BR0309358A - Processo para fabricar cristais de substâncias ativas medicinais, cristais obtìveis com base nesse método e formulações farmacêuticas - Google Patents

Processo para fabricar cristais de substâncias ativas medicinais, cristais obtìveis com base nesse método e formulações farmacêuticas

Info

Publication number
BR0309358A
BR0309358A BR0309358-1A BR0309358A BR0309358A BR 0309358 A BR0309358 A BR 0309358A BR 0309358 A BR0309358 A BR 0309358A BR 0309358 A BR0309358 A BR 0309358A
Authority
BR
Brazil
Prior art keywords
crystals
active substances
pharmaceutical formulations
obtainable
manufacturing
Prior art date
Application number
BR0309358-1A
Other languages
English (en)
Inventor
Detlef Grawe
Annette Eichardt
Hagen Gerecke
Sabine Gliesing
Peter Hoesel
Uwe Mueller
Original Assignee
Schering Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Ag filed Critical Schering Ag
Publication of BR0309358A publication Critical patent/BR0309358A/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J75/00—Processes for the preparation of steroids in general
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Steroid Compounds (AREA)

Abstract

"PROCESSO PARA FABRICAR CRISTAIS DE SUBSTâNCIAS ATIVAS MEDICINAIS, CRISTAIS OBTìVEIS COM BASE NESSE MéTODO E FORMULAçõES FARMACêUTICAS". Sendo o tamanho médio de partícula situado em uma faixa pré-determinada e cujo tamanho máximo de partícula não ultrapassa um valor pré-determinado, sendo que uma solução supersaturada das substâncias ativas medicinais, é submetida a uma moagem úmida durante a cristalização por meio de um dispositivo para moagem úmida, sendo obtida uma suspensão de grão primário. Além disso, são descritos cristais obtíveis com base nesse método bem como formulações farmacêuticas, que contém esses cristais.
BR0309358-1A 2002-04-23 2003-04-22 Processo para fabricar cristais de substâncias ativas medicinais, cristais obtìveis com base nesse método e formulações farmacêuticas BR0309358A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10218106A DE10218106A1 (de) 2002-04-23 2002-04-23 Verfahren zum Herstellen von Kristallen von Arzneimittelwirkstoffen, danach erhältliche Kristalle und deren Verwendung in pharmazeutischen Formulierungen
PCT/EP2003/004153 WO2003090721A2 (de) 2002-04-23 2003-04-22 Verfahren zur herstellung von kristallen von arzneimittelwirkstoffen und deren verwendung in pharmazeutischen formulierungen

Publications (1)

Publication Number Publication Date
BR0309358A true BR0309358A (pt) 2005-02-22

Family

ID=29264786

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0309358-1A BR0309358A (pt) 2002-04-23 2003-04-22 Processo para fabricar cristais de substâncias ativas medicinais, cristais obtìveis com base nesse método e formulações farmacêuticas

Country Status (16)

Country Link
US (1) US20030215516A1 (pt)
EP (1) EP1523302A2 (pt)
JP (1) JP2005535577A (pt)
KR (1) KR20050003388A (pt)
CN (1) CN1812767A (pt)
AU (1) AU2003232490A1 (pt)
BR (1) BR0309358A (pt)
CA (1) CA2480130A1 (pt)
DE (1) DE10218106A1 (pt)
IL (1) IL163984A0 (pt)
MX (1) MXPA04010466A (pt)
NO (1) NO20045071L (pt)
PL (1) PL371518A1 (pt)
RU (1) RU2004134321A (pt)
WO (1) WO2003090721A2 (pt)
ZA (1) ZA200409398B (pt)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI365068B (en) * 2005-05-20 2012-06-01 Merck Sharp & Dohme Formulations of suberoylanilide hydroxamic acid and methods for producing same
WO2007106768A2 (en) * 2006-03-14 2007-09-20 Merck & Co., Inc. Processes and apparatuses for the production of crystalline organic microparticle compositions by micro-milling and crystallization on micro-seed and their use
DE102010003711B4 (de) * 2010-04-08 2015-04-09 Jesalis Pharma Gmbh Verfahren zur Herstellung kristalliner Wirkstoffpartikel
WO2015173157A2 (en) 2014-05-13 2015-11-19 Akzo Nobel Chemicals International B.V. Process to crystallize chelating agents
CN108031142A (zh) * 2017-12-13 2018-05-15 上海合全药物研发有限公司 一种简化的利用湿磨来制备大量微晶种的装置及方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB838654A (en) * 1956-02-08 1960-06-22 Upjohn Co Steroids and the production thereof
US3226389A (en) * 1962-01-04 1965-12-28 Du Pont 11,11,12,12-tetracyano-naphtho-2,6-quinodimethan and its anion-radical salts
CH627449A5 (de) * 1977-03-25 1982-01-15 Hoffmann La Roche Verfahren zur herstellung von mikrokristallinem vitamin a-acetat, sowie von trockenen, frei-fliessenden praeparaten, in welchen vitamin a-acetat in mikrokristalliner form vorliegt.
DE2801705A1 (de) * 1978-01-16 1979-07-19 Metallgesellschaft Ag Verfahren zur gewinnung von kaliumchlorid
DE3014160A1 (de) * 1979-04-16 1980-10-30 Lummus Co Kristallisationsverfahren
DE3306250A1 (de) * 1983-02-23 1984-08-23 Basf Ag, 6700 Ludwigshafen Sphaerische einkristalle fuer pharmazeutische zwecke
US4997637A (en) * 1989-05-09 1991-03-05 Occidental Chemical Corporation Digestive crystallizing process and apparatus for purification of KC1
FR2668945B1 (fr) * 1990-11-12 1993-02-19 Theramex Nouveau procede de cristallisation des substances organiques et les composes ainsi obtenus.
DE4143631A1 (de) * 1991-05-30 1998-04-16 Dynamit Nobel Ag Zerkleinerung von pulverförmigen Initialsprengstoffen
DE4244466C2 (de) * 1992-12-24 1995-02-23 Pharmatech Gmbh Verfahren zur Herstellung von Pseudolatices und Mikro- oder Nanopartikeln und deren Verwendung zur Herstellung von pharmazeutischen Präparaten

Also Published As

Publication number Publication date
KR20050003388A (ko) 2005-01-10
EP1523302A2 (de) 2005-04-20
WO2003090721A2 (de) 2003-11-06
CA2480130A1 (en) 2003-11-06
WO2003090721A3 (de) 2005-02-24
RU2004134321A (ru) 2005-10-10
PL371518A1 (en) 2005-06-27
IL163984A0 (en) 2005-12-18
DE10218106A1 (de) 2003-11-20
NO20045071L (no) 2005-01-21
ZA200409398B (en) 2006-06-28
AU2003232490A1 (en) 2003-11-10
CN1812767A (zh) 2006-08-02
MXPA04010466A (es) 2004-12-13
JP2005535577A (ja) 2005-11-24
US20030215516A1 (en) 2003-11-20

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 6A E 7A ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2051 DE 27/04/2010.