BR0314979A - ácido nucleico isolado, polipeptìdeo, vetor, célula hospedeira, organismo não humano, e, métodos de fabricar uma célula hospedeira recombinante, de produzir um polipeptìdeo, de fabricar pelo menos uma sesquiterpeno sintase, e de fabricar pelo menos um terpenóide - Google Patents

ácido nucleico isolado, polipeptìdeo, vetor, célula hospedeira, organismo não humano, e, métodos de fabricar uma célula hospedeira recombinante, de produzir um polipeptìdeo, de fabricar pelo menos uma sesquiterpeno sintase, e de fabricar pelo menos um terpenóide

Info

Publication number
BR0314979A
BR0314979A BR0314979-0A BR0314979A BR0314979A BR 0314979 A BR0314979 A BR 0314979A BR 0314979 A BR0314979 A BR 0314979A BR 0314979 A BR0314979 A BR 0314979A
Authority
BR
Brazil
Prior art keywords
making
host cell
polypeptide
methods
vector
Prior art date
Application number
BR0314979-0A
Other languages
English (en)
Portuguese (pt)
Inventor
Michel Schalk
Anthony Clark
Original Assignee
Firmenich & Cie
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Firmenich & Cie filed Critical Firmenich & Cie
Publication of BR0314979A publication Critical patent/BR0314979A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/88—Lyases (4.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P5/00—Preparation of hydrocarbons or halogenated hydrocarbons
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P5/00—Preparation of hydrocarbons or halogenated hydrocarbons
    • C12P5/007—Preparation of hydrocarbons or halogenated hydrocarbons containing one or more isoprene units, i.e. terpenes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
BR0314979-0A 2002-10-04 2003-10-02 ácido nucleico isolado, polipeptìdeo, vetor, célula hospedeira, organismo não humano, e, métodos de fabricar uma célula hospedeira recombinante, de produzir um polipeptìdeo, de fabricar pelo menos uma sesquiterpeno sintase, e de fabricar pelo menos um terpenóide BR0314979A (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US41576502P 2002-10-04 2002-10-04
IB0205070 2002-12-02
PCT/IB2003/005072 WO2004031376A2 (en) 2002-10-04 2003-10-02 Sesquiterpene synthases and methods of use

Publications (1)

Publication Number Publication Date
BR0314979A true BR0314979A (pt) 2005-08-02

Family

ID=34590004

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0314979-0A BR0314979A (pt) 2002-10-04 2003-10-02 ácido nucleico isolado, polipeptìdeo, vetor, célula hospedeira, organismo não humano, e, métodos de fabricar uma célula hospedeira recombinante, de produzir um polipeptìdeo, de fabricar pelo menos uma sesquiterpeno sintase, e de fabricar pelo menos um terpenóide

Country Status (9)

Country Link
EP (3) EP1554379B1 (enExample)
JP (1) JP4571862B2 (enExample)
CN (3) CN101914558B (enExample)
AT (1) ATE546521T1 (enExample)
AU (1) AU2003278478A1 (enExample)
BR (1) BR0314979A (enExample)
IL (1) IL167832A (enExample)
RU (1) RU2005113300A (enExample)
WO (1) WO2004031376A2 (enExample)

