BR112012012815B8 - uso de um composto selecionado de 1-[4-metil-tio-fenil]-3-[3,5-dimetil-4-carbóxi-dimetil-metilóxi-fenil]prop-2-en-1-ona e ácido 2-[2,6-dimetil-4-[3-[4-(metil-tio)fenil]-3-oxo-propil]fenóxi]-2-metilpropanóico - Google Patents

uso de um composto selecionado de 1-[4-metil-tio-fenil]-3-[3,5-dimetil-4-carbóxi-dimetil-metilóxi-fenil]prop-2-en-1-ona e ácido 2-[2,6-dimetil-4-[3-[4-(metil-tio)fenil]-3-oxo-propil]fenóxi]-2-metilpropanóico

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Publication number
BR112012012815B8
BR112012012815B8 BR112012012815A BR112012012815A BR112012012815B8 BR 112012012815 B8 BR112012012815 B8 BR 112012012815B8 BR 112012012815 A BR112012012815 A BR 112012012815A BR 112012012815 A BR112012012815 A BR 112012012815A BR 112012012815 B8 BR112012012815 B8 BR 112012012815B8
Authority
BR
Brazil
Prior art keywords
dimethyl
phenyl
thio
methyl
prop
Prior art date
Application number
BR112012012815A
Other languages
English (en)
Other versions
BR112012012815A2 (pt
BR112012012815A8 (pt
BR112012012815B1 (pt
Inventor
Hum Dean
Dufour Ingrid
Darteil Raphaël
Hanf Rémy
Original Assignee
Genfit
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genfit filed Critical Genfit
Publication of BR112012012815A2 publication Critical patent/BR112012012815A2/pt
Publication of BR112012012815A8 publication Critical patent/BR112012012815A8/pt
Publication of BR112012012815B1 publication Critical patent/BR112012012815B1/pt
Publication of BR112012012815B8 publication Critical patent/BR112012012815B8/pt

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
    • C07C49/782—Ketones containing a keto group bound to a six-membered aromatic ring polycyclic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/216—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acids having aromatic rings, e.g. benactizyne, clofibrate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/28—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

composto derivado de 1,3-difenil-prop-2-en-1-ona, uso do referido composto, e, composição farmacêutica. a invenção se refere a derivados de 1,3-difenil-prop-2-en-1-ona e a composições farmacêuticas compreendendo trais derivados para o tratamento de distúrbios hepáticos, em particular aqueles necessitando da redução do nível plasmático de marcadores bioquímicos, tais como aminotransferases. os derivados de 1,3-difenil-prop-2-en-1-ona de fórmula geral (i) têm propriedades hepatoprotetoras e podem ser usados em métodos para tratar os distúrbios hepáticos envolvendo a perturbação patológica, inflamação, degeneração,e/ou proliferação de células hepáticas, tais como fibrose hepática ou doença do fígado gorduroso.
BR112012012815A 2009-11-26 2010-11-26 uso de um composto selecionado de 1-[4-metil-tio-fenil]-3-[3,5-dimetil-4-carbóxi-dimetil-metilóxi-fenil]prop-2-en-1-ona e ácido 2-[2,6-dimetil-4-[3-[4-(metil-tio)fenil]-3-oxo-propil]fenóxi]-2-metilpropanóico BR112012012815B8 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP09306146 2009-11-26
EP09306146.3 2009-11-26
PCT/EP2010/068346 WO2011064350A1 (en) 2009-11-26 2010-11-26 Use of 1,3-diphenylprop-2-en-1-one derivatives for treating liver disorders

Publications (4)

Publication Number Publication Date
BR112012012815A2 BR112012012815A2 (pt) 2017-12-12
BR112012012815A8 BR112012012815A8 (pt) 2018-02-27
BR112012012815B1 BR112012012815B1 (pt) 2021-02-02
BR112012012815B8 true BR112012012815B8 (pt) 2021-05-25

