BR0308492A - Compostos cefem possuindo amplo espectro antibacteriano - Google Patents

Compostos cefem possuindo amplo espectro antibacteriano

Info

Publication number
BR0308492A
BR0308492A BR0308492-2A BR0308492A BR0308492A BR 0308492 A BR0308492 A BR 0308492A BR 0308492 A BR0308492 A BR 0308492A BR 0308492 A BR0308492 A BR 0308492A
Authority
BR
Brazil
Prior art keywords
optionally substituted
antibacterial spectrum
broad antibacterial
compounds
amino
Prior art date
Application number
BR0308492-2A
Other languages
English (en)
Inventor
Yasuhiro Nishitani
Yoshinori Yamano
Original Assignee
Shionogi & Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shionogi & Co filed Critical Shionogi & Co
Publication of BR0308492A publication Critical patent/BR0308492A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/30—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom
    • C07D211/32—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/48—Methylene radicals, substituted by hetero rings
    • C07D501/56—Methylene radicals, substituted by hetero rings with the 7-amino radical acylated by carboxylic acids containing hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/545—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine
    • A61K31/546—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine containing further heterocyclic rings, e.g. cephalothin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/34—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cephalosporin Compounds (AREA)

Abstract

"COMPOSTOS CEFEM POSSUINDO AMPLO ESPECTRO ANTIBACTERIANO". A presente invenção refere-se a um composto da fórmula: (onde, T é S, SO ou 0; X é halogênio, CN, carbomoíla opcionalmente substituída com alquila inferior, alquila inferior, alcóxi inferior, ou alquiltio inferior; A é alquileno inferior substituído (onde o substituinte é monoalquila inferior opcionalmente substituída, alquilideno inferior opcionalmente substituído, ou alquileno inferior opcionalmente substituído); Z^ é um, grupo heterocíclico contendo átomo N e um cátion, opcionalmente substituído) éster, composto protegido por amino onde o amino liga-se a um anel tiazol na posição 7, ou um sal ou solvato farmaceuticamente aceitável do mesmo.
BR0308492-2A 2002-03-18 2003-03-18 Compostos cefem possuindo amplo espectro antibacteriano BR0308492A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2002073526 2002-03-18
PCT/JP2003/003249 WO2003078440A1 (en) 2002-03-18 2003-03-18 Broad-spectrum cephem compounds

Publications (1)

Publication Number Publication Date
BR0308492A true BR0308492A (pt) 2005-05-03

Family

ID=28035247

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0308492-2A BR0308492A (pt) 2002-03-18 2003-03-18 Compostos cefem possuindo amplo espectro antibacteriano

Country Status (11)

Country Link
US (2) US7384928B2 (pt)
EP (1) EP1489084A4 (pt)
JP (1) JP4433383B2 (pt)
KR (1) KR20040091765A (pt)
CN (1) CN1653072A (pt)
AU (1) AU2003221080A1 (pt)
BR (1) BR0308492A (pt)
CA (1) CA2479354A1 (pt)
MX (1) MXPA04008320A (pt)
TW (1) TW200305422A (pt)
WO (1) WO2003078440A1 (pt)

Families Citing this family (30)

