BR0307816A - Composição farmacêutica oral para cápsulas macias contendo vinorelbina e método de tratamento - Google Patents
Composição farmacêutica oral para cápsulas macias contendo vinorelbina e método de tratamentoInfo
- Publication number
- BR0307816A BR0307816A BR0307816-7A BR0307816A BR0307816A BR 0307816 A BR0307816 A BR 0307816A BR 0307816 A BR0307816 A BR 0307816A BR 0307816 A BR0307816 A BR 0307816A
- Authority
- BR
- Brazil
- Prior art keywords
- vinorelbine
- pharmaceutical composition
- soft capsules
- oral pharmaceutical
- treatment method
- Prior art date
Links
- 239000007901 soft capsule Substances 0.000 title abstract 4
- GBABOYUKABKIAF-GHYRFKGUSA-N vinorelbine Chemical compound C1N(CC=2C3=CC=CC=C3NC=22)CC(CC)=C[C@H]1C[C@]2(C(=O)OC)C1=CC([C@]23[C@H]([C@]([C@H](OC(C)=O)[C@]4(CC)C=CCN([C@H]34)CC2)(O)C(=O)OC)N2C)=C2C=C1OC GBABOYUKABKIAF-GHYRFKGUSA-N 0.000 title abstract 4
- 229960002066 vinorelbine Drugs 0.000 title abstract 4
- 238000000034 method Methods 0.000 title abstract 2
- 239000008203 oral pharmaceutical composition Substances 0.000 title abstract 2
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 abstract 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 2
- 239000007788 liquid Substances 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 abstract 2
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 239000002202 Polyethylene glycol Substances 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 239000002552 dosage form Substances 0.000 abstract 1
- 238000005538 encapsulation Methods 0.000 abstract 1
- 229920001223 polyethylene glycol Polymers 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 150000003892 tartrate salts Chemical group 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4808—Preparations in capsules, e.g. of gelatin, of chocolate characterised by the form of the capsule or the structure of the filling; Capsules containing small tablets; Capsules with outer layer for immediate drug release
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4858—Organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
"COMPOSIçãO FARMACêUTICA ORAL PARA CáPSULAS MACIAS CONTENDO VINORELBINA E MéTODO DE TRATAMENTO". A invenção descrita aqui refere-se a uma composição farmacêutica contendo vinorelbina como um ingrediente ativo que é adequado para encapsulação em cápsulas macias. A composição farmacêutica oral líquida adequada para a composição de carga líquida para uma forma de dosagem de cápsula macia compreende: vinorelbina ou um sal farmaceuticamente aceitável deste; etanol; água; glicerol; e polietileno glicol. Na modalidade preferida, a forma de sal de tartrato de vinorelbina é empregada na composição. A invenção também prover a subsistência de um método para tratar câncer compreendendo oralmente administrar, a um paciente em necessidade de tal tratamento, uma cápsula macia compreendendo a composição farmacêutica da invenção.
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0206886A FR2840203B1 (fr) | 2002-05-31 | 2002-05-31 | Composition pharmaceutique orale pour capsules molles contenant vinorelbine et methode de traitement |
| CA2,388,431 | 2002-05-31 | ||
| CA002388431A CA2388431C (en) | 2002-05-31 | 2002-05-31 | Oral pharmaceutical composition for soft capsules containing vinorelbine and method of treatment |
| US10/161,454 | 2002-05-31 | ||
| US10/161,454 US6890558B2 (en) | 2002-05-31 | 2002-05-31 | Oral pharmaceutical composition for soft capsules containing vinorelbine and method of treatment |
| FR0206886 | 2002-05-31 |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| BR0307816A true BR0307816A (pt) | 2005-08-02 |
| BR0307816C1 BR0307816C1 (pt) | 2006-09-19 |
| BRPI0307816B1 BRPI0307816B1 (pt) | 2018-03-06 |
| BRPI0307816B8 BRPI0307816B8 (pt) | 2021-05-25 |
Family
ID=29715700
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0307816A BRPI0307816B8 (pt) | 2002-05-31 | 2003-05-28 | composição farmacêutica oral líquida adequada como uma composição de carga líquida para uma forma de dosagem de cápsula macia |
| BRC10307816A BRPI0307816F1 (pt) | 2002-05-31 | 2006-05-26 | Usos de uma composição de carga farmacêutica oral líquida para forma de dosagem de cápsula macia |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRC10307816A BRPI0307816F1 (pt) | 2002-05-31 | 2006-05-26 | Usos de uma composição de carga farmacêutica oral líquida para forma de dosagem de cápsula macia |
Country Status (15)
| Country | Link |
|---|---|
| EP (1) | EP1530459B1 (pt) |