Family

ID=43587223

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112012012815A BR112012012815B8 (pt) 2009-11-26 2010-11-26 uso de um composto selecionado de 1-[4-metil-tio-fenil]-3-[3,5-dimetil-4-carbóxi-dimetil-metilóxi-fenil]prop-2-en-1-ona e ácido 2-[2,6-dimetil-4-[3-[4-(metil-tio)fenil]-3-oxo-propil]fenóxi]-2-metilpropanóico

Country Status (24)

Country Link
US (2) US8772342B2 (pt)
EP (2) EP2641596B1 (pt)
JP (4) JP5833016B2 (pt)
KR (2) KR101962209B1 (pt)
CN (2) CN102647982B (pt)
AU (1) AU2010323066B2 (pt)
BR (1) BR112012012815B8 (pt)
CA (1) CA2781451C (pt)
CY (2) CY1116548T1 (pt)
DK (2) DK2504005T3 (pt)
EA (1) EA020849B1 (pt)
ES (2) ES2441665T3 (pt)
HK (1) HK1175716A1 (pt)
HU (1) HUE039731T2 (pt)
IL (2) IL219914A (pt)
LT (1) LT2641596T (pt)
MX (1) MX2012006062A (pt)
NZ (1) NZ600439A (pt)
PL (2) PL2641596T3 (pt)
PT (2) PT2641596T (pt)
SI (2) SI2504005T1 (pt)
TR (1) TR201810393T4 (pt)
WO (1) WO2011064350A1 (pt)
ZA (1) ZA201204658B (pt)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9221751B2 (en) 2009-11-26 2015-12-29 Genfit Use of 1,3-diphenylprop-2-en-1-one derivatives for treating liver disorders
US10722575B2 (en) 2009-11-26 2020-07-28 Genfit Use of 1,3-diphenylprop-2-en-1-one derivatives for treating liver disorders
NZ600439A (en) 2009-11-26 2014-06-27 Genfit Use of 1,3-diphenylprop-2-en-1-one derivatives for treating liver disorders
SI2670486T1 (sl) 2011-01-31 2016-09-30 Cadila Healthcare Limited Zydus Tower Satellite Cross Roads Zdravljenje lipodistrofije
PL2948137T3 (pl) * 2013-01-18 2019-02-28 Genfit Sposoby leczenia zwłóknienia i nowotworów
AU2013387996B2 (en) 2013-04-22 2015-12-10 Cadila Healthcare Limited A novel composition for nonalcoholic fatty liver disease (NAFLD)
WO2014195967A2 (en) 2013-05-30 2014-12-11 Cadila Healthcare Limited A process for preparation of pyrroles having hypolipidemic hypocholesteremic activities
TW201636015A (zh) 2013-07-05 2016-10-16 卡地拉保健有限公司 協同性組成物
IN2013MU02470A (pt) 2013-07-25 2015-06-26 Cadila Healthcare Ltd
IN2013MU02905A (pt) 2013-09-06 2015-07-03 Cadila Healthcare Ltd
CN106573058B (zh) 2014-06-13 2020-05-05 伊文蒂瓦公司 用于纤维化疾病的治疗用途的ppar化合物
CR20170356A (es) * 2015-02-06 2018-02-28 Intercept Pharmaceuticals Inc Composiciones farmacéuticas para terapia combinada
EA201890724A1 (ru) * 2015-09-14 2018-10-31 Женфит Способы диагностики и оценки неалкогольного стеатогепатита
US10385017B2 (en) 2015-10-14 2019-08-20 Cadila Healthcare Limited Pyrrole compound, compositions and process for preparation thereof
WO2017143038A1 (en) * 2016-02-16 2017-08-24 Concert Pharmaceuticals, Inc. Deuterated gft-505
US20220133666A1 (en) 2016-03-31 2022-05-05 Genfit Methods of treatment of cholestatic diseases
US11331292B2 (en) 2016-03-31 2022-05-17 Genfit Methods of treatment of cholestatic diseases
CA3018132C (en) * 2016-03-31 2024-02-13 Genfit Use of elafibranor in the treatment of a cholestatic disease
FR3056909B1 (fr) 2016-09-30 2019-04-19 Nashpharm Composition comprenant au moins un sel pharmaceutiquement acceptable d'elafibranor soluble en milieux aqueux presentant une absorption intestinale amelioree
FR3056908B1 (fr) * 2016-09-30 2019-04-19 Nashpharm Sel de metformine et d'elafibranor presentant une activite duale pour le traitement de l'obesite associee a la steato-hepatite non alcoolique (nash) et a l'hypertriglyceridemie
BR112019011740A2 (pt) 2016-12-09 2019-10-29 Cadila Healthcare Ltd composição farmacêutica e método para o tratamento de colangite biliar primária
JP2020505355A (ja) * 2017-01-22 2020-02-20 クリスタル ファーマシューティカル（スーチョウ）カンパニー，リミテッド Ｇｆｔ−５０５の結晶形及びその製造方法並びに用途
EA201991990A1 (ru) 2017-02-24 2020-04-07 Женфит Фармацевтические композиции для комбинированной терапии
MX2019012534A (es) 2017-04-18 2020-08-17 Genfit Combinacion de elafibranor o derivados del mismo con un agente anti-ehna, antifibrotico o anticolestasico.
JP7259850B2 (ja) 2017-11-30 2023-04-18 シチュアン ケルン－バイオテック バイオファーマシューティカル カンパニー リミテッド 芳香族化合物、薬学的組成物及びその使用
TW202019870A (zh) 2018-08-03 2020-06-01 法商Ｇｅｎｆｉｔ公司 艾拉菲諾鹽
BR112021006907A2 (pt) * 2018-10-11 2021-09-08 Basf As Compostos aromáticos e usos farmacêuticos destes
RU2702003C1 (ru) * 2019-03-18 2019-10-03 Федеральное государственное бюджетное образовательное учреждение высшего образования "Санкт-Петербургский государственный химико-фармацевтический университет" Министерства здравоохранения Российской Федерации (ФГБОУ ВО СПХФУ Минздрава России) Антистеатозное средство
EP3952855A1 (en) * 2019-04-10 2022-02-16 Genfit Combination therapy comprising compounds of formula (i) and glp-1 receptor agonists
CN110143890B (zh) * 2019-06-12 2020-12-22 天津科技大学 一种查尔酮衍生物和合成方法及其在制备抗非酒精性脂肪肝炎药物中的应用
CN110143902B (zh) * 2019-06-12 2021-06-04 天津科技大学 含硒查尔酮衍生物Compound 1和合成方法及在抗非酒精性脂肪肝炎药物中的应用
MX2022009778A (es) 2020-02-10 2022-09-09 Genfit Polimorfos de elafibranor.

