BR112012005280B8 - Polímero e composição farmacêutica - Google Patents
Polímero e composição farmacêuticaInfo
- Publication number
- BR112012005280B8 BR112012005280B8 BR112012005280A BR112012005280A BR112012005280B8 BR 112012005280 B8 BR112012005280 B8 BR 112012005280B8 BR 112012005280 A BR112012005280 A BR 112012005280A BR 112012005280 A BR112012005280 A BR 112012005280A BR 112012005280 B8 BR112012005280 B8 BR 112012005280B8
- Authority
- BR
- Brazil
- Prior art keywords
- pharmaceutical composition
- polymer
- cr2r3
- monomer
- polymerization
- Prior art date
Links
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 3
- 229920000642 polymer Polymers 0.000 title abstract 3
- 239000004971 Cross linker Substances 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 229920001400 block copolymer Polymers 0.000 abstract 1
- 239000000178 monomer Substances 0.000 abstract 1
- 238000006116 polymerization reaction Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/58—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. poly[meth]acrylate, polyacrylamide, polystyrene, polyvinylpyrrolidone, polyvinylalcohol or polystyrene sulfonic acid resin
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
- C08F290/00—Macromolecular compounds obtained by polymerising monomers on to polymers modified by introduction of aliphatic unsaturated end or side groups
- C08F290/02—Macromolecular compounds obtained by polymerising monomers on to polymers modified by introduction of aliphatic unsaturated end or side groups on to polymers modified by introduction of unsaturated end groups
- C08F290/06—Polymers provided for in subclass C08G
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
- A61K47/6921—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere
- A61K47/6925—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being a microcapsule, nanocapsule, microbubble or nanobubble
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
- C08F290/00—Macromolecular compounds obtained by polymerising monomers on to polymers modified by introduction of aliphatic unsaturated end or side groups
- C08F290/02—Macromolecular compounds obtained by polymerising monomers on to polymers modified by introduction of aliphatic unsaturated end or side groups on to polymers modified by introduction of unsaturated end groups
- C08F290/06—Polymers provided for in subclass C08G
- C08F290/061—Polyesters; Polycarbonates
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
- C08F290/00—Macromolecular compounds obtained by polymerising monomers on to polymers modified by introduction of aliphatic unsaturated end or side groups
- C08F290/02—Macromolecular compounds obtained by polymerising monomers on to polymers modified by introduction of aliphatic unsaturated end or side groups on to polymers modified by introduction of unsaturated end groups
- C08F290/06—Polymers provided for in subclass C08G
- C08F290/062—Polyethers
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
- C08F299/00—Macromolecular compounds obtained by interreacting polymers involving only carbon-to-carbon unsaturated bond reactions, in the absence of non-macromolecular monomers
- C08F299/02—Macromolecular compounds obtained by interreacting polymers involving only carbon-to-carbon unsaturated bond reactions, in the absence of non-macromolecular monomers from unsaturated polycondensates
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G81/00—Macromolecular compounds obtained by interreacting polymers in the absence of monomers, e.g. block polymers
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L55/00—Compositions of homopolymers or copolymers, obtained by polymerisation reactions only involving carbon-to-carbon unsaturated bonds, not provided for in groups C08L23/00 - C08L53/00
- C08L55/005—Homopolymers or copolymers obtained by polymerisation of macromolecular compounds terminated by a carbon-to-carbon double bond
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L2205/00—Polymer mixtures characterised by other features
- C08L2205/02—Polymer mixtures characterised by other features containing two or more polymers of the same C08L -group
