BR112012010752B1 - Compostos imidazo[1,2-a]piridina - Google Patents
Compostos imidazo[1,2-a]piridina Download PDFInfo
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- BR112012010752B1 BR112012010752B1 BR112012010752-6A BR112012010752A BR112012010752B1 BR 112012010752 B1 BR112012010752 B1 BR 112012010752B1 BR 112012010752 A BR112012010752 A BR 112012010752A BR 112012010752 B1 BR112012010752 B1 BR 112012010752B1
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- 150000005234 imidazo[1,2-a]pyridines Chemical class 0.000 title abstract description 36
- 150000001875 compounds Chemical class 0.000 claims abstract description 116
- -1 imidazo[1,2-a]pyridine compound Chemical class 0.000 claims abstract description 77
- 125000000217 alkyl group Chemical group 0.000 claims description 46
- 125000003118 aryl group Chemical group 0.000 claims description 41
- 125000000753 cycloalkyl group Chemical group 0.000 claims description 36
- 125000001072 heteroaryl group Chemical group 0.000 claims description 28
- 125000000623 heterocyclic group Chemical group 0.000 claims description 25
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 24
- 125000001424 substituent group Chemical group 0.000 claims description 20
- 229910052736 halogen Inorganic materials 0.000 claims description 19
- 150000002367 halogens Chemical class 0.000 claims description 18
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 17
- 150000003839 salts Chemical class 0.000 claims description 15
- 125000000392 cycloalkenyl group Chemical group 0.000 claims description 14
- 125000000547 substituted alkyl group Chemical group 0.000 claims description 14
- 239000000460 chlorine Substances 0.000 claims description 13
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims description 12
- 125000003107 substituted aryl group Chemical group 0.000 claims description 12
- 125000004093 cyano group Chemical group *C#N 0.000 claims description 10
- 125000003545 alkoxy group Chemical group 0.000 claims description 6
- 229910052801 chlorine Inorganic materials 0.000 claims description 6
- 229910052731 fluorine Inorganic materials 0.000 claims description 6
- 125000001624 naphthyl group Chemical group 0.000 claims description 6
- 125000003342 alkenyl group Chemical group 0.000 claims description 5
- 125000000304 alkynyl group Chemical group 0.000 claims description 5
- 229910052794 bromium Inorganic materials 0.000 claims description 5
- 125000000475 sulfinyl group Chemical group [*:2]S([*:1])=O 0.000 claims description 5
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- 229910052740 iodine Inorganic materials 0.000 claims description 4
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- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims description 2
- 125000003386 piperidinyl group Chemical group 0.000 claims 2
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Classifications
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- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
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- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
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- A61P31/04—Antibacterial agents
- A61P31/06—Antibacterial agents for tuberculosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/48—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with two nitrogen atoms as the only ring hetero atoms
- A01N43/50—1,3-Diazoles; Hydrogenated 1,3-diazoles
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- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
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- Medicinal Chemistry (AREA)
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- Chemical Kinetics & Catalysis (AREA)
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- Plant Pathology (AREA)
- Dentistry (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Pulmonology (AREA)
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
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Applications Claiming Priority (4)
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| US25854909P | 2009-11-05 | 2009-11-05 | |
| US61/258.549 | 2009-11-05 | ||
| US61/258,549 | 2009-11-05 | ||
