BR0312677A - Processo para a preparação de um composto, e, composto - Google Patents

Processo para a preparação de um composto, e, composto

Info

Publication number
BR0312677A
BR0312677A BR0312677-3A BR0312677A BR0312677A BR 0312677 A BR0312677 A BR 0312677A BR 0312677 A BR0312677 A BR 0312677A BR 0312677 A BR0312677 A BR 0312677A
Authority
BR
Brazil
Prior art keywords
compound
group
atom
solvates
preparation
Prior art date
Application number
BR0312677-3A
Other languages
English (en)
Inventor
Benjamin Mark Skead
Nicholas David Tyrrell
Stephen Wilfred Jones
Michael Handforth Brookes
Original Assignee
Celltech R&D Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Celltech R&D Ltd filed Critical Celltech R&D Ltd
Publication of BR0312677A publication Critical patent/BR0312677A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C225/00—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones
    • C07C225/20—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to carbon atoms of rings other than six-membered aromatic rings of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/96—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings spiro-condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Pyridine Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

"PROCESSO PARA A PREPARAçãO DE UM COMPOSTO, E, COMPOSTO"'. Um processo para a preparação de uma classe de derivados de fenilalanina enamida é descrito na fórmula (1) em que: Ar^ 1^ é um grupo aromático ou heteroaromático opcionalmente substituído; L^ 2^ é um grupo ligador selecionado de -N(R^ 4^)- [onde R^ 4^ é um átomo de hidrogênio ou um grupo alquila C~ 1-6~ reto ou ramificado opcionalmente substituído], -CON(R^ 4^)-ou -S(O)~ 2~N(R^ 4^)-; R^ 1^ é um ácido carboxílico (-CO~ 2~H) ou um derivado ou bióstero destes; R^ 2^ é um átomo de hidrogênio ou um grupo alquila C~ 1-6~; R^ y^ e R^ z^ que podem ser os mesmos ou diferentes, cada um é um átomo ou grupo L^ 1^(Alk^ 1^)~ n~(R^ 3^)~ v~; e os sais, solvatos, hidratos e N-óxidos destes, que compreendem a reação de um composto da fórmula (2): em que: Q^ a^ é um grupo -N(R^ 4^)H; e os sais, solvatos, HIdratos e N-óxidos destes, com um composto Ar^ 1^W em que W é um grupo selecionado de X^ 1^ (em que X^ 1^ é um átomo ou grupo de partida), -COX^ 2^ (em que X^ 2^ é um átomo de halogênio ou um grupo -OH) ou -SO~ 2~ X^ 3^ (em que X^ 3^ é um átomo de halogênio).
BR0312677-3A 2002-07-17 2003-07-16 Processo para a preparação de um composto, e, composto BR0312677A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0216574.4A GB0216574D0 (en) 2002-07-17 2002-07-17 Chemical compounds
PCT/GB2003/003108 WO2004007428A1 (en) 2002-07-17 2003-07-16 Process for the preparation of phenylalanine enamide derivatives

Publications (1)

Publication Number Publication Date
BR0312677A true BR0312677A (pt) 2005-04-26

Family

ID=9940616

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0312677-3A BR0312677A (pt) 2002-07-17 2003-07-16 Processo para a preparação de um composto, e, composto

Country Status (17)

Country Link
US (1) US6951943B2 (pt)
EP (1) EP1525181A1 (pt)
JP (1) JP2005533098A (pt)
KR (1) KR20050032573A (pt)
CN (1) CN1293040C (pt)
AU (1) AU2003280967B2 (pt)
BR (1) BR0312677A (pt)
CA (1) CA2492441A1 (pt)
EA (1) EA007155B1 (pt)
GB (1) GB0216574D0 (pt)
IL (1) IL165802A0 (pt)
MX (1) MXPA05000596A (pt)
NO (1) NO20050826L (pt)
NZ (1) NZ538160A (pt)
PL (1) PL375370A1 (pt)
WO (1) WO2004007428A1 (pt)
ZA (1) ZA200500422B (pt)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102641718B1 (ko) 2018-10-30 2024-02-29 길리애드 사이언시즈, 인코포레이티드 알파4베타7 인테그린 억제제로서의 이미다조피리딘 유도체
AU2019373240B2 (en) 2018-10-30 2023-04-20 Gilead Sciences, Inc. Quinoline derivatives as alpha4beta7 integrin inhibitors
AU2019373242B2 (en) 2018-10-30 2023-07-13 Gilead Sciences, Inc. Compounds for inhibition of alpha 4 beta 7 integrin
CN112969504B (zh) 2018-10-30 2024-04-09 吉利德科学公司 用于抑制α4β7整合素的化合物
WO2021030438A1 (en) 2019-08-14 2021-02-18 Gilead Sciences, Inc. Compounds for inhibition of alpha 4 beta 7 integrin
US11814367B2 (en) 2021-03-15 2023-11-14 Maze Therapeutics, Inc. Inhibitors of glycogen synthase 1 (GYS1) and methods of use thereof

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2351464A1 (en) * 1998-12-14 2000-06-22 Joan E. Sabalski 3,4-diamino-3-cyclobutene-1,2-dione derivatives which inhibit leukocyte adhesion mediated by vla-4
US6518283B1 (en) * 1999-05-28 2003-02-11 Celltech R&D Limited Squaric acid derivatives
CZ20032259A3 (cs) * 2001-02-22 2004-01-14 Celltech R&D Limited Fenylalaninenamidové deriváty obsahující cyklobutenovou skupinu a jejich použití jako integrinových inhibitorů

Also Published As

Publication number Publication date
KR20050032573A (ko) 2005-04-07
AU2003280967B2 (en) 2008-10-30
JP2005533098A (ja) 2005-11-04
US6951943B2 (en) 2005-10-04
US20040073033A1 (en) 2004-04-15
GB0216574D0 (en) 2002-08-28
WO2004007428A1 (en) 2004-01-22
IL165802A0 (en) 2006-01-15
CA2492441A1 (en) 2004-01-22
ZA200500422B (en) 2006-07-26
EP1525181A1 (en) 2005-04-27
EA200500212A1 (ru) 2005-06-30
CN1293040C (zh) 2007-01-03
AU2003280967A1 (en) 2004-02-02
NO20050826L (no) 2005-04-15
CN1668574A (zh) 2005-09-14
NZ538160A (en) 2006-03-31
MXPA05000596A (es) 2005-04-28
EA007155B1 (ru) 2006-08-25
PL375370A1 (en) 2005-11-28

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Legal Events

Date Code Title Description
B25A Requested transfer of rights approved

Owner name: UCB S.A. (BE)

Free format text: TRANSFERIDO DE: CELLTECH RANDD LIMITED

B25A Requested transfer of rights approved

Owner name: UCB PHARMA S.A. (BE)

Free format text: TRANSFERIDO DE: UCB S.A.

B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 8A ANUIDADE.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2157 DE 08/05/2012.