BR0308492A - Compostos cefem possuindo amplo espectro antibacteriano - Google Patents
Compostos cefem possuindo amplo espectro antibacterianoInfo
- Publication number
- BR0308492A BR0308492A BR0308492-2A BR0308492A BR0308492A BR 0308492 A BR0308492 A BR 0308492A BR 0308492 A BR0308492 A BR 0308492A BR 0308492 A BR0308492 A BR 0308492A
- Authority
- BR
- Brazil
- Prior art keywords
- optionally substituted
- antibacterial spectrum
- broad antibacterial
- compounds
- amino
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/30—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom
- C07D211/32—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/14—Compounds having a nitrogen atom directly attached in position 7
- C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
- C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
- C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
- C07D501/48—Methylene radicals, substituted by hetero rings
- C07D501/56—Methylene radicals, substituted by hetero rings with the 7-amino radical acylated by carboxylic acids containing hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
- A61K31/545—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine
- A61K31/546—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine containing further heterocyclic rings, e.g. cephalothin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/34—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Oncology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Cephalosporin Compounds (AREA)
Abstract
"COMPOSTOS CEFEM POSSUINDO AMPLO ESPECTRO ANTIBACTERIANO". A presente invenção refere-se a um composto da fórmula: (onde, T é S, SO ou 0; X é halogênio, CN, carbomoíla opcionalmente substituída com alquila inferior, alquila inferior, alcóxi inferior, ou alquiltio inferior; A é alquileno inferior substituído (onde o substituinte é monoalquila inferior opcionalmente substituída, alquilideno inferior opcionalmente substituído, ou alquileno inferior opcionalmente substituído); Z^ é um, grupo heterocíclico contendo átomo N e um cátion, opcionalmente substituído) éster, composto protegido por amino onde o amino liga-se a um anel tiazol na posição 7, ou um sal ou solvato farmaceuticamente aceitável do mesmo.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2002073526 | 2002-03-18 | ||
PCT/JP2003/003249 WO2003078440A1 (en) | 2002-03-18 | 2003-03-18 | Broad-spectrum cephem compounds |
Publications (1)
Publication Number | Publication Date |
---|---|
BR0308492A true BR0308492A (pt) | 2005-05-03 |
Family
ID=28035247
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR0308492-2A BR0308492A (pt) | 2002-03-18 | 2003-03-18 | Compostos cefem possuindo amplo espectro antibacteriano |
Country Status (11)
Country | Link |
---|---|
US (2) | US7384928B2 (pt) |
EP (1) | EP1489084A4 (pt) |
JP (1) | JP4433383B2 (pt) |
KR (1) | KR20040091765A (pt) |
CN (1) | CN1653072A (pt) |
AU (1) | AU2003221080A1 (pt) |
BR (1) | BR0308492A (pt) |
CA (1) | CA2479354A1 (pt) |
MX (1) | MXPA04008320A (pt) |
TW (1) | TW200305422A (pt) |
WO (1) | WO2003078440A1 (pt) |
