BR0315807A - Processo para purificação das proteìnas ligadas a tnf usando imac - Google Patents

Processo para purificação das proteìnas ligadas a tnf usando imac

Info

Publication number
BR0315807A
BR0315807A BR0315807-1A BR0315807A BR0315807A BR 0315807 A BR0315807 A BR 0315807A BR 0315807 A BR0315807 A BR 0315807A BR 0315807 A BR0315807 A BR 0315807A
Authority
BR
Brazil
Prior art keywords
imac
tnf
linked proteins
proteins
purifying
Prior art date
Application number
BR0315807-1A
Other languages
English (en)
Inventor
Mara Rossi
Original Assignee
Ares Trading Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ares Trading Sa filed Critical Ares Trading Sa
Publication of BR0315807A publication Critical patent/BR0315807A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/22—Affinity chromatography or related techniques based upon selective absorption processes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
    • C07K14/7151—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for tumor necrosis factor [TNF], for lymphotoxin [LT]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/38—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups B01D15/265 - B01D15/36
    • B01D15/3804—Affinity chromatography
    • B01D15/3828—Ligand exchange chromatography, e.g. complexation, chelation or metal interaction chromatography

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Immunology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Cell Biology (AREA)
  • Analytical Chemistry (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

"PROCESSO PARA PURIFICAçãO DAS PROTEìNAS LIGADAS A TNF USANDO IMAC". Compreendendo um novo processo de purificação das proteínas ligadas ao Fator de Necrose Tumoral é descrito. Particularmente este processo é caracterizado pelo uso de uma etapa de captura de uma Cromatografia de Afinidade com Metal Imobilizado (IMAC) usando cobre como metal. Isso traz vantagens em termos de resultados do processo, pureza do produto final e aplicabilidade em escala industrial.
BR0315807-1A 2002-11-15 2003-11-13 Processo para purificação das proteìnas ligadas a tnf usando imac BR0315807A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP02025755 2002-11-15
PCT/EP2003/050824 WO2004046184A1 (en) 2002-11-15 2003-11-13 Process for the purification of tnf-binding proteins using imac

Publications (1)

Publication Number Publication Date
BR0315807A true BR0315807A (pt) 2005-09-20

Family

ID=32319541

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0315807-1A BR0315807A (pt) 2002-11-15 2003-11-13 Processo para purificação das proteìnas ligadas a tnf usando imac

Country Status (19)

Country Link
US (1) US20060128616A1 (pt)
EP (1) EP1560851A1 (pt)
JP (1) JP2006517187A (pt)
KR (1) KR20050074997A (pt)
CN (1) CN100375753C (pt)
AR (1) AR042038A1 (pt)
AU (1) AU2003298287A1 (pt)
BG (1) BG109152A (pt)
BR (1) BR0315807A (pt)
CA (1) CA2505385A1 (pt)
EA (1) EA200500762A1 (pt)
HK (1) HK1082751A1 (pt)
HR (1) HRP20050406A2 (pt)
MX (1) MXPA05005246A (pt)
NO (1) NO20052916D0 (pt)
PL (1) PL376745A1 (pt)
RS (1) RS20050355A (pt)
WO (1) WO2004046184A1 (pt)
ZA (1) ZA200503702B (pt)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102234332B (zh) * 2010-04-26 2014-12-17 浙江海正药业股份有限公司 一种重组人血白蛋白及其融合蛋白的分离纯化工艺
WO2017049529A1 (en) 2015-09-24 2017-03-30 Innolife Co., Ltd. A pharmaceutical composition comprising a copper chelating tetramine and the use thereof

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5283339A (en) * 1988-11-23 1994-02-01 California Institute Of Technology Immobilized metal aqueous two-phase extraction and precipitation
US5169936A (en) * 1989-04-14 1992-12-08 Biogen, Inc. Protein purification on immobilized metal affinity resins effected by elution using a weak ligand
DE59010941D1 (de) * 1989-04-21 2005-03-24 Amgen Inc TNF-Rezeptor, TNF bindende Proteine und dafür kodierende DNAs
JPH08512323A (ja) * 1993-07-09 1996-12-24 スミスクライン・ビーチャム・コーポレイション タンパク精製方法
US5932102A (en) * 1998-01-12 1999-08-03 Schering Corporation Immobilized metal, affinity chromatography

Also Published As

Publication number Publication date
WO2004046184A1 (en) 2004-06-03
JP2006517187A (ja) 2006-07-20
RS20050355A (en) 2007-06-04
NO20052916L (no) 2005-06-15
HK1082751A1 (en) 2006-06-16
US20060128616A1 (en) 2006-06-15
NO20052916D0 (no) 2005-06-15
HRP20050406A2 (en) 2006-02-28
MXPA05005246A (es) 2005-07-25
AU2003298287A1 (en) 2004-06-15
CN1738835A (zh) 2006-02-22
BG109152A (bg) 2006-04-28
CA2505385A1 (en) 2004-06-03
CN100375753C (zh) 2008-03-19
AR042038A1 (es) 2005-06-08
EA200500762A1 (ru) 2005-12-29
PL376745A1 (pl) 2006-01-09
KR20050074997A (ko) 2005-07-19
ZA200503702B (en) 2006-08-30
EP1560851A1 (en) 2005-08-10

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Legal Events

Date Code Title Description
B08F Application fees: application dismissed [chapter 8.6 patent gazette]

Free format text: REFERENTE A 7A E 8A ANUIDADE(S).

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2129 DE 25/10/2011.