CN102597030B - 可植入的可生物吸收的聚合物 - Google Patents

可植入的可生物吸收的聚合物 Download PDF

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Publication number
CN102597030B
CN102597030B CN2010800456866A CN201080045686A CN102597030B CN 102597030 B CN102597030 B CN 102597030B CN 2010800456866 A CN2010800456866 A CN 2010800456866A CN 201080045686 A CN201080045686 A CN 201080045686A CN 102597030 B CN102597030 B CN 102597030B
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polymkeric substance
monomer
peg
linking agent
absorbable
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CN2010800456866A
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Chinese (zh)
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CN102597030A (zh
Inventor
L·穆瓦纳
L·贝杜埃
A·洛朗
D·拉巴尔
M·瓦塞夫
V·N·源
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Paris Thackeray, University of
Western Dais Paris, University of
Centre National de la Recherche Scientifique CNRS
Assistance Publique Hopitaux de Paris APHP
OCCLUGEL
Universite Paris Cite
Original Assignee
Centre National de la Recherche Scientifique CNRS
Assistance Publique Hopitaux de Paris APHP
Universite Paris Diderot Paris 7
Universite Paris Sud
OCCLUGEL
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/58—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. poly[meth]acrylate, polyacrylamide, polystyrene, polyvinylpyrrolidone, polyvinylalcohol or polystyrene sulfonic acid resin
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F290/00—Macromolecular compounds obtained by polymerising monomers on to polymers modified by introduction of aliphatic unsaturated end or side groups
    • C08F290/02—Macromolecular compounds obtained by polymerising monomers on to polymers modified by introduction of aliphatic unsaturated end or side groups on to polymers modified by introduction of unsaturated end groups
    • C08F290/06—Polymers provided for in subclass C08G
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6921—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere
    • A61K47/6925—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being a microcapsule, nanocapsule, microbubble or nanobubble
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F290/00—Macromolecular compounds obtained by polymerising monomers on to polymers modified by introduction of aliphatic unsaturated end or side groups
    • C08F290/02—Macromolecular compounds obtained by polymerising monomers on to polymers modified by introduction of aliphatic unsaturated end or side groups on to polymers modified by introduction of unsaturated end groups
    • C08F290/06—Polymers provided for in subclass C08G
    • C08F290/061—Polyesters; Polycarbonates
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F290/00—Macromolecular compounds obtained by polymerising monomers on to polymers modified by introduction of aliphatic unsaturated end or side groups
    • C08F290/02—Macromolecular compounds obtained by polymerising monomers on to polymers modified by introduction of aliphatic unsaturated end or side groups on to polymers modified by introduction of unsaturated end groups
    • C08F290/06—Polymers provided for in subclass C08G
    • C08F290/062—Polyethers
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F299/00—Macromolecular compounds obtained by interreacting polymers involving only carbon-to-carbon unsaturated bond reactions, in the absence of non-macromolecular monomers
    • C08F299/02—Macromolecular compounds obtained by interreacting polymers involving only carbon-to-carbon unsaturated bond reactions, in the absence of non-macromolecular monomers from unsaturated polycondensates
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G81/00—Macromolecular compounds obtained by interreacting polymers in the absence of monomers, e.g. block polymers
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L55/00—Compositions of homopolymers or copolymers, obtained by polymerisation reactions only involving carbon-to-carbon unsaturated bonds, not provided for in groups C08L23/00 - C08L53/00
    • C08L55/005—Homopolymers or copolymers obtained by polymerisation of macromolecular compounds terminated by a carbon-to-carbon double bond
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L2205/00—Polymer mixtures characterised by other features
    • C08L2205/02—Polymer mixtures characterised by other features containing two or more polymers of the same C08L -group

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Polymers & Plastics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Nanotechnology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Medicinal Preparation (AREA)
  • Graft Or Block Polymers (AREA)
  • Materials For Medical Uses (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Macromonomer-Based Addition Polymer (AREA)
  • Other Resins Obtained By Reactions Not Involving Carbon-To-Carbon Unsaturated Bonds (AREA)
CN2010800456866A 2009-09-10 2010-09-09 可植入的可生物吸收的聚合物 Active CN102597030B (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US24118309P 2009-09-10 2009-09-10
EP09305830A EP2295480A1 (en) 2009-09-10 2009-09-10 Implantable bio-resorbable polymer
EP09305830.3 2009-09-10
US61/241,183 2009-09-10
PCT/EP2010/063227 WO2011029867A1 (en) 2009-09-10 2010-09-09 Implantable bio-resorbable polymer

Publications (2)

Publication Number Publication Date
CN102597030A CN102597030A (zh) 2012-07-18
CN102597030B true CN102597030B (zh) 2013-11-06

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CN2010800456866A Active CN102597030B (zh) 2009-09-10 2010-09-09 可植入的可生物吸收的聚合物

Country Status (13)