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Polymers & Plastics (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Nanotechnology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Medicinal Preparation (AREA)
- Graft Or Block Polymers (AREA)
- Materials For Medical Uses (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Macromonomer-Based Addition Polymer (AREA)
- Other Resins Obtained By Reactions Not Involving Carbon-To-Carbon Unsaturated Bonds (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US24118309P | 2009-09-10 | 2009-09-10 | |
| EP09305830A EP2295480A1 (en) | 2009-09-10 | 2009-09-10 | Implantable bio-resorbable polymer |
| EP09305830.3 | 2009-09-10 | ||
| US61/241,183 | 2009-09-10 | ||
| PCT/EP2010/063227 WO2011029867A1 (en) | 2009-09-10 | 2010-09-09 | Implantable bio-resorbable polymer |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| BR112012005280A2 BR112012005280A2 (pt) | 2020-10-27 |
| BR112012005280B1 BR112012005280B1 (pt) | 2021-10-05 |
| BR112012005280B8 true BR112012005280B8 (pt) | 2021-10-26 |
Family
ID=41531626
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112012005280A BR112012005280B8 (pt) | 2009-09-10 | 2010-09-09 | Polímero e composição farmacêutica |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US9320804B2 (enExample) |
| EP (2) | EP2295480A1 (enExample) |
| JP (1) | JP5792729B2 (enExample) |
| KR (1) | KR101585588B1 (enExample) |
| CN (1) | CN102597030B (enExample) |
| AU (1) | AU2010294246B2 (enExample) |
| BR (1) | BR112012005280B8 (enExample) |
| CA (1) | CA2773499C (enExample) |
| ES (1) | ES2472426T3 (enExample) |
| IN (1) | IN2012DN02064A (enExample) |
| SG (1) | SG179057A1 (enExample) |
| WO (1) | WO2011029867A1 (enExample) |
| ZA (1) | ZA201201752B (enExample) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8921429B2 (en) * | 2010-11-23 | 2014-12-30 | Howard University | Biodegradable stealth polymeric particles fabricated using the macromonomer approach by free radical dispersion polymerization |
| EP2683750B1 (en) | 2011-03-09 | 2017-04-19 | Occlugel | Implantable swellable bio-resorbable polymer |
| WO2012120139A1 (en) | 2011-03-09 | 2012-09-13 | Occlugel | Implantable bio-resorbable polymer charged with fragile macromolecules |
| CN102304200B (zh) * | 2011-05-27 | 2013-08-21 | 中国海洋石油总公司 | 一种交联聚合物微球及其制备方法 |
| CN103709386B (zh) * | 2012-10-09 | 2016-03-30 | 上海微创医疗器械（集团）有限公司 | 改性聚乳酸可降解支架及其制备方法 |
| CN103113533B (zh) * | 2013-02-01 | 2015-08-05 | 中国科学院长春应用化学研究所 | 聚乳酸共聚物及其制备方法、改性聚乳酸 |
| JP6405369B2 (ja) | 2013-09-19 | 2018-10-17 | テルモ株式会社 | ポリマー粒子 |
| JP6641265B2 (ja) | 2013-09-19 | 2020-02-05 | マイクロベンション インコーポレイテッドＭｉｃｒｏｖｅｎｔｉｏｎ， Ｉｎｃ． | ポリマーフィルム |
| CN105916495B (zh) | 2013-11-08 | 2019-11-12 | 泰尔茂株式会社 | 聚合物颗粒 |
| CN105214145A (zh) * | 2014-06-23 | 2016-01-06 | 李茂全 | 聚乳酸微球在出血性疾病中的应用 |
| FR3024732B1 (fr) * | 2014-08-08 | 2016-08-12 | Snf Sas | Polymere hydroxyalkyle hydrosoluble obtenu par procede de polymerisation en suspension inverse ou emulsion inverse |
| CN104558419B (zh) * | 2014-09-27 | 2017-07-11 | 温州大学 | 一种环境敏感型环糊精衍生物水凝胶的制备方法 |
| US9907880B2 (en) | 2015-03-26 | 2018-03-06 | Microvention, Inc. | Particles |
| US12115289B2 (en) | 2016-02-05 | 2024-10-15 | The General Hospital Corporation | Drug eluting polymer composed of biodegradable polymers applied to surface of medical device |
| EP3416626A4 (en) * | 2016-02-17 | 2019-10-30 | Biosphere Medical, Inc. | MICRO BEARINGS AS THERAPEUTIC COMPOUNDS AND ASSOCIATED METHODS OF USE |
| CN109843941B (zh) * | 2016-06-23 | 2021-11-26 | 科罗拉多大学董事会,法人团体 | 通过纳米凝胶控制聚合物网络结构 |
| KR102566112B1 (ko) | 2016-09-28 | 2023-08-10 | 테루모 가부시키가이샤 | 중합체 입자 |
| CN106543992A (zh) * | 2016-09-30 | 2017-03-29 | 成都西油华巍科技有限公司 | 一种钻井液用聚合物微球封堵剂及其制备方法 |
| US11229604B2 (en) | 2017-08-16 | 2022-01-25 | Biosphere Medical, Inc. | Microspheres containing therapeutic agents and related methods of use |
| CN111150879B (zh) * | 2019-12-31 | 2022-06-17 | 华中科技大学鄂州工业技术研究院 | 一种促凝血和x光显影栓塞剂及其制备方法和应用 |
| WO2022047544A1 (en) * | 2020-09-04 | 2022-03-10 | IP Cornerstone Pty Ltd | Minimally invasive treatment of osteoarthritis and other conditions |
| CN112934198B (zh) * | 2021-01-29 | 2022-07-08 | 浙江理工大学 | 一种环糊精多孔吸附材料及其制备方法与应用 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0131112D0 (en) | 2001-12-31 | 2002-02-13 | Univ London Pharmacy | Block copolymers |
