BR0311311A - Oximas de arila - Google Patents

Oximas de arila

Info

Publication number
BR0311311A
BR0311311A BR0311311-6A BR0311311A BR0311311A BR 0311311 A BR0311311 A BR 0311311A BR 0311311 A BR0311311 A BR 0311311A BR 0311311 A BR0311311 A BR 0311311A
Authority
BR
Brazil
Prior art keywords
arila
oximes
cachexia
phosphodiesterase
allergies
Prior art date
Application number
BR0311311-6A
Other languages
English (en)
Inventor
Hans-Michael Eggenweiler
Norbert Beier
Pierre Schelling
Michael Wolf
Original Assignee
Merck Patent Ges Mit Berschron
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent Ges Mit Berschron filed Critical Merck Patent Ges Mit Berschron
Publication of BR0311311A publication Critical patent/BR0311311A/pt

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
    • C07D237/04—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having less than three double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

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  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Neurosurgery (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pulmonology (AREA)
  • Diabetes (AREA)
  • Communicable Diseases (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Hematology (AREA)
  • Psychiatry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Pain & Pain Management (AREA)
  • Endocrinology (AREA)
  • Psychology (AREA)
  • Dermatology (AREA)
  • Biotechnology (AREA)
  • Addiction (AREA)
  • Ophthalmology & Optometry (AREA)
  • Transplantation (AREA)

Abstract

"OXIMAS DE ARILA". A presente invenção refere-se a derivados de oxima de arila da fórmula (I), em que R^ 1^, R^ 2^, R^ 3^, X e B são como definidos na reivindicação 1, que agem como inibidores de fosfodiesterase IV e podem ser empregados para o tratamento de osteoporose, tumores, caquexia, ateroesclerose, artrite reumatóide, esclerose múltipla, diabetes mellitus, processos inflamatórios, alergias, asma, doenças auto-imunes, doenças do miocárdio e AIDS.
BR0311311-6A 2002-06-10 2003-05-16 Oximas de arila BR0311311A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10225574A DE10225574A1 (de) 2002-06-10 2002-06-10 Aryloxime
PCT/EP2003/005173 WO2003104205A1 (de) 2002-06-10 2003-05-16 Aryloxime

Publications (1)

Publication Number Publication Date
BR0311311A true BR0311311A (pt) 2005-02-15

Family

ID=29557700

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0311311-6A BR0311311A (pt) 2002-06-10 2003-05-16 Oximas de arila

Country Status (17)

Country Link
US (2) US7135471B2 (pt)
EP (1) EP1511737B1 (pt)
JP (1) JP4607582B2 (pt)
KR (1) KR20050008817A (pt)
CN (1) CN1659148A (pt)
AR (1) AR040251A1 (pt)
AT (1) ATE457980T1 (pt)
AU (1) AU2003240259B2 (pt)
BR (1) BR0311311A (pt)
CA (1) CA2488934C (pt)
DE (2) DE10225574A1 (pt)
ES (1) ES2339646T3 (pt)
MX (1) MXPA04012211A (pt)
PL (1) PL371920A1 (pt)
RU (1) RU2004139233A (pt)
WO (1) WO2003104205A1 (pt)
ZA (1) ZA200500134B (pt)

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US20060205708A1 (en) 2006-09-14
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US7135471B2 (en) 2006-11-14
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