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US (1) US9320804B2 (enExample)
EP (2) EP2295480A1 (enExample)
JP (1) JP5792729B2 (enExample)
KR (1) KR101585588B1 (enExample)
CN (1) CN102597030B (enExample)
AU (1) AU2010294246B2 (enExample)
BR (1) BR112012005280B8 (enExample)
CA (1) CA2773499C (enExample)
ES (1) ES2472426T3 (enExample)
IN (1) IN2012DN02064A (enExample)
SG (1) SG179057A1 (enExample)
WO (1) WO2011029867A1 (enExample)
ZA (1) ZA201201752B (enExample)

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US8921429B2 (en) * 2010-11-23 2014-12-30 Howard University Biodegradable stealth polymeric particles fabricated using the macromonomer approach by free radical dispersion polymerization
EP2683750B1 (en) 2011-03-09 2017-04-19 Occlugel Implantable swellable bio-resorbable polymer
WO2012120139A1 (en) 2011-03-09 2012-09-13 Occlugel Implantable bio-resorbable polymer charged with fragile macromolecules
CN102304200B (zh) * 2011-05-27 2013-08-21 中国海洋石油总公司 一种交联聚合物微球及其制备方法
CN103709386B (zh) * 2012-10-09 2016-03-30 上海微创医疗器械（集团）有限公司 改性聚乳酸可降解支架及其制备方法
CN103113533B (zh) * 2013-02-01 2015-08-05 中国科学院长春应用化学研究所 聚乳酸共聚物及其制备方法、改性聚乳酸
JP6405369B2 (ja) 2013-09-19 2018-10-17 テルモ株式会社 ポリマー粒子
JP6641265B2 (ja) 2013-09-19 2020-02-05 マイクロベンション インコーポレイテッドＭｉｃｒｏｖｅｎｔｉｏｎ， Ｉｎｃ． ポリマーフィルム
CN105916495B (zh) 2013-11-08 2019-11-12 泰尔茂株式会社 聚合物颗粒
CN105214145A (zh) * 2014-06-23 2016-01-06 李茂全 聚乳酸微球在出血性疾病中的应用
FR3024732B1 (fr) * 2014-08-08 2016-08-12 Snf Sas Polymere hydroxyalkyle hydrosoluble obtenu par procede de polymerisation en suspension inverse ou emulsion inverse
CN104558419B (zh) * 2014-09-27 2017-07-11 温州大学 一种环境敏感型环糊精衍生物水凝胶的制备方法
US9907880B2 (en) 2015-03-26 2018-03-06 Microvention, Inc. Particles
US12115289B2 (en) 2016-02-05 2024-10-15 The General Hospital Corporation Drug eluting polymer composed of biodegradable polymers applied to surface of medical device
EP3416626A4 (en) * 2016-02-17 2019-10-30 Biosphere Medical, Inc. MICRO BEARINGS AS THERAPEUTIC COMPOUNDS AND ASSOCIATED METHODS OF USE
CN109843941B (zh) * 2016-06-23 2021-11-26 科罗拉多大学董事会,法人团体 通过纳米凝胶控制聚合物网络结构
KR102566112B1 (ko) 2016-09-28 2023-08-10 테루모 가부시키가이샤 중합체 입자
CN106543992A (zh) * 2016-09-30 2017-03-29 成都西油华巍科技有限公司 一种钻井液用聚合物微球封堵剂及其制备方法
US11229604B2 (en) 2017-08-16 2022-01-25 Biosphere Medical, Inc. Microspheres containing therapeutic agents and related methods of use
CN111150879B (zh) * 2019-12-31 2022-06-17 华中科技大学鄂州工业技术研究院 一种促凝血和x光显影栓塞剂及其制备方法和应用
WO2022047544A1 (en) * 2020-09-04 2022-03-10 IP Cornerstone Pty Ltd Minimally invasive treatment of osteoarthritis and other conditions
CN112934198B (zh) * 2021-01-29 2022-07-08 浙江理工大学 一种环糊精多孔吸附材料及其制备方法与应用

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Also Published As

Publication number Publication date
AU2010294246A1 (en) 2012-04-05
BR112012005280B1 (pt) 2021-10-05
WO2011029867A1 (en) 2011-03-17
ZA201201752B (en) 2012-11-28
BR112012005280B8 (pt) 2021-10-26
EP2475695A1 (en) 2012-07-18
EP2475695B1 (en) 2014-04-02
CA2773499A1 (en) 2011-03-17
AU2010294246B2 (en) 2014-12-04
EP2295480A1 (en) 2011-03-16
BR112012005280A2 (pt) 2020-10-27
JP2013504538A (ja) 2013-02-07
ES2472426T3 (es) 2014-07-01
IN2012DN02064A (enExample) 2015-08-21
US9320804B2 (en) 2016-04-26
US20120230937A1 (en) 2012-09-13
CN102597030A (zh) 2012-07-18
KR101585588B1 (ko) 2016-01-14
KR20120099006A (ko) 2012-09-06
SG179057A1 (en) 2012-04-27
JP5792729B2 (ja) 2015-10-14
CA2773499C (en) 2017-12-05

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