BR0307243A - Processo para preparar propionato de fluticasona, e, composto - Google Patents

Processo para preparar propionato de fluticasona, e, composto

Info

Publication number
BR0307243A
BR0307243A BR0307243-6A BR0307243A BR0307243A BR 0307243 A BR0307243 A BR 0307243A BR 0307243 A BR0307243 A BR 0307243A BR 0307243 A BR0307243 A BR 0307243A
Authority
BR
Brazil
Prior art keywords
compound
fluticasone propionate
preparing fluticasone
preparing
formula
Prior art date
Application number
BR0307243-6A
Other languages
English (en)
Inventor
Steven John Coote
Rosalyn Kay Nice
Mark David Wipperman
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of BR0307243A publication Critical patent/BR0307243A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
    • C07J31/006—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pulmonology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

"PROCESSO PARA PREPARAR PROPIONATO DE FLUTICASONA, E, COMPOSTO". é descrito um processo para preparar propionato de fluticasona como Forma polimórfica cristalina 1, que compreende reagir um composto de fórmula (II) ou um seu sal com um composto de fórmula LCH2F, em que L representa um grupo de partida, opcionalmente na presença de um catalisador por transferência de fase, um solvente líquido, orgânico, não solvatante e imiscível em água e água.
BR0307243-6A 2002-02-04 2003-02-03 Processo para preparar propionato de fluticasona, e, composto BR0307243A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0202564.1A GB0202564D0 (en) 2002-02-04 2002-02-04 Process
PCT/EP2003/001115 WO2003066653A2 (en) 2002-02-04 2003-02-03 Process for the production of fluticasone propionate, in particular of polymorphic form 1

Publications (1)

Publication Number Publication Date
BR0307243A true BR0307243A (pt) 2004-12-14

Family

ID=9930366

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0307243-6A BR0307243A (pt) 2002-02-04 2003-02-03 Processo para preparar propionato de fluticasona, e, composto

Country Status (22)

Country Link
US (1) US20050222107A1 (pt)
EP (1) EP1474436B1 (pt)
JP (1) JP2005517019A (pt)
KR (1) KR20040086331A (pt)
CN (1) CN100338087C (pt)
AR (1) AR038390A1 (pt)
AT (1) ATE446965T1 (pt)
AU (1) AU2003206836B2 (pt)
BR (1) BR0307243A (pt)
CA (1) CA2473896A1 (pt)
CO (1) CO5611115A2 (pt)
DE (1) DE60329824D1 (pt)
GB (1) GB0202564D0 (pt)
IS (1) IS7373A (pt)
MX (1) MXPA04007530A (pt)
NO (1) NO327138B1 (pt)
NZ (1) NZ534320A (pt)
PL (1) PL372214A1 (pt)
RU (1) RU2333218C2 (pt)
TW (1) TW200410982A (pt)
WO (1) WO2003066653A2 (pt)
ZA (1) ZA200405826B (pt)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL153462A0 (en) * 2002-12-16 2003-07-06 Chemagis Ltd Thiocarboxylic acid organic salts and processes utilizing the same
EP2402360B1 (en) * 2006-06-14 2020-04-01 Generics [UK] Limited Process for the preparation of S-fluoromethyl-6,9-difluoro-11-hydroxy-16-methyl-17-propionyloxy-3-oxo-androsta-1,4-diene-17-carbothioate and intermediates
AU2013202843B2 (en) * 2006-06-14 2015-11-12 Generics [Uk] Limited Process for the preparation of S-fluoromethyl-6,9-difluoro-11-hydroxy-16-methyl-17-propionyloxy-3-oxo-androsta-1, 4-diene-17-carbothioate and intermediates
EP2611821A2 (en) * 2010-09-01 2013-07-10 Cadila Healthcare Limited Process for preparing fluticasone propionate/furoate
WO2013009591A1 (en) * 2011-07-08 2013-01-17 Pfizer Limited Process for the preparation of fluticasone propionate form 1
US8765725B2 (en) 2012-05-08 2014-07-01 Aciex Therapeutics, Inc. Preparations of hydrophobic therapeutic agents, methods of manufacture and use thereof
EP2847207B1 (en) 2012-05-08 2019-03-27 Nicox Ophthalmics, Inc. Fluticasone propionate nanocrystals
DE102012221219B4 (de) * 2012-11-20 2014-05-28 Jesalis Pharma Gmbh Verfahren zur Vergrößerung der Partikelgröße kristalliner Wirkstoff-Mikropartikel
US9815865B2 (en) 2013-01-07 2017-11-14 Nicox Ophthalmics, Inc. Preparations of hydrophobic therapeutic agents, methods of manufacture and use thereof

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2455976A1 (de) * 1974-11-27 1976-08-12 Merck Patent Gmbh Prostensaeurederivate
US4335121A (en) * 1980-02-15 1982-06-15 Glaxo Group Limited Androstane carbothioates
US5783677A (en) * 1993-09-24 1998-07-21 Procter & Gamble Pharmaceuticals, Inc. Deoxy and oxygen-substituted sugar-containing 14-aminosteroid compounds
US5488188A (en) * 1994-09-29 1996-01-30 Merrell Dow Pharmaceuticals Inc. Process for the preparation of (E)-1-amino-2-(fluoromethylene)-4-(p-fluorophenyl)butane, novel processes for preparing an intermediate thereof, and novel intermediates thereof
GB9622173D0 (en) * 1996-10-24 1996-12-18 Glaxo Group Ltd Particulate Products
GB9925934D0 (en) * 1999-11-03 1999-12-29 Glaxo Group Ltd Novel apparatus and process
SK287576B6 (sk) * 2000-08-05 2011-03-04 Glaxo Group Limited S-fluórmetylester kyseliny 6alfa, 9alfa-difluór-17alfa-[(2- furanylkarboxyl)oxy]-11beta-hydroxy-16alfa-metyl-3-oxo-androsta- 1,4-dién-17beta-karbotiovej, spôsob jeho prípravy, farmaceutický prostriedok s jeho obsahom, jeho použitie a medziprodukty

Also Published As

Publication number Publication date
MXPA04007530A (es) 2004-11-10
EP1474436A2 (en) 2004-11-10
NO327138B1 (no) 2009-05-04
NZ534320A (en) 2007-07-27
RU2333218C2 (ru) 2008-09-10
IS7373A (is) 2004-07-26
PL372214A1 (en) 2005-07-11
AU2003206836B2 (en) 2009-01-08
ATE446965T1 (de) 2009-11-15
RU2004122928A (ru) 2005-05-27
ZA200405826B (en) 2005-08-11
NO20043664L (no) 2004-09-01
CO5611115A2 (es) 2006-02-28
AR038390A1 (es) 2005-01-12
GB0202564D0 (en) 2002-03-20
WO2003066653A2 (en) 2003-08-14
EP1474436B1 (en) 2009-10-28
US20050222107A1 (en) 2005-10-06
CN100338087C (zh) 2007-09-19
WO2003066653A3 (en) 2003-12-24
KR20040086331A (ko) 2004-10-08
TW200410982A (en) 2004-07-01
AU2003206836A1 (en) 2003-09-02
CN1642969A (zh) 2005-07-20
CA2473896A1 (en) 2003-08-14
JP2005517019A (ja) 2005-06-09
DE60329824D1 (de) 2009-12-10

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A(S) 8A ANUIDADE(S).

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2112 DE 28/06/2011.