BR0309357A - Método para fabricar cristais de esteróides, cristais obtìveis de acordo com esse método, e formulações farmacêuticas - Google Patents
Método para fabricar cristais de esteróides, cristais obtìveis de acordo com esse método, e formulações farmacêuticasInfo
- Publication number
- BR0309357A BR0309357A BR0309357-3A BR0309357A BR0309357A BR 0309357 A BR0309357 A BR 0309357A BR 0309357 A BR0309357 A BR 0309357A BR 0309357 A BR0309357 A BR 0309357A
- Authority
- BR
- Brazil
- Prior art keywords
- crystals
- pharmaceutical formulations
- obtainable
- steroid
- particle size
- Prior art date
Links
- 239000013078 crystal Substances 0.000 title abstract 6
- 238000000034 method Methods 0.000 title abstract 5
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 3
- 150000003431 steroids Chemical class 0.000 title abstract 3
- 239000002245 particle Substances 0.000 abstract 2
- 238000001238 wet grinding Methods 0.000 abstract 2
- 238000002425 crystallisation Methods 0.000 abstract 1
- 230000008025 crystallization Effects 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 239000000725 suspension Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
- C07J1/0051—Estrane derivatives
- C07J1/0081—Substituted in position 17 alfa and 17 beta
- C07J1/0085—Substituted in position 17 alfa and 17 beta the substituent in position 17 alfa being a saturated hydrocarbon group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Steroid Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
"MéTODO PARA FABRICAR CRISTAIS DE ESTERóIDES, CRISTAIS OBTìVEIS DE ACORDO COM ESSE MéTODO, E FORMULAçõES FARMACêUTICAS". Sendo o tamanho médio de partícula situa-se em uma faixa pré-determinada e cujo tamanho máximo de partícula não ultrapassa um valor pré-determinado, sendo que uma solução supersaturada dos esteróides, é submetida a uma moagem úmida durante a cristalização por meio de um dispositivo para moagem úmida, sendo obtida uma suspensão de grão primário. Além disso, são descritos cristais obtíveis com base nesse método bem como formulações farmacêuticas, que contém esses cristais.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10218107A DE10218107A1 (de) | 2002-04-23 | 2002-04-23 | Verfahren zum Herstellen von Kristallen von Steroiden, danach erhältliche Kristalle und deren Verwendung in pharmazeutischen Formulierungen |
| PCT/EP2003/004154 WO2003091272A1 (de) | 2002-04-23 | 2003-04-22 | Verfahren zum herstellen von kristallen von steroiden, danach erhältliche kristalle und deren verwendung in pharmazeutischen formulierungen |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR0309357A true BR0309357A (pt) | 2005-02-22 |
Family
ID=29264787
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR0309357-3A BR0309357A (pt) | 2002-04-23 | 2003-04-22 | Método para fabricar cristais de esteróides, cristais obtìveis de acordo com esse método, e formulações farmacêuticas |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US7148212B2 (pt) |
| EP (1) | EP1497308B1 (pt) |
| JP (1) | JP4490116B2 (pt) |
| KR (1) | KR20040106380A (pt) |
| CN (1) | CN1646555A (pt) |
| AT (1) | ATE340186T1 (pt) |
| AU (1) | AU2003232491A1 (pt) |
| BR (1) | BR0309357A (pt) |
| CA (1) | CA2480004C (pt) |
