BR112012018587A2 - móleculas de ácido nucleico de influenza e vacinas feitas das mesmas - Google Patents
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- BR112012018587A2 BR112012018587A2 BR112012018587-0A BR112012018587A BR112012018587A2 BR 112012018587 A2 BR112012018587 A2 BR 112012018587A2 BR 112012018587 A BR112012018587 A BR 112012018587A BR 112012018587 A2 BR112012018587 A2 BR 112012018587A2
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| US9238679B2 (en) | 2011-02-11 | 2016-01-19 | The Trustees Of The University Of Pennslyvania | Nucleic acid molecule encoding hepatitis B virus core protein and surface antigen protein and vaccine comprising the same |
| JP6113155B2 (ja) | 2011-06-20 | 2017-04-12 | ユニバーシティ オブ ピッツバーグ − オブ ザ コモンウェルス システム オブ ハイヤー エデュケイション | 計算で最適化した広い反応性を示すｈ１ｎ１インフルエンザの抗原 |
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| RU2018113521A (ru) * | 2012-02-07 | 2019-03-04 | Юниверсити Оф Питтсбург - Оф Зе Коммонвэлс Систем Оф Хайе Эдьюкейшн | Рекомбинантный полипептид гемагглютинин (ha) вируса гриппа для вызова иммунного ответа в отношении вирусов гриппа h2n2 или b |
| EP3305806B1 (en) | 2012-02-13 | 2020-08-26 | University of Pittsburgh - Of the Commonwealth System of Higher Education | Computationally optimized broadly reactive antigens for human and avian h5n1 influenza |
| CA2868330A1 (en) | 2012-03-30 | 2013-10-03 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | Computationally optimized broadly reactive antigens for h5n1 and h1n1 influenza viruses |
| EP3511337A1 (en) | 2012-04-10 | 2019-07-17 | The Trustees of The University of Pennsylvania | Human respiratory syncytial virus concensus antigens, nucleic acid constructs and vaccines made thereform, and methods of using same |
| SG11201503989PA (en) | 2012-11-27 | 2015-06-29 | Univ Pittsburgh | Computationally optimized broadly reactive antigens for h1n1 influenza |
| HK1213481A1 (zh) * | 2012-12-13 | 2016-07-08 | The Trustees Of The University Of Pennsylvania | Dna抗体构建体及其使用方法 |
| KR102877281B1 (ko) | 2012-12-13 | 2025-10-28 | 더 트러스티스 오브 더 유니버시티 오브 펜실베니아 | Ｗｔ１ 백신 |
| EP4154907A1 (en) | 2012-12-18 | 2023-03-29 | Icahn School of Medicine at Mount Sinai | Influenza virus vaccines and uses thereof |
| WO2014159960A1 (en) | 2013-03-14 | 2014-10-02 | Icahn School Of Medicine At Mount Sinai | Antibodies against influenza virus hemagglutinin and uses thereof |
| AU2014240116B2 (en) * | 2013-03-15 | 2016-12-15 | The Trustees Of The University Of Pennsylvania | Mono or multivalent botulinum neurotoxin based vaccine using the heavy chain from serotypes of Clostridium botulinum |
| EP2969005B1 (en) | 2013-03-15 | 2019-10-16 | The Research Foundation for The State University of New York | Attenuated influenza viruses and vaccines |
| US10022434B2 (en) * | 2013-03-15 | 2018-07-17 | The Trustees Of The University Of Pennsylvania | Influenza nucleic acid molecules and vaccines made therefrom |
| WO2015023461A2 (en) * | 2013-08-06 | 2015-02-19 | The Trustees Of The University Of Pennsylvania | Influenza nucleic acid molecules and vaccines made therefrom |
| CA2926025A1 (en) | 2013-10-07 | 2015-04-16 | The Trustees Of The University Of Pennsylvania | Vaccines with interleukin-33 as an adjuvant |
| US10166288B2 (en) * | 2014-10-01 | 2019-01-01 | The Trustees Of The University Of Pennsylvania | Vaccines having an antigen and interleukin-21 as an adjuvant |
| CN107427566B (zh) | 2014-12-01 | 2021-08-17 | 宾夕法尼亚大学理事会 | Dna抗体构建体及其使用方法 |
| JP2018504412A (ja) | 2015-01-23 | 2018-02-15 | アイカーン スクール オブ メディシン アット マウント サイナイ | インフルエンザウイルスワクチン接種レジメン |
| US10925961B2 (en) | 2015-03-20 | 2021-02-23 | The Trustees Of The University Of Pennsylvania | Vaccines with CD40 ligand as an adjuvant |
| AU2017207448A1 (en) * | 2016-01-15 | 2018-07-26 | Etubics Corporation | Methods and compositions for influenza vaccination |
| CN117887735A (zh) | 2016-05-05 | 2024-04-16 | 宾夕法尼亚大学理事会 | 丝状病毒共有抗原、核酸构建体和由其制成的疫苗及其使用方法 |
| CN105999257A (zh) * | 2016-05-11 | 2016-10-12 | 长春海基亚生物技术股份有限公司 | 无针注射流感疫苗系统与应用 |
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| US11254733B2 (en) | 2017-04-07 | 2022-02-22 | Icahn School Of Medicine At Mount Sinai | Anti-influenza B virus neuraminidase antibodies and uses thereof |
| RU2020124143A (ru) | 2017-12-22 | 2022-01-24 | Кодадженикс Инк. | Рекомбинантный вирус с областью деоптимизированной пары кодонов и его применение для лечения рака |
| BR112020018188A2 (pt) | 2018-03-08 | 2021-02-02 | Codagenix Inc. | flavivírus atenuados |
| EP3810634A4 (en) | 2018-06-21 | 2022-07-27 | Icahn School of Medicine at Mount Sinai | Mosaic influenza virus hemagglutinin polypeptides and uses thereof |
| EP3852799A4 (en) * | 2018-09-21 | 2022-10-05 | Board of Regents of the University of Nebraska | METHODS FOR THE PRODUCTION AND USE OF UNIVERSAL CENTRALIZED FLU VACCINE GENES |
| CN111514287A (zh) * | 2020-04-29 | 2020-08-11 | 河南大学 | 甲型流感通用型dna疫苗及其制备方法和应用 |
| KR102818854B1 (ko) * | 2021-07-29 | 2025-06-13 | 주식회사 에스엠엘바이오팜 | 발현 시스템 및 이를 이용한 핵산 기반 백신 |
| CN114854777B (zh) * | 2022-04-15 | 2024-06-25 | 中山大学 | 一种基于优化na序列的广谱流感疫苗及其应用 |
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