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH04202129A (ja) 1990-11-30 1992-07-22 Terumo Corp 肝障害治療薬
CZ40996A3 (en) * 1993-08-19 1996-09-11 Warner Lambert Co Substituted derivatives of 2(5h) furanone, 2(5h)-thiophenone or 2(5h) pyrrole and and pharmaceutical composition based thereon
AU2291001A (en) 1999-12-23 2001-07-03 Emory University Chalcone and its analogs as agents for the inhibition of angiogenesis and related disease states
WO2001098291A2 (en) 2000-06-20 2001-12-27 Atherogenics, Inc. 1,3-bis-(substituted-phenyl)-2-propen-1-ones and their use to treat vcam-1 mediated disorders
KR100567125B1 (ko) 2001-11-01 2006-03-31 주식회사 안지오랩 칼콘 또는 이의 유도체를 함유하는 매트릭스메탈로프로테아제 활성 억제용 약학 조성물
FR2841900B1 (fr) 2002-07-08 2007-03-02 Genfit S A Nouveaux derives de 1,3-diphenylprop-2-en-1-one substitues, preparation et utilisations
FR2841784B1 (fr) 2002-07-08 2007-03-02 Composition a base de derives de 1,3-diphenylprop-2en-1-one substitues, preparation et utilisations
FR2857361B1 (fr) 2003-07-08 2005-09-09 Genfit S A PREPARATION DE DERIVES DE 1,3-DIPHENYPROP-2-¼n-1-one
BRPI0506718A (pt) 2004-01-08 2007-05-02 Genfit compostos, processo de preparação dos mesmos, e, composição farmacêutica ou cosmética
JP4689331B2 (ja) 2005-04-19 2011-05-25 三菱電機株式会社 撮像装置
FR2902789A1 (fr) * 2006-06-21 2007-12-28 Genfit Sa Derives de 1,3-diphenylpropane substitues, preparations et utilisations
DE102006062264A1 (de) * 2006-12-22 2008-06-26 Joh. Barth & Sohn Gmbh & Co. Kg Verwendung von Xanthohumol zur Vorbeugung und/oder Bekämpfung von Lebererkrankungen
NZ600439A (en) * 2009-11-26 2014-06-27 Genfit Use of 1,3-diphenylprop-2-en-1-one derivatives for treating liver disorders