| PCT/US2010/055728 WO2011057145A2 (en) | 2009-11-05 | 2010-11-05 | Imidazo[1,2-a] pyridine compounds, synthesis thereof, and methods of using same |
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| BR112012010752A2 BR112012010752A2 (pt) | 2020-09-15 |
| BR112012010752B1 true BR112012010752B1 (pt) | 2021-07-20 |
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| EP (2) | EP2496578A4 (enExample) |
| CN (3) | CN110483499A (enExample) |
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| RU2576662C2 (ru) * | 2010-03-18 | 2016-03-10 | Энститю Пастер Корея | Противоинфекционные соединения |
| KR20140048079A (ko) | 2011-02-01 | 2014-04-23 | 교와 핫꼬 기린 가부시키가이샤 | 축환 복소환 유도체 |
| WO2012143796A2 (en) * | 2011-04-21 | 2012-10-26 | Institut Pasteur Korea | Anti-inflammation compounds |
| CA2852615A1 (en) | 2011-10-21 | 2013-04-25 | Torrent Pharmaceuticals Limited | Novel substituted imidazopyrimidines as gpbar1 receptor modulators |
| CN104619707A (zh) | 2012-07-31 | 2015-05-13 | 协和发酵麒麟株式会社 | 稠环杂环化合物 |
| WO2015014993A2 (en) * | 2013-08-02 | 2015-02-05 | Institut Pasteur Korea | Anti-infective compounds |
| WO2015143652A1 (en) * | 2014-03-26 | 2015-10-01 | Merck Sharp & Dohme Corp. | TrkA KINASE INHIBITORS,COMPOSITIONS AND METHODS THEREOF |
| CN103965193B (zh) * | 2014-05-30 | 2016-04-06 | 浙江司太立制药股份有限公司 | N-(苯氧烷基)咪唑并[1,2-a]吡啶-3-酰胺类化合物及其制备方法 |
| CN104628721A (zh) * | 2015-01-22 | 2015-05-20 | 湖南华腾制药有限公司 | 一种咪唑并[1,2-a]吡啶衍生物的制备方法 |
| MD3316969T2 (ro) | 2015-07-02 | 2022-07-31 | Janssen Sciences Ireland Unlimited Co | Compuși antibacterieni |
| PE20181352A1 (es) * | 2015-09-17 | 2018-08-22 | Marvin J Miller | Compuestos heterociclicos que contienen bencilamina y composiciones utiles contra infeccion por micobacterias |
| MA45377A (fr) | 2016-06-16 | 2019-04-24 | Janssen Sciences Ireland Unlimited Co | Composés hétérocycliques en tant qu'agents antibacteriens |
| EP3472152A1 (en) * | 2016-06-16 | 2019-04-24 | Janssen Sciences Ireland Unlimited Company | Heterocyclic compounds as antibacte rials |
| CN106588916A (zh) * | 2016-11-21 | 2017-04-26 | 浙江司太立制药股份有限公司 | N‑(苯氧乙基)咪唑并[1,2‑a]吡啶‑3‑酰胺类化合物及其制备方法 |
| JP2020502110A (ja) * | 2016-12-16 | 2020-01-23 | バイエル・アクチエンゲゼルシヤフト | 殺虫剤として使用するためのメソイオン性イミダゾピリジン類 |
| MA47676A (fr) | 2017-03-01 | 2021-06-02 | Janssen Sciences Ireland Unlimited Co | Polythérapie |
| CN108159049B (zh) * | 2018-02-01 | 2021-01-05 | 中国科学院广州生物医药与健康研究院 | 一种吡啶类化合物的新用途 |
| WO2019175737A1 (en) * | 2018-03-12 | 2019-09-19 | University Of Notre Dame Du Lac | Deuterated imidazopyridines |
| CN110759913B (zh) * | 2018-07-26 | 2022-01-28 | 南开大学 | 吲哚酰腙衍生物及其制备方法和在防治植物病毒、杀菌、杀虫方面的应用 |
| CN111662283B (zh) * | 2019-03-07 | 2021-11-16 | 湖南化工研究院有限公司 | 咪唑并吡啶类化合物及其中间体、制备方法与应用 |
| KR20210150405A (ko) * | 2019-04-08 | 2021-12-10 | 피아이 인더스트리스 엘티디. | 식물병원성 진균을 방제 또는 예방하기 위한 신규한 옥사디아졸 화합물 |
| TWI861208B (zh) | 2019-09-10 | 2024-11-11 | 日商鹽野義製藥股份有限公司 | 對分枝桿菌感染有用之含苄胺的 5,6-雜芳族化合物 |
| AU2021283568B2 (en) | 2020-06-02 | 2023-12-14 | Cspc Zhongqi Pharmaceutical Technology (Shijiazhuang) Co., Ltd | 3,4-dihydroisoquinoline compound and use thereof |
| CN115073454B (zh) * | 2022-08-09 | 2024-03-08 | 贵州大学 | 一种咪唑并吡啶-2-噁唑啉类化合物及其制备方法和应用 |
| WO2024161423A1 (en) * | 2023-02-02 | 2024-08-08 | Council Of Scientific And Industrial Research An Indian Registered Body Incorporated Under The Regn. Of Soc. Act (Act Xxi Of 1860) | Small molecules for the treatment of mycobacterial diseases |
| CN117964621A (zh) * | 2024-03-01 | 2024-05-03 | 河北科技大学 | 一种咪唑并吡啶类衍生物及其制备方法和应用 |
| CN117964622B (zh) * | 2024-03-01 | 2026-08-07 | 河北科技大学 | 一种异噁唑类化合物及其制备方法和应用 |
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| EP2496578A2 (en) | 2012-09-12 |
| IL219564A (en) | 2017-01-31 |
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| RU2012122653A (ru) | 2013-12-10 |
| CN102762556B (zh) | 2017-04-26 |
| BR112012010752A2 (pt) | 2020-09-15 |
| WO2011057145A2 (en) | 2011-05-12 |
| US10913737B2 (en) | 2021-02-09 |
| CN106866667A (zh) | 2017-06-20 |
| RU2608611C2 (ru) | 2017-01-23 |
| US9908876B2 (en) | 2018-03-06 |
| HK1248676A1 (en) | 2018-10-19 |
| EP2496578A4 (en) | 2013-08-21 |
| US20180354944A1 (en) | 2018-12-13 |
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