WO2006028620A8 - Medical radioisotopes and methods for producing the same - Google Patents

Medical radioisotopes and methods for producing the same

Info

Publication number
WO2006028620A8
WO2006028620A8 PCT/US2005/027558 US2005027558W WO2006028620A8 WO 2006028620 A8 WO2006028620 A8 WO 2006028620A8 US 2005027558 W US2005027558 W US 2005027558W WO 2006028620 A8 WO2006028620 A8 WO 2006028620A8
Authority
WO
WIPO (PCT)
Prior art keywords
molybdenum
producing
technetium
methods
same
Prior art date
Application number
PCT/US2005/027558
Other languages
French (fr)
Other versions
WO2006028620A3 (en
WO2006028620A2 (en
Inventor
Robert E Schenter
Dennis W Wester
Glen W Hollenberg
Brian M Rapko
Gregg J Lumetta
Original Assignee
Battelle Memorial Institute
Robert E Schenter
Dennis W Wester
Glen W Hollenberg
Brian M Rapko
Gregg J Lumetta
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Battelle Memorial Institute, Robert E Schenter, Dennis W Wester, Glen W Hollenberg, Brian M Rapko, Gregg J Lumetta filed Critical Battelle Memorial Institute
Priority to US11/659,394 priority Critical patent/US8126104B2/en
Publication of WO2006028620A2 publication Critical patent/WO2006028620A2/en
Publication of WO2006028620A3 publication Critical patent/WO2006028620A3/en
Publication of WO2006028620A8 publication Critical patent/WO2006028620A8/en

Links

Classifications

    • G—PHYSICS
    • G21—NUCLEAR PHYSICS; NUCLEAR ENGINEERING
    • G21G—CONVERSION OF CHEMICAL ELEMENTS; RADIOACTIVE SOURCES
    • G21G4/00—Radioactive sources
    • G21G4/04—Radioactive sources other than neutron sources
    • G21G4/06—Radioactive sources other than neutron sources characterised by constructional features
    • G21G4/08—Radioactive sources other than neutron sources characterised by constructional features specially adapted for medical application
    • G—PHYSICS
    • G21—NUCLEAR PHYSICS; NUCLEAR ENGINEERING
    • G21G—CONVERSION OF CHEMICAL ELEMENTS; RADIOACTIVE SOURCES
    • G21G1/00—Arrangements for converting chemical elements by electromagnetic radiation, corpuscular radiation or particle bombardment, e.g. producing radioactive isotopes
    • G21G1/001—Recovery of specific isotopes from irradiated targets
    • G—PHYSICS
    • G21—NUCLEAR PHYSICS; NUCLEAR ENGINEERING
    • G21G—CONVERSION OF CHEMICAL ELEMENTS; RADIOACTIVE SOURCES
    • G21G1/00—Arrangements for converting chemical elements by electromagnetic radiation, corpuscular radiation or particle bombardment, e.g. producing radioactive isotopes
    • G21G1/04—Arrangements for converting chemical elements by electromagnetic radiation, corpuscular radiation or particle bombardment, e.g. producing radioactive isotopes outside nuclear reactors or particle accelerators
    • G21G1/10—Arrangements for converting chemical elements by electromagnetic radiation, corpuscular radiation or particle bombardment, e.g. producing radioactive isotopes outside nuclear reactors or particle accelerators by bombardment with electrically charged particles
    • G—PHYSICS
    • G21—NUCLEAR PHYSICS; NUCLEAR ENGINEERING
    • G21G—CONVERSION OF CHEMICAL ELEMENTS; RADIOACTIVE SOURCES
    • G21G1/00—Arrangements for converting chemical elements by electromagnetic radiation, corpuscular radiation or particle bombardment, e.g. producing radioactive isotopes
    • G21G1/001—Recovery of specific isotopes from irradiated targets
    • G21G2001/0036—Molybdenum
    • G—PHYSICS
    • G21—NUCLEAR PHYSICS; NUCLEAR ENGINEERING
    • G21G—CONVERSION OF CHEMICAL ELEMENTS; RADIOACTIVE SOURCES
    • G21G1/00—Arrangements for converting chemical elements by electromagnetic radiation, corpuscular radiation or particle bombardment, e.g. producing radioactive isotopes
    • G21G1/001—Recovery of specific isotopes from irradiated targets
    • G21G2001/0042—Technetium

