CA2388431A1 - Oral pharmaceutical composition for soft capsules containing vinorelbine and method of treatment - Google Patents

Oral pharmaceutical composition for soft capsules containing vinorelbine and method of treatment Download PDF

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Publication number
CA2388431A1
CA2388431A1 CA002388431A CA2388431A CA2388431A1 CA 2388431 A1 CA2388431 A1 CA 2388431A1 CA 002388431 A CA002388431 A CA 002388431A CA 2388431 A CA2388431 A CA 2388431A CA 2388431 A1 CA2388431 A1 CA 2388431A1
Authority
CA
Canada
Prior art keywords
pharmaceutical composition
vinorelbine
treatment
soft capsules
oral pharmaceutical
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002388431A
Other languages
French (fr)
Other versions
CA2388431C (en
Inventor
Joel Bougaret
Elie Leverd
Marie-Madeleine Bohn
Norbert Heintz
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
RP Scherer Technologies LLC
Original Assignee
RP Scherer Technologies LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to CA002388431A priority Critical patent/CA2388431C/en
Application filed by RP Scherer Technologies LLC filed Critical RP Scherer Technologies LLC
Priority to AU2003240808A priority patent/AU2003240808B2/en
Priority to CNB038044390A priority patent/CN1287794C/en
Priority to JP2004508741A priority patent/JP4718170B2/en
Priority to DE60331920T priority patent/DE60331920D1/en
Priority to MXPA04006054A priority patent/MXPA04006054A/en
Priority to AT03731404T priority patent/ATE462419T1/en
Priority to PCT/US2003/016732 priority patent/WO2003101383A2/en
Priority to ES03731404T priority patent/ES2343790T3/en
Priority to PT03731404T priority patent/PT1530459E/en
Priority to BRPI0307816A priority patent/BRPI0307816B8/en
Priority to SI200331808T priority patent/SI1530459T1/en
Priority to DK03731404.4T priority patent/DK1530459T3/en
Priority to EP03731404A priority patent/EP1530459B1/en
Publication of CA2388431A1 publication Critical patent/CA2388431A1/en
Priority to HK05110442.8A priority patent/HK1079421A1/en
Publication of CA2388431C publication Critical patent/CA2388431C/en
Application granted granted Critical
Priority to BRC10307816A priority patent/BRPI0307816F1/en
Priority to CY20101100516T priority patent/CY1110184T1/en
Priority to JP2010221628A priority patent/JP5334937B2/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4858—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/475—Quinolines; Isoquinolines having an indole ring, e.g. yohimbine, reserpine, strychnine, vinblastine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4866—Organic macromolecular compounds

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

The invention described herein relates to a pharmaceutical composition containing vinorelbine as an active ingredient which is suitable for encapsulation in soft capsules. The liquid oral pharmaceutical composition suitable for a liquid fill composition for a soft capsule dosage form comprises: vinorelbine or a pharmaceutically acceptable salt thereof; ethanol; water; glycerol; and polyethylene glycol. In a preferred embodiment, the tartrate salt form of vinorelbine is used in the composition.
The invention also provides for a method of treating cancer comprising orally administering, to a patient in need of treatment thereof, a soft capsule comprising the pharmaceutical composition of the invention.
CA002388431A 2002-05-31 2002-05-31 Oral pharmaceutical composition for soft capsules containing vinorelbine and method of treatment Expired - Lifetime CA2388431C (en)

Priority Applications (18)

Application Number Priority Date Filing Date Title
CA002388431A CA2388431C (en) 2002-05-31 2002-05-31 Oral pharmaceutical composition for soft capsules containing vinorelbine and method of treatment
DK03731404.4T DK1530459T3 (en) 2002-05-31 2003-05-28 Oral pharmaceutical composition for soft capsules containing vinorelbine and method of treatment
CNB038044390A CN1287794C (en) 2002-05-31 2003-05-28 Oral pharmaceutical composition for soft capsules containing vinorelbine and method of treatment
DE60331920T DE60331920D1 (en) 2002-05-31 2003-05-28 ORAL PHARMACEUTICAL COMPOSITION FOR SOAP CAPSULES WITH VINORELBIN AND TREATMENT PROCEDURES
MXPA04006054A MXPA04006054A (en) 2002-05-31 2003-05-28 Oral pharmaceutical composition for soft capsules containing vinorelbine and method of treatment.
AT03731404T ATE462419T1 (en) 2002-05-31 2003-05-28 ORAL PHARMACEUTICAL COMPOSITION FOR SOFT CAPSULES WITH VINORELBIN AND TREATMENT METHOD
PCT/US2003/016732 WO2003101383A2 (en) 2002-05-31 2003-05-28 Oral pharmaceutical composition for soft capsules containing vinorelbine and method of treatment
ES03731404T ES2343790T3 (en) 2002-05-31 2003-05-28 ORAL PHARMACEUTICAL COMPOSITION FOR SOFT CAPSULES CONTAINING VINORELBINE AND A TREATMENT METHOD.
EP03731404A EP1530459B1 (en) 2002-05-31 2003-05-28 Oral pharmaceutical composition for soft capsules containing vinorelbine and method of treatment
BRPI0307816A BRPI0307816B8 (en) 2002-05-31 2003-05-28 liquid oral pharmaceutical composition suitable as a liquid filler composition for a soft capsule dosage form
AU2003240808A AU2003240808B2 (en) 2002-05-31 2003-05-28 Oral pharmaceutical composition for soft capsules containing vinorelbine and method of treatment
JP2004508741A JP4718170B2 (en) 2002-05-31 2003-05-28 Oral pharmaceutical composition for soft capsules containing vinorelbine and method of treatment
PT03731404T PT1530459E (en) 2002-05-31 2003-05-28 Oral pharmaceutical composition for soft capsules containing vinorelbine and method of treatment
SI200331808T SI1530459T1 (en) 2002-05-31 2003-05-28 Oral pharmaceutical composition for soft capsules containing vinorelbine and method of treatment
HK05110442.8A HK1079421A1 (en) 2002-05-31 2005-11-18 Oral pharmaceutical composition for soft capsules containing vinorelbine and method of treatment
BRC10307816A BRPI0307816F1 (en) 2002-05-31 2006-05-26 Uses of a liquid oral pharmaceutical filler composition for soft capsule dosage form
CY20101100516T CY1110184T1 (en) 2002-05-31 2010-06-11 PHARMACEUTICAL COMPOSITION FOR SMOKE COFFEE FOR ORAL ADMINISTRATION CONTAINING VINORELBINE AND METHOD OF TREATMENT
JP2010221628A JP5334937B2 (en) 2002-05-31 2010-09-30 Oral pharmaceutical composition for soft capsules containing vinorelbine and method of treatment

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CA002388431A CA2388431C (en) 2002-05-31 2002-05-31 Oral pharmaceutical composition for soft capsules containing vinorelbine and method of treatment

Publications (2)

Publication Number Publication Date
CA2388431A1 true CA2388431A1 (en) 2003-11-30
CA2388431C CA2388431C (en) 2006-05-09

Family

ID=29783841

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002388431A Expired - Lifetime CA2388431C (en) 2002-05-31 2002-05-31 Oral pharmaceutical composition for soft capsules containing vinorelbine and method of treatment

Country Status (1)

Country Link
CA (1) CA2388431C (en)

Also Published As

Publication number Publication date
CA2388431C (en) 2006-05-09

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EEER Examination request
MKEX Expiry

Effective date: 20220531