BR112012020790A2 - anticorpo de neutralização da integrina alfavbeta8 - Google Patents
anticorpo de neutralização da integrina alfavbeta8Info
- Publication number
- BR112012020790A2 BR112012020790A2 BR112012020790A BR112012020790A BR112012020790A2 BR 112012020790 A2 BR112012020790 A2 BR 112012020790A2 BR 112012020790 A BR112012020790 A BR 112012020790A BR 112012020790 A BR112012020790 A BR 112012020790A BR 112012020790 A2 BR112012020790 A2 BR 112012020790A2
- Authority
- BR
- Brazil
- Prior art keywords
- neutralizing antibody
- integrin
- integrin neutralizing
- sym
- compositions
- Prior art date
Links
- 230000003472 neutralizing effect Effects 0.000 title abstract 2
- 108010004785 integrin alphavbeta8 Proteins 0.000 title 1
- 229940127121 immunoconjugate Drugs 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- 230000004913 activation Effects 0.000 abstract 1
- 239000005557 antagonist Substances 0.000 abstract 1
- 102000006495 integrins Human genes 0.000 abstract 1
- 108010044426 integrins Proteins 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2839—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6854—Immunoglobulins
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
- G01N2333/70546—Integrin superfamily, e.g. VLAs, leuCAM, GPIIb/GPIIIa, LPAM
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Gastroenterology & Hepatology (AREA)
- Biomedical Technology (AREA)
- Pulmonology (AREA)
- Epidemiology (AREA)
- Zoology (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Toxicology (AREA)
- Rheumatology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Analytical Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Cell Biology (AREA)
- Pathology (AREA)
- Food Science & Technology (AREA)
- Physics & Mathematics (AREA)
Abstract
anticorpo de neutralização da integrina alfavbeta8. a presente invenção diz respeito de <244>v <sym>8, anticorpos anti-<244>v <sym>8 ou imunoconjugados para reduzir a ativação de tgf <225> em um indivíduo. ainda fornecidas são composições compreendendo um dos antagonistas de <244>v<225>8, anticorpos anti-<244> <225> ou imunoconjugados, métodos para usar as composições, e questões relacionadas.
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US30574910P | 2010-02-18 | 2010-02-18 | |
US61/305,749 | 2010-02-18 | ||
US201061428814P | 2010-12-30 | 2010-12-30 | |
US61/428,814 | 2010-12-30 | ||
PCT/US2011/025514 WO2011103490A2 (en) | 2010-02-18 | 2011-02-18 | INTEGRIN αVβ8 NEUTRALIZING ANTIBODY |
Publications (2)
Publication Number | Publication Date |
---|---|
BR112012020790A2 true BR112012020790A2 (pt) | 2016-05-03 |
BR112012020790B1 BR112012020790B1 (pt) | 2021-09-28 |
Family
ID=44483602
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112012020790-3A BR112012020790B1 (pt) | 2010-02-18 | 2011-02-18 | Anticorpo isolado anti-integrina alfavbeta8 e composição farmacêutica |
Country Status (12)
Country | Link |
---|---|
US (2) | US9290572B2 (pt) |
EP (2) | EP4219560A3 (pt) |
JP (2) | JP2013520173A (pt) |
KR (1) | KR101838763B1 (pt) |
CN (2) | CN105315370A (pt) |
AU (1) | AU2011217848B8 (pt) |
BR (1) | BR112012020790B1 (pt) |
CA (1) | CA2790488C (pt) |
MX (1) | MX342270B (pt) |
RU (1) | RU2565539C2 (pt) |
SG (1) | SG183356A1 (pt) |
WO (1) | WO2011103490A2 (pt) |
Families Citing this family (14)
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CN105315370A (zh) * | 2010-02-18 | 2016-02-10 | 加利福尼亚大学董事会 | 整合素αVβ8中和抗体 |
