CN101914558B - 倍半萜烯合成酶及其使用方法 - Google Patents

倍半萜烯合成酶及其使用方法 Download PDF

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Publication number
CN101914558B
CN101914558B CN2010102391730A CN201010239173A CN101914558B CN 101914558 B CN101914558 B CN 101914558B CN 2010102391730 A CN2010102391730 A CN 2010102391730A CN 201010239173 A CN201010239173 A CN 201010239173A CN 101914558 B CN101914558 B CN 101914558B
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seq
nucleic acid
polypeptide
sesquiterpene
synthase
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CN101914558A (zh
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米歇尔·沙尔克
安东尼·克拉克
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Firmenich SA
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/88—Lyases (4.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P5/00—Preparation of hydrocarbons or halogenated hydrocarbons
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P5/00—Preparation of hydrocarbons or halogenated hydrocarbons
    • C12P5/007—Preparation of hydrocarbons or halogenated hydrocarbons containing one or more isoprene units, i.e. terpenes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group

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  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
CN2010102391730A 2002-10-04 2003-10-02 倍半萜烯合成酶及其使用方法 Expired - Fee Related CN101914558B (zh)

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US41576502P 2002-10-04 2002-10-04
US60/415,765 2002-10-04
IB0205070 2002-12-02
IBPCT/IB02/05070 2002-12-02

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CN2003801009412A Division CN1703507B (zh) 2002-10-04 2003-10-02 倍半萜烯合成酶及其使用方法

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CN101914558B true CN101914558B (zh) 2013-05-29

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CN2010102392305A Expired - Fee Related CN101914559B (zh) 2002-10-04 2003-10-02 倍半萜烯合成酶及其使用方法
CN2003801009412A Expired - Fee Related CN1703507B (zh) 2002-10-04 2003-10-02 倍半萜烯合成酶及其使用方法

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CN2003801009412A Expired - Fee Related CN1703507B (zh) 2002-10-04 2003-10-02 倍半萜烯合成酶及其使用方法

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EP (3) EP1554379B1 (enExample)
JP (1) JP4571862B2 (enExample)
CN (3) CN101914558B (enExample)
AT (1) ATE546521T1 (enExample)
AU (1) AU2003278478A1 (enExample)
BR (1) BR0314979A (enExample)
IL (1) IL167832A (enExample)
RU (1) RU2005113300A (enExample)
WO (1) WO2004031376A2 (enExample)