Also Published As

Publication number Publication date
PT2641596T (pt) 2018-07-31
BR112012012815A2 (pt) 2017-12-12
ES2681794T3 (es) 2018-09-17
EP2504005B1 (en) 2013-11-06
BR112012012815A8 (pt) 2018-02-27
US20120252725A1 (en) 2012-10-04
EP2641596A1 (en) 2013-09-25
CN102647982B (zh) 2014-10-15
KR20120101472A (ko) 2012-09-13
CN104434891A (zh) 2015-03-25
CN104434891B (zh) 2018-03-30
LT2641596T (lt) 2018-08-10
EA201290389A8 (ru) 2014-05-30
CY1120444T1 (el) 2019-07-10
TR201810393T4 (tr) 2018-08-27
JP5833016B2 (ja) 2015-12-16
ZA201204658B (en) 2013-05-29
WO2011064350A1 (en) 2011-06-03
CN102647982A (zh) 2012-08-22
JP2013512228A (ja) 2013-04-11
JP2016074670A (ja) 2016-05-12
EA201290389A1 (ru) 2013-01-30
DK2641596T3 (en) 2018-08-06
PL2641596T3 (pl) 2018-10-31
MX2012006062A (es) 2012-06-28
KR20180031825A (ko) 2018-03-28
NZ600439A (en) 2014-06-27
DK2504005T3 (da) 2014-01-13
IL219914A (en) 2015-10-29
KR101865677B1 (ko) 2018-07-16
US8895619B2 (en) 2014-11-25
HUE039731T2 (hu) 2019-01-28
PT2504005E (pt) 2014-01-10
BR112012012815B1 (pt) 2021-02-02
US8772342B2 (en) 2014-07-08
IL219914A0 (en) 2012-07-31
ES2441665T3 (es) 2014-02-05
SI2641596T1 (sl) 2018-09-28
AU2010323066B2 (en) 2014-12-11
EA020849B1 (ru) 2015-02-27
JP2020073468A (ja) 2020-05-14
JP2018070642A (ja) 2018-05-10
CY1116548T1 (el) 2017-03-15
IL241791A0 (en) 2015-11-30
AU2010323066A1 (en) 2012-06-07
SI2504005T1 (sl) 2014-04-30
CA2781451C (en) 2019-04-16
CA2781451A1 (en) 2011-06-03
US20140309165A1 (en) 2014-10-16
EP2641596B1 (en) 2018-05-02
PL2504005T3 (pl) 2014-03-31
EP2504005A1 (en) 2012-10-03
KR101962209B1 (ko) 2019-03-26
HK1175716A1 (en) 2013-07-12
JP6594400B2 (ja) 2019-10-23

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