WO2013026004A2 (en) * | 2011-08-17 | 2013-02-21 | The Regents Of The University Of California | Antibodies that bind integrin alpha-v beta-8 |
CN104428000A (zh) * | 2012-05-02 | 2015-03-18 | 纽约大学 | 治疗和预防金黄色葡萄球菌感染和相关病状的方法 |
ES2823648T3 (es) | 2013-04-01 | 2021-05-07 | Univ California | Métodos y composiciones para tratar y prevenir enfermedades asociadas con la integrina AVB8 |
EP3157561B1 (en) | 2014-06-17 | 2019-12-18 | MedImmune Limited | Improved alpha-v beta-8 antibodies |
EP3009147A1 (en) | 2014-10-16 | 2016-04-20 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Method for treating resistant glioblastoma |
WO2017182834A1 (en) | 2016-04-19 | 2017-10-26 | INSERM (Institut National de la Santé et de la Recherche Médicale) | New method for treating resistant glioblastoma |
AU2017335991B2 (en) | 2016-09-29 | 2023-07-06 | The Regents Of The University Of California | Neutralizing antibodies to the αVβ8 integrin complex for immunotherapy |
EP3847194A1 (en) * | 2018-09-07 | 2021-07-14 | Pfizer Inc. | Anti-avb8 antibodies and compositions and uses thereof |
WO2020210650A1 (en) * | 2019-04-12 | 2020-10-15 | Medimmune, Llc | Neutralization of tgf-beta or alpha-v-beta-8 integrin for s. aureus infections |
TW202140554A (zh) * | 2020-01-27 | 2021-11-01 | 英商梅迪繆思有限公司 | 用於治療腎臟疾病之抗αvβ8整聯蛋白抗體 |
WO2024056668A1 (en) | 2022-09-12 | 2024-03-21 | Institut National de la Santé et de la Recherche Médicale | New anti-itgb8 antibodies and its uses thereof |
CN117126282B (zh) * | 2023-10-26 | 2024-01-12 | 迈威(上海)生物科技股份有限公司 | 抗体及其在制备阻断αvβ8与Latent TGF-β的结合的药物中的应用 |
CN117143241B (zh) * | 2023-10-26 | 2024-02-23 | 迈威(上海)生物科技股份有限公司 | 与人整合素蛋白itgav/itgb8特异性结合的单克隆抗体 |
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CN102137873A (zh) | 2008-08-29 | 2011-07-27 | 西福根有限公司 | 抗cd5抗体 |
CN105315370A (zh) * | 2010-02-18 | 2016-02-10 | 加利福尼亚大学董事会 | 整合素αVβ8中和抗体 |
WO2013026004A2 (en) * | 2011-08-17 | 2013-02-21 | The Regents Of The University Of California | Antibodies that bind integrin alpha-v beta-8 |
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2011
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- 2011-02-18 CN CN201180018213.1A patent/CN102834412B/zh active Active
- 2011-02-18 EP EP23151118.9A patent/EP4219560A3/en active Pending
- 2011-02-18 US US13/580,105 patent/US9290572B2/en active Active
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KR20120137482A (ko) | 2012-12-21 |
AU2011217848A1 (en) | 2012-09-13 |
SG183356A1 (en) | 2012-09-27 |
RU2012139829A (ru) | 2014-03-27 |
CN102834412B (zh) | 2016-01-20 |
MX342270B (es) | 2016-09-21 |
WO2011103490A3 (en) | 2011-10-27 |
US9845357B2 (en) | 2017-12-19 |
WO2011103490A2 (en) | 2011-08-25 |
US20130064837A1 (en) | 2013-03-14 |
BR112012020790B1 (pt) | 2021-09-28 |
CN102834412A (zh) | 2012-12-19 |
EP4219560A2 (en) | 2023-08-02 |
JP6212159B2 (ja) | 2017-10-11 |
EP2536762A4 (en) | 2014-01-01 |
AU2011217848B8 (en) | 2015-09-24 |
EP2536762A2 (en) | 2012-12-26 |
US20160137737A1 (en) | 2016-05-19 |
CN105315370A (zh) | 2016-02-10 |
JP2013520173A (ja) | 2013-06-06 |
AU2011217848B2 (en) | 2015-08-27 |
RU2565539C2 (ru) | 2015-10-20 |
CA2790488A1 (en) | 2011-08-25 |
JP2016196457A (ja) | 2016-11-24 |
KR101838763B1 (ko) | 2018-03-14 |
EP4219560A3 (en) | 2023-08-23 |
MX2012009564A (es) | 2013-01-29 |
CA2790488C (en) | 2018-09-25 |
AU2011217848A8 (en) | 2015-09-24 |
US9290572B2 (en) | 2016-03-22 |
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