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8106260B2 (en) 1996-04-12 2012-01-31 The Board Of Trustees Of The University Of Kentucky Chimeric isoprenoid synthases and uses thereof
US7442785B2 (en) 2003-07-24 2008-10-28 The University Of Kentucky Research Foundation Sesquiterpene synthase gene and protein
WO2005021705A2 (en) * 2003-09-02 2005-03-10 State Of Israel, Ministry Of Agriculture, Agricultural Research Organization Citrus sesquiterpene synthase, methods of production and uses thereof
CN101163795B (zh) 2005-04-19 2014-04-23 肯塔基大学研究机构 积聚萜的转化的植物
EP2311940B1 (en) 2005-06-17 2017-08-09 Firmenich SA Novel sesquiterpene synthases and methods of their use
US20080201796A1 (en) 2005-07-01 2008-08-21 University Of Kentucky Research Foundation Transformed plants accumulating mono-and/or sesquiterpenes
WO2008100251A1 (en) * 2007-02-13 2008-08-21 Ls9, Inc. Modified microorganism uses therefor
ATE475711T1 (de) * 2006-02-14 2010-08-15 Firmenich & Cie Verfahren zur herstellung von terpenen und mep- transformierte mikroorganismen dafür
US8110670B2 (en) 2006-05-19 2012-02-07 Ls9, Inc. Enhanced production of fatty acid derivatives
US20100242345A1 (en) 2006-05-19 2010-09-30 LS9, Inc Production of fatty acids & derivatives thereof
WO2009109597A1 (en) 2008-03-06 2009-09-11 Firmenich Sa Method for producing alpha- santalene
WO2010019696A2 (en) 2008-08-12 2010-02-18 Allylix, Inc. Method for production of isoprenoids
WO2010064897A1 (en) * 2008-12-05 2010-06-10 Keygene N.V. Farmesene synthase
BRPI1015313B1 (pt) 2009-04-27 2021-06-01 Genomatica, Inc. Método fermentativo para produzir um éster de ácido graxo empregando um microorganismo geneticamente modificado e método para a produção de ésteres de ácidos graxos
EP2449107B1 (en) 2009-06-29 2015-04-08 The University Of Western Australia Terpene synthases from santalum
ES2608480T4 (es) 2009-10-28 2017-10-05 Fundo De Defesa Da Citricultura - Fundecitrus Composiciones repelentes y enfoques genéticos para controlar el Huanglongbing
EP2569427B1 (en) * 2010-05-10 2017-11-08 Firmenich SA Method for producing patchoulol and 7-epi-alpha-selinene
JP2013544084A (ja) 2010-10-29 2013-12-12 アリリクス・インコーポレイテッド 改変されたバレンセンシンターゼポリペプチド、コーディング核酸分子およびその使用
EP2537926A1 (en) * 2011-06-21 2012-12-26 Isobionics B.V. Valencene synthase
CN104053770A (zh) * 2011-10-19 2014-09-17 凯金公司 用于产生肉桂酸内酯和/或补身二醇的方法
US9550815B2 (en) 2012-01-23 2017-01-24 University Of British Columbia ABC terpenoid transporters and methods of using the same
CN103243083B (zh) * 2012-02-06 2015-06-03 中国科学院上海生命科学研究院 一种新的倍半萜合成酶及其用途
WO2014150599A1 (en) 2013-03-14 2014-09-25 Allylix, Inc. Valencene synthase polypeptides, encoding nucleic acid molecules and uses thereof
ES2540791B1 (es) * 2013-12-13 2016-05-09 Consejo Superior De Investigaciones Científicas (Csic) Nuevas sesquiterpeno sintasas aisladas de la piel de naranja.
EP3183353A2 (en) * 2014-08-21 2017-06-28 Givaudan S.A. Process for producing oxygenated products of valencene
ES2861444T3 (es) * 2015-11-05 2021-10-06 Firmenich & Cie Drimenol sintasas III
CN105524908B (zh) * 2016-02-04 2018-12-28 中国农业科学院植物保护研究所 一种与(E)-β-石竹烯和(E)-a-律草烯合成相关的蛋白及其应用
CN110093329B (zh) * 2018-01-30 2023-07-04 深圳艾格鑫科技有限公司 萜类合酶及其应用
CN108977426B (zh) * 2018-06-29 2020-08-14 中国林业科学研究院热带林业研究所 一种油楠倍半萜合成酶及其编码基因和应用
CN109852600B (zh) * 2018-12-25 2021-12-31 天津大学 一种小萼苔倍半萜合成酶MTb及其基因序列
CN109666668B (zh) * 2019-01-24 2022-04-15 天津大学 一种小萼苔倍半萜合成酶MTa及其基因序列
CN109837266B (zh) * 2019-01-24 2021-12-31 天津大学 一种小萼苔倍半萜合成酶MTc及其基因序列
CN109929828A (zh) * 2019-01-30 2019-06-25 天津大学 一种苦皮藤倍半萜合成酶CaTPS1及其基因序列
CN111004763B (zh) * 2019-12-26 2022-06-03 中国科学院青岛生物能源与过程研究所 一种生产β-石竹烯的工程菌及其构建方法与应用
CN115404228B (zh) * 2021-05-28 2024-03-08 中国中医科学院中药研究所 山沉香倍半萜合酶蛋白tps1及其编码基因和应用
CN116004490A (zh) * 2022-07-12 2023-04-25 华东理工大学 一种生物合成右旋-双环吉玛烯的重组大肠杆菌、构建方法及应用
CN116555238B (zh) * 2023-06-09 2023-10-20 中国中医科学院中药研究所 SoSTPS1在作为倍半萜合酶中的应用
CN117126835B (zh) * 2023-08-11 2025-04-25 武汉合生科技有限公司 瓦伦烯合成酶及其应用
CN119899828B (zh) * 2025-01-17 2026-01-30 中国药科大学 利用SsDMS突变体高效生产新颖drimane型倍半萜化合物

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA811368B (en) 1980-03-24 1982-04-28 Genentech Inc Bacterial polypedtide expression employing tryptophan promoter-operator
NZ201705A (en) 1981-08-31 1986-03-14 Genentech Inc Recombinant dna method for production of hepatitis b surface antigen in yeast
US4737462A (en) 1982-10-19 1988-04-12 Cetus Corporation Structural genes, plasmids and transformed cells for producing cysteine depleted muteins of interferon-β
US4518584A (en) 1983-04-15 1985-05-21 Cetus Corporation Human recombinant interleukin-2 muteins
US5990387A (en) 1988-06-10 1999-11-23 Pioneer Hi-Bred International, Inc. Stable transformation of plant cells
DE60031025T2 (de) * 1999-03-31 2007-05-24 Firmenich S.A. Verwendung von Cubebol als Aromastoff

Also Published As

Publication number Publication date
EP3109319A1 (en) 2016-12-28
ATE546521T1 (de) 2012-03-15
AU2003278478A1 (en) 2004-04-23
JP4571862B2 (ja) 2010-10-27
WO2004031376A2 (en) 2004-04-15
IL167832A (en) 2010-11-30
EP2365070A1 (en) 2011-09-14
CN1703507A (zh) 2005-11-30
RU2005113300A (ru) 2005-10-27
CN1703507B (zh) 2010-09-29
EP1554379A2 (en) 2005-07-20
AU2003278478A8 (en) 2004-04-23
CN101914558A (zh) 2010-12-15
EP1554379B1 (en) 2012-02-22
CN101914559B (zh) 2012-04-04
CN101914558B (zh) 2013-05-29
WO2004031376A3 (en) 2005-05-26
JP2006500942A (ja) 2006-01-12
EP2365070B1 (en) 2016-09-14
CN101914559A (zh) 2010-12-15

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Legal Events

Date Code Title Description
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B07G Grant request does not fulfill article 229-c lpi (prior consent of anvisa) [chapter 7.7 patent gazette]

Free format text: NOTIFICACAO DE DEVOLUCAO DO PEDIDO POR NAO SE ENQUADRAR NO ART. 229-C DA LPI.

B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]
B12B Appeal against refusal [chapter 12.2 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 22/10/2019, OBSERVADAS AS CONDICOES LEGAIS.