Families Citing this family (30)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR20070026295A (ko) * | 2003-08-25 | 2007-03-08 | 레박스 파마슈티칼즈, 엘엘씨 | 경구 신경치료 세파졸린 조성물 |
WO2005085258A1 (ja) * | 2004-03-05 | 2005-09-15 | Shionogi & Co., Ltd. | 3−ピリジニウムメチルセフェム化合物 |
US7327803B2 (en) * | 2004-10-22 | 2008-02-05 | Parkervision, Inc. | Systems and methods for vector power amplification |
JP2006206529A (ja) * | 2005-01-31 | 2006-08-10 | Shionogi & Co Ltd | N−(4−ピリジル)エチレンジアミン誘導体 |
CN101210023B (zh) * | 2006-12-30 | 2010-12-08 | 山东轩竹医药科技有限公司 | 一种头孢菌素衍生物 |
CN101230069B (zh) * | 2006-12-31 | 2010-12-08 | 山东轩竹医药科技有限公司 | 新的头孢菌素衍生物 |
CA2935651A1 (en) | 2007-10-09 | 2009-04-16 | Gladius Pharmaceuticals Corporation | Broad spectrum beta-lactamase inhibitors |
CN101759710B (zh) * | 2008-10-06 | 2011-10-05 | 山东轩竹医药科技有限公司 | 含有取代的氮杂环的头孢菌素衍生物 |
ME02666B (me) | 2008-10-31 | 2017-06-20 | Shionogi & Co | Cefalosporin sa kateholskom grupom |
JP5852559B2 (ja) * | 2010-04-05 | 2016-02-03 | 塩野義製薬株式会社 | 擬似カテコール基を有するセフェム化合物 |
AU2011236933A1 (en) * | 2010-04-05 | 2013-05-02 | Shionogi & Co., Ltd. | Cephem compound having catechol group |
JP5852562B2 (ja) * | 2010-04-28 | 2016-02-03 | 塩野義製薬株式会社 | 新規なセフェム誘導体 |
KR101719556B1 (ko) * | 2011-03-30 | 2017-03-24 | 주식회사 레고켐 바이오사이언스 | 신규한 세파로스포린 유도체 및 이를 함유하는 의약 조성물 |
JP6006201B2 (ja) * | 2011-04-28 | 2016-10-12 | 塩野義製薬株式会社 | カテコールまたは擬似カテコール構造を有する新規セフェム化合物 |
CN103619853A (zh) | 2011-06-27 | 2014-03-05 | 盐野义制药株式会社 | 具有吡啶鎓基的头孢烯化合物 |
EA028342B1 (ru) | 2011-09-09 | 2017-11-30 | Мерк Шарп И Доум Корп. | Способы лечения пневмонии |
TWI547496B (zh) | 2011-10-04 | 2016-09-01 | 葛蘭素集團公司 | 抗菌化合物 |
WO2013051597A1 (ja) * | 2011-10-04 | 2013-04-11 | 塩野義製薬株式会社 | カテコール基を有するセフェム誘導体 |
US8809314B1 (en) | 2012-09-07 | 2014-08-19 | Cubist Pharmacueticals, Inc. | Cephalosporin compound |
US8476425B1 (en) | 2012-09-27 | 2013-07-02 | Cubist Pharmaceuticals, Inc. | Tazobactam arginine compositions |
KR20150076223A (ko) | 2012-10-29 | 2015-07-06 | 시오노기세야쿠 가부시키가이샤 | 2-알킬 세펨 화합물을 위한 중간체의 제조 방법 |
UY35103A (es) | 2012-10-29 | 2014-05-30 | Glaxo Group Ltd | Compuestos de cefem 2-sustituidos |
CN102977123B (zh) * | 2012-12-03 | 2015-04-29 | 邓世碧 | 一种头孢类化合物及其药学可接受盐 |
US9872906B2 (en) | 2013-03-15 | 2018-01-23 | Merck Sharp & Dohme Corp. | Ceftolozane antibiotic compositions |
NZ700372A (en) | 2013-03-15 | 2016-01-29 | Merck Sharp & Dohme | Ceftolozane antibiotic compositions |
US20140274997A1 (en) | 2013-03-15 | 2014-09-18 | Cubist Pharmaceuticals, Inc. | Cephalosporin pharmaceutical compositions |
EP3043797B1 (en) | 2013-09-09 | 2020-04-08 | Merck Sharp & Dohme Corp. | Treating infections with ceftolozane/tazobactam in subjects having impaired renal function |
US8906898B1 (en) | 2013-09-27 | 2014-12-09 | Calixa Therapeutics, Inc. | Solid forms of ceftolozane |
KR20180066264A (ko) * | 2015-12-10 | 2018-06-18 | 나에자-알지엠 파마슈티칼스 유엘씨 | 세펨 화합물, 그의 제조 및 용도 |
AR110451A1 (es) * | 2016-12-26 | 2019-03-27 | Shionogi & Co | Compuesto tricíclico que tiene sulfinilo y composición farmacéutica que lo comprende |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4427677A (en) * | 1980-12-31 | 1984-01-24 | Fujisawa Pharmaceutical Co., Ltd. | Cephem compounds |
