BR112012015693A2 - métodos para diagnosticar e tratar doença renal em um canino, para tratar melhorar ou atrasar a progressão de uma doença renal, sonda de ácido nucléico, e, uso de sonda - Google Patents

métodos para diagnosticar e tratar doença renal em um canino, para tratar melhorar ou atrasar a progressão de uma doença renal, sonda de ácido nucléico, e, uso de sonda

Info

Publication number
BR112012015693A2
BR112012015693A2 BR112012015693A BR112012015693A BR112012015693A2 BR 112012015693 A2 BR112012015693 A2 BR 112012015693A2 BR 112012015693 A BR112012015693 A BR 112012015693A BR 112012015693 A BR112012015693 A BR 112012015693A BR 112012015693 A2 BR112012015693 A2 BR 112012015693A2
Authority
BR
Brazil
Prior art keywords
kidney disease
treating
canine
diagnosing
methods
Prior art date
Application number
BR112012015693A
Other languages
English (en)
Other versions
BR112012015693A8 (pt
Inventor
Al-Murrani Samer
Malladi Sukhaswami
Gao Xiangming
Original Assignee
Hills Pet Nutrition Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hills Pet Nutrition Inc filed Critical Hills Pet Nutrition Inc
Publication of BR112012015693A2 publication Critical patent/BR112012015693A2/pt
Publication of BR112012015693A8 publication Critical patent/BR112012015693A8/pt

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/34—Genitourinary disorders
    • G01N2800/347—Renal failures; Glomerular diseases; Tubulointerstitial diseases, e.g. nephritic syndrome, glomerulonephritis; Renovascular diseases, e.g. renal artery occlusion, nephropathy

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • Immunology (AREA)
  • Urology & Nephrology (AREA)
  • General Health & Medical Sciences (AREA)
  • Pathology (AREA)
  • Zoology (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Hematology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • Wood Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Food Science & Technology (AREA)
  • Cell Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

composições e métodos para diagnosticar e tratar doença renal em um canico a presente invenção fornece métodos para: diagnosticar, elaborar e monitorar um plano de tratamento para, e monitorar o estado de uma doença renal caracterizada por uma perda anormal da função renal, falha renal, taxa de filtração glomerular reduzido ou glomerulonefrite, em um canino, em que a doença renal é detectável usando pelo menos um biomarcador relevante isolado e medido de uma amostra de teste biológico tirada de tal canino. a invenção adicionalmente relaciona a composições, reagentes e kits para realizar os métodos específicos.
BR112012015693A 2009-12-23 2010-12-23 métodos para diagnosticar uma doença renal em um canino, para tratar melhorar ou atrasar a progressão de uma doença renal, sonda de ácido nucléico, e, uso de uma sonda BR112012015693A8 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US28977309P 2009-12-23 2009-12-23
PCT/US2010/062031 WO2011079280A2 (en) 2009-12-23 2010-12-23 Compositions and methods for diagnosing and treating kidney disorders in a canine

Publications (2)

Publication Number Publication Date
BR112012015693A2 true BR112012015693A2 (pt) 2018-05-29
BR112012015693A8 BR112012015693A8 (pt) 2018-06-26

Family

ID=43927763

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112012015693A BR112012015693A8 (pt) 2009-12-23 2010-12-23 métodos para diagnosticar uma doença renal em um canino, para tratar melhorar ou atrasar a progressão de uma doença renal, sonda de ácido nucléico, e, uso de uma sonda

Country Status (10)

Country Link
US (1) US9476868B2 (pt)
EP (1) EP2517020B1 (pt)
JP (2) JP6199558B2 (pt)
CN (1) CN102713632B (pt)
AU (1) AU2010336392B2 (pt)
BR (1) BR112012015693A8 (pt)
CA (1) CA2785406A1 (pt)
RU (1) RU2546016C2 (pt)
WO (1) WO2011079280A2 (pt)
ZA (2) ZA201204531B (pt)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5855094B2 (ja) 2010-06-03 2016-02-09 アイデックス ラボラトリーズ インコーポレイテッドＩＤＥＸＸ Ｌａｂｏｒａｔｏｒｉｅｓ， Ｉｎｃ． 腎疾患のためのマーカー
EP2813851B1 (en) * 2011-02-24 2016-06-08 Hill's Pet Nutrition, Inc. Compositions and methods for diagnosing kidney disorders in a feline
US20140309167A1 (en) * 2011-11-09 2014-10-16 Universita ; Degli Studi Bari Combination of active ingredients for the treatment of acute kidney injury
KR101609113B1 (ko) * 2013-11-20 2016-04-05 영동제약 주식회사 신부전증 진단용 키트 및 그 방법
US9976142B2 (en) 2014-04-02 2018-05-22 Nitto Denko Corporation Targeting molecule and a use thereof
NZ745263A (en) * 2016-03-02 2022-07-01 Idexx Lab Inc Methods and compositions for the detection and diagnosis of renal disease and periodontal disease
WO2018094221A1 (en) * 2016-11-18 2018-05-24 Mayo Foundation For Medical Education And Research Assessing and treating fibrillary glomerulonephritis
JP2018096710A (ja) * 2016-12-08 2018-06-21 国立大学法人金沢大学 血中タンパク質を測定することにより、ネフローゼ症候群の疾患活動性を判定する方法
CN109293763B (zh) * 2018-10-26 2021-10-26 中国农业科学院特产研究所 水貂激活素b蛋白及其制备与应用
KR102167792B1 (ko) * 2019-10-01 2020-10-19 대한민국 개의 고칼슘혈증 조기 예측 또는 진단용 조성물
CN111733140B (zh) * 2020-04-04 2022-07-01 华中农业大学 一种抗犬基质金属蛋白酶的杂交瘤细胞株及其制备方法和一种单克隆抗体及其应用

