BR112012018626A8 - novo polimorfo de cloridrato de éster de (4-hdiroxicarbamoil-fenil)-ácido carbâmico (6-dimetilamino metil-2-naftalenil) - Google Patents
novo polimorfo de cloridrato de éster de (4-hdiroxicarbamoil-fenil)-ácido carbâmico (6-dimetilamino metil-2-naftalenil)Info
- Publication number
- BR112012018626A8 BR112012018626A8 BR112012018626A BR112012018626A BR112012018626A8 BR 112012018626 A8 BR112012018626 A8 BR 112012018626A8 BR 112012018626 A BR112012018626 A BR 112012018626A BR 112012018626 A BR112012018626 A BR 112012018626A BR 112012018626 A8 BR112012018626 A8 BR 112012018626A8
- Authority
- BR
- Brazil
- Prior art keywords
- hydroxycarbamoyl
- naphthalenyl
- phenyl
- carbamic acid
- ester hydrochloride
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
- C07C271/26—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a six-membered aromatic ring
- C07C271/28—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a six-membered aromatic ring to a carbon atom of a non-condensed six-membered aromatic ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/27—Esters, e.g. nitroglycerine, selenocyanates of carbamic or thiocarbamic acids, meprobamate, carbachol, neostigmine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Emergency Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Rheumatology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Pain & Pain Management (AREA)
- Transplantation (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
novo polimorfo de cloridrato de éster de (4-hidroxicarbamoil-fenil) - ácido carbâmico (6-dimetilamino metil-2-naftalenil). a se descreve uma nova forma cristalina do cloridrato de éster de (4-hidroxicarbamoil-fenil)-ácido carbâmico (6-dimetilamino metil-2-naftalenil). em particular, descreve-se aqui um polimorfo do cloridrato do éster do (4-hidroxicarbamoil-fenil)-ácido carbâmico (6-dimetilamino metil-2-naftalenil, caracterizado por um espectro de difração de raio x de pó como indicado na figura 1, e/ou por um perfil de dsc como indicado na figura 2, e/ou por um perfil de tga como indicado na figura 3 e/ou por um espectro de ir como indicado na figura 4.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ITMI2010A000121 | 2010-01-28 | ||
| ITMI2010A000121A IT1397912B1 (it) | 2010-01-28 | 2010-01-28 | Nuovo polimorfo dell'estere 6-dietilamminometil-2-naftilico dell'acido 4-idrossicarbamoil-fenil-carbammico cloridrato. |
| PCT/IB2010/055560 WO2011092556A1 (en) | 2010-01-28 | 2010-12-03 | Novel polymorph of the hydrochloride of the (4-hydroxycarbamoyl-phenyl)-carbamic acid (6-dimethylamino methyl-2-naphtalenyl) ester |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| BR112012018626A2 BR112012018626A2 (pt) | 2016-05-03 |
| BR112012018626A8 true BR112012018626A8 (pt) | 2017-12-19 |
| BR112012018626B1 BR112012018626B1 (pt) | 2021-06-08 |
Family
ID=42288805
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112012018626-4A BR112012018626B1 (pt) | 2010-01-28 | 2010-12-03 | Novo polimorfo de cloridrato do éster do (4-hdroxicarbamoil-fenil)-ácido carbâmico (6- dietilamino metil-2-naftalenil) |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US8518988B2 (pt) |
| EP (1) | EP2528599B1 (pt) |
| JP (1) | JP2013518091A (pt) |
| KR (1) | KR101723532B1 (pt) |
| CN (1) | CN102665712B (pt) |
| AU (1) | AU2010344330B2 (pt) |
| BR (1) | BR112012018626B1 (pt) |
| CA (1) | CA2780432C (pt) |
| CY (1) | CY1115409T1 (pt) |
| DK (1) | DK2528599T3 (pt) |
| ES (1) | ES2489467T3 (pt) |
| HK (1) | HK1175699A1 (pt) |
| HR (1) | HRP20140610T1 (pt) |
| IT (1) | IT1397912B1 (pt) |
| MX (1) | MX2012008777A (pt) |
| PL (1) | PL2528599T4 (pt) |
| PT (1) | PT2528599E (pt) |
| RU (1) | RU2552354C2 (pt) |
| SI (1) | SI2528599T1 (pt) |
