BR0318049A - Processo para produção de uma forma farmacêutica oral com imediata desintegração e liberação de ingrediente ativo - Google Patents

Processo para produção de uma forma farmacêutica oral com imediata desintegração e liberação de ingrediente ativo

Info

Publication number
BR0318049A
BR0318049A BR0318049-2A BR0318049A BR0318049A BR 0318049 A BR0318049 A BR 0318049A BR 0318049 A BR0318049 A BR 0318049A BR 0318049 A BR0318049 A BR 0318049A
Authority
BR
Brazil
Prior art keywords
producing
active ingredient
active ingredients
release
oral pharmaceutical
Prior art date
Application number
BR0318049-2A
Other languages
English (en)
Other versions
BRPI0318049B8 (pt
BRPI0318049B1 (pt
Inventor
Hans-Ulrich Petereit
Christian Meier
Andreas Gryczke
Original Assignee
R Hm Gmbh & Co Kg
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by R Hm Gmbh & Co Kg filed Critical R Hm Gmbh & Co Kg
Publication of BR0318049A publication Critical patent/BR0318049A/pt
Publication of BRPI0318049B1 publication Critical patent/BRPI0318049B1/pt
Publication of BRPI0318049B8 publication Critical patent/BRPI0318049B8/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
    • A61J3/10—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of compressed tablets
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Physiology (AREA)
  • Nutrition Science (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

"PROCESSO PARA PRODUçãO DE UMA FORMA FARMACêUTICA ORAL COM IMEDIATA DESINTEGRAçãO E LIBERAçãO DE INGREDIENTE ATIVO". A presente invenção refere-se a um processo para produção de uma forma oral de administração que decompõe imediatamente e libera ingredientes ativos na boca. De acordo com o dito processo, (a) um ingrediente ativo farmacêutico aniónico é intensamente misturado com (b) um copolímero consistindo em ésteres C~ 1- 4~ polimerizados com radical, de ácido acrílico ou metacrílico e outros monómeros (met)acrilato contendo grupos amino terciários funcionais, e (c) entre 5 e 50% em peso, em relação a (b), de um ácido carboxílico C~ 12-22~ na massa fundida; a mistura é solidificada e triturada para formar um pó contendo os ingredientes ativos tendo um tamanho de partícula médio de 200 <109>m ou menos; e o pó é encapsulado em uma matriz solúvel em água consistindo em adjuvantes farmaceuticamente padrão, na condição de que não mais que 3% em peso, em relação ao copolímero, de emulsificantes com um valor HLB de pelo menos 14 estejam ali contidos. A invenção também refere-se ao pó contendo ingredientes ativos e os usos do mesmo.
BRPI0318049A 2003-01-28 2003-11-21 processo para produção de uma forma farmacêutica oral com imediata desintegração e liberação de ingrediente ativo, pó contendo ingrediente ativo e seu uso BRPI0318049B8 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE10304403A DE10304403A1 (de) 2003-01-28 2003-01-28 Verfahren zur Herstellung einer oralen Arzneiform mit unmittelbarem Zerfall und Wirkstofffreisetzung
DE10304403.5 2003-01-28
PCT/EP2003/013059 WO2004066976A1 (de) 2003-01-28 2003-11-21 Verfahren zur herstellung einer oralen arzneiform mit unmittelbarem zerfall und wirkstofffreisetzung

Publications (3)

Publication Number Publication Date
BR0318049A true BR0318049A (pt) 2005-12-20
BRPI0318049B1 BRPI0318049B1 (pt) 2018-04-03
BRPI0318049B8 BRPI0318049B8 (pt) 2021-05-25

Family

ID=32667988

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0318049A BRPI0318049B8 (pt) 2003-01-28 2003-11-21 processo para produção de uma forma farmacêutica oral com imediata desintegração e liberação de ingrediente ativo, pó contendo ingrediente ativo e seu uso

Country Status (14)

Country Link
US (2) US8343542B2 (pt)
EP (1) EP1587497B1 (pt)
JP (2) JP5537756B2 (pt)
KR (1) KR100983461B1 (pt)
AU (1) AU2003292061A1 (pt)
BR (1) BRPI0318049B8 (pt)
CA (1) CA2512738C (pt)
DE (1) DE10304403A1 (pt)
ES (1) ES2528359T3 (pt)
IL (1) IL169886A (pt)
MX (1) MXPA05007643A (pt)
PL (1) PL206413B1 (pt)
SI (1) SI1587497T1 (pt)
WO (1) WO2004066976A1 (pt)

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Also Published As

Publication number Publication date
MXPA05007643A (es) 2005-09-30
DE10304403A1 (de) 2004-08-05
KR20050096952A (ko) 2005-10-06
JP5537756B2 (ja) 2014-07-02
US20060051412A1 (en) 2006-03-09
CA2512738A1 (en) 2004-08-12
US8999385B2 (en) 2015-04-07
BRPI0318049B8 (pt) 2021-05-25
KR100983461B1 (ko) 2010-09-27
US20130071475A1 (en) 2013-03-21
IL169886A (en) 2010-11-30
EP1587497B1 (de) 2014-11-12
PL376483A1 (en) 2005-12-27
SI1587497T1 (sl) 2015-03-31
BRPI0318049B1 (pt) 2018-04-03
CA2512738C (en) 2013-08-13
US8343542B2 (en) 2013-01-01
AU2003292061A1 (en) 2004-08-23
WO2004066976A1 (de) 2004-08-12
PL206413B1 (pl) 2010-08-31
ES2528359T3 (es) 2015-02-09
IL169886A0 (en) 2007-07-04
EP1587497A1 (de) 2005-10-26
JP2006514660A (ja) 2006-05-11
JP2014159424A (ja) 2014-09-04

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