Family Cites Families (47)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS60153762A (ja) 1984-01-24 1985-08-13 Nippon Nousan Kogyo Kk 家畜、家禽用飼料
US4683195A (en) 1986-01-30 1987-07-28 Cetus Corporation Process for amplifying, detecting, and/or-cloning nucleic acid sequences
US4965188A (en) 1986-08-22 1990-10-23 Cetus Corporation Process for amplifying, detecting, and/or cloning nucleic acid sequences using a thermostable enzyme
US4683202A (en) 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
US5333675C1 (en) 1986-02-25 2001-05-01 Perkin Elmer Corp Apparatus and method for performing automated amplification of nucleic acid sequences and assays using heating and cooling steps
US4800159A (en) 1986-02-07 1989-01-24 Cetus Corporation Process for amplifying, detecting, and/or cloning nucleic acid sequences
US5856092A (en) 1989-02-13 1999-01-05 Geneco Pty Ltd Detection of a nucleic acid sequence or a change therein
US5143854A (en) 1989-06-07 1992-09-01 Affymax Technologies N.V. Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof
US6309822B1 (en) 1989-06-07 2001-10-30 Affymetrix, Inc. Method for comparing copy number of nucleic acid sequences
US5800992A (en) 1989-06-07 1998-09-01 Fodor; Stephen P.A. Method of detecting nucleic acids
US5547839A (en) 1989-06-07 1996-08-20 Affymax Technologies N.V. Sequencing of surface immobilized polymers utilizing microflourescence detection
US5744101A (en) 1989-06-07 1998-04-28 Affymax Technologies N.V. Photolabile nucleoside protecting groups
US6040138A (en) 1995-09-15 2000-03-21 Affymetrix, Inc. Expression monitoring by hybridization to high density oligonucleotide arrays
ATE293011T1 (de) 1991-11-22 2005-04-15 Affymetrix Inc A Delaware Corp Kombinatorische strategien für die polymersynthese
US5541061A (en) 1992-04-29 1996-07-30 Affymax Technologies N.V. Methods for screening factorial chemical libraries
US5858659A (en) 1995-11-29 1999-01-12 Affymetrix, Inc. Polymorphism detection
EP0705271B1 (en) 1993-06-25 2002-11-13 Affymetrix, Inc. (a Delaware Corporation) Hybridization and sequencing of nucleic acids
US6156501A (en) 1993-10-26 2000-12-05 Affymetrix, Inc. Arrays of modified nucleic acid probes and methods of use
US5556752A (en) 1994-10-24 1996-09-17 Affymetrix, Inc. Surface-bound, unimolecular, double-stranded DNA
JPH08191668A (ja) 1994-11-18 1996-07-30 Lion Corp ペットフード
US6300063B1 (en) 1995-11-29 2001-10-09 Affymetrix, Inc. Polymorphism detection
US6811995B1 (en) 1996-04-26 2004-11-02 Children's Medical Center Corporation Non-invasive enzyme screen for cancer
CN1226967A (zh) 1996-08-01 1999-08-25 日本化药株式会社 器官移植后慢性排斥反应的检验方法以及尿液组分的测定方法
US6368799B1 (en) 1997-06-13 2002-04-09 Affymetrix, Inc. Method to detect gene polymorphisms and monitor allelic expression employing a probe array
US6333179B1 (en) 1997-06-20 2001-12-25 Affymetrix, Inc. Methods and compositions for multiplex amplification of nucleic acids
AU1287799A (en) 1997-10-31 1999-05-24 Affymetrix, Inc. Expression profiles in adult and fetal organs
US6013449A (en) 1997-11-26 2000-01-11 The United States Of America As Represented By The Department Of Health And Human Services Probe-based analysis of heterozygous mutations using two-color labelling
US6020135A (en) 1998-03-27 2000-02-01 Affymetrix, Inc. P53-regulated genes