| WO2005079856A1 (en) * | 2004-02-23 | 2005-09-01 | The University Of British Columbia | Drug delivery compositions comprising hydrophobic polymers and amphipathic molecules |
| JP2005330246A (ja) * | 2004-05-21 | 2005-12-02 | Toray Ind Inc | 膨潤性ヒドロゲルマトリックスを含む医薬組成物 |
| WO2006045183A1 (en) * | 2004-10-25 | 2006-05-04 | The University Of British Columbia | Polymer barrier compositions for surgical wounds |
| US20110182805A1 (en) * | 2005-06-17 | 2011-07-28 | Desimone Joseph M | Nanoparticle fabrication methods, systems, and materials |
| FI20060077A7 (fi) * | 2006-01-26 | 2007-07-27 | Jvs Polymers Oy | Biohajoavien polymeerien käyttö |
| WO2009132206A1 (en) * | 2008-04-25 | 2009-10-29 | Liquidia Technologies, Inc. | Compositions and methods for intracellular delivery and release of cargo |
| CN101265311A (zh) * | 2008-05-07 | 2008-09-17 | 天津大学 | Pvp-peg-pla壳层交联的纳米胶束的制备方法 |
-
2009
- 2009-09-10 EP EP09305830A patent/EP2295480A1/en not_active Withdrawn
-
2010
- 2010-09-09 ES ES10750132.2T patent/ES2472426T3/es active Active
- 2010-09-09 WO PCT/EP2010/063227 patent/WO2011029867A1/en not_active Ceased
- 2010-09-09 CA CA2773499A patent/CA2773499C/en active Active
- 2010-09-09 IN IN2064DEN2012 patent/IN2012DN02064A/en unknown
- 2010-09-09 AU AU2010294246A patent/AU2010294246B2/en active Active
- 2010-09-09 KR KR1020127009158A patent/KR101585588B1/ko active Active
- 2010-09-09 BR BR112012005280A patent/BR112012005280B8/pt active IP Right Grant
- 2010-09-09 US US13/395,610 patent/US9320804B2/en active Active
- 2010-09-09 JP JP2012528358A patent/JP5792729B2/ja active Active
- 2010-09-09 CN CN2010800456866A patent/CN102597030B/zh active Active
- 2010-09-09 SG SG2012016515A patent/SG179057A1/en unknown
- 2010-09-09 EP EP10750132.2A patent/EP2475695B1/en active Active
-
2012
- 2012-03-09 ZA ZA2012/01752A patent/ZA201201752B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU2010294246A1 (en) | 2012-04-05 |
| BR112012005280B1 (pt) | 2021-10-05 |
| WO2011029867A1 (en) | 2011-03-17 |
| ZA201201752B (en) | 2012-11-28 |
| EP2475695A1 (en) | 2012-07-18 |
| EP2475695B1 (en) | 2014-04-02 |
| CA2773499A1 (en) | 2011-03-17 |
| AU2010294246B2 (en) | 2014-12-04 |
| EP2295480A1 (en) | 2011-03-16 |
| BR112012005280A2 (pt) | 2020-10-27 |
| JP2013504538A (ja) | 2013-02-07 |
| ES2472426T3 (es) | 2014-07-01 |
| IN2012DN02064A (enExample) | 2015-08-21 |
| US9320804B2 (en) | 2016-04-26 |
| CN102597030B (zh) | 2013-11-06 |
| US20120230937A1 (en) | 2012-09-13 |
| CN102597030A (zh) | 2012-07-18 |
| KR101585588B1 (ko) | 2016-01-14 |
| KR20120099006A (ko) | 2012-09-06 |
| SG179057A1 (en) | 2012-04-27 |
| JP5792729B2 (ja) | 2015-10-14 |
| CA2773499C (en) | 2017-12-05 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
| B06U | Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette] | ||
| B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] |
Free format text: DE ACORDO COM O ARTIGO 229-C DA LEI NO 10196/2001, QUE MODIFICOU A LEI NO 9279/96, A CONCESSAO DA PATENTE ESTA CONDICIONADA A ANUENCIA PREVIA DA ANVISA. CONSIDERANDO A APROVACAO DOS TERMOS DO PARECER NO 337/PGF/EA/2010, BEM COMO A PORTARIA INTERMINISTERIAL NO 1065 DE 24/05/2012, ENCAMINHA-SE O PRESENTE PEDIDO PARA AS PROVIDENCIAS CABIVEIS. |
|
| B07E | Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] | ||
| B06A | Patent application procedure suspended [chapter 6.1 patent gazette] | ||
| B15K | Others concerning applications: alteration of classification |
Free format text: AS CLASSIFICACOES ANTERIORES ERAM: C08F 290/06 , A61K 47/48 Ipc: C08F 290/06 (2006.01), A61K 47/50 (2017.01) |
|
| B09A | Decision: intention to grant [chapter 9.1 patent gazette] | ||
| B16A | Patent or certificate of addition of invention granted [chapter 16.1 patent gazette] |
Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 09/09/2010, OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF, QUE DETERMINA A ALTERACAO DO PRAZO DE CONCESSAO. |
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| B16C | Correction of notification of the grant [chapter 16.3 patent gazette] |
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