PT2504005E - Utilização de derivados de 1,3-difenilprop-2-en-1-ona para tratamento de doenças hepáticas - Google Patents
Utilização de derivados de 1,3-difenilprop-2-en-1-ona para tratamento de doenças hepáticas Download PDFInfo
- Publication number
- PT2504005E PT2504005E PT107873630T PT10787363T PT2504005E PT 2504005 E PT2504005 E PT 2504005E PT 107873630 T PT107873630 T PT 107873630T PT 10787363 T PT10787363 T PT 10787363T PT 2504005 E PT2504005 E PT 2504005E
- Authority
- PT
- Portugal
- Prior art keywords
- diphenylprop
- derivatives
- treating liver
- liver disorders
- disorders
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
- C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
- C07C49/782—Ketones containing a keto group bound to a six-membered aromatic ring polycyclic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/216—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acids having aromatic rings, e.g. benactizyne, clofibrate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/28—Insulins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Gastroenterology & Hepatology (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Zoology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Child & Adolescent Psychology (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP09306146 | 2009-11-26 |
Publications (1)
Publication Number | Publication Date |
---|---|
PT2504005E true PT2504005E (pt) | 2014-01-10 |
Family
ID=43587223
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PT107873630T PT2504005E (pt) | 2009-11-26 | 2010-11-26 | Utilização de derivados de 1,3-difenilprop-2-en-1-ona para tratamento de doenças hepáticas |
PT131701286T PT2641596T (pt) | 2009-11-26 | 2010-11-26 | Utilização de derivados de 1,3-difenilprop-2-en-1-ona para tratamento de doenças hepáticas |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PT131701286T PT2641596T (pt) | 2009-11-26 | 2010-11-26 | Utilização de derivados de 1,3-difenilprop-2-en-1-ona para tratamento de doenças hepáticas |
Country Status (24)
Country | Link |
---|---|
US (2) | US8772342B2 (pt) |
EP (2) | EP2641596B1 (pt) |
JP (4) | JP5833016B2 (pt) |
KR (2) | KR101865677B1 (pt) |
CN (2) | CN104434891B (pt) |
AU (1) | AU2010323066B2 (pt) |
BR (1) | BR112012012815B8 (pt) |
CA (1) | CA2781451C (pt) |
CY (2) | CY1116548T1 (pt) |
DK (2) | DK2641596T3 (pt) |
EA (1) | EA020849B1 (pt) |
ES (2) | ES2681794T3 (pt) |
HK (1) | HK1175716A1 (pt) |
HU (1) | HUE039731T2 (pt) |
IL (2) | IL219914A (pt) |
LT (1) | LT2641596T (pt) |
MX (1) | MX2012006062A (pt) |
NZ (1) | NZ600439A (pt) |
PL (2) | PL2641596T3 (pt) |
PT (2) | PT2504005E (pt) |
SI (2) | SI2641596T1 (pt) |
TR (1) | TR201810393T4 (pt) |
WO (1) | WO2011064350A1 (pt) |
ZA (1) | ZA201204658B (pt) |
Families Citing this family (32)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9221751B2 (en) | 2009-11-26 | 2015-12-29 | Genfit | Use of 1,3-diphenylprop-2-en-1-one derivatives for treating liver disorders |
SI2641596T1 (sl) * | 2009-11-26 | 2018-09-28 | Genfit | Uporaba 1,3-difenilprop-2-en-1-on derivatov za zdravljenje motenj jeter |
US10722575B2 (en) | 2009-11-26 | 2020-07-28 | Genfit | Use of 1,3-diphenylprop-2-en-1-one derivatives for treating liver disorders |
SG191772A1 (en) | 2011-01-31 | 2013-08-30 | Cadila Healthcare Ltd | Treatment for lipodystrophy |
EA031718B1 (ru) * | 2013-01-18 | 2019-02-28 | Женфит | Лечение фиброза и рака, связанных с тирозинкиназой |
AU2013387996B2 (en) | 2013-04-22 | 2015-12-10 | Cadila Healthcare Limited | A novel composition for nonalcoholic fatty liver disease (NAFLD) |
US20160107989A1 (en) | 2013-05-30 | 2016-04-21 | Cadila Healthcare Limited | A process for preparation of pyrroles having hypolipidemic hypocholesteremic activities |
TW201513857A (zh) | 2013-07-05 | 2015-04-16 | Cadila Healthcare Ltd | 協同性組成物 |
IN2013MU02470A (pt) | 2013-07-25 | 2015-06-26 | Cadila Healthcare Ltd | |
IN2013MU02905A (pt) | 2013-09-06 | 2015-07-03 | Cadila Healthcare Ltd | |