| DE (2) | DE10218107A1 (pt) |
| DK (1) | DK1497308T3 (pt) |
| ES (1) | ES2274258T3 (pt) |
| IL (1) | IL163986A0 (pt) |
| MX (1) | MXPA04010467A (pt) |
| NO (1) | NO20045023L (pt) |
| PL (1) | PL371340A1 (pt) |
| PT (1) | PT1497308E (pt) |
| RU (1) | RU2315056C2 (pt) |
| WO (1) | WO2003091272A1 (pt) |
| ZA (1) | ZA200409401B (pt) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10218109A1 (de) * | 2002-04-23 | 2003-11-20 | Jenapharm Gmbh | Verfahren zum Herstellen von Kristallen, danach erhältliche Kristalle und deren Verwendung in pharmazeutischen Formulierungen |
| US20080038350A1 (en) * | 2006-08-10 | 2008-02-14 | Hagen Gerecke | Low-dosage peroral medication for contraception containing crystalline dienogest and ethinyl estradiol |
| PL1886694T3 (pl) * | 2006-08-10 | 2009-11-30 | Jenapharm Gmbh | Doustna postać leku do antykoncepcji |
| DE102008037025C5 (de) * | 2008-08-08 | 2016-07-07 | Jesalis Pharma Gmbh | Verfahren zur Herstellung kristalliner Wirkstoff-Mikropartikel bzw. einer Wirkstoffpartikel-Festkörperform |
| DE102010003711B4 (de) | 2010-04-08 | 2015-04-09 | Jesalis Pharma Gmbh | Verfahren zur Herstellung kristalliner Wirkstoffpartikel |
| RU2642244C2 (ru) * | 2010-04-12 | 2018-01-24 | Кларус Терапеутикс, Инк. | Оральные фармацевтические композиции сложных эфиров тестостерона и способы лечения недостатка тестостерона с их использованием |
| US20180153904A1 (en) | 2010-11-30 | 2018-06-07 | Lipocine Inc. | High-strength testosterone undecanoate compositions |
| US9034858B2 (en) | 2010-11-30 | 2015-05-19 | Lipocine Inc. | High-strength testosterone undecanoate compositions |
| CN106458851B (zh) | 2014-05-13 | 2019-01-11 | 阿克苏诺贝尔化学品国际有限公司 | 将螯合剂结晶的方法 |
| EP3544614A4 (en) | 2016-11-28 | 2020-08-05 | Lipocine Inc. | ORAL TESTOSTERONE UNDECANOATE THERAPY |
| WO2021230308A1 (ja) | 2020-05-15 | 2021-11-18 | 塩野義製薬株式会社 | 不純物の生成を抑制した医薬組成物 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3226389A (en) | 1962-01-04 | 1965-12-28 | Du Pont | 11,11,12,12-tetracyano-naphtho-2,6-quinodimethan and its anion-radical salts |
| JP2843857B2 (ja) * | 1988-10-05 | 1999-01-06 | ファルマシア・アンド・アップジョン・カンパニー | 反溶剤への沈澱を介する微細分化固体結晶性粉末 |
| DE3917617A1 (de) * | 1989-05-31 | 1990-12-06 | Boehringer Ingelheim Kg | Mikronisierte bioabbaubare partikel, verfahren zur ihrer herstellung und ihre verwendung |
| FR2668945B1 (fr) | 1990-11-12 | 1993-02-19 | Theramex | Nouveau procede de cristallisation des substances organiques et les composes ainsi obtenus. |
| EP0522700B1 (en) | 1991-07-10 | 1997-01-29 | Chiyoda Corporation | Process for the production of crystalline adduct of bisphenol A and phenol and apparatus therefor |
| NZ248813A (en) * | 1992-11-25 | 1995-06-27 | Eastman Kodak Co | Polymeric grinding media used in grinding pharmaceutical substances |
| DE4332283A1 (de) * | 1993-09-20 | 1995-04-13 | Jenapharm Gmbh | Neue 11-Benzaldoximestradien-Derivate, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel |
| CN1052194C (zh) * | 1993-12-27 | 2000-05-10 | 日本曹达株式会社 | 用于彩色显影的含有4-羟基-4'-异丙氧基二苯砜的组合物及其湿性研磨法和分散液 |
| US5718388A (en) * | 1994-05-25 | 1998-02-17 | Eastman Kodak | Continuous method of grinding pharmaceutical substances |
| US5534270A (en) * | 1995-02-09 | 1996-07-09 | Nanosystems Llc | Method of preparing stable drug nanoparticles |
