BR112012006679A8 - sistema de síntese de microfluidos radiofarmacêuticos, método para produzir uma quantidade de radiofármaco e sintetizar um radioquímico - Google Patents

sistema de síntese de microfluidos radiofarmacêuticos, método para produzir uma quantidade de radiofármaco e sintetizar um radioquímico

Info

Publication number
BR112012006679A8
BR112012006679A8 BR112012006679A BR112012006679A BR112012006679A8 BR 112012006679 A8 BR112012006679 A8 BR 112012006679A8 BR 112012006679 A BR112012006679 A BR 112012006679A BR 112012006679 A BR112012006679 A BR 112012006679A BR 112012006679 A8 BR112012006679 A8 BR 112012006679A8
Authority
BR
Brazil
Prior art keywords
radiopharmaceutical
production
synthesizing
producing
synthesis
Prior art date
Application number
BR112012006679A
Other languages
English (en)
Other versions
BR112012006679B1 (pt
BR112012006679A2 (pt
Inventor
Mcfarland Aaron
M Giamis Anthony
Nutt Ronald
Original Assignee
Abt Molecular Imaging Inc
Mcfarland Aaron
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abt Molecular Imaging Inc, Mcfarland Aaron filed Critical Abt Molecular Imaging Inc
Publication of BR112012006679A2 publication Critical patent/BR112012006679A2/pt
Publication of BR112012006679A8 publication Critical patent/BR112012006679A8/pt
Publication of BR112012006679B1 publication Critical patent/BR112012006679B1/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0491—Sugars, nucleosides, nucleotides, oligonucleotides, nucleic acids, e.g. DNA, RNA, nucleic acid aptamers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/0006—Controlling or regulating processes
    • B01J19/004—Multifunctional apparatus for automatic manufacturing of various chemical products
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/0093—Microreactors, e.g. miniaturised or microfabricated reactors
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/00788—Three-dimensional assemblies, i.e. the reactor comprising a form other than a stack of plates
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/00873—Heat exchange
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/00891—Feeding or evacuation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/00905—Separation

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Public Health (AREA)
  • Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Optics & Photonics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Veterinary Medicine (AREA)
  • Manufacturing & Machinery (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nuclear Medicine (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)

Abstract

sistema de síntese de microfluidos radiofarmacêuticos, método para produzir uma quantidade de radiofármaco e sintetizar um radioquímico. é descrito um sistema para produção de microfluidos radiofarmacêuticos e processo para sintetizar por corrida aproximadamente de um (1) a quatro (4) doses unitáriasl de um biomarcador radiofarmacêutico para uso em tomografia de emissão de pósitron (pet). o sistema inclui um recipiente de reação que recebe um radioisótopo a partir de um acelerador ou outro gerador de radioisótopo a partir de um acelerador ou outro gerador de radiosótopo. reagentes aquosos e orgânicos são introduzidos no recipiente da reação, e a mistura é aquecida para sintetizar a solução de um radiofármaco pré-selecionado. a solução radiofarmacêutica é passada através de uma coluna de extração sólida e um filtro para purificação. o processo de síntese reduz gasto e permite a produção. o processo de síntese reduz gasto e permite a produção de radiofármaco de acordo com a necessidade. o processo de síntese permite a produção no local e próximo ao local onde a dose unitária irá ser administrada ao paciente, que reduz o tempo entre sínteses e administração, por causa disso minimizando a perda de isótopos ativos através da desintegração e permitindo a produção da menor quantidade de radioisótopos total.
BR112012006679-0A 2009-09-23 2010-09-21 sistema para síntese de um radiofármaco microfluido BR112012006679B1 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US12/565,544 2009-09-23
US12/565,544 US8333952B2 (en) 2009-09-23 2009-09-23 Dose synthesis module for biomarker generator system
PCT/US2010/002577 WO2011037615A1 (en) 2009-09-23 2010-09-21 Chemical production module and dose synthesis card for pet biomarker production system

Publications (3)

Publication Number Publication Date
BR112012006679A2 BR112012006679A2 (pt) 2016-05-10
BR112012006679A8 true BR112012006679A8 (pt) 2018-01-23
BR112012006679B1 BR112012006679B1 (pt) 2021-04-20