Abstract

This disclosure concerns a new method for preparing radioisotopes, such as molybdenum-99, by alpha particle irradiation, such as by alpha particle irradiation of zirconium-96. Molybdenum-99 is a precursor to the medically-significant radioisotope technetium-99m. Also disclosed are novel compositions containing one or more of technetium-99m, molybdenum-99 and zirconium species. Systems for producing molybdenum-99 and technetium-99m, including alpha particle generators and irradiation targets, also are described.
PCT/US2005/027558 2004-08-02 2005-08-02 Medical radioisotopes and methods for producing the same WO2006028620A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
US11/659,394 US8126104B2 (en) 2004-08-02 2005-08-02 Medical radioisotopes and methods for producing the same

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10/911,407 US20060023829A1 (en) 2004-08-02 2004-08-02 Medical radioisotopes and methods for producing the same
US10/911,407 2004-08-02

Publications (3)

Publication Number Publication Date
WO2006028620A2 WO2006028620A2 (en) 2006-03-16
WO2006028620A3 WO2006028620A3 (en) 2006-08-17
WO2006028620A8 true WO2006028620A8 (en) 2008-10-02

Family

ID=35652288

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2005/027558 WO2006028620A2 (en) 2004-08-02 2005-08-02 Medical radioisotopes and methods for producing the same

Country Status (2)

Country Link
US (2) US20060023829A1 (en)
WO (1) WO2006028620A2 (en)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7700926B2 (en) * 2006-01-12 2010-04-20 Draximage General Partnership Systems and methods for radioisotope generation
US20070158271A1 (en) * 2006-01-12 2007-07-12 Draxis Health Inc. Systems and Methods for Radioisotope Generation
EP2142284A4 (en) * 2007-03-31 2015-12-23 Advanced Applied Physics Solutions Inc Method and apparatus for isolating 186rhenium
RU2494484C2 (en) 2008-05-02 2013-09-27 Шайн Медикал Текнолоджис, Инк. Production device and method of medical isotopes
EP2131369A1 (en) * 2008-06-06 2009-12-09 Technische Universiteit Delft A process for the production of no-carrier added 99Mo
US20100290575A1 (en) * 2009-05-15 2010-11-18 Rosenthal Glenn B Particle beam isotope generator apparatus, system and method
US9587292B2 (en) * 2009-10-01 2017-03-07 Advanced Applied Physics Solutions, Inc. Method and apparatus for isolating the radioisotope molybdenum-99
US9196388B2 (en) 2009-12-07 2015-11-24 Varian Medical Systems, Inc. System and method for generating molybdenum-99 and metastable technetium-99, and other isotopes
WO2012003009A2 (en) 2010-01-28 2012-01-05 Shine Medical Technologies, Inc. Segmented reaction chamber for radioisotope production
DE102010006435B3 (en) * 2010-02-01 2011-07-21 Siemens Aktiengesellschaft, 80333 Method and apparatus for the production of 99mTc
US9177679B2 (en) * 2010-02-11 2015-11-03 Uchicago Argonne, Llc Accelerator-based method of producing isotopes
US8450629B2 (en) * 2010-05-10 2013-05-28 Los Alamos National Security, Llc Method of producing molybdenum-99
EP2398023A1 (en) 2010-06-21 2011-12-21 The European Union, represented by the European Commission Production of molybdenum-99
ITBO20100484A1 (en) * 2010-07-29 2012-01-30 Phizero S R L METHOD AND DEVICE FOR METASTABLE TECHNICAL PRODUCTION-99
US10734126B2 (en) 2011-04-28 2020-08-04 SHINE Medical Technologies, LLC Methods of separating medical isotopes from uranium solutions
JP5817977B2 (en) * 2011-08-08 2015-11-18 国立研究開発法人日本原子力研究開発機構 Method for producing technetium-99m solution having high concentration and high radioactivity
WO2013187974A2 (en) 2012-04-05 2013-12-19 Shine Medical Technologies, Inc. Aqueous assembly and control method
US9576690B2 (en) 2012-06-15 2017-02-21 Dent International Research, Inc. Apparatus and methods for transmutation of elements
US9997267B2 (en) 2013-02-13 2018-06-12 Battelle Memorial Institute Nuclear reactor target assemblies, nuclear reactor configurations, and methods for producing isotopes, modifying materials within target material, and/or characterizing material within a target material
US9449726B2 (en) 2013-05-31 2016-09-20 Washington University 100Mo compounds as accelerator targets for production of 99mTc
CN111164709B (en) * 2017-10-31 2023-10-31 国立研究开发法人量子科学技术研究开发机构 Method and apparatus for producing radioisotope
US20220153607A1 (en) 2019-03-21 2022-05-19 Technische Universität München Preparation of metal fluorides and separation processes
HUP2000235A1 (en) * 2020-07-16 2022-01-28 Syniq Kft Method and apparatus for metallic radioisotope production