| US6582940B1 (en) * | 1998-12-25 | 2003-06-24 | Daiichi Fine Chemical Co., Ltd. | Method for producing calcium pantothenate |
| EP1157996A1 (de) * | 2000-05-23 | 2001-11-28 | JENAPHARM GmbH | Neue Festkörperformen des Mesoprogestins 11Beta-[4E-(Hydroxyiminomethyl)-phenyl]-17Alpha-methoxymethyl-17Beta-methoxy-estra-4,9-dien-3-on |
| DE10218109A1 (de) * | 2002-04-23 | 2003-11-20 | Jenapharm Gmbh | Verfahren zum Herstellen von Kristallen, danach erhältliche Kristalle und deren Verwendung in pharmazeutischen Formulierungen |
-
2002
- 2002-04-23 DE DE10218107A patent/DE10218107A1/de not_active Ceased
-
2003
- 2003-04-17 US US10/417,557 patent/US7148212B2/en not_active Expired - Lifetime
- 2003-04-22 KR KR10-2004-7017079A patent/KR20040106380A/ko not_active Application Discontinuation
- 2003-04-22 IL IL16398603A patent/IL163986A0/xx unknown
- 2003-04-22 CN CNA038090376A patent/CN1646555A/zh active Pending
- 2003-04-22 CA CA002480004A patent/CA2480004C/en not_active Expired - Lifetime
- 2003-04-22 DK DK03747107T patent/DK1497308T3/da active
- 2003-04-22 WO PCT/EP2003/004154 patent/WO2003091272A1/de active IP Right Grant
- 2003-04-22 JP JP2003587830A patent/JP4490116B2/ja not_active Expired - Fee Related
- 2003-04-22 ES ES03747107T patent/ES2274258T3/es not_active Expired - Lifetime
- 2003-04-22 MX MXPA04010467A patent/MXPA04010467A/es unknown
- 2003-04-22 AU AU2003232491A patent/AU2003232491A1/en not_active Abandoned
- 2003-04-22 PT PT03747107T patent/PT1497308E/pt unknown
- 2003-04-22 RU RU2004134324/04A patent/RU2315056C2/ru not_active IP Right Cessation
- 2003-04-22 AT AT03747107T patent/ATE340186T1/de not_active IP Right Cessation
- 2003-04-22 EP EP03747107A patent/EP1497308B1/de not_active Expired - Lifetime
- 2003-04-22 DE DE50305122T patent/DE50305122D1/de not_active Expired - Lifetime
- 2003-04-22 BR BR0309357-3A patent/BR0309357A/pt not_active IP Right Cessation
- 2003-04-22 PL PL03371340A patent/PL371340A1/xx not_active Application Discontinuation
-
2004
- 2004-11-18 NO NO20045023A patent/NO20045023L/no not_active Application Discontinuation
- 2004-11-22 ZA ZA200409401A patent/ZA200409401B/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU2003232491A1 (en) | 2003-11-10 |
| JP2005524698A (ja) | 2005-08-18 |
| IL163986A0 (en) | 2005-12-18 |
| US20030216360A1 (en) | 2003-11-20 |
| DE50305122D1 (de) | 2006-11-02 |
| RU2315056C2 (ru) | 2008-01-20 |
| KR20040106380A (ko) | 2004-12-17 |
| CA2480004A1 (en) | 2003-11-06 |
| DE10218107A1 (de) | 2003-11-20 |
| JP4490116B2 (ja) | 2010-06-23 |
| ZA200409401B (en) | 2006-02-22 |
| EP1497308A1 (de) | 2005-01-19 |
| PL371340A1 (en) | 2005-06-13 |
| RU2004134324A (ru) | 2006-02-10 |
| EP1497308B1 (de) | 2006-09-20 |
| NO20045023L (no) | 2004-11-18 |
| MXPA04010467A (es) | 2004-12-13 |
| ES2274258T3 (es) | 2007-05-16 |
| CN1646555A (zh) | 2005-07-27 |
| US7148212B2 (en) | 2006-12-12 |
| PT1497308E (pt) | 2007-01-31 |
| CA2480004C (en) | 2007-11-13 |
| WO2003091272A1 (de) | 2003-11-06 |
| ATE340186T1 (de) | 2006-10-15 |
| DK1497308T3 (da) | 2007-01-29 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 6A E 7A ANUIDADES. |
|
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2051 DE 27/04/2010. |