BR0315740A - Formas de dosagem com multicamadas que contêm substâncias ativas e que compreendem um núcleo neutro e um revestimento interno e externo composto por copolìmeros de metacrilato e monÈmeros de metacrilato - Google Patents

Formas de dosagem com multicamadas que contêm substâncias ativas e que compreendem um núcleo neutro e um revestimento interno e externo composto por copolìmeros de metacrilato e monÈmeros de metacrilato

Info

Publication number
BR0315740A
BR0315740A BR0315740-7A BR0315740A BR0315740A BR 0315740 A BR0315740 A BR 0315740A BR 0315740 A BR0315740 A BR 0315740A BR 0315740 A BR0315740 A BR 0315740A
Authority
BR
Brazil
Prior art keywords
methacrylate
outer coating
dosage forms
active substances
containing active
Prior art date
Application number
BR0315740-7A
Other languages
English (en)
Other versions
BRPI0315740B8 (pt
BRPI0315740B1 (pt
Inventor
Hans-Ulrich Petereit
Markus Rudolph
Jennifer Dressman
Thomas Beckert
Original Assignee
Roehm Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roehm Gmbh filed Critical Roehm Gmbh
Publication of BR0315740A publication Critical patent/BR0315740A/pt
Publication of BRPI0315740B1 publication Critical patent/BRPI0315740B1/pt
Publication of BRPI0315740B8 publication Critical patent/BRPI0315740B8/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
    • A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
    • A61K9/209—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat containing drug in at least two layers or in the core and in at least one outer layer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/284—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone
    • A61K9/2846—Poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5026—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates

Landscapes

  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

"FORMAS DE DOSAGEM COM MULTICAMADAS QUE CONTêM SUBSTâNCIAS ATIVAS E QUE COMPREENDEM UM NúCLEO NEUTRO E UM REVESTIMENTO INTERNO E EXTERNO COMPOSTO POR COPOLìMEROS DE METACRILATO E MONÈMEROS DE METACRILATO". A presente invenção refere-se a uma forma de dosagem multicamadas compreendida por: a) um núcleo neutro; b) um revestimento interno consistindo em um copolímero de metacrilato; c) um revestimento externo consistindo em um copolímero do qual 40 a 95% em peso são compostos por C~ 1-4~ alquil éster radicalmente polimerizados de ácido acrílico ou de ácido metacrílico e dos quais 5 a 60% em peso são compostos por monómeros (met)acrilato tendo um grupo aniónico no radical alquila. A invenção é caracterizada em que o revestimento interno é essencialmente compreendido por um copolímero de metacrilato, do qual pelo menos até 90% em peso consistem em monómeros (met)acrilato com radicais neutros, que, de acordo com DIN 53 787, tem uma temperatura de formação de filme mínima não maior que 30<39>C, e que contém a substância farmacêutica ativa em forma ligada.
BRPI0315740A 2002-10-29 2003-09-04 formas de dosagem com multicamadas que contêm substâncias ativas e que compreendem um núcleo neutro e um revestimento interno e externo composto por copolímeros de metacrilato e monômeros de metacrilato BRPI0315740B8 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE10250543A DE10250543A1 (de) 2002-10-29 2002-10-29 Mehrschichtige Arzneiform
DE10250543.8 2002-10-29
PCT/EP2003/009800 WO2004039357A1 (de) 2002-10-29 2003-09-04 Mehrschichtige wirkstoffhaltige arzneiformen, die einen neutralen kern sowie einen inneren und äusseren überzug aus methacrylat-copolymeren und -monomeren umfassen

Publications (3)

Publication Number Publication Date
BR0315740A true BR0315740A (pt) 2005-09-06
BRPI0315740B1 BRPI0315740B1 (pt) 2018-06-19
BRPI0315740B8 BRPI0315740B8 (pt) 2021-05-25

Family

ID=32114959

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0315740A BRPI0315740B8 (pt) 2002-10-29 2003-09-04 formas de dosagem com multicamadas que contêm substâncias ativas e que compreendem um núcleo neutro e um revestimento interno e externo composto por copolímeros de metacrilato e monômeros de metacrilato

Country Status (16)

Country Link
US (2) US20060204576A1 (pt)
EP (1) EP1556016B1 (pt)
JP (1) JP4819362B2 (pt)
KR (1) KR20050083847A (pt)
CN (1) CN1688295B (pt)
AT (1) ATE406876T1 (pt)
AU (1) AU2003266351A1 (pt)
BR (1) BRPI0315740B8 (pt)
CA (1) CA2502371C (pt)
DE (2) DE10250543A1 (pt)
ES (1) ES2312853T3 (pt)
IL (1) IL167334A (pt)
MX (1) MXPA05004573A (pt)
PL (1) PL206707B1 (pt)
SI (1) SI1556016T1 (pt)
WO (1) WO2004039357A1 (pt)

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Also Published As

Publication number Publication date
ATE406876T1 (de) 2008-09-15
KR20050083847A (ko) 2005-08-26
JP4819362B2 (ja) 2011-11-24
US20180256606A1 (en) 2018-09-13
PL206707B1 (pl) 2010-09-30
PL374907A1 (en) 2005-11-14
EP1556016B1 (de) 2008-09-03
JP2006508087A (ja) 2006-03-09
CA2502371A1 (en) 2004-05-13
BRPI0315740B8 (pt) 2021-05-25
AU2003266351A1 (en) 2004-05-25
MXPA05004573A (es) 2005-11-23
WO2004039357A1 (de) 2004-05-13
CN1688295A (zh) 2005-10-26
US20060204576A1 (en) 2006-09-14
SI1556016T1 (sl) 2009-02-28
EP1556016A1 (de) 2005-07-27
BRPI0315740B1 (pt) 2018-06-19
DE50310448D1 (de) 2008-10-16
DE10250543A1 (de) 2004-05-19
CN1688295B (zh) 2011-08-24
IL167334A (en) 2010-11-30
CA2502371C (en) 2011-04-12
ES2312853T3 (es) 2009-03-01

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