Family Cites Families (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2887357A (en) * 1944-11-03 1959-05-19 Glenn T Seaborg Dry fluorine separation method
US3519385A (en) * 1968-03-12 1970-07-07 Atomic Energy Commission Method for separating molybdenum from technetium
US3940318A (en) * 1970-12-23 1976-02-24 Union Carbide Corporation Preparation of a primary target for the production of fission products in a nuclear reactor
US3799883A (en) * 1971-06-30 1974-03-26 Union Carbide Corp Production of high purity fission product molybdenum-99
NL165872C (en) * 1973-02-20 1981-05-15 Byk Mallinckrodt Cil Bv ISOTOPE GENERATOR FOR THE PRODUCTION OF LIQUIDS CONTAINING 99M TC.
US4158700A (en) * 1976-03-08 1979-06-19 Karageozian Hampar L Method of producing radioactive technetium-99M
US4123498A (en) * 1977-02-17 1978-10-31 General Electric Company Process for separating fission product molybdenum from an irradiated target material
US4206358A (en) * 1977-10-19 1980-06-03 Australian Atomic Energy Commission Technetium-99 generators
DE2800496A1 (en) * 1978-01-05 1979-07-19 Heyden Chem Fab RADIONUCLID GENERATOR
US4284472A (en) * 1978-10-16 1981-08-18 General Electric Company Method for enhanced control of radioiodine in the production of fission product molybdenum 99
US4567025A (en) * 1983-07-28 1986-01-28 Westinghouse Electric Corp. Chemical separation method for uranium isotopes
US4634864A (en) * 1983-10-27 1987-01-06 Atom Sciences, Inc. Ultrasensitive method for measuring isotope abundance ratios
CS255601B1 (en) * 1984-05-18 1988-03-15 Kristian Svoboda 99 mtc elution unit-built generator and method of its production
DE3531355A1 (en) * 1985-09-03 1987-03-12 Hoechst Ag TECHNETIUM 99M GENERATOR, ITS PRODUCTION AND USE
DD272726A1 (en) * 1988-05-30 1989-10-18 Akad Wissenschaften Ddr METHOD FOR OBTAINING RADIONUCLIDICALLY PURE SCANDIUM-43
JPH07122136B2 (en) * 1990-05-10 1995-12-25 株式会社日立製作所 Ion beam sputtering device and operating method
US5167938A (en) * 1991-08-14 1992-12-01 United States Department Of Energy Process for strontium-82 separation
US5512256A (en) * 1992-05-08 1996-04-30 Battelle Memorial Institute Method of separation of yttrium-90 from strontium-90
GB2282478B (en) * 1993-10-01 1997-08-13 Us Energy Method of fabricating 99Mo production targets using low enriched uranium
US5784423A (en) * 1995-09-08 1998-07-21 Massachusetts Institute Of Technology Method of producing molybdenum-99
US6208704B1 (en) * 1995-09-08 2001-03-27 Massachusetts Institute Of Technology Production of radioisotopes with a high specific activity by isotopic conversion
WO1997020620A1 (en) * 1995-12-07 1997-06-12 The Regents Of The University Of California Improvements in method and apparatus for isotope enhancement in a plasma apparatus
US5764715A (en) * 1996-02-20 1998-06-09 Sandia Corporation Method and apparatus for transmutation of atomic nuclei
US5774782A (en) * 1996-05-22 1998-06-30 Lockheed Martin Energy Systems, Inc. Technetium-99m generator system
US5848100A (en) * 1996-05-28 1998-12-08 Matsushita Electric Industrial Co., Ltd. Frequency conversion and modulation circuits
JP3665682B2 (en) * 1996-06-21 2005-06-29 日本山村硝子株式会社 Method for producing fluoride thin film
US5782742A (en) * 1997-01-31 1998-07-21 Cardiovascular Dynamics, Inc. Radiation delivery balloon
US5802439A (en) * 1997-02-19 1998-09-01 Lockheed Martin Idaho Technologies Company Method for the production of 99m Tc compositions from 99 Mo-containing materials
US6907106B1 (en) * 1998-08-24 2005-06-14 Varian Medical Systems, Inc. Method and apparatus for producing radioactive materials for medical treatment using x-rays produced by an electron accelerator
US6157036A (en) * 1998-12-02 2000-12-05 Cedars-Sinai Medical Center System and method for automatically eluting and concentrating a radioisotope
WO2000056428A2 (en) * 1999-03-24 2000-09-28 The Regents Of The University Of Michigan Method for laser induced isotope enrichment
MXPA02008280A (en) * 2000-02-23 2004-04-05 Univ Alberta The University Of System and method for the production of 18.
US6998052B2 (en) 2002-04-12 2006-02-14 Pg Research Foundation Multicolumn selectivity inversion generator for production of ultrapure radionuclides
US6751280B2 (en) * 2002-08-12 2004-06-15 Ut-Battelle, Llc Method of preparing high specific activity platinum-195m