DE69909298T2 (de) 1998-09-02 2004-05-27 Heska Corp., Fort Collins Verfahren zur herstellung einer zusammensetzung zum schutz eines fleischfressenden haustieres gegen krankheiten des abnormalen kohlenhydrat-metabolismus
US7763580B2 (en) 1999-01-05 2010-07-27 University Of Utah Research Foundation Methods for treating conditions associated with the accumulation of excess extracellular matrix
US6177248B1 (en) 1999-02-24 2001-01-23 Affymetrix, Inc. Downstream genes of tumor suppressor WT1
US6300070B1 (en) 1999-06-04 2001-10-09 Mosaic Technologies, Inc. Solid phase methods for amplifying multiple nucleic acids
EP1282823B1 (en) 2000-05-17 2014-05-07 Nederlandse Organisatie voor toegepast -natuurwetenschappelijk onderzoek TNO Proteolytic enzymes for the diagnosis of kidney disorders
AU2001281322A1 (en) 2000-07-13 2002-01-30 Biogen, Inc. Methods of identifying renal protective factors
US20030073100A1 (en) 2001-03-30 2003-04-17 Peyman John A. Method of identifying renalgenerative agents using differential gene expression
WO2002085285A2 (en) * 2001-04-18 2002-10-31 Wyeth Methods and reagents for regulating bone and cartilage formation
ATE382060T1 (de) 2001-06-01 2008-01-15 Biogen Idec Inc Moleküle und verfahren zur inhibierung der freisetzung von kim-1
AU2002362055A1 (en) 2001-12-03 2003-06-17 Oncomedx, Inc. Detection of matrix metalloproteinase rna in plasma and serum
AU2003229305A1 (en) 2002-05-17 2003-12-02 Scios, Inc. TREATMENT OF FIBROPROLIFERATIVE DISORDERS USING TGF-Beta INHIBITORS
WO2004005934A2 (en) 2002-07-04 2004-01-15 Oxford Glycosciences (Uk) Ltd Toxicity markers
GB0215509D0 (en) 2002-07-04 2002-08-14 Novartis Ag Marker genes
WO2005002416A2 (en) 2003-06-04 2005-01-13 Joslin Diabetes Center, Inc. Predictors of renal disease
US20090203547A1 (en) * 2005-02-18 2009-08-13 Albert Banes Gene and Cognate Protein Profiles and Methods to Determine Connective Tissue Markers in Normal and Pathologic Conditions
JP2008541696A (ja) * 2005-04-27 2008-11-27 エミリーム インコーポレイテッド 毒物を評価するための新規な方法およびデバイス
US8158107B2 (en) 2005-09-30 2012-04-17 National Jewish Health Genes and proteins associated with angiogenesis and uses thereof
EP1808694A1 (en) * 2006-01-17 2007-07-18 Universitätsklinikum Freiburg Method for diagnosing polycystic kidney disease
TW200728718A (en) 2006-01-20 2007-08-01 Nat Defense Medical Ct Biomarkers for diagnosis of crescentic glomerulonephritis

Also Published As

Publication number Publication date
ZA201204531B (en) 2015-08-26
JP6199558B2 (ja) 2017-09-20
EP2517020A2 (en) 2012-10-31
RU2546016C2 (ru) 2015-04-10
WO2011079280A3 (en) 2011-11-17
AU2010336392B2 (en) 2014-01-23
JP2013515489A (ja) 2013-05-09
CN102713632B (zh) 2015-10-07
BR112012015693A8 (pt) 2018-06-26
US20120283129A1 (en) 2012-11-08
ZA201407857B (en) 2015-04-29
WO2011079280A2 (en) 2011-06-30
JP6174777B2 (ja) 2017-08-02
JP2017079763A (ja) 2017-05-18
US9476868B2 (en) 2016-10-25
CA2785406A1 (en) 2011-06-30
RU2012131367A (ru) 2014-01-27
EP2517020B1 (en) 2015-10-21
CN102713632A (zh) 2012-10-03
AU2010336392A1 (en) 2012-06-21

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B06F Objections, documents and/or translations needed after an examination request according art. 34 industrial property law
B08F Application fees: dismissal - article 86 of industrial property law

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B08K Lapse as no evidence of payment of the annual fee has been furnished to inpi (acc. art. 87)

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