BR0215172A - Derivados de benzodifuranimidazolina e benzofuranimidazolina e seu emprego para o tratamento de glaucoma - Google Patents

Derivados de benzodifuranimidazolina e benzofuranimidazolina e seu emprego para o tratamento de glaucoma

Info

Publication number
BR0215172A
BR0215172A BR0215172-3A BR0215172A BR0215172A BR 0215172 A BR0215172 A BR 0215172A BR 0215172 A BR0215172 A BR 0215172A BR 0215172 A BR0215172 A BR 0215172A
Authority
BR
Brazil
Prior art keywords
derivatives
benzofuranimidazoline
benzodifuranimidazoline
glaucoma
treatment
Prior art date
Application number
BR0215172-3A
Other languages
English (en)
Portuguese (pt)
Inventor
Zixia Feng
Mark R Hellberg
Original Assignee
Alcon Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alcon Inc filed Critical Alcon Inc
Publication of BR0215172A publication Critical patent/BR0215172A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Ophthalmology & Optometry (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
BR0215172-3A 2001-12-20 2002-12-09 Derivados de benzodifuranimidazolina e benzofuranimidazolina e seu emprego para o tratamento de glaucoma BR0215172A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US34337801P 2001-12-20 2001-12-20
PCT/US2002/039316 WO2003053436A1 (en) 2001-12-20 2002-12-09 Novel benzodifuranimidazoline and benzofuranimidazoline derivatives and their use for the treatment of glaucoma

Publications (1)

Publication Number Publication Date
BR0215172A true BR0215172A (pt) 2004-10-19

Family

ID=23345873

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0215172-3A BR0215172A (pt) 2001-12-20 2002-12-09 Derivados de benzodifuranimidazolina e benzofuranimidazolina e seu emprego para o tratamento de glaucoma

Country Status (13)

Country Link
US (1) US7208512B2 (https=)
EP (1) EP1455780A4 (https=)
JP (1) JP2005513103A (https=)
KR (1) KR20040068315A (https=)
CN (1) CN1268334C (https=)
AR (1) AR037880A1 (https=)
AU (1) AU2002353088B2 (https=)
BR (1) BR0215172A (https=)
CA (1) CA2469904A1 (https=)
MX (1) MXPA04006029A (https=)
TW (1) TW593302B (https=)
WO (1) WO2003053436A1 (https=)
ZA (1) ZA200404473B (https=)

Families Citing this family (10)

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US6960579B1 (en) 1998-05-19 2005-11-01 Alcon Manufacturing, Ltd. Serotonergic 5HT7 receptor compounds for treating ocular and CNS disorders
TW593302B (en) 2001-12-20 2004-06-21 Alcon Inc Novel benzodifuranimidazoline and benzofuranimidazoline derivatives and their use for the treatment of glaucoma
CA2506204A1 (en) 2002-12-13 2004-07-01 Alcon, Inc. Novel benzopyran analogs and their use for the treatment of glaucoma
US7476687B2 (en) * 2003-11-26 2009-01-13 Alcon, Inc. Substituted furo[2,3-g]indazoles for the treatment of glaucoma
US7338972B1 (en) 2003-12-15 2008-03-04 Alcon, Inc. Substituted 1-alkylamino-1H-indazoles for the treatment of glaucoma
US7129257B1 (en) 2003-12-15 2006-10-31 Alcon, Inc. Pyrazolo[3,4- e]benzoxazoles for the treatment of glaucoma
WO2005058911A2 (en) 2003-12-15 2005-06-30 Alcon, Inc. Substituted [1,4]oxazino[2,3-g]indazoles for the treatment of glaucoma
WO2006062839A1 (en) 2004-12-08 2006-06-15 Alcon, Inc. Use of dioxindoindazoles and dioxoloindazoles for treating glaucoma
TW200744567A (en) * 2005-09-23 2007-12-16 Alcon Inc Phenylethylamine analogs and their use for treating glaucoma
US20070293475A1 (en) * 2006-06-20 2007-12-20 Alcon Manufacturing Ltd. Aryl and heteroaryl tetrahydrobenzazepine derivatives and their use for treating glaucoma