DE3177090D1 (en) * | 1980-12-31 | 1989-09-28 | Fujisawa Pharmaceutical Co | 7-acylaminocephalosporanic acid derivatives and processes for the preparation thereof |
JPS5859991A (ja) * | 1981-09-14 | 1983-04-09 | Fujisawa Pharmaceut Co Ltd | 新規セフェム化合物 |
DE3247614A1 (de) * | 1982-12-23 | 1984-07-05 | Hoechst Ag, 6230 Frankfurt | Cephalosporinderivate und verfahren zu ihrer herstellung |
US4525473A (en) | 1983-03-30 | 1985-06-25 | Bristol-Myers Company | Cephalosporins |
DE3316797A1 (de) * | 1983-05-07 | 1984-11-08 | Hoechst Ag, 6230 Frankfurt | Verfahren zur herstellung von cephemverbindungen |
JPS60120886A (ja) | 1983-12-02 | 1985-06-28 | Takeda Chem Ind Ltd | セフェムカルボン酸のナトリウム塩の結晶 |
US5484928A (en) * | 1984-04-10 | 1996-01-16 | Biochemie Gesellschaft M.B.H. | 2-(2-aminothiazol-4-yl)-2-oxoacetic acid derivatives |
US4788185A (en) | 1984-04-23 | 1988-11-29 | Takeda Chemical Industries, Ltd. | Cephalosporin compounds |
AUPN955596A0 (en) * | 1996-04-30 | 1996-05-23 | Fujisawa Pharmaceutical Co., Ltd. | New compound |
US7067481B2 (en) * | 2003-05-23 | 2006-06-27 | Theravance, Inc. | Cross-linked glycopeptide-cephalosporin antibiotics |
EP1644382B1 (en) * | 2003-07-11 | 2008-03-05 | Theravance, Inc. | Cross-linked glycopeptide-cephalosporin antibiotics |
-
2003
- 2003-03-17 TW TW092105741A patent/TW200305422A/zh unknown
- 2003-03-18 JP JP2003576445A patent/JP4433383B2/ja not_active Expired - Fee Related
- 2003-03-18 AU AU2003221080A patent/AU2003221080A1/en not_active Abandoned
- 2003-03-18 CA CA002479354A patent/CA2479354A1/en not_active Abandoned
- 2003-03-18 MX MXPA04008320A patent/MXPA04008320A/es unknown
- 2003-03-18 US US10/507,502 patent/US7384928B2/en not_active Expired - Fee Related
- 2003-03-18 KR KR10-2004-7014741A patent/KR20040091765A/ko not_active Application Discontinuation
- 2003-03-18 EP EP03712748A patent/EP1489084A4/en not_active Withdrawn
- 2003-03-18 BR BR0308492-2A patent/BR0308492A/pt not_active IP Right Cessation
- 2003-03-18 WO PCT/JP2003/003249 patent/WO2003078440A1/ja active Application Filing
- 2003-03-18 CN CNA038109697A patent/CN1653072A/zh active Pending
-
2008
- 2008-04-09 US US12/100,307 patent/US7696354B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
US20090131655A1 (en) | 2009-05-21 |
US7696354B2 (en) | 2010-04-13 |
JPWO2003078440A1 (ja) | 2005-07-14 |
US20050153950A1 (en) | 2005-07-14 |
EP1489084A1 (en) | 2004-12-22 |
CA2479354A1 (en) | 2003-09-25 |
MXPA04008320A (es) | 2004-11-26 |
JP4433383B2 (ja) | 2010-03-17 |
KR20040091765A (ko) | 2004-10-28 |
US7384928B2 (en) | 2008-06-10 |
EP1489084A4 (en) | 2010-06-09 |
TW200305422A (en) | 2003-11-01 |
CN1653072A (zh) | 2005-08-10 |
AU2003221080A1 (en) | 2003-09-29 |
WO2003078440A1 (en) | 2003-09-25 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B08F | Application fees: application dismissed [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 6A E 7A ANUIDADE(S). |
|
B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2051 DE 27/04/2010. |