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EP2311940B1 (en) 2005-06-17 2017-08-09 Firmenich SA Novel sesquiterpene synthases and methods of their use
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ATE475711T1 (de) * 2006-02-14 2010-08-15 Firmenich & Cie Verfahren zur herstellung von terpenen und mep- transformierte mikroorganismen dafür
US8110670B2 (en) 2006-05-19 2012-02-07 Ls9, Inc. Enhanced production of fatty acid derivatives
US20100242345A1 (en) 2006-05-19 2010-09-30 LS9, Inc Production of fatty acids & derivatives thereof
WO2009109597A1 (en) 2008-03-06 2009-09-11 Firmenich Sa Method for producing alpha- santalene
WO2010019696A2 (en) 2008-08-12 2010-02-18 Allylix, Inc. Method for production of isoprenoids
WO2010064897A1 (en) * 2008-12-05 2010-06-10 Keygene N.V. Farmesene synthase
BRPI1015313B1 (pt) 2009-04-27 2021-06-01 Genomatica, Inc. Método fermentativo para produzir um éster de ácido graxo empregando um microorganismo geneticamente modificado e método para a produção de ésteres de ácidos graxos
EP2449107B1 (en) 2009-06-29 2015-04-08 The University Of Western Australia Terpene synthases from santalum
ES2608480T4 (es) 2009-10-28 2017-10-05 Fundo De Defesa Da Citricultura - Fundecitrus Composiciones repelentes y enfoques genéticos para controlar el Huanglongbing
EP2569427B1 (en) * 2010-05-10 2017-11-08 Firmenich SA Method for producing patchoulol and 7-epi-alpha-selinene
JP2013544084A (ja) 2010-10-29 2013-12-12 アリリクス・インコーポレイテッド 改変されたバレンセンシンターゼポリペプチド、コーディング核酸分子およびその使用
EP2537926A1 (en) * 2011-06-21 2012-12-26 Isobionics B.V. Valencene synthase
CN104053770A (zh) * 2011-10-19 2014-09-17 凯金公司 用于产生肉桂酸内酯和/或补身二醇的方法
US9550815B2 (en) 2012-01-23 2017-01-24 University Of British Columbia ABC terpenoid transporters and methods of using the same
CN103243083B (zh) * 2012-02-06 2015-06-03 中国科学院上海生命科学研究院 一种新的倍半萜合成酶及其用途
WO2014150599A1 (en) 2013-03-14 2014-09-25 Allylix, Inc. Valencene synthase polypeptides, encoding nucleic acid molecules and uses thereof
ES2540791B1 (es) * 2013-12-13 2016-05-09 Consejo Superior De Investigaciones Científicas (Csic) Nuevas sesquiterpeno sintasas aisladas de la piel de naranja.
EP3183353A2 (en) * 2014-08-21 2017-06-28 Givaudan S.A. Process for producing oxygenated products of valencene
ES2861444T3 (es) * 2015-11-05 2021-10-06 Firmenich & Cie Drimenol sintasas III
CN105524908B (zh) * 2016-02-04 2018-12-28 中国农业科学院植物保护研究所 一种与(E)-β-石竹烯和(E)-a-律草烯合成相关的蛋白及其应用
CN110093329B (zh) * 2018-01-30 2023-07-04 深圳艾格鑫科技有限公司 萜类合酶及其应用
CN108977426B (zh) * 2018-06-29 2020-08-14 中国林业科学研究院热带林业研究所 一种油楠倍半萜合成酶及其编码基因和应用
CN109852600B (zh) * 2018-12-25 2021-12-31 天津大学 一种小萼苔倍半萜合成酶MTb及其基因序列
CN109666668B (zh) * 2019-01-24 2022-04-15 天津大学 一种小萼苔倍半萜合成酶MTa及其基因序列
CN109837266B (zh) * 2019-01-24 2021-12-31 天津大学 一种小萼苔倍半萜合成酶MTc及其基因序列
CN109929828A (zh) * 2019-01-30 2019-06-25 天津大学 一种苦皮藤倍半萜合成酶CaTPS1及其基因序列
CN111004763B (zh) * 2019-12-26 2022-06-03 中国科学院青岛生物能源与过程研究所 一种生产β-石竹烯的工程菌及其构建方法与应用
CN115404228B (zh) * 2021-05-28 2024-03-08 中国中医科学院中药研究所 山沉香倍半萜合酶蛋白tps1及其编码基因和应用
CN116004490A (zh) * 2022-07-12 2023-04-25 华东理工大学 一种生物合成右旋-双环吉玛烯的重组大肠杆菌、构建方法及应用
CN116555238B (zh) * 2023-06-09 2023-10-20 中国中医科学院中药研究所 SoSTPS1在作为倍半萜合酶中的应用
CN117126835B (zh) * 2023-08-11 2025-04-25 武汉合生科技有限公司 瓦伦烯合成酶及其应用
CN119899828B (zh) * 2025-01-17 2026-01-30 中国药科大学 利用SsDMS突变体高效生产新颖drimane型倍半萜化合物

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EP3109319A1 (en) 2016-12-28
BR0314979A (pt) 2005-08-02
ATE546521T1 (de) 2012-03-15
AU2003278478A1 (en) 2004-04-23
JP4571862B2 (ja) 2010-10-27
WO2004031376A2 (en) 2004-04-15
IL167832A (en) 2010-11-30
EP2365070A1 (en) 2011-09-14
CN1703507A (zh) 2005-11-30
RU2005113300A (ru) 2005-10-27
CN1703507B (zh) 2010-09-29
EP1554379A2 (en) 2005-07-20
AU2003278478A8 (en) 2004-04-23
CN101914558A (zh) 2010-12-15
EP1554379B1 (en) 2012-02-22
CN101914559B (zh) 2012-04-04
WO2004031376A3 (en) 2005-05-26
JP2006500942A (ja) 2006-01-12
EP2365070B1 (en) 2016-09-14
CN101914559A (zh) 2010-12-15

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