BR0318503A - quinolinas substituìdas como inibidores de enzima proteìna tirosina cinase - Google Patents
quinolinas substituìdas como inibidores de enzima proteìna tirosina cinaseInfo
- Publication number
- BR0318503A BR0318503A BRPI0318503-6A BR0318503A BR0318503A BR 0318503 A BR0318503 A BR 0318503A BR 0318503 A BR0318503 A BR 0318503A BR 0318503 A BR0318503 A BR 0318503A
- Authority
- BR
- Brazil
- Prior art keywords
- tyrosine kinase
- protein tyrosine
- enzyme inhibitors
- kinase enzyme
- substituted quinolines
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US66227303A | 2003-09-15 | 2003-09-15 | |
| PCT/US2003/032612 WO2005034955A1 (fr) | 2003-09-15 | 2003-10-15 | Utilisation de quinolines substituees comme inhibiteurs de la tyrosine kinase |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR0318503A true BR0318503A (pt) | 2006-09-12 |
Family
ID=34435322
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0318503-6A BR0318503A (pt) | 2003-09-15 | 2003-10-15 | quinolinas substituìdas como inibidores de enzima proteìna tirosina cinase |
Country Status (7)
| Country | Link |
|---|---|
| EP (1) | EP1670473A1 (fr) |
| AU (1) | AU2003304497B2 (fr) |
| BR (1) | BR0318503A (fr) |
| CA (1) | CA2537978C (fr) |
| MX (1) | MXPA06002846A (fr) |
| UA (1) | UA85394C2 (fr) |
| WO (1) | WO2005034955A1 (fr) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2006210572B2 (en) | 2005-02-03 | 2011-08-04 | The General Hospital Corporation | Method for treating gefitinib resistant cancer |
| BRPI0610147A2 (pt) * | 2005-05-25 | 2010-06-01 | Wyeth Corp | método para preparar e sintetizar 3-cianoquinolinas substituìdas e 4-amino-3-cianoquinolinas |
| AU2006311877A1 (en) | 2005-11-04 | 2007-05-18 | Wyeth Llc | Antineoplastic combinations with mTOR inhibitor, herceptin, and/orHKI-272 |
| PT2010496E (pt) * | 2006-04-14 | 2010-10-13 | Astrazeneca Ab | 4-anilinoquinolina-3-carboxamidas como inibidores de csf-1r cinase |
| US8022216B2 (en) | 2007-10-17 | 2011-09-20 | Wyeth Llc | Maleate salts of (E)-N-{4-[3-chloro-4-(2-pyridinylmethoxy)anilino]-3-cyano-7-ethoxy-6-quinolinyl}-4-(dimethylamino)-2-butenamide and crystalline forms thereof |
| KR20180128078A (ko) | 2008-06-17 | 2018-11-30 | 와이어쓰 엘엘씨 | Ｈｋｉ-272 및 비노렐빈을 함유하는 항신생물성 조합물 |
| NZ590464A (en) | 2008-08-04 | 2012-10-26 | Wyeth Llc | Antineoplastic combinations of the 4-anilino-3-cyanoquinoline neratinib and capecitabine |
| CN101723854A (zh) | 2008-10-24 | 2010-06-09 | 上海特化医药科技有限公司 | 6-取代氨基-3-氰基喹啉类化合物的制备方法及其中间体 |
| HUE061640T2 (hu) | 2009-04-06 | 2023-07-28 | Wyeth Llc | Gyógykezelési rendszer mellrákhoz neratinib alkalmazásával |
| GB0922302D0 (en) * | 2009-12-22 | 2010-02-03 | Imp Innovations Ltd | Compounds |
| CN102146084B (zh) * | 2010-02-04 | 2014-05-07 | 江苏恒瑞医药股份有限公司 | 3-氰基-6-氨基喹啉类衍生物、其制备方法及其在医药上的应用 |
| AU2012232670A1 (en) | 2011-03-23 | 2013-09-12 | Ariel-University Research And Development Company Ltd. | Treatment of proliferative disorders with a chemiluminescent agent |
| CN102718679B (zh) * | 2011-03-30 | 2016-06-08 | 北京万全阳光医药科技有限公司 | 一种诺那替尼关键中间体的制备方法 |
| CN102731395B (zh) * | 2011-04-15 | 2015-02-04 | 中国科学院上海药物研究所 | 抗肿瘤药物来那替尼的中间体及其制备与应用 |
| CN104080774B (zh) | 2012-01-17 | 2017-02-22 | 安斯泰来制药株式会社 | 吡嗪甲酰胺化合物 |
| CN104926669A (zh) * | 2014-03-18 | 2015-09-23 | 江苏豪森医药集团连云港宏创医药有限公司 | 反式-4-二甲基胺基巴豆酸盐酸盐的制备方法 |
| EP3677583A4 (fr) * | 2017-09-01 | 2021-07-21 | Shanghai Pharmaceuticals Holding Co., Ltd. | Composé hétérocyclique azoté, procédé de préparation, intermédiaire, composition et application |