CN106573058B (zh) | 2014-06-13 | 2020-05-05 | 伊文蒂瓦公司 | 用于纤维化疾病的治疗用途的ppar化合物 |
DK3253382T3 (da) * | 2015-02-06 | 2022-02-14 | Intercept Pharmaceuticals Inc | Farmaceutiske sammensætninger til kombinationsterapi |
DK3350341T3 (da) * | 2015-09-14 | 2021-09-27 | Genfit | Fremgangsmåder til diagnosticering og evaluering af non-alkoholisk steatohepatitis |
US10385017B2 (en) | 2015-10-14 | 2019-08-20 | Cadila Healthcare Limited | Pyrrole compound, compositions and process for preparation thereof |
US10442761B2 (en) | 2016-02-16 | 2019-10-15 | Concert Pharmaceuticals, Inc. | Deuterated GFT-505 |
US20220133666A1 (en) | 2016-03-31 | 2022-05-05 | Genfit | Methods of treatment of cholestatic diseases |
IL311687A (en) * | 2016-03-31 | 2024-05-01 | Genfit | Methods for treating gallstone disease |
US11331292B2 (en) | 2016-03-31 | 2022-05-17 | Genfit | Methods of treatment of cholestatic diseases |
FR3056908B1 (fr) * | 2016-09-30 | 2019-04-19 | Nashpharm | Sel de metformine et d'elafibranor presentant une activite duale pour le traitement de l'obesite associee a la steato-hepatite non alcoolique (nash) et a l'hypertriglyceridemie |
FR3056909B1 (fr) | 2016-09-30 | 2019-04-19 | Nashpharm | Composition comprenant au moins un sel pharmaceutiquement acceptable d'elafibranor soluble en milieux aqueux presentant une absorption intestinale amelioree |
BR112019011740A2 (pt) | 2016-12-09 | 2019-10-29 | Cadila Healthcare Ltd | composição farmacêutica e método para o tratamento de colangite biliar primária |
EP3572399A4 (en) * | 2017-01-22 | 2020-01-22 | Crystal Pharmaceutical (Suzhou) Co., Ltd. | CRYSTALLINE FORM OF GFT-505 AND METHOD OF PREPARING AND USING THE SAME |
CN110418641A (zh) * | 2017-02-24 | 2019-11-05 | 基恩菲特公司 | 用于组合疗法的药物组合物 |
EP3612175A1 (en) * | 2017-04-18 | 2020-02-26 | Genfit | Combination of elafibranor or derivatives thereof with an anti-nash, anti-fibrotic or anti-cholestatic agent |
EP3719010B1 (en) | 2017-11-30 | 2023-07-26 | Sichuan Kelun-Biotech Biopharmaceutical Co., Ltd. | Aromatic compound, pharmaceutical composition thereof and use thereof |
TW202019870A (zh) | 2018-08-03 | 2020-06-01 | 法商Genfit公司 | 艾拉菲諾鹽 |
US20210380521A1 (en) * | 2018-10-11 | 2021-12-09 | Basf As | Aromatic compounds and pharmaceutical uses thereof |
RU2702003C1 (ru) * | 2019-03-18 | 2019-10-03 | Федеральное государственное бюджетное образовательное учреждение высшего образования "Санкт-Петербургский государственный химико-фармацевтический университет" Министерства здравоохранения Российской Федерации (ФГБОУ ВО СПХФУ Минздрава России) | Антистеатозное средство |
US20220362187A1 (en) * | 2019-04-10 | 2022-11-17 | Genfit | Combination therapy comprising compounds of formula (i) and glp-1 receptor agonists |
CN110143890B (zh) * | 2019-06-12 | 2020-12-22 | 天津科技大学 | 一种查尔酮衍生物和合成方法及其在制备抗非酒精性脂肪肝炎药物中的应用 |
CN110143902B (zh) * | 2019-06-12 | 2021-06-04 | 天津科技大学 | 含硒查尔酮衍生物Compound 1和合成方法及在抗非酒精性脂肪肝炎药物中的应用 |
BR112022015807A2 (pt) | 2020-02-10 | 2023-03-14 | Genfit | Polimorfos de elafibranor |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH04202129A (ja) | 1990-11-30 | 1992-07-22 | Terumo Corp | 肝障害治療薬 |
KR960703901A (ko) * | 1993-08-19 | 1996-08-31 | 로즈 암스트롱 | 치환된 2(5H)푸라논, 2(5H)티오페논 및 2(5H)피롤론 유도체, 그의 제조 방법 및 엔도텔린 길항제로서의 그의 용도(Substituted 2(5H)Furanone, 2(5H)Thiophenone and 2(5H)Pyrrolone Derivatives, Their Preparation and Their Use as Endothelin antagonists) |
AU2291001A (en) | 1999-12-23 | 2001-07-03 | Emory University | Chalcone and its analogs as agents for the inhibition of angiogenesis and related disease states |
CA2413878A1 (en) * | 2000-06-20 | 2001-12-27 | Atherogenics, Inc. | 1,3-bis-(substituted-phenyl)-2-propen-1-ones and their use to treat vcam-1 mediated disorders |
KR100567125B1 (ko) | 2001-11-01 | 2006-03-31 | 주식회사 안지오랩 | 칼콘 또는 이의 유도체를 함유하는 매트릭스메탈로프로테아제 활성 억제용 약학 조성물 |
FR2841900B1 (fr) * | 2002-07-08 | 2007-03-02 | Genfit S A | Nouveaux derives de 1,3-diphenylprop-2-en-1-one substitues, preparation et utilisations |