| WO (1) | WO2011092556A1 (pt) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX349767B (es) * | 2012-02-03 | 2017-08-11 | Italfarmaco Spa | Cloruro de dietil-[6-(4-hidroxicarbamoil-fenil-carbamoiloxi-metil) -naftalen-2-il-metil]-amonio para su uso en el tratamiento de distrofia muscular. |
| ITUB20155193A1 (it) * | 2015-11-03 | 2017-05-03 | Italfarmaco Spa | Sospensioni orali di Givinostat fisicamente e chimicamente stabili |
| IT201900003281A1 (it) * | 2019-03-06 | 2020-09-06 | Chemi Spa | Processo per preparare {6-[(dietilammino)metil]naftalen-2-il}metil [4-(idrossicarbamoil)fenil]carbammato ad elevata purezza |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3574185B2 (ja) * | 1994-09-02 | 2004-10-06 | 小松屋化学株式会社 | 無水クエン酸トリマグネシウムおよびその製法 |
| IT1283637B1 (it) * | 1996-05-14 | 1998-04-23 | Italfarmaco Spa | Composti ad attivita' antinfiammatoria ed immunosoppressiva |
| WO1997046526A1 (en) * | 1996-06-07 | 1997-12-11 | Eisai Co., Ltd. | Stable polymorphs of donepezil (1-benzyl-4-[(5,6-dimethoxy-1-indanon)-2-yl]methylpiperidine) hydrochloride and process for production |
| ITMI20030063A1 (it) * | 2003-01-17 | 2004-07-18 | Italfarmaco Spa | Cloridrato monoidrato dell'estere (6-dietilamminometil-naftalen-2-il)metilico dell'acido (4-idrossicarbammoil-fenil)carbammico. |
| JP2008538581A (ja) * | 2005-04-22 | 2008-10-30 | ワイス | ｛［（２ｒ）−７−（２，６−ジクロロフェニル）−５−フルオロ−２，３−ジヒドロ−１−ベンゾフラン−２−イル］メチル｝アミン塩酸塩の結晶形態 |
| EP1805148A2 (en) * | 2005-08-16 | 2007-07-11 | Teva Pharmaceutical Industries Ltd. | Crystalline rosuvastatin intermediate |
| KR100830003B1 (ko) * | 2006-10-31 | 2008-05-15 | 씨제이제일제당 (주) | 결정성 ｓ-(-)-암로디핀 아디핀산 염 무수물 및 이의 제조방법 |
| EP2185559A1 (en) * | 2007-08-03 | 2010-05-19 | Boehringer Ingelheim International GmbH | Crystalline form of a dihydropteridione derivative |
-
2010
- 2010-01-28 IT ITMI2010A000121A patent/IT1397912B1/it active
- 2010-12-03 RU RU2012134703/04A patent/RU2552354C2/ru active
- 2010-12-03 SI SI201030697T patent/SI2528599T1/sl unknown
- 2010-12-03 MX MX2012008777A patent/MX2012008777A/es active IP Right Grant
- 2010-12-03 AU AU2010344330A patent/AU2010344330B2/en active Active
- 2010-12-03 ES ES10796492.6T patent/ES2489467T3/es active Active
- 2010-12-03 KR KR1020127013835A patent/KR101723532B1/ko active IP Right Grant
- 2010-12-03 CN CN2010800535567A patent/CN102665712B/zh active Active
- 2010-12-03 PT PT107964926T patent/PT2528599E/pt unknown
- 2010-12-03 PL PL10796492T patent/PL2528599T4/pl unknown
- 2010-12-03 BR BR112012018626-4A patent/BR112012018626B1/pt active IP Right Grant
- 2010-12-03 DK DK10796492.6T patent/DK2528599T3/da active
- 2010-12-03 WO PCT/IB2010/055560 patent/WO2011092556A1/en active Application Filing
- 2010-12-03 US US13/575,641 patent/US8518988B2/en active Active
- 2010-12-03 JP JP2012550524A patent/JP2013518091A/ja active Pending
- 2010-12-03 EP EP10796492.6A patent/EP2528599B1/en active Active
- 2010-12-03 CA CA2780432A patent/CA2780432C/en active Active
-
2013
- 2013-03-07 HK HK13102853.7A patent/HK1175699A1/xx unknown
-
2014
- 2014-06-26 HR HRP20140610AT patent/HRP20140610T1/hr unknown
- 2014-08-04 CY CY20141100586T patent/CY1115409T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CN102665712B (zh) | 2013-10-16 |
| EP2528599B1 (en) | 2014-05-21 |
| RU2012134703A (ru) | 2014-03-10 |
| BR112012018626B1 (pt) | 2021-06-08 |
| SI2528599T1 (sl) | 2014-09-30 |
| HK1175699A1 (pt) | 2013-07-12 |
| KR20120123259A (ko) | 2012-11-08 |
| JP2013518091A (ja) | 2013-05-20 |
| PT2528599E (pt) | 2014-07-18 |
| CN102665712A (zh) | 2012-09-12 |
| ITMI20100121A1 (it) | 2011-07-29 |
| EP2528599A1 (en) | 2012-12-05 |
| IT1397912B1 (it) | 2013-02-04 |
| PL2528599T4 (pl) | 2014-11-28 |
| MX2012008777A (es) | 2012-09-07 |