Also Published As

Publication number Publication date
WO2006028620A3 (en) 2006-08-17
US20090060812A1 (en) 2009-03-05
US8126104B2 (en) 2012-02-28
US20060023829A1 (en) 2006-02-02
WO2006028620A2 (en) 2006-03-16

Similar Documents

Publication Publication Date Title
WO2006028620A3 (en) Medical radioisotopes and methods for producing the same
IL181529A (en) Method for radiofluorination, a radiofluorinated compound and its use for the manufacture of a radiopharmaceutical
DE60140219D1 (en) RADIO-PHARMACEUTICAL FORMULATIONS
BRPI0519913A2 (en) methods of producing metallic titanium, making metallic titanium powder, preparing a titanium artifact and recovering titanium, and titanium powder
WO2007042781A3 (en) Automated method for preparing technetium complexes
PL1891004T3 (en) Pentafluorosulphanyl-substituted compound and its use for producing medicaments
ATE443539T1 (en) CONVERTIBLE RADIOTHERAPY DEVICE AND METHOD OF MANUFACTURING
BR112012006679A8 (en) radiopharmaceutical microfluidics synthesis system, method for producing a quantity of radiopharmaceutical and synthesizing a radiochemical
IL178877A0 (en) Activatable particles, preparations and uses
WO2006055294A3 (en) Methods and apparatus for energy conversion using materials comprising molecular deuterium and molecular hydrogen-deuterium
UA92894C2 (en) Method for the producing and use of phosphate adsorbent composition, phosphate adsorbent, and the composition therein
CA2331211A1 (en) Method for producing ac-225 by irradiation of ra-226 with protons
WO2007013060A3 (en) A radioactive surface source and a method for producing the same
WO2006096206A3 (en) Method for preparing particles of radioactive powder containing cesium-131 for use in brachytherapy sources
WO2012097116A3 (en) Isotopologues of isoindole derivatives
TW200725181A (en) Positive resist composition and pattern forming method using the same
WO2013027207A9 (en) Molybdenum-converter based electron linear accelerator and method for producing radioisotopes
MX2010005015A (en) Methods for preparing capecitabine and beta-anomer-rich trialkyl carbonate compound used therein.
DE60334382D1 (en) METHOD FOR PRODUCING TEMPERATURE-INDUCED TUMOR CELL LYSATES FOR USE AS IMMUNOGENIC COMPOUNDS
MX2012014378A (en) A cellulose based sustained release macronutrient composition for fertilizer application.
WO2005072781A3 (en) Method and kit for the production of particles labelled with rhenium-188
WO2006037988A3 (en) Novel technetium and rhenium complexes, ligands used in their preparation and their use as radiopharmaceuticals
WO2004109716A3 (en) Method for producing a gamma radiation source
HK1096581A1 (en) Prosthetic groups attached to stannyl polymer in the synthesis of radiopharmaceuticals
MY141805A (en) Radioactive arsenic-containing compounds and their uses in the treatment of tumors

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BW BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE EG ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KM KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NA NG NI NO NZ OM PG PH PL PT RO RU SC SD SE SG SK SL SM SY TJ TM TN TR TT TZ UA UG US UZ VC VN YU ZA ZM ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): BW GH GM KE LS MW MZ NA SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LT LU LV MC NL PL PT RO SE SI SK TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase
WWE Wipo information: entry into national phase

Ref document number: 11659394

Country of ref document: US