FR2841784B1 (fr) | 2002-07-08 | 2007-03-02 | Composition a base de derives de 1,3-diphenylprop-2en-1-one substitues, preparation et utilisations | |
FR2857361B1 (fr) | 2003-07-08 | 2005-09-09 | Genfit S A | PREPARATION DE DERIVES DE 1,3-DIPHENYPROP-2-¼n-1-one |
BRPI0506718A (pt) | 2004-01-08 | 2007-05-02 | Genfit | compostos, processo de preparação dos mesmos, e, composição farmacêutica ou cosmética |
JP4689331B2 (ja) | 2005-04-19 | 2011-05-25 | 三菱電機株式会社 | 撮像装置 |
FR2902789A1 (fr) | 2006-06-21 | 2007-12-28 | Genfit Sa | Derives de 1,3-diphenylpropane substitues, preparations et utilisations |
DE102006062264A1 (de) | 2006-12-22 | 2008-06-26 | Joh. Barth & Sohn Gmbh & Co. Kg | Verwendung von Xanthohumol zur Vorbeugung und/oder Bekämpfung von Lebererkrankungen |
SI2641596T1 (sl) | 2009-11-26 | 2018-09-28 | Genfit | Uporaba 1,3-difenilprop-2-en-1-on derivatov za zdravljenje motenj jeter |
-
2010
- 2010-11-26 SI SI201031723T patent/SI2641596T1/sl unknown
- 2010-11-26 LT LTEP13170128.6T patent/LT2641596T/lt unknown
- 2010-11-26 MX MX2012006062A patent/MX2012006062A/es active IP Right Grant
- 2010-11-26 PT PT107873630T patent/PT2504005E/pt unknown
- 2010-11-26 EP EP13170128.6A patent/EP2641596B1/en active Active
- 2010-11-26 AU AU2010323066A patent/AU2010323066B2/en active Active
- 2010-11-26 KR KR1020127016566A patent/KR101865677B1/ko active IP Right Grant
- 2010-11-26 ES ES13170128.6T patent/ES2681794T3/es active Active
- 2010-11-26 TR TR2018/10393T patent/TR201810393T4/tr unknown
- 2010-11-26 CN CN201410458131.4A patent/CN104434891B/zh active Active
- 2010-11-26 EP EP10787363.0A patent/EP2504005B1/en active Active
- 2010-11-26 DK DK13170128.6T patent/DK2641596T3/en active
- 2010-11-26 PT PT131701286T patent/PT2641596T/pt unknown
- 2010-11-26 NZ NZ600439A patent/NZ600439A/en unknown
- 2010-11-26 EA EA201290389A patent/EA020849B1/ru not_active IP Right Cessation
- 2010-11-26 DK DK10787363.0T patent/DK2504005T3/da active
- 2010-11-26 PL PL13170128T patent/PL2641596T3/pl unknown
- 2010-11-26 HU HUE13170128A patent/HUE039731T2/hu unknown
- 2010-11-26 SI SI201030472T patent/SI2504005T1/sl unknown
- 2010-11-26 JP JP2012540447A patent/JP5833016B2/ja active Active
- 2010-11-26 ES ES10787363.0T patent/ES2441665T3/es active Active
- 2010-11-26 US US13/511,170 patent/US8772342B2/en active Active
- 2010-11-26 CA CA2781451A patent/CA2781451C/en active Active
- 2010-11-26 WO PCT/EP2010/068346 patent/WO2011064350A1/en active Application Filing
- 2010-11-26 BR BR112012012815A patent/BR112012012815B8/pt active IP Right Grant
- 2010-11-26 KR KR1020187008005A patent/KR101962209B1/ko active IP Right Grant
- 2010-11-26 CN CN201080053762.8A patent/CN102647982B/zh active Active
- 2010-11-26 PL PL10787363T patent/PL2504005T3/pl unknown
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2012
- 2012-05-21 IL IL219914A patent/IL219914A/en active IP Right Grant
- 2012-06-22 ZA ZA2012/04658A patent/ZA201204658B/en unknown
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2013
- 2013-03-13 HK HK13103133.7A patent/HK1175716A1/xx unknown
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2014
- 2014-01-07 CY CY20141100010T patent/CY1116548T1/el unknown
- 2014-05-28 US US14/288,482 patent/US8895619B2/en active Active
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2015
- 2015-09-21 IL IL241791A patent/IL241791A0/en active IP Right Grant
- 2015-10-28 JP JP2015212306A patent/JP2016074670A/ja active Pending
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2017
- 2017-12-14 JP JP2017239237A patent/JP6594400B2/ja active Active
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2018
- 2018-07-20 CY CY20181100759T patent/CY1120444T1/el unknown
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2019
- 2019-09-24 JP JP2019173268A patent/JP2020073468A/ja active Pending
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