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US5011846A (en) 1988-02-23 1991-04-30 Merrell Dow Pharmaceuticals Inc. Medicament compositions derived from quinolizine and quinolizinone and methods of use thereof
AU7124691A (en) 1990-02-27 1991-08-29 Ciba-Geigy Ag Benzofurans
WO1992000338A1 (en) 1990-06-26 1992-01-09 Commonwealth Scientific And Industrial Research Organisation Polyurethane or polyurethane-urea elastomeric compositions
US5578612A (en) 1990-10-15 1996-11-26 Pfizer Inc. Indole derivatives
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GB9216380D0 (en) 1992-07-31 1992-09-16 Glaxo Group Ltd Medicaments
US5290781A (en) 1993-01-05 1994-03-01 Iolab Corporation Ketaneserinol as an agent to reduce intraocular pressure
US5891131A (en) 1993-02-01 1999-04-06 Arizona Board Of Regents Method and apparatus for automated simulation and design of corneal refractive procedures
TW334423B (en) 1993-10-22 1998-06-21 Hoffmann La Roche Tricyclic 1-aminoethylpyrrole-derivatives
TW270114B (https=) 1993-10-22 1996-02-11 Hoffmann La Roche
US5538974A (en) 1994-01-27 1996-07-23 Senju Pharamceutical Co., Ltd. Ophthalmic composition for lowering intraocular pressure
EP0686393B1 (en) 1994-03-18 1998-05-20 Senju Pharmaceutical Co., Ltd. Ophthalmic preparations containing sarpogrelate for reducing intraocular pressure
US5874477A (en) 1994-08-12 1999-02-23 The University Of Hawaii Method of treatment for malaria utilizing serotonin receptor ligands
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US5998467A (en) 1995-10-25 1999-12-07 Mitsubishi Chemical Corporation Medicine for oculopathy
AU2340997A (en) 1996-03-27 1997-10-17 Merck & Co., Inc. A method for inhibiting clot formation
US5902815A (en) 1996-09-03 1999-05-11 Washington University Use of 5HT-2A serotonin agonists to prevent adverse effects of NMDA receptor hypofunction
AU4249297A (en) 1996-10-31 1998-05-22 Alcon Laboratories, Inc. Opthalmological compositions containing serotonin 5-ht1a receptor agonist and their use in the treatment of glaucoma
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US6107324A (en) 1998-04-14 2000-08-22 Arena Pharmaceuticals Inc. 5-HT2A receptor inverse agonists
JP2002515408A (ja) 1998-05-19 2002-05-28 アルコン ラボラトリーズ， インコーポレーテッド 眼および中枢神経系疾患治療用セロトニン作動性５ｈｔ７受容体化合物
GB9819035D0 (en) 1998-09-01 1998-10-28 Cerebrus Res Ltd Chemical compounds VII
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ATE310566T1 (de) 1998-09-18 2005-12-15 Alcon Mfg Ltd 5ht2-agoniste zur behandlung des glaukoms
NZ512765A (en) 1998-12-17 2003-10-31 Wyeth Corp 2,3,4,4A-tetrahydro-1H-pyrazino(1,2-A)quinoxalin- 5(6H)one derivatives being 5HT2C agonists
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AU2042301A (en) 1999-12-03 2001-06-12 Alcon Universal Limited 1-aminoalkyl-1H-indoles for treating glaucoma
US6806285B1 (en) 2000-03-17 2004-10-19 Alcon, Inc. 5-Hydroxyl indole derivatives for treating glaucoma
PL358481A1 (en) 2000-03-17 2004-08-09 Alcon Inc. 6-hydroxy-indazole derivatives for treating glaucoma
AU1918001A (en) 2000-03-17 2001-10-03 Alcon Universal Ltd 5-hydroxy indazole derivatives for treating glaucoma
MXPA02009071A (es) 2000-03-17 2003-05-23 Alcon Inc Compuestos con actividad agonista de 5-ht 1a para tratar glaucoma..
CN1231214C (zh) 2000-03-17 2005-12-14 爱尔康公司 用于控制iop并治疗青光眼的5ht2兴奋剂
AU2001219185A1 (en) 2000-03-17 2001-10-03 Alcon, Inc. 2-acylaminobenzimidazole derivatives for treating glaucoma
DE60005566T2 (de) 2000-03-17 2004-07-29 Alcon, Inc. Pyranoindole zur glaukombehandlung
EP1392658A4 (en) 2001-06-01 2004-10-13 Alcon Inc NOVEL FUSED INDAZOLES AND INDOLES AND THEIR USE IN THE TREATMENT OF GLAUCOMES
AU2002259312B2 (en) 2001-06-01 2007-01-04 Alcon, Inc. Novel arylaminopropane analogues and their use for the treatment of glaucoma
EP1392292B1 (en) 2001-06-01 2006-03-01 Alcon, Inc. Pyranoindazoles and their use for the treatment of glaucoma
US6884816B2 (en) 2001-08-31 2005-04-26 Alcon, Inc. Hydroxy substituted fused naphthyl-azoles and fused indeno-azoles and their use for the treatment of glaucoma
AU2002364711A1 (en) 2001-12-14 2003-06-30 Alcon, Inc. Substituted 5-hydroxy-indole compounds for the treatment of glaucoma
CA2469663A1 (en) 2001-12-14 2003-06-26 Alcon, Inc. Aminoalkyl-benzofuran-5-ol compounds for the treatment of glaucoma
TW593302B (en) 2001-12-20 2004-06-21 Alcon Inc Novel benzodifuranimidazoline and benzofuranimidazoline derivatives and their use for the treatment of glaucoma
PL375564A1 (en) 2002-08-30 2005-11-28 Alcon, Inc. Substituted 5-chroman-5-yl-ethylamine compounds and their use for the treatment of glaucoma
BR0314459A (pt) 2002-09-24 2005-07-26 Univ Virginia Commonwealth Método para baixar e controlar a pressão intra-ocular e/ou para o tratamento de mamìferos sofrendo a partir de glaucoma e composto
CA2506204A1 (en) 2002-12-13 2004-07-01 Alcon, Inc. Novel benzopyran analogs and their use for the treatment of glaucoma
AU2003303477A1 (en) 2002-12-23 2004-07-22 Alcon, Inc. 1-alkyl-3-aminoindazoles

