharides
WO2019046646A1 (en) 2017-08-30 2019-03-07 Whole Biome Inc. METHODS AND COMPOSITIONS FOR THE TREATMENT OF MICROBIOMA ASSOCIATED DISORDERS
KR20200091438A (ko) * 2017-11-30 2020-07-30 글리콤 에이/에스 미생물총 조절을 위한 인간 밀크 올리고당 및 그의 합성 조성물
KR20210107736A (ko) * 2018-12-18 2021-09-01 인바이오스 엔.브이. 3-푸코실락토스 및 락토스 전환 α-1,3-푸코실트란스퍼라제 효소를 제조하는 방법
EP3751003A1 (en) 2019-06-12 2020-12-16 Jennewein Biotechnologie GmbH Production of fucosylated oligosaccharides in bacillus
WO2022168992A1 (ja) 2021-02-08 2022-08-11 協和発酵バイオ株式会社 １，３－フコシルトランスフェラーゼ活性を有する蛋白質及びフコース含有糖質の製造法
CN115058465A (zh) * 2022-06-30 2022-09-16 山东大学 一种岩藻糖基化软骨素及其制备方法和应用
CN117187206B (zh) * 2023-05-19 2024-06-18 无锡特殊食品与营养健康研究院有限公司 肠道微生物来源的岩藻糖基转移酶及其应用

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Also Published As

Publication number Publication date
US20130217068A1 (en) 2013-08-22
EP2439264B1 (en) 2015-06-03
AU2011315656B2 (en) 2016-01-21
CN103201380B (zh) 2018-07-24
PL2944690T3 (pl) 2018-05-30
AU2011315656A1 (en) 2013-05-02
MY189569A (en) 2022-02-17
DK2439264T3 (en) 2015-08-03
US9441211B2 (en) 2016-09-13
MX344691B (es) 2016-12-29
EP2944690A2 (en) 2015-11-18
DK2944690T3 (en) 2018-04-03
RU2013120902A (ru) 2014-11-20
CN103201380A (zh) 2013-07-10
BR112013008822A2 (pt) 2017-09-19
RU2642307C2 (ru) 2018-01-24
EP2439264A1 (en) 2012-04-11
ES2663627T3 (es) 2018-04-16
WO2012049083A3 (en) 2012-06-14
JP6097691B2 (ja) 2017-03-15
JP2013541952A (ja) 2013-11-21
NZ609127A (en) 2014-10-31
SG189300A1 (en) 2013-05-31
EP2944690A3 (en) 2016-03-09
WO2012049083A2 (en) 2012-04-19
MX2013004055A (es) 2013-06-05
EP2944690B1 (en) 2017-12-20

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Legal Events

Date Code Title Description
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B06T Formal requirements before examination [chapter 6.20 patent gazette]
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]
B12B Appeal against refusal [chapter 12.2 patent gazette]
B25D Requested change of name of applicant approved

Owner name: CHR. HANSEN HMO GMBH (DE)