Family

ID=43756796

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112012006679-0A BR112012006679B1 (pt) 2009-09-23 2010-09-21 sistema para síntese de um radiofármaco microfluido

Country Status (11)

Country Link
US (1) US8333952B2 (pt)
EP (1) EP2480258B1 (pt)
JP (1) JP2013505294A (pt)
AU (1) AU2010298725B2 (pt)
BR (1) BR112012006679B1 (pt)
CA (1) CA2775034A1 (pt)
CO (1) CO6541527A2 (pt)
MX (1) MX2012003572A (pt)
NZ (1) NZ599555A (pt)
RU (1) RU2541254C2 (pt)
WO (1) WO2011037615A1 (pt)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11135321B2 (en) 2009-09-23 2021-10-05 Best Medical International, Inc. Automated radiopharmaceutical production and quality control system
US10109385B2 (en) 2009-09-23 2018-10-23 Abt Molecular Imaging, Inc. Dose synthesis card for use with automated biomarker production system
CN103974762A (zh) * 2011-09-30 2014-08-06 通用电气健康护理有限公司 用于多步放射化学的反应器
EP2650681B1 (en) * 2012-04-13 2015-12-30 ABT Molecular Imaging, Inc. Radiopharmaceutical production system and quality control system utilizing high performance liquid chromatography
US8937287B2 (en) 2012-04-19 2015-01-20 Abt Molecular Imaging, Inc. Self-referencing radiation detector for use with a radiopharmaceutical quality control testing system
US9192934B2 (en) 2012-10-25 2015-11-24 General Electric Company Insert assembly for a microfluidic device
US9399216B2 (en) * 2013-12-30 2016-07-26 General Electric Company Fluid transport in microfluidic applications with sensors for detecting fluid presence and pressure
JP6408223B2 (ja) 2014-01-31 2018-10-17 株式会社日立製作所 医薬品提供システムおよび医薬品提供方法
JP2017528509A (ja) * 2014-06-06 2017-09-28 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア 自己遮蔽ベンチトップ型ケミストリシステム
GB201418893D0 (en) 2014-10-23 2014-12-10 Univ Hull Monolithic body
GB201418897D0 (en) * 2014-10-23 2014-12-10 Univ Hull Methods and apparatus for the analysis of compounds
GB201418899D0 (en) 2014-10-23 2014-12-10 Univ Hull System for radiopharmaceutical production
WO2016130463A1 (en) * 2015-02-10 2016-08-18 Abt Molecular Imaging, Inc. Automated radiopharmaceutical production and quality control system
CN107530455A (zh) * 2015-02-10 2018-01-02 Abt分子成像公司 与自动化生物标记物生产系统联用的剂量合成卡
US11426489B2 (en) 2015-06-10 2022-08-30 Globus Medical, Inc. Biomaterial compositions, implants, and methods of making the same
EP3192583A1 (en) 2016-01-12 2017-07-19 ETH Zurich Apparatus and process for the automated chemical synthesis of compounds
US10344314B2 (en) 2016-05-04 2019-07-09 Curium Us Llc Systems and methods for sterility testing of radionuclide generator column assemblies
KR101903695B1 (ko) * 2016-11-28 2018-10-04 가천대학교 산학협력단 고온 불활성 기체를 이용한 불소-18 화합물 합성장치
US20180209921A1 (en) * 2017-01-20 2018-07-26 Mallinckrodt Nuclear Medicine Llc Systems and methods for assaying an eluate of a radionuclide generator
FR3072301B1 (fr) * 2017-10-18 2022-01-07 P M B Cassette microfluidique de synthese d'un radio-traceur et procede de synthese d'un radio-traceur avec une telle cassette
RU2689399C1 (ru) * 2018-06-19 2019-05-28 ВАВИЛИН Андрей Владимирович Умножитель нейтронов
CN113447578A (zh) * 2021-05-24 2021-09-28 华东理工大学 一种磁性固相萃取微流控芯片-质谱联用装置及其应用