Also Published As

Publication number Publication date
TW200301257A (en) 2003-07-01
MXPA04006029A (es) 2004-09-27
CN1606441A (zh) 2005-04-13
AU2002353088B2 (en) 2006-09-21
US7208512B2 (en) 2007-04-24
AU2002353088A1 (en) 2003-07-09
EP1455780A4 (en) 2005-04-06
EP1455780A1 (en) 2004-09-15
CN1268334C (zh) 2006-08-09
TW593302B (en) 2004-06-21
ZA200404473B (en) 2005-06-07
WO2003053436A1 (en) 2003-07-03
US20060009503A1 (en) 2006-01-12
KR20040068315A (ko) 2004-07-30
AR037880A1 (es) 2004-12-09
CA2469904A1 (en) 2003-07-03
JP2005513103A (ja) 2005-05-12

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Legal Events

Date Code Title Description
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B15K Others concerning applications: alteration of classification

Free format text: PARA: INT. CL. A61K 31/4178; C07D 403/06; A61P 27/02; A61P 27/06

Ipc: A61K 31/4178 (2011.01), C07D 403/06 (2011.01), A61

B08F Application fees: application dismissed [chapter 8.6 patent gazette]

Free format text: REFERENTE 8A. ANUIDADE(S).

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2108 DE 31/05/2011.