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KR20070026295A (ko) * 2003-08-25 2007-03-08 레박스 파마슈티칼즈, 엘엘씨 경구 신경치료 세파졸린 조성물
WO2005085258A1 (ja) * 2004-03-05 2005-09-15 Shionogi & Co., Ltd. ３−ピリジニウムメチルセフェム化合物
US7327803B2 (en) * 2004-10-22 2008-02-05 Parkervision, Inc. Systems and methods for vector power amplification
JP2006206529A (ja) * 2005-01-31 2006-08-10 Shionogi & Co Ltd Ｎ−（４−ピリジル）エチレンジアミン誘導体
CN101210023B (zh) * 2006-12-30 2010-12-08 山东轩竹医药科技有限公司 一种头孢菌素衍生物
CN101230069B (zh) * 2006-12-31 2010-12-08 山东轩竹医药科技有限公司 新的头孢菌素衍生物
CA2935651A1 (en) 2007-10-09 2009-04-16 Gladius Pharmaceuticals Corporation Broad spectrum beta-lactamase inhibitors
CN101759710B (zh) * 2008-10-06 2011-10-05 山东轩竹医药科技有限公司 含有取代的氮杂环的头孢菌素衍生物
ME02666B (me) 2008-10-31 2017-06-20 Shionogi & Co Cefalosporin sa kateholskom grupom
JP5852559B2 (ja) * 2010-04-05 2016-02-03 塩野義製薬株式会社 擬似カテコール基を有するセフェム化合物
AU2011236933A1 (en) * 2010-04-05 2013-05-02 Shionogi & Co., Ltd. Cephem compound having catechol group
JP5852562B2 (ja) * 2010-04-28 2016-02-03 塩野義製薬株式会社 新規なセフェム誘導体
KR101719556B1 (ko) * 2011-03-30 2017-03-24 주식회사 레고켐 바이오사이언스 신규한 세파로스포린 유도체 및 이를 함유하는 의약 조성물
JP6006201B2 (ja) * 2011-04-28 2016-10-12 塩野義製薬株式会社 カテコールまたは擬似カテコール構造を有する新規セフェム化合物
CN103619853A (zh) 2011-06-27 2014-03-05 盐野义制药株式会社 具有吡啶鎓基的头孢烯化合物
EA028342B1 (ru) 2011-09-09 2017-11-30 Мерк Шарп И Доум Корп. Способы лечения пневмонии
TWI547496B (zh) 2011-10-04 2016-09-01 葛蘭素集團公司 抗菌化合物
WO2013051597A1 (ja) * 2011-10-04 2013-04-11 塩野義製薬株式会社 カテコール基を有するセフェム誘導体
US8809314B1 (en) 2012-09-07 2014-08-19 Cubist Pharmacueticals, Inc. Cephalosporin compound
US8476425B1 (en) 2012-09-27 2013-07-02 Cubist Pharmaceuticals, Inc. Tazobactam arginine compositions
KR20150076223A (ko) 2012-10-29 2015-07-06 시오노기세야쿠 가부시키가이샤 2-알킬 세펨 화합물을 위한 중간체의 제조 방법
UY35103A (es) 2012-10-29 2014-05-30 Glaxo Group Ltd Compuestos de cefem 2-sustituidos
CN102977123B (zh) * 2012-12-03 2015-04-29 邓世碧 一种头孢类化合物及其药学可接受盐
US9872906B2 (en) 2013-03-15 2018-01-23 Merck Sharp & Dohme Corp. Ceftolozane antibiotic compositions
NZ700372A (en) 2013-03-15 2016-01-29 Merck Sharp & Dohme Ceftolozane antibiotic compositions
US20140274997A1 (en) 2013-03-15 2014-09-18 Cubist Pharmaceuticals, Inc. Cephalosporin pharmaceutical compositions
EP3043797B1 (en) 2013-09-09 2020-04-08 Merck Sharp & Dohme Corp. Treating infections with ceftolozane/tazobactam in subjects having impaired renal function
US8906898B1 (en) 2013-09-27 2014-12-09 Calixa Therapeutics, Inc. Solid forms of ceftolozane
KR20180066264A (ko) * 2015-12-10 2018-06-18 나에자-알지엠 파마슈티칼스 유엘씨 세펨 화합물, 그의 제조 및 용도
AR110451A1 (es) * 2016-12-26 2019-03-27 Shionogi & Co Compuesto tricíclico que tiene sulfinilo y composición farmacéutica que lo comprende

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Also Published As

Publication number Publication date
US20090131655A1 (en) 2009-05-21
US7696354B2 (en) 2010-04-13
JPWO2003078440A1 (ja) 2005-07-14
US20050153950A1 (en) 2005-07-14
EP1489084A1 (en) 2004-12-22
CA2479354A1 (en) 2003-09-25
MXPA04008320A (es) 2004-11-26
JP4433383B2 (ja) 2010-03-17
KR20040091765A (ko) 2004-10-28
US7384928B2 (en) 2008-06-10
EP1489084A4 (en) 2010-06-09
TW200305422A (en) 2003-11-01
CN1653072A (zh) 2005-08-10
AU2003221080A1 (en) 2003-09-29
WO2003078440A1 (en) 2003-09-25

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Legal Events

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B08F Application fees: application dismissed [chapter 8.6 patent gazette]

Free format text: REFERENTE A 6A E 7A ANUIDADE(S).

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2051 DE 27/04/2010.