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2006527367A (ja) * 2003-04-22 2006-11-30 モレキュラー テクノロジーズ インコーポレイテッド Ｆｄｇ等の分子画像化プローブを合成するためのシステム及び方法
US20050232861A1 (en) * 2004-04-20 2005-10-20 Buchanan Charles R Microfluidic apparatus and method for synthesis of molecular imaging probes including FDG
WO2006071470A2 (en) * 2004-12-03 2006-07-06 California Institute Of Technology Microfluidic devices with chemical reaction circuits
GB0520529D0 (en) * 2005-10-10 2005-11-16 Ge Healthcare Ltd Automated radiolabelling method
US7476883B2 (en) * 2006-05-26 2009-01-13 Advanced Biomarker Technologies, Llc Biomarker generator system
US7884340B2 (en) * 2006-05-26 2011-02-08 Advanced Biomarker Technologies, Llc Low-volume biomarker generator
US7741121B2 (en) * 2006-08-24 2010-06-22 Siemens Medical Solutions Usa, Inc. System for purification and analysis of radiochemical products yielded by microfluidic synthesis devices
US9326742B2 (en) * 2007-01-01 2016-05-03 Bayer Healthcare Llc Systems for integrated radiopharmaceutical generation, preparation, transportation and administration
WO2008091694A2 (en) * 2007-01-23 2008-07-31 Siemens Medical Solutions Usa, Inc. Fully-automated microfluidic system for the synthesis of radiolabeled biomarkers for positron emission tomography
US8071035B2 (en) * 2007-04-12 2011-12-06 Siemens Medical Solutions Usa, Inc. Microfluidic radiosynthesis system for positron emission tomography biomarkers
US8214159B2 (en) * 2008-12-04 2012-07-03 Siemens Medical Solutions Usa, Inc. Apparatus and method for automated quality control
EP2606334B1 (en) * 2010-08-20 2018-04-25 GE Healthcare Limited Quality control cassette and method for radiopharmaceuticals

Also Published As

Publication number Publication date
BR112012006679B1 (pt) 2021-04-20
CO6541527A2 (es) 2012-10-16
CA2775034A1 (en) 2011-03-31
AU2010298725A1 (en) 2012-04-12
MX2012003572A (es) 2012-10-09
NZ599555A (en) 2013-10-25
AU2010298725B2 (en) 2016-11-03
US20110070160A1 (en) 2011-03-24
BR112012006679A2 (pt) 2016-05-10
RU2541254C2 (ru) 2015-02-10
RU2012116143A (ru) 2013-10-27
EP2480258A1 (en) 2012-08-01
EP2480258B1 (en) 2021-07-21
WO2011037615A1 (en) 2011-03-31
US8333952B2 (en) 2012-12-18
JP2013505294A (ja) 2013-02-14
EP2480258A4 (en) 2017-03-22

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Legal Events

Date Code Title Description
B11A Dismissal acc. art.33 of ipl - examination not requested within 36 months of filing
B04C Request for examination: application reinstated [chapter 4.3 patent gazette]
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07G Grant request does not fulfill article 229-c lpi (prior consent of anvisa) [chapter 7.7 patent gazette]

Free format text: NOTIFICACAO DE DEVOLUCAO DO PEDIDO POR NAO SE ENQUADRAR NO ART. 229-C DA LPI.

B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B25A Requested transfer of rights approved

Owner name: ABT MOLECULAR IMAGING, INC. (US)

B25A Requested transfer of rights approved

Owner name: BEST ABT, INC. (US)

B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 21/09/2010, OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME MEDIDA CAUTELAR DE 07/04/2021 - ADI 5.529/DF

B21F Lapse acc. art. 78, item iv - on non-payment of the annual fees in time

Free format text: REFERENTE A 12A ANUIDADE.

B24J Lapse because of non-payment of annual fees (definitively: art 78 iv lpi, resolution 113/2013 art. 12)

Free format text: EM VIRTUDE DA EXTINCAO PUBLICADA NA RPI 2688 DE 12-07-2022 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDA A EXTINCAO DA PATENTE E SEUS CERTIFICADOS, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.