| JP (2) | JP4718170B2 (pt) |
| CN (1) | CN1287794C (pt) |
| AT (1) | ATE462419T1 (pt) |
| AU (1) | AU2003240808B2 (pt) |
| BR (2) | BRPI0307816B8 (pt) |
| CY (1) | CY1110184T1 (pt) |
| DE (1) | DE60331920D1 (pt) |
| DK (1) | DK1530459T3 (pt) |
| ES (1) | ES2343790T3 (pt) |
| HK (1) | HK1079421A1 (pt) |
| MX (1) | MXPA04006054A (pt) |
| PT (1) | PT1530459E (pt) |
| SI (1) | SI1530459T1 (pt) |
| WO (1) | WO2003101383A2 (pt) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ554793A (en) * | 2004-12-30 | 2010-04-30 | Pf Medicament | Stable solid dispersion of a derivative of a vinca alkaloid such as vinorelbine ditartrate in polyethylene glycol |
| FR2880274B1 (fr) * | 2004-12-30 | 2007-04-13 | Pierre Fabre Medicament Sa | Dispersion solide stable d'un derive d'alcaloides de vinca et son procede de fabrication |
| CN101134026B (zh) * | 2006-08-31 | 2011-12-07 | 江苏豪森药业股份有限公司 | 长春瑞滨软胶囊及其制备方法和其应用 |
| FR2918566B1 (fr) | 2007-07-11 | 2009-10-09 | Pierre Fabre Medicament Sa | Composition pharmaceutique stable d'un sel hydrosoluble de vinflunine. |
| FR2918567B1 (fr) * | 2007-07-11 | 2012-08-03 | Pf Medicament | Composition pharmaceutique stable d'un sel hydrosoluble de vinorelbine. |
| WO2009105937A1 (zh) * | 2008-02-29 | 2009-09-03 | 江苏豪森药业股份有限公司 | 长春瑞滨软胶囊及其制备方法和其应用 |
| CA3014473A1 (en) | 2016-03-09 | 2017-09-14 | Synbias Pharma Ag | Vinorelbine monotartrate and its pharmaceutical use |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4623629A (en) * | 1983-10-31 | 1986-11-18 | Daniel Kerschensteiner | Solid-phase immunoassay support and method of use thereof |
| US5447936A (en) * | 1993-12-22 | 1995-09-05 | Bionumerik Pharmaceuticals, Inc. | Lactone stable formulation of 10-hydroxy 7-ethyl camptothecin and methods for uses thereof |
| US5641512A (en) * | 1995-03-29 | 1997-06-24 | The Procter & Gamble Company | Soft gelatin capsule compositions |
| DE19545043A1 (de) * | 1995-12-02 | 1997-06-05 | Scherer Gmbh R P | Pharmazeutische Präparate zur oralen Anwendung und Verfahren zu ihrer Herstellung |
| EP1185276B1 (en) * | 1999-05-24 | 2003-12-10 | Southern Research Institute | Isophosphoramide mustard analogs and use thereof |
-
2003
- 2003-05-28 AU AU2003240808A patent/AU2003240808B2/en not_active Expired
- 2003-05-28 ES ES03731404T patent/ES2343790T3/es not_active Expired - Lifetime
- 2003-05-28 WO PCT/US2003/016732 patent/WO2003101383A2/en active Application Filing
- 2003-05-28 BR BRPI0307816A patent/BRPI0307816B8/pt not_active IP Right Cessation
- 2003-05-28 DE DE60331920T patent/DE60331920D1/de not_active Expired - Lifetime
- 2003-05-28 JP JP2004508741A patent/JP4718170B2/ja not_active Expired - Lifetime
- 2003-05-28 PT PT03731404T patent/PT1530459E/pt unknown
- 2003-05-28 SI SI200331808T patent/SI1530459T1/sl unknown
- 2003-05-28 AT AT03731404T patent/ATE462419T1/de active
- 2003-05-28 CN CNB038044390A patent/CN1287794C/zh not_active Expired - Lifetime
- 2003-05-28 MX MXPA04006054A patent/MXPA04006054A/es active IP Right Grant
- 2003-05-28 EP EP03731404A patent/EP1530459B1/en not_active Revoked
- 2003-05-28 DK DK03731404.4T patent/DK1530459T3/da active
-
2005
- 2005-11-18 HK HK05110442.8A patent/HK1079421A1/xx not_active IP Right Cessation
-
2006
- 2006-05-26 BR BRC10307816A patent/BRPI0307816F1/pt unknown
-
2010
- 2010-06-11 CY CY20101100516T patent/CY1110184T1/el unknown
- 2010-09-30 JP JP2010221628A patent/JP5334937B2/ja not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| JP2010280739A (ja) | 2010-12-16 |
| JP5334937B2 (ja) | 2013-11-06 |
| BR0307816C1 (pt) | 2006-09-19 |
| AU2003240808B2 (en) | 2008-05-08 |
| BRPI0307816B8 (pt) | 2021-05-25 |
| BRPI0307816B1 (pt) | 2018-03-06 |
| AU2003240808A1 (en) | 2003-12-19 |
| EP1530459A4 (en) | 2007-08-22 |
| CN1287794C (zh) | 2006-12-06 |
| SI1530459T1 (sl) | 2010-08-31 |
| WO2003101383A2 (en) | 2003-12-11 |
| JP2006516111A (ja) | 2006-06-22 |
| EP1530459A2 (en) | 2005-05-18 |
| BRPI0307816F1 (pt) | 2022-02-15 |
| ATE462419T1 (de) | 2010-04-15 |
| ES2343790T3 (es) | 2010-08-10 |
| DK1530459T3 (da) | 2010-07-19 |
| WO2003101383A3 (en) | 2004-09-30 |
| DE60331920D1 (de) | 2010-05-12 |
| MXPA04006054A (es) | 2004-09-27 |
| EP1530459B1 (en) | 2010-03-31 |
| CY1110184T1 (el) | 2015-01-14 |
| JP4718170B2 (ja) | 2011-07-06 |
| HK1079421A1 (en) | 2006-04-07 |
| PT1530459E (pt) | 2010-05-20 |
| CN1638745A (zh) | 2005-07-13 |
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| B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] |
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