| CN110357854A (zh) * | 2018-03-26 | 2019-10-22 | 江苏创诺制药有限公司 | 一种来那替尼的制备方法 |
| CN111848581B (zh) * | 2020-08-19 | 2021-08-10 | 昆明学院 | 3-氰基-4-苯胺基-6-氨基喹啉衍生物的制备方法 |
| CN111943933B (zh) * | 2020-09-02 | 2021-05-28 | 重庆医科大学 | 一种来那替尼杂质d的制备方法 |
| CN111995618B (zh) * | 2020-09-02 | 2021-06-11 | 重庆医科大学 | 一种来那替尼杂质g的制备方法 |
| CN114920695B (zh) * | 2022-06-29 | 2023-06-20 | 深圳大学总医院 | 一种喹唑啉衍生物及其制备方法、药物组合物和应用 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6288082B1 (en) * | 1998-09-29 | 2001-09-11 | American Cyanamid Company | Substituted 3-cyanoquinolines |
| KR20050044599A (ko) * | 2001-11-27 | 2005-05-12 | 와이어쓰 홀딩스 코포레이션 | Ｅｇｆ-ｒ 및 ｈｅｒ2 키나아제의 억제제로서의3-시아노퀴놀린 |
-
2003
- 2003-10-15 AU AU2003304497A patent/AU2003304497B2/en not_active Ceased
- 2003-10-15 BR BRPI0318503-6A patent/BR0318503A/pt not_active IP Right Cessation
- 2003-10-15 CA CA2537978A patent/CA2537978C/fr not_active Expired - Lifetime
- 2003-10-15 WO PCT/US2003/032612 patent/WO2005034955A1/fr active Application Filing
- 2003-10-15 UA UAA200604144A patent/UA85394C2/ru unknown
- 2003-10-15 MX MXPA06002846A patent/MXPA06002846A/es active IP Right Grant
- 2003-10-15 EP EP03818857A patent/EP1670473A1/fr not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| MXPA06002846A (es) | 2006-06-14 |
| EP1670473A1 (fr) | 2006-06-21 |
| WO2005034955A1 (fr) | 2005-04-21 |
| CA2537978C (fr) | 2011-08-02 |
| AU2003304497A1 (en) | 2005-04-27 |
| AU2003304497B2 (en) | 2010-06-24 |
| UA85394C2 (ru) | 2009-01-26 |
| CA2537978A1 (fr) | 2005-04-21 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
| B15K | Others concerning applications: alteration of classification |
Free format text: PARA INT.CL: A61K 31/4706, C07D 215/54, C07D 401/12, C07D 417/12, C07D 407/12, C07D 413/12, C07D 405/12, C07D 409/12, A61K 31/4709, A61K 31/506, A61P 35/00 Ipc: A61K 31/4706 (2011.01), C07D 215/54 (2011.01), C07 |
|
| B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] | ||
| B07E | Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] | ||
| B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
| B09A | Decision: intention to grant [chapter 9.1 patent gazette] | ||
| B16A | Patent or certificate of addition of invention granted [chapter 16.1 patent gazette] |
Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 02/10/2018, OBSERVADAS AS CONDICOES LEGAIS. |
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| B21F | Lapse acc. art. 78, item iv - on non-payment of the annual fees in time |
Free format text: REFERENTE A 17A ANUIDADE. |
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| B24D | Patent annual fee: restoration after fee payment | ||
| B22O | Other matters related to patents and certificates of addition of invention: legal action concerning patent |
Free format text: INPI NO 52402.004187/2021-24 ORIGEM: 31O VF DO RIO DE JANEIRO PROCESSO NO: 5031286-04.2021.4.02.5101 NULIDADE DE ATO ADMINISTRATIVO AUTOR: LIBBS FARMACEUTICA LTDA. REU(S): WYETH (US) E INSTITUTO NACIONAL DA PROPRIEDADE INDUSTRIAL ? INPI |
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| B22O | Other matters related to patents and certificates of addition of invention: legal action concerning patent |
Free format text: INPI NO 52402.011680/2021-09 ORIGEM: 21A VARA FEDERAL CIVEL DA SJDF (TRF1) PROCESSO NO: 1080400-66.2021.4.01.3400 ACAO PELO PROCEDIMENTO COMUM AUTOR: WYETH LLC REU(S): INSTITUTO NACIONAL DA PROPRIEDADE INDUSTRIAL |