| CA2780432C (en) | 2017-02-21 |
| PL2528599T3 (pl) | 2014-10-31 |
| AU2010344330B2 (en) | 2014-11-13 |
| KR101723532B1 (ko) | 2017-04-06 |
| BR112012018626A2 (pt) | 2016-05-03 |
| DK2528599T3 (da) | 2014-06-30 |
| CY1115409T1 (el) | 2017-01-04 |
| ES2489467T3 (es) | 2014-09-02 |
| WO2011092556A1 (en) | 2011-08-04 |
| US20120302633A1 (en) | 2012-11-29 |
| RU2552354C2 (ru) | 2015-06-10 |
| US8518988B2 (en) | 2013-08-27 |
| HRP20140610T1 (hr) | 2014-08-15 |
| AU2010344330A1 (en) | 2012-05-24 |
| CA2780432A1 (en) | 2011-08-04 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JOP20210065A1 (ar) | عملية لتحضير 5- فلورو-1h- بيرازولوبيريدينات مستبدلة | |
| ZA201401482B (en) | Use of acylsulfonamides for improving plant yield | |
| EP2593983B8 (en) | Anode material, metal secondary battery, and method for production of anode material | |
| HK1184492A1 (zh) | 體細胞至誘導的重編程神經幹細胞 的轉化 | |
| PL2690952T3 (pl) | Kompozycja regulująca wzrost roślin | |
| MY158648A (en) | Compositions for modulating a kinase cascade and methods of use thereof | |
| SG11202109034VA (en) | Fermentative production of carbohydrates by microbial cells utilizing a mixed feedstock | |
| HUE035861T2 (hu) | Egy pleuromutilin kristályos formája | |
| MX2013005069A (es) | Formas cristalinas de sal de clorhidrato de (4a-r, 9a-s)-1-(1h-benzoimidazol-5-carbonil)-2,3,4,4a,9,9a,-hexahidro-1h -indeno[2,1-b]piridin-6-carbonitrilo y su uso como inhibidores de 11 beta-hidroxiesteroide deshidrogenasa 1. | |
| EP2791317A4 (en) | NEW METHOD OF BACTERIA BREEDING TO INCREASE THE CAPACITY OF CAPSULAR POLYESES | |
| LT2525641T (lt) | Augalų sėklų daigumo savybių įvertinimo būdas | |
| EP2463266A4 (en) | PROCESS FOR PRODUCING BIS-QUATERNARY AMMONIUM SALT, AND NOVEL INTERMEDIATE | |
| IN2012DN01342A (pt) | ||
| EP2465293A4 (en) | TRANSFER METHOD FOR MINIMIZING DATA TREATED TO A TARGET NODE | |
| BR112014009775A2 (pt) | composição, método, semente e composto de fórmula 1 | |
| BR112012018626A8 (pt) | novo polimorfo de cloridrato de éster de (4-hdiroxicarbamoil-fenil)-ácido carbâmico (6-dimetilamino metil-2-naftalenil) | |
| MX2011013057A (es) | Metodo para producir derivado de benzotioamida 4-sustituida. | |
| MX2014003883A (es) | Inhibidores de monoacilglicerol lipasa para el tratamiento de enfermedades metabolicas y transtornos relacionados. | |
| EP2192189A4 (en) | PROCESS FOR THE PRODUCTION OF STARCHIC ACID | |
| EP2527297A4 (en) | METHOD FOR THE PRODUCTION OF ZINC TOLUENESULFONATE, ZINC TOLUENESULFONATE AND METHOD FOR THE PRODUCTION OF CARBAMATE | |
| SG11201504058SA (en) | Highly Efficient Production Of Lactic Acid From Hemicellulose Sugars By Newly Isolated Thermophilic Bacillus Coagulans Strains | |
| WO2010146595A3 (en) | Novel polymorphs of flibanserin hydrochloride | |
| ZA201402773B (en) | Use of phenylpyrazolin-3-carboxylates for improving plant yield | |
| ZA201304704B (en) | Indirect substrates for microorganisms metabolizing 1,2-propanediol | |
| PL2658987T3 (pl) | Fermentacyjne wytwarzanie hydroksyanalogu metioniny |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] | ||
| B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
| B07E | Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] |
Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI |
|
| B06T | Formal requirements before examination [chapter 6.20 patent gazette] | ||
| B09A | Decision: intention to grant [chapter 9.1 patent gazette] | ||
| B09X | Republication of the decision to grant [chapter 9.1.3 patent gazette] | ||
| B16A | Patent or certificate of addition of invention granted [chapter 16.1 patent gazette] |
Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 03/12/2010, OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF |