NO20050826L - Fremgangsmate for fremstilling av fenylalaninenamid-derivater - Google Patents

Fremgangsmate for fremstilling av fenylalaninenamid-derivater

Info

Publication number
NO20050826L
NO20050826L NO20050826A NO20050826A NO20050826L NO 20050826 L NO20050826 L NO 20050826L NO 20050826 A NO20050826 A NO 20050826A NO 20050826 A NO20050826 A NO 20050826A NO 20050826 L NO20050826 L NO 20050826L
Authority
NO
Norway
Prior art keywords
group
atom
preparation
amide derivatives
phenylalanine amide
Prior art date
Application number
NO20050826A
Other languages
English (en)
Inventor
Benjamin Mark Skead
Nicholas David Tyrrell
Stephen Wilfred Jones
Michael Handforth Brookes
Original Assignee
Celltech R&D Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Celltech R&D Ltd filed Critical Celltech R&D Ltd
Publication of NO20050826L publication Critical patent/NO20050826L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C225/00—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones
    • C07C225/20—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to carbon atoms of rings other than six-membered aromatic rings of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/96—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings spiro-condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Abstract

Fremgangsmåte for fremstilling av en klasse fenylalaninenamidderivater med f ormel (1) hvor: Ar1 er en eventuelt substituert aromatisk eller heteroaromatisk gruppe; L2 er en sammenbindende gruppe valgt blant -N(R4) - [hvor R4 er et hydrogenatom eller en eventuelt substituert rett eller forgrenet C1-6-alkylgruppel, -CON(R4)- og S(0)2N(R4 )-; R1 er en karboksylsyre (-C02H) eller et derivat eller en bioster derav; R2 er et hydrogenatom eller en C1-6-alkylgruppe; Rx, Ry og Rz, som kan være like eller forskjellige, er alle et atom eller en gruppe -L1-(Alk1)n(R3)v; og saltene, solvatene, hydratene og N-oksidene derav, omfatter å omsette en forbindelse som har formel (2) hvor: Qa er en gruppe -N(R4 )H; og saltene, solvatene, hydratene og N-oksidene derav, med en forbindelse Ar1W, hvor W er en gruppe valgt blant X1 (hvor X1 er et forlatende atom eller en gruppe), -COX2 (hvor X2 er et halogenatom eller en -OH-gruppe) og -SO2 X3 (hvor X3 er et halogenatom).
NO20050826A 2002-07-17 2005-02-16 Fremgangsmate for fremstilling av fenylalaninenamid-derivater NO20050826L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0216574.4A GB0216574D0 (en) 2002-07-17 2002-07-17 Chemical compounds
PCT/GB2003/003108 WO2004007428A1 (en) 2002-07-17 2003-07-16 Process for the preparation of phenylalanine enamide derivatives

Publications (1)

Publication Number Publication Date
NO20050826L true NO20050826L (no) 2005-04-15

Family

ID=9940616

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20050826A NO20050826L (no) 2002-07-17 2005-02-16 Fremgangsmate for fremstilling av fenylalaninenamid-derivater

Country Status (17)

Country Link
US (1) US6951943B2 (no)
EP (1) EP1525181A1 (no)
JP (1) JP2005533098A (no)
KR (1) KR20050032573A (no)
CN (1) CN1293040C (no)
AU (1) AU2003280967B2 (no)
BR (1) BR0312677A (no)
CA (1) CA2492441A1 (no)
EA (1) EA007155B1 (no)
GB (1) GB0216574D0 (no)
IL (1) IL165802A0 (no)
MX (1) MXPA05000596A (no)
NO (1) NO20050826L (no)
NZ (1) NZ538160A (no)
PL (1) PL375370A1 (no)
WO (1) WO2004007428A1 (no)
ZA (1) ZA200500422B (no)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11179383B2 (en) 2018-10-30 2021-11-23 Gilead Sciences, Inc. Compounds for inhibition of α4β7 integrin
AU2019373242B2 (en) 2018-10-30 2023-07-13 Gilead Sciences, Inc. Compounds for inhibition of alpha 4 beta 7 integrin
CR20210213A (es) 2018-10-30 2021-06-24 Gilead Sciences Inc Derivados de quinolina como inhibidores de la integrina alfa4beta7
US11174256B2 (en) 2018-10-30 2021-11-16 Gilead Sciences, Inc. Imidazopyridine derivatives
AU2020329207B2 (en) 2019-08-14 2024-02-29 Gilead Sciences, Inc. Compounds for inhibition of alpha 4 beta 7 integrin
EP4308095A1 (en) 2021-03-15 2024-01-24 Maze Therapeutics, Inc. Inhibitors of glycogen synthase 1 (gys1) and methods of use thereof

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1140792A1 (en) * 1998-12-14 2001-10-10 American Home Products Corporation 3,4-diamino-3-cyclobutene-1,2-dione derivatives which inhibit leukocyte adhesion mediated by vla-4
US6518283B1 (en) 1999-05-28 2003-02-11 Celltech R&D Limited Squaric acid derivatives
EP1780201A3 (en) * 2001-02-22 2007-05-16 Celltech R&D Limited Phenylalanine enamide derivatives possessing a cyclobutene group, for use as integrin inhibitors

Also Published As

Publication number Publication date
NZ538160A (en) 2006-03-31
GB0216574D0 (en) 2002-08-28
EA007155B1 (ru) 2006-08-25
AU2003280967B2 (en) 2008-10-30
KR20050032573A (ko) 2005-04-07
US6951943B2 (en) 2005-10-04
ZA200500422B (en) 2006-07-26
AU2003280967A1 (en) 2004-02-02
CA2492441A1 (en) 2004-01-22
WO2004007428A1 (en) 2004-01-22
US20040073033A1 (en) 2004-04-15
EA200500212A1 (ru) 2005-06-30
EP1525181A1 (en) 2005-04-27
IL165802A0 (en) 2006-01-15
BR0312677A (pt) 2005-04-26
CN1293040C (zh) 2007-01-03
CN1668574A (zh) 2005-09-14
MXPA05000596A (es) 2005-04-28
JP2005533098A (ja) 2005-11-04
PL375370A1 (en) 2005-11-28

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FC2A Withdrawal, rejection or dismissal of laid open patent application